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Volumn 1375, Issue 1, 2016, Pages 52-65

Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice

Author keywords

deferoxamine; iron; nonalcoholic fatty liver disease; ob ob mice

Indexed keywords

CASPASE 3; CYTOKINE; DEFEROXAMINE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; IRON; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCOUPLING PROTEIN 1;

EID: 84982840493     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.13174     Document Type: Article
Times cited : (28)

References (67)
  • 2
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    • Marchesini, G. et al. 2001. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50: 1844–1850.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1
  • 3
    • 79960847840 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment
    • Smith, B.W. & L.A. Adams. 2011. Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment. Nat. Rev. Endocrinol. 7: 456–465.
    • (2011) Nat. Rev. Endocrinol , vol.7 , pp. 456-465
    • Smith, B.W.1    Adams, L.A.2
  • 4
    • 84877039529 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: current issues and novel treatment approaches
    • Lomonaco, R. et al. 2013. Nonalcoholic fatty liver disease: current issues and novel treatment approaches. Drugs 73: 1–14.
    • (2013) Drugs , vol.73 , pp. 1-14
    • Lomonaco, R.1
  • 5
    • 84875679556 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals
    • Masuoka, H.C. & N. Chalasani. 2013. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann. N.Y. Acad. Sci. 1281: 106–122.
    • (2013) Ann. N.Y. Acad. Sci , vol.1281 , pp. 106-122
    • Masuoka, H.C.1    Chalasani, N.2
  • 6
    • 1442281989 scopus 로고    scopus 로고
    • Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    • Bugianesi, E. et al. 2004. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology 39: 179–187.
    • (2004) Hepatology , vol.39 , pp. 179-187
    • Bugianesi, E.1
  • 7
    • 0031915149 scopus 로고    scopus 로고
    • Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
    • George, D.K. et al. 1998. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 114: 311–318.
    • (1998) Gastroenterology , vol.114 , pp. 311-318
    • George, D.K.1
  • 8
    • 84939178806 scopus 로고    scopus 로고
    • The potential role of iron and copper in pediatric obesity and nonalcoholic fatty liver disease
    • Feldman, A. et al. 2015. The potential role of iron and copper in pediatric obesity and nonalcoholic fatty liver disease. Biomed. Res. Int. 2015: 287401.
    • (2015) Biomed. Res. Int , vol.2015 , pp. 287401
    • Feldman, A.1
  • 9
    • 69249240216 scopus 로고    scopus 로고
    • Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury
    • Kim, Y.W. et al. 2009. Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury. Free Radic. Biol. Med. 47: 1082–1092.
    • (2009) Free Radic. Biol. Med , vol.47 , pp. 1082-1092
    • Kim, Y.W.1
  • 10
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case–control study
    • Valenti, L. et al. 2007. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case–control study. Am. J. Gastroenterol. 102: 1251–1258.
    • (2007) Am. J. Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1
  • 11
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
    • Facchini, F.S., N.W. Hua & R.A. Stoohs. 2002. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology 122: 931–939.
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 12
    • 79957930356 scopus 로고    scopus 로고
    • Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats
    • Kaji, K. et al. 2011. Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 300: G1094–G1104.
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol , vol.300 , pp. G1094-G1104
    • Kaji, K.1
  • 13
    • 43549087627 scopus 로고    scopus 로고
    • Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
    • Aigner, E. et al. 2008. Pathways underlying iron accumulation in human nonalcoholic fatty liver disease. Am. J. Clin. Nutr. 87: 1374–1383.
    • (2008) Am. J. Clin. Nutr , vol.87 , pp. 1374-1383
    • Aigner, E.1
  • 14
    • 84871697072 scopus 로고    scopus 로고
    • [Iron chelating therapy in adults: how and when?]
    • Ruivard, M. 2013. [Iron chelating therapy in adults: how and when?]. Rev. Med. Interne 34: 32–38.
    • (2013) Rev. Med. Interne , vol.34 , pp. 32-38
    • Ruivard, M.1
  • 15
    • 84869080922 scopus 로고    scopus 로고
    • Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease
    • Guo, C. et al. 2013. Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease. Neurobiol. Aging 34: 562–575.
