-
1
-
-
84861733799
-
MET: A promising anticancer therapeutic target
-
Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol. 2012;9(6):314–26.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, Issue.6
, pp. 314-326
-
-
Peters, S.1
Adjei, A.A.2
-
2
-
-
84898922599
-
The Met receptor tyrosine kinase: A key player in oncogenesis and drug resistance
-
Maroun CR, Rowlands T. The Met receptor tyrosine kinase: a key player in oncogenesis and drug resistance. Pharmacol Ther. 2014;142(3):316–38.
-
(2014)
Pharmacol Ther
, vol.142
, Issue.3
, pp. 316-338
-
-
Maroun, C.R.1
Rowlands, T.2
-
3
-
-
0021241398
-
Molecular cloning of a new transforming gene from a chemically transformed human cell line
-
Cooper CS, Park M, Blair DG, et al., Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature. 1984;311(5981):29–33.
-
(1984)
Nature
, vol.311
, Issue.5981
, pp. 29-33
-
-
Cooper, C.S.1
Park, M.2
Blair, D.G.3
-
4
-
-
84856152266
-
Targeting MET in cancer: Rationale and progress
-
Gherardi E, Birchmeier W, Birchmeier C, et al. Targeting MET in cancer: rationale and progress. Nat Rev Cancer. 2012;12(2):89–103.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.2
, pp. 89-103
-
-
Gherardi, E.1
Birchmeier, W.2
Birchmeier, C.3
-
5
-
-
0035930341
-
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
-
Peschard P, Fornier TM, Lamorte L, et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell. 2001;8(5):995–1004.
-
(2001)
Mol Cell
, vol.8
, Issue.5
, pp. 995-1004
-
-
Peschard, P.1
Fornier, T.M.2
Lamorte, L.3
-
7
-
-
78649420006
-
MET signalling: Principles and functions in development, organ regeneration and cancer
-
Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 2010;11(12):834–48.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, Issue.12
, pp. 834-848
-
-
Trusolino, L.1
Bertotti, A.2
Comoglio, P.M.3
-
8
-
-
84916896506
-
Thirty years of research on met receptor to move a biomarker from bench to bedside
-
Furlan A, Kherrouche Z, Montagne R, et al. Thirty years of research on met receptor to move a biomarker from bench to bedside. Cancer Res. 2014;74(23):6737–44.
-
(2014)
Cancer Res
, vol.74
, Issue.23
, pp. 6737-6744
-
-
Furlan, A.1
Kherrouche, Z.2
Montagne, R.3
-
9
-
-
51049117095
-
A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
-
Basilico C, Arnesano A, Galluzzo M, et al. A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met. J Biol Chem. 2008;283(30):21267–77.
-
(2008)
J Biol Chem
, vol.283
, Issue.30
, pp. 21267-21277
-
-
Basilico, C.1
Arnesano, A.2
Galluzzo, M.3
-
10
-
-
3142595278
-
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
-
Stamos J, Lazarus RA, Yao X, et al. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J. 2004;23(12):2325–35.
-
(2004)
EMBO J
, vol.23
, Issue.12
, pp. 2325-2335
-
-
Stamos, J.1
Lazarus, R.A.2
Yao, X.3
-
11
-
-
84902313522
-
The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment
-
Parikh RA, Wang P, Beumer JH, et al. The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment. Onco Targets Ther. 2014;7:969–83.
-
(2014)
Onco Targets Ther
, vol.7
, pp. 969-983
-
-
Parikh, R.A.1
Wang, P.2
Beumer, J.H.3
-
12
-
-
0028911690
-
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
-
Uehara Y, Monowa O, Mori C, et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature. 1995;373(6516):702–5.
-
(1995)
Nature
, vol.373
, Issue.6516
, pp. 702-705
-
-
Uehara, Y.1
Monowa, O.2
Mori, C.3
-
13
-
-
0028899952
-
Scatter factor/hepatocyte growth factor is essential for liver development
-
Schmidt C, Bladt F, Goedecke S, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995;373(6516):699–702.
-
(1995)
Nature
, vol.373
, Issue.6516
, pp. 699-702
-
-
Schmidt, C.1
Bladt, F.2
Goedecke, S.3
-
14
-
-
0028327202
-
The Met proto-oncogene mesenchymal to epithelial cell conversion
-
Tsarfaty I, Rong S, resau JH, et al. The Met proto-oncogene mesenchymal to epithelial cell conversion. Science. 1994;263(5143):98–101.
-
(1994)
Science
, vol.263
, Issue.5143
, pp. 98-101
-
-
Tsarfaty, I.1
Rong, S.2
Resau, J.H.3
-
16
-
-
0026722243
-
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
-
Bussolino F, Di Renzo MF, Ziche M, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol. 1992;119(3):629–41.
-
(1992)
J Cell Biol
, vol.119
, Issue.3
, pp. 629-641
-
-
Bussolino, F.1
Di Renzo, M.F.2
Ziche, M.3
-
17
-
-
84925223695
-
MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure
-
Boccaccio C, Comoglio PM. MET, a driver of invasive growth and cancer clonal evolution under therapeutic pressure. Curr Opin Cell Biol. 2014;31:98–105.
