Case report: Histological resolution of steatohepatitis after iron depletion

Digestive Diseases and Sciences

Volumn 49, Issue 6, 2004, Pages 1012-1015

  Riquelme, Arnoldo ^a   Soza, Alejandro ^a   Nazal, Leyla ^a   Martínez, Gabriel ^a   Kolbach, Marianne ^a   Patillo, Alejandro ^a   Arellano, Marcos ^a   Duarte, Ignacio ^a   Martínez, Jorge ^a   Molgó, Monserrat ^a   Arrese, Marco ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

iron overload; nonalcoholic steatohepatitis; phlebotomy; porphyria cutanea tarda

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; HEMOGLOBIN; HFE PROTEIN; IRON;

ADULT; ARTICLE; BETA THALASSEMIA; BILE DUCT STONE; CASE REPORT; CHOLECYSTECTOMY; CLINICAL FEATURE; ECHOGRAPHY; ELECTROPHORESIS; FEMALE; GENE MUTATION; GENETIC ANALYSIS; HEPATITIS VIRUS; HISTOLOGY; HUMAN; IRON BLOOD LEVEL; IRON DEPLETION; LIVER BIOPSY; LIVER SURGERY; MICROCYTIC ANEMIA; NONALCOHOLIC FATTY LIVER; PHLEBOTOMY; PORPHYRIA CUTANEA TARDA; PRIORITY JOURNAL; FATTY LIVER; HEPATITIS; IRON OVERLOAD; MIDDLE AGED; PATHOLOGY;

FATTY LIVER; FEMALE; HEPATITIS; HUMANS; IRON OVERLOAD; MIDDLE AGED; PHLEBOTOMY;

EID: 3543038191     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:DDAS.0000034564.68307.39     Document Type: Article

References (24)

1. Ludwig J, Viggiano TR, McGill DB, Oh BJ: Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55:434-438, 1980
2. Matteoni CA, Younossi ZM, Gramlich T, Boparai N, Liu YC, McCullough AJ: Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity. Gastroenterology 116:1413-1419, 1999
3. Day CP, James OF: Steatohepatitis: A tale of two "hits"? Gastroenterology 114:842-845, 1998
4. Chitturi S, George J: Interaction of iron, insulin resistance, and non-alcoholic steatohepatitis. Curr Gastroenterol Rep 5:18-25, 2003
5. Khan MF, Wu X, Tipnis UR, Ansari GA, Boor PJ: Protein adducts of malondialdehyde and 4-hydroxynonenal in livers of iron loaded rats: quantitation and localization. Toxicology 173:193-201, 2002
6. George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, Jazwinska EC, et al.: Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 114:311-318, 1998
7. Fernandez-Real JM, Penarroja G, Castro A, Garcia-Bragado F, Hernandez-Aguado I, Ricart W: Blood letting in high-ferritin type 2 diabetes: Effects on insulin sensitivity and beta-cell function. Diabetes 51:1000-1004, 2002
8. Yu AS, Keeffe EB: Nonalcoholic fatty liver disease. Rev Gastroenterol Disord 2:11-19, 2002
9. Harrison SA, Torgerson S, Hayashi PH: The natural history of non-alcoholic fatty liver disease: A clinical histopathological study. Am J Gastroenterol 98:2042-2047, 2003
10. Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, et al.: Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123:134-140, 2002
11. Marrero JA, Fontana RJ, Su GL, Conjeevaram HS, Emick DM, Lok AS: NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States. Hepatology 36:1349-1354, 2002
12. Angulo P, Keach JC, Batts KP, Lindor KD: Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30:1356-1362, 1999
13. Letteron P, Fromenty B, Terris B, Degott C, Pessayre D: Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice. J Hepatol 24:200-208, 1996
14. Strauss RS: Comparison of serum concentrations of alpha-tocopherol and beta-carotene in a cross-sectional sample of obese and nonobese children (NHANES III). National Health and Nutrition Examination Survey. J Pediatr 134:160-165, 1999
15. Tilg H, Diehl AM: Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 343:1467-1476, 2000
16. Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G, Colina F, et al.: Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 38:999-1007, 2003
17. Robertson G, Leclercq I, Farrell GC: Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 281:G1135-G1139, 2001
18. Lee KS, Buck M, Houglum K, Chojkier M: Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-2468, 1995
19. Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M: Stimulation of collagen alpha 1(1) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis? Hepatology 19:1262-1271, 1994
20. Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA: Nonalcoholic steatohepatitis: An expanded clinical entity. Gastroenterology 107:1103-1109, 1994
21. Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, Natale S, et al.: Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37:917-923, 2003
22. Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, Karim R, et al.: NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 35:373-379, 2002
23. Facchini FS, Hua NW, Stoohs RA: Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology 122:931-939, 2002
24. Valenti L, Fracanzani AL, Fargion S: Effect of iron depletion in patients with nonalcoholic fatty liver disease without carbohydrate intolerance. Gastroenterology 124:866, 2003