    • (2013) Neurobiol. Aging , vol.34 , pp. 562-575
    • Guo, C.1
  • 16
    • 84925348570 scopus 로고    scopus 로고
    • Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinson's disease
    • Fine, J.M. et al. 2014. Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinson's disease. Brain Res. 1574: 96–104.
    • (2014) Brain Res , vol.1574 , pp. 96-104
    • Fine, J.M.1
  • 17
    • 84936118142 scopus 로고    scopus 로고
    • Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice
    • Guo, C. et al. 2015. Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice. Front. Aging Neurosci. 7: 104.
    • (2015) Front. Aging Neurosci , vol.7 , pp. 104
    • Guo, C.1
  • 18
    • 84907999177 scopus 로고    scopus 로고
    • The role of iron in brain ageing and neurodegenerative disorders
    • Ward, R.J. et al. 2014. The role of iron in brain ageing and neurodegenerative disorders. Lancet Neurol. 13: 1045–1060.
    • (2014) Lancet Neurol , vol.13 , pp. 1045-1060
    • Ward, R.J.1
  • 19
    • 51049103235 scopus 로고    scopus 로고
    • Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals
    • Tacchini, L. et al. 2008. Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J. Biol. Chem. 283: 20674–20686.
    • (2008) J. Biol. Chem , vol.283 , pp. 20674-20686
    • Tacchini, L.1
  • 20
    • 83455242995 scopus 로고    scopus 로고
    • Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice
    • Tajima, S. et al. 2011. Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice. Am. J. Physiol. Endocrinol. Metab. 302: E77–E86.
    • (2011) Am. J. Physiol. Endocrinol. Metab , vol.302 , pp. E77-E86
    • Tajima, S.1
  • 21
    • 72249123561 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine, deferoxamine and selenium on doxorubicin-induced hepatotoxicity
    • Bulucu, F. et al. 2009. Effects of N-acetylcysteine, deferoxamine and selenium on doxorubicin-induced hepatotoxicity. Biol. Trace Elem. Res. 132: 184–196.
    • (2009) Biol. Trace Elem. Res , vol.132 , pp. 184-196
    • Bulucu, F.1
  • 22
    • 40449120460 scopus 로고    scopus 로고
    • Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver
    • Dongiovanni, P. et al. 2008. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am. J. Pathol. 172: 738–747.
    • (2008) Am. J. Pathol , vol.172 , pp. 738-747
    • Dongiovanni, P.1
  • 23
    • 0030999169 scopus 로고    scopus 로고
    • The long-acting parenteral iron chelator, hydroxyethyl starch–deferoxamine, fails to protect against alcohol-induced liver injury in rats
    • Sadrzadeh, S.M., P.E. Hallaway & A.A. Nanji. 1997. The long-acting parenteral iron chelator, hydroxyethyl starch–deferoxamine, fails to protect against alcohol-induced liver injury in rats. J. Pharmacol. Exp. Ther. 280: 1038–1042.
    • (1997) J. Pharmacol. Exp. Ther , vol.280 , pp. 1038-1042
    • Sadrzadeh, S.M.1    Hallaway, P.E.2    Nanji, A.A.3
  • 24
    • 84923348924 scopus 로고    scopus 로고
    • Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice
    • Zhang, Y. et al. 2014. Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice. Sci. Rep. 4: 7375.
    • (2014) Sci. Rep , vol.4 , pp. 7375
    • Zhang, Y.1
  • 25
    • 84889763950 scopus 로고    scopus 로고
    • Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease
    • Wang, C.Y. et al. 2013. Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-κB pathway in a transgenic mouse model of Alzheimer's disease. Antioxid. Redox Signal. 19: 2024–2039.
    • (2013) Antioxid. Redox Signal , vol.19 , pp. 2024-2039
    • Wang, C.Y.1
  • 26
    • 84929629712 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: a search for factual animal models
    • Sanches, S.C. et al. 2015. Nonalcoholic steatohepatitis: a search for factual animal models. Biomed. Res. Int. 2015: 574832.
    • (2015) Biomed. Res. Int , vol.2015 , pp. 574832
    • Sanches, S.C.1
  • 27
    • 84859615812 scopus 로고    scopus 로고
    • Dichotomous effects of VEGF-A on adipose tissue dysfunction
    • Sun, K. et al. 2012. Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc. Natl. Acad. Sci. U.S.A. 109: 5874–5879.
