Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death

Cellular Immunology

Volumn 220, Issue 2, 2002, Pages 96-106

  Kim, Beom Su ^a   Yoon, Kwon Ha ^a   Oh, Hyun Mee ^a   Choi, Eun Young ^a   Kim, Sang Wook ^a   Han, Weon Cheol ^a   Kim, Eun A ^a   Choi, Suck Chei ^a   Kim, Tae Hyeon ^a   Yun, Ki Jung ^a   Kim, Eun Cheol ^b   Lyou, June Hyung ^a   Nah, Yong Ho ^a   Chung, Hun Taeg ^a   Cha, Young Nam ^c   Jun, Chang Duk ^a  

^a Wonkwang University School of Medicine   (South Korea)

^b Wonkwang University   (South Korea)

^c Inha University School of Medicine   (South Korea)

Author keywords

c Jun N terminal kinase stress activated protein kinase; Caspase 3; Caspase 8; Cytochrome c; Deferoxamine; Extracellular signal regulated kinase; Iron; P38 MAP kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CASPASE 8; CHELATING AGENT; CYTOCHROME C; DEFEROXAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0345382798     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-8749(03)00031-5     Document Type: Article

References (61)

1. Crichton R.R., Ward R.J. Iron metabolism-new perspectives in view. Biochemistry. 31:1992;11255-11264.
2. Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic. Biol. Med. 20:1996;553-566.
3. Weinberg E.D. Iron, asbestos, and carcinogenicity. Lancet. 1:1989;1399-1400.
4. Fukuchi K., Tomoyasu S., Tsuruoka N., Gomi K. Iron deprivation-induced apoptosis in HL-60 cells. FEBS Lett. 350:1994;139-142.
5. Pahl P.M., Horwitz M.A., Horwitz K.B., Horwitz L.D. Desferri-exochelin induces death by apoptosis in human breast cancer cells but does not kill normal breast cells. Breast Cancer Res. Treat. 69:2001;69-79.
6. Fan L., lyer J., Zhu S., Frick K.K., Wada R.K., Eskenazi A.E., Berg P.E., Ikegaki N., Kennett R.H., Frantz C.N. Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells. Cancer Res. 61:2001;1073-1079.
7. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:1995;16483-16486.
8. Cobb M.H., Goldsmith E.J. How MAP kinases are regulated. J. Biol. Chem. 270:1995;14843-14846.
9. Hunter T. Oncoprotein networks. Cell. 88:1997;333-346.
10. Boulton T.G., Yancopoulos G.D., Gregory J.S., Slaughter C., Moomaw C., Hsu J., Cobb M.H. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science. 249:1990;64-67.
11. Zhou G., Bao Z.Q., Dixon J.E. Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270:1995;12665-12669.
12. Hibi M., Lin A., Smeal T., Minden A., Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:1993;2135-2148.
13. Derijard B., Hibi M., Wu I.H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1994;1025-1037.
14. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., Avruch J., Woodgett J.R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:1994;156-160.
15. Han J., Lee J.D., Bibbs L., Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265:1994;808-811.
16. Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T., Nebreda A.R. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78:1994;1027-1037.
17. Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D., McNulty D., Blumenthal M.J., Heys J.R., Landvatter S.W.et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:1994;739-746.
18. Cano E., Mahadevan L.C. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20:1995;117-122.
19. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 371:1994;346-347.
20. Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 86:1996;147-157.
21. Golstein P. Controlling cell death. Science. 275:1997;1081-1082.
22. Georgiou N.A., van der Bruggen T., Oudshoorn M., Hider R.C., Marx J.J., van Asbeck B.S. Human immunodeficiency virus type 1 replication inhibition by the bidentate iron chelators CP502 and CP511 is caused by proliferation inhibition and the onset of apoptosis. Eur. J. Clin. Invest. 32(Suppl 1):2002;91-96.
23. Ido Y., Muto N., Inada A., Kohroki J., Mano M., Odani T., Itoh N., Yamamoto K., Tanaka K. Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. Cell Prolif. 32:1999;63-73.
24. Wilson M.R. Apoptotic signal transduction: emerging pathways. Biochem. Cell. Biol. 76:1998;573-582.
25. Kruidering M., Evan G.I. Caspase-8 in apoptosis: the beginning of "the end"? IUBMB Life. 50:2000;85-90.
26. Greene B.T., Thorburn J., Willingham M.C., Thorburn A., Planalp R.P., Brechbiel M.W., Jennings-Gee J., Wilkinson J.t., Torti F.M., Torti S.V. Activation of caspase pathways during iron chelator-mediated apoptosis. J. Biol. Chem. 277:2002;25568-25575.
27. Krishan A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66:1975;188-193.
28. Maciejewski J.P., Selleri C., Sato T., Cho H.J., Keefer L.K., Nathan C.F., Young N.S. Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-γ and tumor necrosis factor-α J. Clin. Invest. 96:1995;1085-1092.
29. Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science. 281:1998;1312-1316.
30. Carson D.A., Ribeiro J.M. Apoptosis and disease. Lancet. 341:1993;1251-1254.