-
(2014)
Curr Opin Cell Biol
, vol.31
, pp. 98-105
-
-
Boccaccio, C.1
Comoglio, P.M.2
-
18
-
-
0028351702
-
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
-
Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 1994;77(2):261–71.
-
(1994)
Cell
, vol.77
, Issue.2
, pp. 261-271
-
-
Ponzetto, C.1
Bardelli, A.2
Zhen, Z.3
-
19
-
-
0034693753
-
Met receptor tyrosine kinase: Enhanced signaling through adapter proteins
-
Furge KA, Zhang YW, Vande Woude GF. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene. 2000;19(49):5582–9.
-
(2000)
Oncogene
, vol.19
, Issue.49
, pp. 5582-5589
-
-
Furge, K.A.1
Zhang, Y.W.2
Vande Woude, G.F.3
-
20
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298(5600):1911–2.
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
21
-
-
14944348618
-
Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection
-
Fan S, Gao M, Meng Q, et al. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene. 2005;24(10):1749–66.
-
(2005)
Oncogene
, vol.24
, Issue.10
, pp. 1749-1766
-
-
Fan, S.1
Gao, M.2
Meng, Q.3
-
22
-
-
0036007194
-
Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis
-
Muller M, Morotti A, Ponzetto C. Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis. Mol Cell Biol. 2002;22(4):1060–72.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.4
, pp. 1060-1072
-
-
Muller, M.1
Morotti, A.2
Ponzetto, C.3
-
23
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 2007;26(22):3291–310.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
24
-
-
1042268043
-
MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2in fibroblasts
-
Kesavan K, Lobel-Rice K, Sun W, et al. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2in fibroblasts. J Cell Physiol. 2004;199(1):140–8.
-
(2004)
J Cell Physiol
, vol.199
, Issue.1
, pp. 140-148
-
-
Kesavan, K.1
Lobel-Rice, K.2
Sun, W.3
-
25
-
-
34248583886
-
MAP kinase signalling pathways in cancer
-
Dhillon AS, Hagan S, Rath O, et al. MAP kinase signalling pathways in cancer. Oncogene. 2007;26(22):3279–90.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
-
26
-
-
0029007694
-
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
-
Pelicci G, Giordano S, Zhen Z, et al. The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene. 1995;10(8):1631–8.
-
(1995)
Oncogene
, vol.10
, Issue.8
, pp. 1631-1638
-
-
Pelicci, G.1
Giordano, S.2
Zhen, Z.3
-
27
-
-
0033761488
-
The tyrosine phosphataseSHP-2 is required for sustained activation of extracellular signal-regulated kinase andepithelial morphogenesis downstream from the met receptor tyrosine kinase
-
Maroun CR, Naujokas MA, Holgado-Madruga M, et al. The tyrosine phosphataseSHP-2 is required for sustained activation of extracellular signal-regulated kinase andepithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol Cell Biol. 2000;20(22):8513–25.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.22
, pp. 8513-8525
-
-
Maroun, C.R.1
Naujokas, M.A.2
Holgado-Madruga, M.3
-
28
-
-
14044272770
-
A novel role for Gab1 and SHP2in epidermal growth factor-induced Ras activation
-
Montagner A, Yart A, Dance M, et al. A novel role for Gab1 and SHP2in epidermal growth factor-induced Ras activation. J Biol Chem. 2005;280(7):5350–60.
-
(2005)
J Biol Chem
, vol.280
, Issue.7
, pp. 5350-5360
-
-
Montagner, A.1
Yart, A.2
Dance, M.3
-
30
-
-
84908161000
-
Revisiting STAT3signalling in cancer: New and unexpected biological functions
-
Yu H, Lee H, Herrmann A, et al. Revisiting STAT3signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014;14(11):736–46.
-
(2014)
Nat Rev Cancer
, vol.14
, Issue.11
, pp. 736-746
-
-
Yu, H.1
Lee, H.2
Herrmann, A.3
-
31
-
-
1042302005
-
The STATs of cancer – new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer – new molecular targets come of age. Nat Rev Cancer. 2004;4(2):97–105.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
32
-
-
21344435775
-
Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer
-
Haura EB, Turkson J, Jove R. Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Prat Oncol. 2005;2(6):315–24.
-
(2005)
Nat Clin Prat Oncol
, vol.2
, Issue.6
, pp. 315-324
-
-
Haura, E.B.1
Turkson, J.2
Jove, R.3
-
33
-
-
0032518375
-
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
-
Boccaccio C, Ando M, Tamagnone L, et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature. 1998;391(6664):285–8.
-
(1998)
Nature
, vol.391
, Issue.6664
, pp. 285-288
-
-
Boccaccio, C.1
O, M.2
Tamagnone, L.3
-
34
-
-
84924503690
-
To be an allyor an adversaryin bladder cancer: TheNF-κB storyhas not unfolded
-
Mukherjee N, Houston TJ, Cardenas E, et al. To be an allyor an adversaryin bladder cancer: theNF-κB storyhas not unfolded. Carcinogenesis. 2015;36(3):299–306.