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 5874-5879
    • Sun, K.1
  • 28
    • 0033695790 scopus 로고    scopus 로고
    • Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice
    • Memon, R.A. et al. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 141: 4021–4031.
    • (2000) Endocrinology , vol.141 , pp. 4021-4031
    • Memon, R.A.1
  • 29
    • 33745151403 scopus 로고    scopus 로고
    • Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity
    • Uno, K. et al. 2006. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science 312: 1656–1659.
    • (2006) Science , vol.312 , pp. 1656-1659
    • Uno, K.1
  • 30
    • 41749107727 scopus 로고    scopus 로고
    • Long-term hypoxia modulates expression of key genes regulating adipose function in the late-gestation ovine fetus
    • Myers, D.A. et al. 2008. Long-term hypoxia modulates expression of key genes regulating adipose function in the late-gestation ovine fetus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R1312–R1318.
    • (2008) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.294 , pp. R1312-R1318
    • Myers, D.A.1
  • 31
    • 70349972775 scopus 로고    scopus 로고
    • Apoptosis and cytokines in non-alcoholic steatohepatitis
    • Syn, W.K., S.S. Choi & A.M. Diehl. 2009. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin. Liver Dis. 13: 565–580.
    • (2009) Clin. Liver Dis , vol.13 , pp. 565-580
    • Syn, W.K.1    Choi, S.S.2    Diehl, A.M.3
  • 32
    • 0032898080 scopus 로고    scopus 로고
    • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
    • Rashid, A. et al. 1999. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 29: 1131–1138.
    • (1999) Hepatology , vol.29 , pp. 1131-1138
    • Rashid, A.1
  • 33
    • 84884984539 scopus 로고    scopus 로고
    • Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
    • Begriche, K. et al. 2013. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology 58: 1497–1507.
    • (2013) Hepatology , vol.58 , pp. 1497-1507
    • Begriche, K.1
  • 34
    • 69249233513 scopus 로고    scopus 로고
    • Role of hepatic iron in non-alcoholic steatohepatitis
    • Sumida, Y., T. Yoshikawa & T. Okanoue. 2009. Role of hepatic iron in non-alcoholic steatohepatitis. Hepatol. Res. 39: 213–222.
    • (2009) Hepatol. Res , vol.39 , pp. 213-222
    • Sumida, Y.1    Yoshikawa, T.2    Okanoue, T.3
  • 35
    • 1642450652 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice
    • Redaelli, C.A. et al. 2004. Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice. J. Hepatol. 40: 305–312.
    • (2004) J. Hepatol , vol.40 , pp. 305-312
    • Redaelli, C.A.1
  • 36
    • 37049034490 scopus 로고    scopus 로고
    • Liver proteome analysis of adaptive response in rat immediately after partial hepatectomy
    • Sun, Y. et al. 2007. Liver proteome analysis of adaptive response in rat immediately after partial hepatectomy. Proteomics 7: 4398–4407.
    • (2007) Proteomics , vol.7 , pp. 4398-4407
    • Sun, Y.1
  • 37
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
    • Richard, D.E. et al. 1999. p42/p44 Mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274: 32631–32637.
    • (1999) J. Biol. Chem , vol.274 , pp. 32631-32637
    • Richard, D.E.1
  • 38
    • 10844278331 scopus 로고    scopus 로고
    • 2-terminal kinase activation contributes to hypoxia-inducible factor 1α–dependent P-glycoprotein expression in hypoxia
    • 2-terminal kinase activation contributes to hypoxia-inducible factor 1α–dependent P-glycoprotein expression in hypoxia. Cancer Res. 64: 9057–9061.
    • (2004) Cancer Res , vol.64 , pp. 9057-9061
    • Comerford, K.M.1    Cummins, E.P.2    Taylor, C.T.3
  • 39
    • 52649094346 scopus 로고    scopus 로고
    • Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice
    • Yu, X.X. et al. 2008. Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice. Am. J. Physiol. Endocrinol. Metab. 295: E436–E445.
