Shikonin suppresses nlrp3 and aim2 inflammasomes by direct inhibition of caspase-1

PLoS ONE

Volumn 11, Issue 7, 2016, Pages

  Zorman, Jernej ^a,d   Sušjan, Petra ^a,b   Hafner Bratkoviè, Iva ^a,c  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c EN FIST Centre of Excellence   (Slovenia)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 PROTEIN; CRYOPYRIN; DOUBLE STRANDED DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTATE DEHYDROGENASE; SHIKONIN; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; CASPASE INHIBITOR; DNA BINDING PROTEIN; NAPHTHOQUINONE; NIGERICIN; NLRP3 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME RELEASE; LITHOSPERMUM; LITHOSPERMUM ERYTHRORHIZON; MOUSE; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; DRUG EFFECTS; METABOLISM; TRANSFORMED CELL LINE;

ANIMALS; CASPASE 1; CASPASE INHIBITORS; CELL LINE, TRANSFORMED; DNA-BINDING PROTEINS; INFLAMMASOMES; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; NIGERICIN; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN;

EID: 84982709267     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0159826     Document Type: Article

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