-
(2015)
Carcinogenesis
, vol.36
, Issue.3
, pp. 299-306
-
-
Mukherjee, N.1
Houston, T.J.2
Cardenas, E.3
-
35
-
-
0036546501
-
NF-kappaB in cancer: From innocent bystander to major culprit
-
Karin M, Cao Y, Greten FR, et al. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002;2(4):301–10.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.4
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
-
36
-
-
84989897315
-
NF-kappaB inhibition reveals a novel role for HGF during skeletal muscle repair
-
Proto JD, Tang Y, Lu A, et al. NF-kappaB inhibition reveals a novel role for HGF during skeletal muscle repair. Cell Death Dis. 2015;6:e1730.
-
(2015)
Cell Death Dis
, vol.6
-
-
Proto, J.D.1
Tang, Y.2
Lu, A.3
-
37
-
-
84917736132
-
Mesenchymal stem cells promote liver regeneration and prolong survival in small-for-size liver grafts: Involvement of C-Jun N-terminal kinase, cyclin D1, and NF-kappaB
-
Wang W, Du Z, Yan J, et al. Mesenchymal stem cells promote liver regeneration and prolong survival in small-for-size liver grafts: involvement of C-Jun N-terminal kinase, cyclin D1, and NF-kappaB. PLoS One. 2014;9(12):e112532.
-
(2014)
Plos One
, vol.9
, Issue.12
-
-
Wang, W.1
Du, Z.2
Yan, J.3
-
38
-
-
84919703143
-
Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic
-
Jardim DL, Tang C, Gagliato D, et al. Analysis of 1,115 patients tested for MET amplification and therapy response in the MD Anderson Phase I Clinic. Clin Cancer Res. 2014;20(24):6336–45.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.24
, pp. 6336-6345
-
-
Jardim, D.L.1
Tang, C.2
Gagliato, D.3
-
39
-
-
44449151030
-
Drug development of MET inhibitors: Targeting oncogene addiction and expedience
-
Comoglio PM., Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov. 2008;7(6):504–16.
-
(2008)
Nat Rev Drug Discov
, vol.7
, Issue.6
, pp. 504-516
-
-
Comoglio, P.M.1
Giordano, S.2
Trusolino, L.3
-
40
-
-
19944399371
-
C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu
-
Lengyel E, Prechtel D, Resau JH, et al. C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu. Int J Cancer. 2005;113(4):678–82.
-
(2005)
Int J Cancer
, vol.113
, Issue.4
, pp. 678-682
-
-
Lengyel, E.1
Prechtel, D.2
Resau, J.H.3
-
41
-
-
84555190809
-
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
-
Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011;29(36):4803–10.
-
(2011)
J Clin Oncol
, vol.29
, Issue.36
, pp. 4803-4810
-
-
Lennerz, J.K.1
Kwak, E.L.2
Ackerman, A.3
-
42
-
-
0036896226
-
Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion
-
Lorenzato A, Olivero M, Patane S, et al. Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion. Cancer Res. 2002;62(23):7025–30.
-
(2002)
Cancer Res
, vol.62
, Issue.23
, pp. 7025-7030
-
-
Lorenzato, A.1
Olivero, M.2
Patane, S.3
-
43
-
-
78650426144
-
MET mutations in cancers of unknown primary origin (CUPs)
-
Stella GM, Benvenuti S, Gramaglia D, et al. MET mutations in cancers of unknown primary origin (CUPs). Hum Mutat. 2011;32(1):44–50.
-
(2011)
Hum Mutat
, vol.32
, Issue.1
, pp. 44-50
-
-
Stella, G.M.1
Benvenuti, S.2
Gramaglia, D.3
-
44
-
-
84891370054
-
A survey of c-MET expression and amplification in 287 patients with hepatocellular carcinoma
-
Lee SJ, Lee J, Sohn I, et al. A survey of c-MET expression and amplification in 287 patients with hepatocellular carcinoma. Anticancer Res. 2013;33(11):5179–86.
-
(2013)
Anticancer Res
, vol.33
, Issue.11
, pp. 5179-5186
-
-
Lee, S.J.1
Lee, J.2
Sohn, I.3
-
45
-
-
84874605065
-
Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
-
Kato H, Arao T, Matsumoto K, et al. Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma. Int J Oncol. 2013;42(4):1151–8.
-
(2013)
Int J Oncol
, vol.42
, Issue.4
, pp. 1151-1158
-
-
Kato, H.1
Arao, T.2
Matsumoto, K.3
-
46
-
-
84555202718
-
Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer
-
Graziano F, Galluccio N, Lorenzini P, et al. Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer. J Clin Oncol. 2011;29(36):4789–95.
-
(2011)
J Clin Oncol
, vol.29
, Issue.36
, pp. 4789-4795
-
-
Graziano, F.1
Galluccio, N.2
Lorenzini, P.3
-
47
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman R, Morikawa T, Shee K, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012;487(7408):500–4.
-
(2012)
Nature
, vol.487
, Issue.7408
, pp. 500-504
-
-
Straussman, R.1
Morikawa, T.2
Shee, K.3
-
48
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3signaling. Science. 2007;316(5827):1039–43.