    • (2008) Am. J. Physiol. Endocrinol. Metab , vol.295 , pp. E436-E445
    • Yu, X.X.1
  • 40
    • 84920416403 scopus 로고    scopus 로고
    • Transdermal deferoxamine prevents pressure-induced diabetic ulcers
    • Duscher, D. et al. 2015. Transdermal deferoxamine prevents pressure-induced diabetic ulcers. Proc. Natl. Acad. Sci. U.S.A. 112: 94–99.
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. 94-99
    • Duscher, D.1
  • 41
    • 84879601468 scopus 로고    scopus 로고
    • Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1α
    • Hou, Z. et al. 2013. Deferoxamine enhances neovascularization and accelerates wound healing in diabetic rats via the accumulation of hypoxia-inducible factor-1α. Diabetes Res. Clin. Pract. 101: 62–71.
    • (2013) Diabetes Res. Clin. Pract , vol.101 , pp. 62-71
    • Hou, Z.1
  • 42
    • 33646109792 scopus 로고    scopus 로고
    • Gene expression analysis identifies novel genes participating in early murine liver development and adult liver regeneration
    • Jochheim-Richter, A. et al. 2006. Gene expression analysis identifies novel genes participating in early murine liver development and adult liver regeneration. Differentiation 74: 167–173.
    • (2006) Differentiation , vol.74 , pp. 167-173
    • Jochheim-Richter, A.1
  • 43
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: getting both pathology and metabolic context right
    • Larter, C.Z. & M.M. Yeh. 2008. Animal models of NASH: getting both pathology and metabolic context right. J. Gastroenterol. Hepatol. 23: 1635–1648.
    • (2008) J. Gastroenterol. Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 44
    • 33644903818 scopus 로고    scopus 로고
    • Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis
    • Selzner, N. et al. 2006. Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis. J. Hepatol. 44: 694–701.
    • (2006) J. Hepatol , vol.44 , pp. 694-701
    • Selzner, N.1
  • 45
    • 84903530386 scopus 로고    scopus 로고
    • Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia
    • Chu, M.J. et al. 2014. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia. PLoS One 9: e100609.
    • (2014) PLoS One , vol.9
    • Chu, M.J.1
  • 46
    • 3543038191 scopus 로고    scopus 로고
    • Histological resolution of steatohepatitis after iron depletion
    • Riquelme, A. et al. 2004. Histological resolution of steatohepatitis after iron depletion. Dig. Dis. Sci. 49: 1012–1015.
    • (2004) Dig. Dis. Sci , vol.49 , pp. 1012-1015
    • Riquelme, A.1
  • 47
    • 79957930356 scopus 로고    scopus 로고
    • Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats
    • Kaji, K. et al. 2010. Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 300: G1094–G1104.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol , vol.300 , pp. G1094-G1104
    • Kaji, K.1
  • 48
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression
    • Yu, S. et al. 2003. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression. J. Biol. Chem. 278: 498–505.
    • (2003) J. Biol. Chem , vol.278 , pp. 498-505
    • Yu, S.1
  • 49
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Minokoshi, Y. et al. 2002. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415: 339–343.
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1
  • 50
    • 33747175979 scopus 로고    scopus 로고
    • Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets
    • Lee, Y.M. et al. 2006. Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition 22: 956–964.
    • (2006) Nutrition , vol.22 , pp. 956-964
    • Lee, Y.M.1
  • 51
    • 84902096220 scopus 로고    scopus 로고
    • The molecular biology of human iron metabolism
    • Winter, W.E., L.A. Bazydlo & N.S. Harris. 2014. The molecular biology of human iron metabolism. Lab. Med. 45: 92–102.
    • (2014) Lab. Med , vol.45 , pp. 92-102
    • Winter, W.E.1    Bazydlo, L.A.2    Harris, N.S.3
  • 52
    • 0037354165 scopus 로고    scopus 로고
    • Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells
    • Videla, L.A. et al. 2003. Oxidative stress-mediated hepatotoxicity of iron and copper: role of Kupffer cells. Biometals 16: 103–111.
    • (2003) Biometals , vol.16 , pp. 103-111
    • Videla, L.A.1
  • 53
    • 23744439083 scopus 로고    scopus 로고
    • Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
    • Gunton, J.E. et al. 2005. Loss of ARNT/HIF1β mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122: 337–349.
