In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases

Journal of Hepatology

Volumn 37, Issue 1, 2002, Pages 56-62

  Seki, Shuichi ^a   Kitada, Takuya ^a   Yamada, Takao ^a   Sakaguchi, Hiroki ^a   Nakatani, Kazuki ^a   Wakasa, Kenichi ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

4 hydroxy 2 nonenal; 8 hydroxydeoxyguanosine; Immunohistochemistry; Non alcoholic fatty liver disease; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; 4-HYDROXY-2-NONENAL; 8-OXO-7-HYDRODEOXYGUANOSINE; ALDEHYDE; DEOXYGUANOSINE; 8-HYDROXY-2'-DEOXYGUANOSINE; DRUG DERIVATIVE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DISEASE MARKER; DNA DAMAGE; FATTY LIVER; FEMALE; HEPATITIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER CARCINOGENESIS; LIVER CELL; LIVER FIBROSIS; LIVER SINUSOID; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; CHEMISTRY; LIVER; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; ALDEHYDES; DEOXYGUANOSINE; DNA DAMAGE; FATTY LIVER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; MALE; MIDDLE AGED; OXIDATIVE STRESS;

EID: 0035991444     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(02)00073-9     Document Type: Article

References (50)

1. Non-alcoholic fatty liver disease: A spectrum of clinical and pathological study
2. Non-alcoholic steatohepatitis (NASH): A disease of emerging identity and importance
3. Non-alcoholic steatohepatitis
4. Review: Non-alcoholic steatohepatitis
5. Non-alcoholic steatohepatitis: An expanded clinical entity
6. The natural history of non-alcoholic fatty liver: A follow-up study
7. The natural history of non-alcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
8. Non-alcoholic steatohepatitis: A study of 49 patient
9. Non-alcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
10. Non-alcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
11. Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis
12. Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes
13. Steatohepatitis: A tale of two 'Hits'
14. Free radicals, antioxidant, and human disease: Curiosity, cause, or consequence?
15. Free-radical mechanisms in tissue injury
16. Mechanism and effects of lipid peroxidation
17. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes
18. The role of lipid peroxidation in liver damage
19. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen expression in human fat-storing cells
20. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis
21. Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?
22. In situ detection of lipid peroxidation by-products in chronic liver diseases
23. In situ detection of lipid peroxidation in chronic hepatitis C: Correlation with pathological features
24. Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury
25. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxoG
26. Analysis of a form of oxidative DNA damage 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
27. Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA
28. Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress
29. Formation of 8-hydroxydeoxyguanosine in DNA by oxygen radicals and its biological significance
30. Increased formation of oxidative DNA damage 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis
31. In situ detection of oxidative DNA damage 8-hydroxydeoxyguanosine, in chronic human liver disease
32. Non-alcoholic steatohepatitis: A proposal for grading and staging the histological lesions
33. Alcoholic and non-alcoholic steatohepatitis pathology
34. The monoclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct
35. Quantitative immunohistochemical detection of 8-hydroxy-2-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis
36. The lipid peroxidation product 4-hydroxynonenal is formed by-and is able to attract-rat neutrophiis in vivo
37. Reactive oxygen species activate the transcription factor NF-κB in the liver by induction of lipid peroxidation
38. The cellular basis of hepatic fibrosis
39. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers
40. Hepatic stellate cell activation in non-alcoholic steatohepatitis and fatty liver
41. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis
42. Persistent oxidative stress in human colorectal carcinoma, but not in adenoma
43. 8-Hydroxyguanosine, a DNA adduct formed by oxygen radicals: Its implication on oxygen radical-involved mutagenesis/carcinogenesis
44. Role of oxidative DNA damage in cancer initiation and promotion
45. The role of 8-hydroxyguanine in carcinogenesis
46. Energy balance and cancers
47. Increased blood glucose, insulin, body size and incident of colorectal cancer
48. Adiposity as a risk determinant for postmenopausal breast cancer
49. Hepatic hyperplasia in non-cirrhotic fatty livers: Is obesity-related hepatic steatosis a premalignant condition?
50. Mitochondrial adaptations to obesity-related oxidant stress