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
49
-
-
78650339354
-
HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors
-
Shojaei F, Lee JH, Simmons BH, et al. HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res. 2010;70(24):10090–100.
-
(2010)
Cancer Res
, vol.70
, Issue.24
, pp. 10090-10100
-
-
Shojaei, F.1
Lee, J.H.2
Simmons, B.H.3
-
50
-
-
84877739371
-
MTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistance by HGF
-
Ishikawa D, Takeuchi S, Nakagawa T, et al. mTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistance by HGF. PLoS One. 2013;8(5):e62104.
-
(2013)
Plos One
, vol.8
, Issue.5
-
-
Ishikawa, D.1
Takeuchi, S.2
Nakagawa, T.3
-
51
-
-
84865436737
-
Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer
-
Minuti G, et al. Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer. Br J Cancer. 2012;107(5):793–9.
-
(2012)
Br J Cancer
, vol.107
, Issue.5
, pp. 793-799
-
-
Minuti, G.1
-
52
-
-
0026646946
-
Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity
-
Gak E, Taylor WG, Chan AM, et al. Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity. FEBS Lett. 1992;311(1):17–21.
-
(1992)
FEBS Lett
, vol.311
, Issue.1
, pp. 17-21
-
-
Gak, E.1
Taylor, W.G.2
Chan, A.M.3
-
53
-
-
0028912590
-
Biological activation of pro-HGF (Hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction
-
Naldini L, Vigna E, Bardelli A, et al. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J Biol Chem. 1995;270(2):603–11.
-
(1995)
J Biol Chem
, vol.270
, Issue.2
, pp. 603-611
-
-
Naldini, L.1
Vigna, E.2
Bardelli, A.3
-
54
-
-
77950808485
-
Hepatocyte growth factor activation inhibitors–therapeutic potential in cancer
-
Parr C, Sanders AJ, Jiang WG. Hepatocyte growth factor activation inhibitors–therapeutic potential in cancer. Anticancer Agents Med Chem.2010;10(1):47–57.
-
(2010)
Anticancer Agents Med Chem
, vol.10
, Issue.1
, pp. 47-57
-
-
Parr, C.1
Sanders, A.J.2
Jiang, W.G.3
-
55
-
-
84898870317
-
Expression of hepatocyte growth factor activator inhibitor-1 (HAI-1) gene in prostate cancer: Clinical and biological significance
-
Hu C, Jiang N, Wang G, et al. Expression of hepatocyte growth factor activator inhibitor-1 (HAI-1) gene in prostate cancer: clinical and biological significance. J BUON. 2014;19(1):215–20.
-
(2014)
J BUON
, vol.19
, Issue.1
, pp. 215-220
-
-
Hu, C.1
Jiang, N.2
Wang, G.3
-
56
-
-
84885199880
-
HAI-2suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase
-
Tsai CH, Teng CH, Tu YT, et al. HAI-2suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase. Oncogene. 2014;33(38):4643–52.
-
(2014)
Oncogene
, vol.33
, Issue.38
, pp. 4643-4652
-
-
Tsai, C.H.1
Teng, C.H.2
Tu, Y.T.3
-
57
-
-
68649091709
-
Rilotumumab, a mAb against human hepatocyte growth factor for the treatment of cancer
-
Giordano S. Rilotumumab, a mAb against human hepatocyte growth factor for the treatment of cancer. Curr Opin Mol Ther. 2009;11(4):448–55.
-
(2009)
Curr Opin Mol Ther
, vol.11
, Issue.4
, pp. 448-455
-
-
Giordano, S.1
-
58
-
-
77958603109
-
Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
-
Buchanan IM, Scott T, Tandle AT, et al. Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102. J Cell Mol Med. 2011;15(9):1999–2006.
-
(2011)
J Cell Mol Med
, vol.15
, Issue.9
, pp. 1999-2006
-
-
Buchanan, I.M.1
Scott, T.2
Tandle, A.T.3
-
59
-
-
36749042647
-
AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
-
Jun HT, Sun J, Rex K, et al. AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res. 2007;13(22 Pt 1):6735–42.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.22
, pp. 6735-6742
-
-
Jun, H.T.1
Sun, J.2
Rex, K.3
-
60
-
-
84922141174
-
Exposure-response analysis of rilotumumab in gastric cancer: The role of tumour MET expression
-
Zhu M, Tang R, Doshi S, et al. Exposure-response analysis of rilotumumab in gastric cancer: the role of tumour MET expression. Br J Cancer. 2015;112(3):429–37.
-
(2015)
Br J Cancer
, vol.112
, Issue.3
, pp. 429-437
-
-
Zhu, M.1
Tang, R.2
Doshi, S.3
-
61
-
-
77958463931
-
Phase I study of SCH 900105 (SC), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb), as a single agent and in combination with erlotinib (E) in patients (pts) with advanced solid tumors
-
Patnaik A, Weiss GJ, Papadopoulos K. et al. Phase I study of SCH 900105 (SC), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb), as a single agent and in combination with erlotinib (E) in patients (pts) with advanced solid tumors. J Clin Oncol. (Meeting abstracts) 2010;28(15):2525.