    • (2005) Cell , vol.122 , pp. 337-349
    • Gunton, J.E.1
  • 54
    • 79954567178 scopus 로고    scopus 로고
    • Cell death and nonalcoholic steatohepatitis: where is ballooning relevant
    • Machado, M.V. & H. Cortez-Pinto. 2011. Cell death and nonalcoholic steatohepatitis: where is ballooning relevant? Expert Rev. Gastroenterol. Hepatol. 5: 213–222.
    • (2011) Expert Rev. Gastroenterol. Hepatol , vol.5 , pp. 213-222
    • Machado, M.V.1    Cortez-Pinto, H.2
  • 55
    • 33750628734 scopus 로고    scopus 로고
    • Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease
    • Panasiuk, A. et al. 2006. Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease. World J. Gastroenterol. 12: 6198–6202.
    • (2006) World J. Gastroenterol , vol.12 , pp. 6198-6202
    • Panasiuk, A.1
  • 56
    • 0035991444 scopus 로고    scopus 로고
    • In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
    • Seki, S. et al. 2002. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J. Hepatol. 37: 56–62.
    • (2002) J. Hepatol , vol.37 , pp. 56-62
    • Seki, S.1
  • 57
    • 15444375341 scopus 로고    scopus 로고
    • Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling
    • Schattenberg, J.M. et al. 2005. Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. J. Biol. Chem. 280: 9887–9894.
    • (2005) J. Biol. Chem , vol.280 , pp. 9887-9894
    • Schattenberg, J.M.1
  • 58
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro, P.S. et al. 2004. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am. J. Gastroenterol. 99: 1708–1717.
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1
  • 59
    • 0345382798 scopus 로고    scopus 로고
    • Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death
    • Kim, B. S. et al. 2002. Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death. Cell. Immunol. 220: 96–106.
    • (2002) Cell. Immunol , vol.220 , pp. 96-106
    • Kim, B.S.1
  • 60
    • 33747359592 scopus 로고    scopus 로고
    • p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes
    • Lee, S.K. et al. 2006. p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes. Life Sci. 79: 1419–1427.
    • (2006) Life Sci , vol.79 , pp. 1419-1427
    • Lee, S.K.1
  • 61
    • 30344450087 scopus 로고    scopus 로고
    • Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells
    • Jin, H.O. et al. 2006. Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric oxide in human glioblastoma cells. J. Cell. Physiol. 206: 477–486.
    • (2006) J. Cell. Physiol , vol.206 , pp. 477-486
    • Jin, H.O.1
  • 62
    • 33746101818 scopus 로고    scopus 로고
    • Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
    • Tuncman, G. et al. 2006. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 103: 10741–10746.
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 10741-10746
    • Tuncman, G.1
  • 63
    • 77952579449 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression
    • Jung, Y. & A.M. Diehl. 2010. Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progression. Dig. Dis. 28: 225–228.
    • (2010) Dig. Dis , vol.28 , pp. 225-228
    • Jung, Y.1    Diehl, A.M.2
  • 64
    • 84910045079 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha in hepatic fibrosis: a promising therapeutic target
    • Zhan, L. et al. 2015. Hypoxia-inducible factor-1alpha in hepatic fibrosis: a promising therapeutic target. Biochimie 108: 1–7.
    • (2015) Biochimie , vol.108 , pp. 1-7
    • Zhan, L.1
  • 65
    • 11244315697 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    • Manalo, D.J. et al. 2005. Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659–669.
    • (2005) Blood , vol.105 , pp. 659-669
    • Manalo, D.J.1
  • 66
    • 38349111676 scopus 로고    scopus 로고
    • Role of the hypoxia inducible factors HIF in iron metabolism
    • Peyssonnaux, C., V. Nizet & R.S. Johnson. 2008. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 7: 28–32.
    • (2008) Cell Cycle , vol.7 , pp. 28-32
    • Peyssonnaux, C.1    Nizet, V.2    Johnson, R.S.3
  • 67
    • 0033985856 scopus 로고    scopus 로고
    • Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway
    • Selzner, M. & P.A. Clavien. 2000. Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Hepatology 31: 35–42.
    • (2000) Hepatology , vol.31 , pp. 35-42
    • Selzner, M.1    Clavien, P.A.2


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