The molecular biology of human iron metabolism

Lab Medicine

Volumn 45, Issue 2, 2014, Pages 92-102

  Winter, William E ^a,b   Bazydlo, Lindsay A L ^a   Harris, Neil S ^a  

^a and Laboratory Medicine ^*  (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Bone morphogenetic protein; Ceruloplasmin; Divalent metal ion transporter 1; Ferritin; Ferroportin; Hemochromatosis; Hemojuvelin; Hepcidin; Hephaestin; HFE; Iron; Total body iron; Transferrin; Transferrin receptor

Indexed keywords

HEPCIDIN; IRON; TRANSFERRIN; CATION TRANSPORT PROTEIN; FERRITIN; HEMOGLOBIN; HEMOSIDERIN; METAL TRANSPORTING PROTEIN 1; MYOGLOBIN; TRANSFERRIN RECEPTOR;

ARTICLE; BONE MARROW; ERYTHROBLAST; ERYTHROPOIESIS; HEMOGLOBIN SYNTHESIS; HUMAN; INFLAMMATION; INTESTINE CELL; IRON DEFICIENCY; IRON METABOLISM; IRON TRANSPORT; LIVER CELL; MACROPHAGE; MOLECULAR BIOLOGY; OXYGEN TENSION; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIESIS; HOMEOSTASIS; IRON DEFICIENCY ANEMIA; IRON OVERLOAD; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN SUBUNIT; REVIEW;

ANEMIA, IRON-DEFICIENCY; CATION TRANSPORT PROTEINS; FERRITINS; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HEMOGLOBINS; HEMOSIDERIN; HEPCIDINS; HOMEOSTASIS; HUMANS; IRON; IRON OVERLOAD; MYOGLOBIN; PROTEIN SUBUNITS; RECEPTORS, TRANSFERRIN; TRANSFERRIN;

EID: 84902096220     PISSN: 00075027     EISSN: 19437730     Source Type: Journal    
DOI: 10.1309/LMF28S2GIMXNWHMM     Document Type: Article

References (43)