-
(2010)
J Clin Oncol. (Meeting Abstracts)
, vol.28
, Issue.15
, pp. 2525
-
-
Patnaik, A.1
Weiss, G.J.2
Papadopoulos, K.3
-
62
-
-
84861309234
-
Monotherapeutic and combination antitumor activities of TAK701, a humanized anti-hepatocyte growth factor neutralizing antibody, against multiple types of cancer
-
Hori A. et al. Monotherapeutic and combination antitumor activities of TAK701, a humanized anti-hepatocyte growth factor neutralizing antibody, against multiple types of cancer. Proceedings of the American Association of Cancer Res. 2009;1244.
-
(2009)
Proceedings of the American Association of Cancer Res
-
-
Hori, A.1
-
63
-
-
77958074157
-
TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation
-
Okamoto W, Okamoto I, Tanaka K, et al. TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation. Mol Cancer Ther. 2010;9(10):2785–92.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.10
, pp. 2785-2792
-
-
Okamoto, W.1
Okamoto, I.2
Tanaka, K.3
-
64
-
-
84923343875
-
Combining onartuzumab with erlotinib inhibits growth of non-small cell lung cancer with activating EGFR mutations and HGF overexpression
-
Sano Y, Hashimoto E, Nakatani N, et al. Combining onartuzumab with erlotinib inhibits growth of non-small cell lung cancer with activating EGFR mutations and HGF overexpression. Mol Cancer Ther. 2015;14(2):533–41.
-
(2015)
Mol Cancer Ther
, vol.14
, Issue.2
, pp. 533-541
-
-
Sano, Y.1
Hashimoto, E.2
Nakatani, N.3
-
65
-
-
84890108571
-
Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
-
Spigel DR, Ervin TJ, Ramlau RA, et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol2013;31:4105–14.
-
(2013)
J Clin Oncol
, vol.31
, pp. 4105-4114
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.A.3
-
66
-
-
77953458271
-
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity
-
Munshi N, Jeay S, Li Y, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther.2010;9(6):1544–53.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.6
, pp. 1544-1553
-
-
Munshi, N.1
Jeay, S.2
Li, Y.3
-
67
-
-
84922092250
-
Phase 1 trial of tivantinibin combination with sorafenib in adult patients with advanced solid tumors
-
Puzanov I, Sosman J, Santoro A, et al. Phase 1 trial of tivantinibin combination with sorafenib in adult patients with advanced solid tumors. Invest New Drugs. 2015;33(1):159–68.
-
(2015)
Invest New Drugs
, vol.33
, Issue.1
, pp. 159-168
-
-
Puzanov, I.1
Sosman, J.2
Santoro, A.3
-
68
-
-
84911900480
-
Tivantinib plus erlotinib versus placebo plus erlotinib in Asian patients with previously treated nonsquamous NSCLC with wild-type EGFR: First report of a phase III ATTENTION trial
-
Azuma K, Yoshioka H, Yamamoto N, et al. Tivantinib plus erlotinib versus placebo plus erlotinib in Asian patients with previously treated nonsquamous NSCLC with wild-type EGFR: First report of a phase III ATTENTION trial. J Clin Oncol. (Meeting abstracts). 2014;32:5s, a8044.
-
(2014)
J Clin Oncol. (Meeting Abstracts)
, vol.32
, Issue.5s
-
-
Azuma, K.1
Yoshioka, H.2
Yamamoto, N.3
-
69
-
-
84871029860
-
Tivantinib in hepatocellular carcinoma
-
Trojan J, Zeuzem S. Tivantinib in hepatocellular carcinoma. Expert Opin Investig Drugs. 2013;22(1):141–7.
-
(2013)
Expert Opin Investig Drugs.
, vol.22
, Issue.1
, pp. 141-147
-
-
Trojan, J.1
Zeuzem, S.2
-
70
-
-
84907573581
-
Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2, 3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer
-
Jia H, Dai G, Weng J, et al. Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2, 3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer. J Med Chem. 2014;57:7577–89.
-
(2014)
J Med Chem
, vol.57
, pp. 7577-7589
-
-
Jia, H.1
Dai, G.2
Weng, J.3
-
71
-
-
84937457062
-
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models
-
Schuller AG, Barry ER, Jones RD, et al. The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models. Clin Cancer Res. 2015;21(12):2811–9.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.12
, pp. 2811-2819
-
-
Schuller, A.G.1
Barry, E.R.2
Jones, R.D.3
-
72
-
-
84914095781
-
First-in-human phase I study of a selective c-Met inhibitor volitinib (HMP504/AZD6094) in patients with advanced solid tumors (Meeting abstracts)
-
Hui Kong Gan JL, Michael Millward, et al. First-in-human phase I study of a selective c-Met inhibitor volitinib (HMP504/AZD6094) in patients with advanced solid tumors (Meeting abstracts). J Clin Oncol. 2014;32:11111.
-
(2014)
J Clin Oncol
, vol.32
-
-
Hui Kong Gan, J.L.1
Millward, M.2
-
73
-
-
84922571357
-
Management of crizotinib therapy for ALK-rearranged non-small cell lung carcinoma: An expert consensus
-
Cappuzzo F, Moro-Sibilot D, Gautschi O, et al. Management of crizotinib therapy for ALK-rearranged non-small cell lung carcinoma: an expert consensus. Lung Cancer. 2015;87(2):89–95.
