p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes

Life Sciences

Volumn 79, Issue 15, 2006, Pages 1419-1427

  Lee, Sun Kyung ^a   Jang, Hyun Ju ^a   Lee, Hwa Jeong ^a   Lee, Jun ^a   Jeon, Byung Hun ^b   Jun, Chang Duk ^c   Lee, Suk Keun ^d   Kim, Eun Cheol ^a  

^a Wonkwang University   (South Korea)

^b Wonkwang University   (South Korea)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

^d Gangneung Wonju National University   (South Korea)

Author keywords

Apoptosis; Deferoxamine; Differentiation; ERK; Immortalized keratinocytes; Iron; MAP kinase; Oral cancer; p38

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CASPASE 8; CYTOCHROME C; CYTOKERATIN 19; CYTOKERATIN 6; DEFEROXAMINE; INVOLUCRIN; IRON CHELATING AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL DEATH; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KERATINOCYTE; MOUTH CANCER;

APOPTOSIS; CASPASE 3; CASPASE 8; CASPASES; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOCHROMES C; DEFEROXAMINE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FERRIC COMPOUNDS; FLAVONOIDS; HUMANS; IMIDAZOLES; IRON CHELATING AGENTS; KERATINOCYTES; MOUTH NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PROTEIN PRECURSORS; PYRIDINES;

EID: 33747359592     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.04.011     Document Type: Article

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