1. Tandara L, Salamunic I. Iron metabolism: current facts and future directions. Biochem Med (Zagreb). 2012;22(3):311-328.
2. Lozoff B. Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction. J Nutr. 2011;141(4):740S-746S.
3. Peirano PD, Algarín CR, Chamorro R, et al. Sleep and neurofunctions throughout child development: lasting effects of early iron deficiency. J Pediatr Gastroenterol Nutr. 2009;48 Suppl 1:S8-S15.
4. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64(5, pt 2):S34-S43.
5. Andrews NC. Disorders of iron metabolism. N Engl J Med. 1999;341:1986-1995.
6. Ponka P, Beaumont C, Richardson DR. Function and regulation of transferrin and ferritin. Semin Hematol. 1998;35(1):35-54.
7. Hershko C, Patz J, Ronson A. The anemia of achylia gastrica revisited. Blood Cells Mol Dis. 2007;39(2):178-183.
8. Muhsen K, Cohen D. Helicobacter pylori infection and iron stores: a systematic review and meta-analysis. Helicobacter. 2008;13(5):323-340.
9. Hershko C, Skikne B. Pathogenesis and management of iron deficiency anemia: emerging role of celiac disease, Helicobacter pylori, and autoimmune gastritis. Semin Hematol. 2009;46(4):339-350.
10. Wang J, Pantopoulos K. Regulation of cellular iron metabolism. Biochem J. 2011;434(3):365-381.
11. Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu Rev Med. 2011;62:347-360.
12. Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program. 2011;2011:538-542.
13. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012;1823:1434-1443.
14. De Domenico I, Ward DM, Kaplan J. Hepcidin and ferroportin: the new players in iron metabolism. Semin Liver Dis. 2011;31(3):272-279.
15. Ward DM, Kaplan J. Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012;1823(9):1426-1433.
16. Anderson CP, Shen M, Eisenstein RS, Leibold EA. Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta. 2012;1823(9):1468-1483.
17. Núñez MT. Regulatory mechanisms of intestinal iron absorption: uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis. Biofactors. 2010;36(2):88-97.
18. Wally J, Buchanan SK. A structural comparison of human serum transferrin and human lactoferrin. Biometals. 2007;20:249-262.
19. Sargent PJ, Farnaud S, Evans RW. Structure/function overview of proteins involved in iron storage and transport. Curr Med Chem. 2005;12:2683-2693.
20. Cabantchik ZI, Breuer W, Zanninelli G, Cianciulli P. LPI-labile plasma iron in iron overload. Best Pract Res Clin Haematol. 2005;18(2):277-287.
21. Taher AT, Musallam KM, Inati A. Iron overload: consequences, assessment, and monitoring. Hemoglobin. 2009;33 Suppl 1:S46-S57.
22. Knutson MD. Steap proteins: implications for iron and copper metabolism. Nutr Rev. 2007;65(7):335-340.
23. Lill R, Hoffmann B, Molik S, et al. The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism. Biochim Biophys Acta. 2012;1823(9):1491-1508.
24. Recalcati S, Locati M, Cairo G. Systemic and cellular consequences of macrophage control of iron metabolism. Semin Immunol. 2012;24(6):393-398.
25. Leone A and Mercer JFB, eds. Copper Transport and its Disorders: Molecular and Cellular Aspects. Philadelphia: Springer; 1999.
26. Anderson GJ, Frazer DM, McLaren GD. Iron absorption and metabolism. Curr Opin Gastroenterol. 2009;25(2):129-135.
27. Vermeulen E, Vermeersch P. Hepcidin as a biomarker for the diagnosis of iron metabolism disorders: a review. Acta Clin Belg. 2012;67(3):190-197.
28. Stoian I, Manolescu B, Atanasiu V, Lupescu O, Buşu C.IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism. Rom J Intern Med. 2007;45(3):305-309.
29. Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML. The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin Immunol. 2006;121(2):144-158.
30. Sebastiani G, Walker AP. HFE gene in primary and secondary hepatic iron overload. World J Gastroenterol. 2007;13(35):4673-4689.
31. Camaschella C, Poggiali E. Inherited disorders of iron metabolism. Curr Opin Pediatr. 2011;23(1):14-20.
32. Browne SA, Reddan D. Potential role of bone morphogenetic protein (BMP) signalling as a potential therapeutic target for modification of iron balance. Nephrol Dial Transplant. 2009;24(1):28-30.
33. Ponka P. Rare causes of hereditary iron overload. Semin Hematol. 2002;39(4):249-262.
34. 2 tension. Proc Natl Acad Sci U S A. 1995;92(12):5510-5514.
35. Ganz T, Nemeth E. Iron metabolism: interactions with normal and disordered erythropoiesis. Cold Spring Harb Perspect Med. 2012;2(5):a011668.
36. Ramsay AJ, Hooper JD, Folgueras AR, Velasco G, López-Otín C. Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis. Haematologica. 2009;94(6):840-849.
37. Silvestri L, Pagani A, Camaschella C. Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood. 200815;111(2):924-931.
38. Thomas G. Furin at the cutting edge: From protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002;3:753-766.
39. Muñoz M, García-Erce JA, Remacha AF. Disorders of iron metabolism. Part 1: molecular basis of iron homoeostasis. J Clin Pathol. 2011;64(4):281-286.
40. Muñoz M, García-Erce JA, Remacha ÁF. Disorders of iron metabolism. Part II: iron deficiency and iron overload. J Clin Pathol. 2011;64(4):287-296.
41. Aigner E, Theurl I, Theurl M, et al. Pathways underlying iron accumulation in human nonalcoholic fatty liver disease. Am J Clin Nutr. 2008;87(5):1374-1383.
42. Fujita N, Sugimoto R, Takeo M, et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med. 2007;13(1-2):97-104.
43. Ohtake T, Saito H, Hosoki Y, et al. Hepcidin is down-regulated in alcohol loading. Alcohol Clin Exp Res. 2007 Jan;31(1 Suppl):S2-S8.