-
(2015)
Lung Cancer
, vol.87
, Issue.2
, pp. 89-95
-
-
Cappuzzo, F.1
Moro-Sibilot, D.2
Gautschi, O.3
-
74
-
-
84911493241
-
Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
Reck M, Popat S, Reinmuth N, et al. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(3):iii27–39.
-
(2014)
Ann Oncol.
, vol.25
, Issue.3
, pp. iii27-iii39
-
-
Reck, M.1
Popat, S.2
Reinmuth, N.3
-
76
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385–94.
-
(2013)
N Engl J Med
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
77
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–77.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.W.3
-
78
-
-
84912097465
-
The efficacy and safety of crizotinibin the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer: A meta-analysisof clinical trials
-
Qian H, Gao F, Wang H, et al. The efficacy and safety of crizotinibin the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer: a meta-analysisof clinical trials. BMC Cancer. 2014;14:683.
-
(2014)
BMC Cancer
, vol.14
-
-
Qian, H.1
Gao, F.2
Wang, H.3
-
79
-
-
84881306446
-
Cabozantinib (XL184) for the treatment of locally advanced or metastatic progressive medullary thyroid cancer
-
Viola D, Cappagli V, Elisei R. Cabozantinib (XL184) for the treatment of locally advanced or metastatic progressive medullary thyroid cancer. Future Oncol. 2013;9(8):1083–92.
-
(2013)
Future Oncol
, vol.9
, Issue.8
, pp. 1083-1092
-
-
Viola, D.1
Cappagli, V.2
Elisei, R.3
-
80
-
-
84867754481
-
An international, double-blind, randomized, placebo-controlled phase III trial (EXAM) of cabozantinib (XL184) in medullary thyroid carcinoma (MTC) patients (pts) with documented RECIST progression at baseline
-
Schoffski P, Elisei R, Muller S, et al. An international, double-blind, randomized, placebo-controlled phase III trial (EXAM) of cabozantinib (XL184) in medullary thyroid carcinoma (MTC) patients (pts) with documented RECIST progression at baseline. J Clin Oncol. (Meeting abstracts). 2012;30:5508.
-
(2012)
J Clin Oncol. (Meeting Abstracts).
, vol.30
-
-
Schoffski, P.1
Elisei, R.2
Muller, S.3
-
81
-
-
84924080130
-
The role of HGF/METand FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistanceof esophageal squamous cell carcinoma
-
Saito S, Morishima K, Ui T, et al. The role of HGF/METand FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistanceof esophageal squamous cell carcinoma. BMC Cancer. 2015;15(1):1065.
-
(2015)
BMC Cancer
, vol.15
, Issue.1
-
-
Saito, S.1
Morishima, K.2
Ui, T.3
-
82
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507–16.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
83
-
-
84997909291
-
C-MET as a potential therapeutic target and biomarker in cancer
-
Sierra JR, Tsao MS. c-MET as a potential therapeutic target and biomarker in cancer. Ther Adv Med Oncol. 2011;3(1):S21–35.
-
(2011)
Ther Adv Med Oncol
, vol.3
, Issue.1
, pp. S21-S35
-
-
Sierra, J.R.1
Tsao, M.S.2
-
84
-
-
84931340760
-
Targeted therapy fornon-small cell lung cancer: Current standards and the promise of the future
-
Chan BA, Hughes BG. Targeted therapy fornon-small cell lung cancer: current standards and the promise of the future. Transl Lung Cancer Res. 2015;4(1):36–54.
-
(2015)
Transl Lung Cancer Res
, vol.4
, Issue.1
, pp. 36-54
-
-
Chan, B.A.1
Hughes, B.G.2
-
85
-
-
84925872286
-
CMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance
-
Van Der Steen N, Pauwels P, Gil-Bazo I, et al. cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance. Cancers (Basel). 2015;7(2):556–73.
-
(2015)
Cancers (Basel)
, vol.7
, Issue.2
, pp. 556-573
-
-
Van Der Steen, N.1
Pauwels, P.2
Gil-Bazo, I.3
-
86
-
-
84907054995
-
Treatment algorithms for patients with metastaticnon-small cell, non-squamous lung cancer
-
Melosky B. Treatment algorithms for patients with metastaticnon-small cell, non-squamous lung cancer. Front Oncol. 2014;4:256.
-
(2014)
Front Oncol
, vol.4
-
-
Melosky, B.1
-
87
-
-
84892452794
-
The current state of molecularly targeted drugs targeting HGF/Met
-
Yano S, Nakagawa T. The current state of molecularly targeted drugs targeting HGF/Met. Jpn J Clin Oncol. 2014;44(1):9–12.
-
(2014)
Jpn J Clin Oncol
, vol.44
, Issue.1
, pp. 9-12
-
-
Yano, S.1
Nakagawa, T.2
-
88
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3signaling. Science. 2007;316(5827):1039–43.
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
89
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3(75):75ra26.
-
(2011)
Sci Transl Med.