31. Muzio M., Stockwell B.R., Stennicke H.R., Salvesen G.S., Dixit V.M. An induced proximity model for caspase-8 activation. J. Biol. Chem. 273:1998;2926-2930.
32. Desole M.S., Sciola L., Sircana S., Godani C., Migheli R., Delogu M.R., Piras G., De Natale G., Miele E. Protective effect of deferoxamine on sodium nitroprusside-induced apoptosis in PC12 cells. Neurosci. Lett. 247:1998;1-4.
33. + exchanger in C6 glioma cells J. Neurochem. 74:2000;1505-1513.
34. Zaman K., Ryu H., Hall D., O'Donovan K., Lin K.I., Miller M.P., Marquis J.C., Baraban J.M., Semenza G.L., Ratan R.R. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin. J. Neurosci. 19:1999;9821-9830.
35. Terwel D., Nieland L.J., Schutte B., Reutelingsperger C.P., Ramaekers F.C., Steinbusch H.W. S-Nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules. Eur. J. Pharmacol. 400:2000;19-33.
36. Nara K., Konno D., Uchida J., Kiuchi Y., Oguchi K. Protective effect of nitric oxide against iron-induced neuronal damage. J. Neural. Transm. 106:1999;835-848.
37. Xia Z., Dickens M., Raingeaud J., Davis R.J., Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
38. Brenner B., Koppenhoefer U., Weinstock C., Linderkamp O., Lang F., Gulbins E. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J. Biol. Chem. 272:1997;22173-22181.
39. Roulston A., Reinhard C., Amiri P., Williams L.T. Early activation of c-Jun N-terminal kinase and p38 kinase regulate cell survival in response to tumor necrosis factor α J. Biol. Chem. 273:1998;10232-10239.
40. Nemoto S., Xiang J., Huang S., Lin A. Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase. J. Biol. Chem. 273:1998;16415-16420.
41. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:1995;229-233.
42. Kumar S., McDonnell P.C., Gum R.J., Hand A.T., Lee J.C., Young P.R. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 235:1997;533-538.
43. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
44. Bonny C., Oberson A., Negri S., Sauser C., Schorderet D.F. Cell-permeable peptide inhibitors of JNK: novel blockers of β-cell death. Diabetes. 50:2001;77-82.
45. Fukunaga R., Hunter T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1997;1921-1933.
46. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science. 275:1997;1129-1132.
47. Rollet-Labelle E., Grange M.J., Elbim C., Marquetty C., Gougerot-Pocidalo M.A., Pasquier C. Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis. Free Radic. Biol. Med. 24:1998;563-572.
48. Weinberg E.D. Development of clinical methods of iron deprivation for suppression of neoplastic and infectious diseases. Cancer Invest. 17:1999;507-513.
49. Ip Y.T., Davis R.J. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell. Biol. 10:1998;205-219.
50. Schalinske K.L., Eisenstein R.S. Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells. J. Biol. Chem. 271:1996;7168-7176.
51. de Silva D.M., Aust S.D. Ferritin and ceruloplasmin in oxidative damage: review and recent findings. Can. J. Physiol. Pharmacol. 71:1993;715-720.
52. Eisenstein R.S., Garcia-Mayol D., Pettingell W., Munro H.N. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc. Natl. Acad. Sci. USA. 88:1991;688-692.
53. Thomson A.M., Rogers J.T., Leedman P.J. Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. J. Biol. Chem. 275:2000;31609-31615.
54. Harada J., Sugimoto M. An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons. Jpn. J. Pharmacol. 79:1999;369-378.
55. Cheng A., Chan S.L., Milhavet O., Wang S., Mattson M.P. p38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells. J. Biol. Chem. 276:2001;43320-43327.
56. Feger F., Ferry-Dumazet H., Mamani Matsuda M., Bordenave J., Dupouy M., Nussler A.K., Arock M., Devevey L., Nafziger J., Guillosson J.J., Reiffers J., Mossalayi M.D. Role of iron in tumor cell protection from the pro-apoptotic effect of nitric oxide. Cancer Res. 61:2001;5289-5294.
57. Leardi A., Caraglia M., Selleri C., Pepe S., Pizzi C., Notaro R., Fabbrocini A., De Lorenzo S., Musico M., Abbruzzese A., Bianco A.R., Tagliaferri P. Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells. Br. J. Haematol. 102:1998;746-752.
58. Jun C.D., Oh C.D., Kwak H.J., Pae H.O., Yoo J.C., Choi B.M., Chun J.S., Park R.K., Chung H.T. Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N- terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. J. Immunol. 162:1999;3395-3401.
59. Jun C.D., Pae H.O., Kwak H.J., Yoo J.C., Choi B.M., Oh C.D., Chun J.S., Paik S.G., Park Y.H., Chung H.T. Modulation of nitric oxide-induced apoptotic death of HL-60 cells by protein kinase C and protein kinase A through mitogen-activated protein kinases and CPP32-like protease pathways. Cell. Immunol. 194:1999;36-46.
60. Pantopoulos K., Hentze M.W. Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts. Proc. Natl. Acad. Sci. USA. 92:1995;1267-1271.
61. Kim S., Ponka P. Control of transferrin receptor expression via nitric oxide-mediated modulation of iron-regulatory protein 2. J. Biol. Chem. 274:1999;33035-33042.