Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA

Nature Neuroscience

Volumn 17, Issue 9, 2014, Pages 1180-1189

  Cortes, Constanza J ^a   Miranda, Helen C ^a,b   Frankowski, Harald ^a   Batlevi, Yakup ^a   Young, Jessica E ^b   Le, Amy ^a   Ivanov, Nishi ^c   Sopher, Bryce L ^c   Carromeu, Cassiano ^a   Muotri, Alysson R ^a,b,d,e,f   Garden, Gwenn A ^c   La Spada, Albert R ^a,b,d,e,f,g  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f RADY CHILDREN'S HOSPITAL   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; POLYGLUTAMINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; AR PROTEIN, HUMAN; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; PEPTIDE; TCFEB PROTEIN, MOUSE; TFEB PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL REPROGRAMMING TECHNIQUE; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INDUCED PLURIPOTENT STEM CELL; KENNEDY DISEASE; MOUSE; NEURAL STEM CELL; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN METABOLISM; TRANSACTIVATION; TRANSCRIPTION REGULATION; ANIMAL; CYTOLOGY; DISEASE MODEL; FEMALE; MALE; METABOLISM; MOTONEURON; MUSCLE ATROPHY; NUCLEAR REPROGRAMMING; PATHOLOGY; PHAGOSOME; PHYSIOLOGY; PLURIPOTENT STEM CELL; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELLULAR REPROGRAMMING; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCULAR DISORDERS, ATROPHIC; PEPTIDES; PHAGOSOMES; RECEPTORS, ANDROGEN;

EID: 84906674973     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.3787     Document Type: Article

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