, vol.3
, Issue.75
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
90
-
-
84898764896
-
Cetuximab-inducedMET activation acts as a novel resistance mechanism in colon cancer cells
-
Song N, Liu S, Zhang J, et al. Cetuximab-inducedMET activation acts as a novel resistance mechanism in colon cancer cells. Int J Mol Sci. 2014;15(4):5838–51.
-
(2014)
Int J Mol Sci
, vol.15
, Issue.4
, pp. 5838-5851
-
-
Song, N.1
Liu, S.2
Zhang, J.3
-
91
-
-
77956296140
-
MET kinase inhibitor SGX523synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth
-
Zhang YW, Staal B, Essenburg C, et al. MET kinase inhibitor SGX523synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res.2010;70(17):6880–90.
-
(2010)
Cancer Res
, vol.70
, Issue.17
, pp. 6880-6890
-
-
Zhang, Y.W.1
Staal, B.2
Essenburg, C.3
-
92
-
-
79551559942
-
Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors
-
Qi J, McTigue MA, Rogers A, et al. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res. 2011;71(3):1081–91.
-
(2011)
Cancer Res
, vol.71
, Issue.3
, pp. 1081-1091
-
-
Qi, J.1
McTigue, M.A.2
Rogers, A.3
-
93
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385.
-
(2013)
N Engl J Med
, vol.368
, Issue.25
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
94
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–77.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.W.3
-
95
-
-
79955458487
-
Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
-
Ou SH, Kwak EL, Siwak-Tapp C, et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol.2011;6(5):942–6.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.5
, pp. 942-946
-
-
Ou, S.H.1
Kwak, E.L.2
Siwak-Tapp, C.3
-
96
-
-
84921934141
-
Activated MET acts as a salvage signal after treatment with alectinib, a selective ALK inhibitor, in ALK-positivenon-small cell lung cancer
-
Kogita A, Togashi Y, Hayashi H, et al. Activated MET acts as a salvage signal after treatment with alectinib, a selective ALK inhibitor, in ALK-positivenon-small cell lung cancer. Int J Oncol. 2015;46(3):1025–30.
-
(2015)
Int J Oncol
, vol.46
, Issue.3
, pp. 1025-1030
-
-
Kogita, A.1
Togashi, Y.2
Hayashi, H.3
-
97
-
-
84899115483
-
HighMET receptor expressionbut not gene amplification in ALK 2p23 rearrangement positive non-small-cell lung cancer
-
Feng Y, Minca EC, Lanigan C, et al. HighMET receptor expressionbut not gene amplification in ALK 2p23 rearrangement positive non-small-cell lung cancer. J Thorac Oncol. 2014;9(5):646–53.
-
(2014)
J Thorac Oncol
, vol.9
, Issue.5
, pp. 646-653
-
-
Feng, Y.1
Minca, E.C.2
Lanigan, C.3
-
98
-
-
84920548555
-
Cabozantinib overcomes crizotinib resistance in ROS1 fusion-positive cancer
-
Katayama R, Kobayashi Y, Friboulet L, et al. Cabozantinib overcomes crizotinib resistance in ROS1 fusion-positive cancer. Clin Cancer Res. 2015;21(1):166–74.
-
(2015)
Clin Cancer Res
, vol.21
, Issue.1
, pp. 166-174
-
-
Katayama, R.1
Kobayashi, Y.2
Friboulet, L.3
-
99
-
-
84951172109
-
Cabozantinib (C), erlotinib (E) or the combination (E+C) as second- or third-line therapy in patients with EGFR wild-type (wt) non-small cell lung cancer (NSCLC): A randomized phase 2 trial of the ECOG-ACRIN Cancer Research Group
-
Neal JW, Dahlberg SE, Wakelee HA, et al. Cabozantinib (C), erlotinib (E) or the combination (E+C) as second- or third-line therapy in patients with EGFR wild-type (wt) non-small cell lung cancer (NSCLC): A randomized phase 2 trial of the ECOG-ACRIN Cancer Research Group. J Clin Oncol. (Meeting abstracts). 2015;33:8003.
-
(2015)
J Clin Oncol. (Meeting Abstracts).
, vol.33
-
-
Neal, J.W.1
Dahlberg, S.E.2
Wakelee, H.A.3
-
101
-
-
0030788677
-
Papillary renal cell carcinoma: A clinicopathologic and immunohistochemical study of 105 tumors
-
Delahunt B, Eble JN. Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol. 1997;10(6):537–44.
-
(1997)
Mod Pathol
, vol.10
, Issue.6
, pp. 537-544
-
-
Delahunt, B.1
Eble, J.N.2
-
102
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet. 1994;7(1):85–90.
-
(1994)
Nat Genet
, vol.7
, Issue.1
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
103
-
-
84961287855
-
Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models
-
Ciamporcero E, Miles KM, Adelaiye R, et al. Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models. Mol Cancer Ther. 2015;14(1):101–10.
-
(2015)
Mol Cancer Ther
, vol.14
, Issue.1
, pp. 101-110
-
-
Ciamporcero, E.1
Miles, K.M.2
Adelaiye, R.3
-
104
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S, Michieli P, Galluzzo M, et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 2003;3(4):347–61.
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
-
105
-
-
84903843228
-
MET is a potential target across all papillary renal cell carcinomas: Result from a large molecular study of pRCC with CGH array and matching gene expression array
-
Albiges L, Guegan J, Le Formal A, et al. MET is a potential target across all papillary renal cell carcinomas: result from a large molecular study of pRCC with CGH array and matching gene expression array. Clin Cancer Res. 2014;20(13):3411–21.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.13
, pp. 3411-3421
-
-
Albiges, L.1
Guegan, J.2
Le Formal, A.3
-
107
-
-
70349678985
-
Trisomy 7 and 17mark papillary renal cell tumours irrespectively of variation of the phenotype
-
Balint I, Szponar A, Jauch A, et al. Trisomy 7 and 17mark papillary renal cell tumours irrespectively of variation of the phenotype. J Clin Pathol. 2009;62(10):892–5.
-
(2009)
J Clin Pathol
, vol.62
, Issue.10
, pp. 892-895
-
-
Balint, I.1
Szponar, A.2
Jauch, A.3
-
108
-
-
84911499584
-
Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
Escudier B, Porta C, Schmidinger M, et al. Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(3):iii49–56.
-
(2014)
Ann Oncol.
, vol.25
, Issue.3
, pp. iii49-iii56
-
-
Escudier, B.1
Porta, C.2
Schmidinger, M.3
-
109
-
-
84877098516
-
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
-
Jahangiri A, De Lay M, Miller LM, et al. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res. 2013;9(7):1773–83.
-
(2013)
Clin Cancer Res
, vol.9
, Issue.7
, pp. 1773-1783
-
-
Jahangiri, A.1
De Lay, M.2
Miller, L.M.3
-
110
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009;15(3):232–9.
-
(2009)
Cancer Cell
, vol.15
, Issue.3
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
-
111
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Pàez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009;15(3):220–31.
-
(2009)
Cancer Cell
, vol.15
, Issue.3
, pp. 220-231
-
-
Pàez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
112
-
-
84872548337
-
Phase II and biomarker study of the dual MET/VEGFR2inhibitor foretinib in patients with papillary renal cell carcinoma
-
Choueiri TK, Vaishampayan U, Rosenberg JE, et al. Phase II and biomarker study of the dual MET/VEGFR2inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol. 2013;31(2):181–6.
-
(2013)
J Clin Oncol
, vol.31
, Issue.2
, pp. 181-186
-
-
Choueiri, T.K.1
Vaishampayan, U.2
Rosenberg, J.E.3
-
113
-
-
84920385249
-
Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models
-
Gavine PR, Ren Y, Han L, et al. Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models. Mol Oncol. 2015;9:323–33.
-
(2015)
Mol Oncol
, vol.9
, pp. 323-333
-
-
Gavine, P.R.1
Ren, Y.2
Han, L.3
-
114
-
-
77953033291
-
Relationship between exposure to sunitinib and efficacy and tolerability end-points in patients with cancer: Results of a pharmacokinetic/pharmacodynamic meta-analysis
-
Houk BE, Bello CL, Poland B, et al. Relationship between exposure to sunitinib and efficacy and tolerability end-points in patients with cancer: results of a pharmacokinetic/pharmacody-namic meta-analysis. Cancer Chemother Pharmacol. 2010;66:357–71.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 357-371
-
-
Houk, B.E.1
Bello, C.L.2
Poland, B.3
-
115
-
-
84877739371
-
MTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistanceby HGF
-
Ishikawa D, Takeuchi S, Nakagawa T, et al. mTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistanceby HGF. mTOR PLoS One. 2013;8(5):e62104.
-
(2013)
Mtor Plos One.
, vol.8
, Issue.5
-
-
Ishikawa, D.1
Takeuchi, S.2
Nakagawa, T.3
-
116
-
-
84857675728
-
The mTOR signalling pathway in human cancer
-
Pópulo H, Lopes JM, Soares P. The mTOR signalling pathway in human cancer. Int J Mol Sci. 2012;13(2):1886–918.
-
(2012)
Int J Mol Sci
, vol.13
, Issue.2
, pp. 1886-1918
-
-
Pópulo, H.1
Lopes, J.M.2
Soares, P.3
-
118
-
-
84928483000
-
Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer
-
Garajová I, Le Large TY, Frampton AE, et al. Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer. Biomed Res Int. 2014;2014:678401.
-
(2014)
Biomed Res Int
, vol.2014
-
-
Garajová, I.1
Le Large, T.Y.2
Frampton, A.E.3
-
119
-
-
84943359065
-
Highc-Met expression in stage I–II pancreatic adenocarcinoma: Proposition of an immunostaining scoring method and correlation with poor prognosis
-
Neuzillet C, Couvelard A, Tijeras-Raballand A, et al. Highc-Met expression in stage I–II pancreatic adenocarcinoma: proposition of an immunostaining scoring method and correlation with poor prognosis. Histopathology. 2015;67:664–76.
-
(2015)
Histopathology
, vol.67
, pp. 664-676
-
-
Neuzillet, C.1
Couvelard, A.2
Tijeras-Raballand, A.3
-
120
-
-
84905675342
-
The roleof the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: Antiangiogenic implications in pancreatic cancer
-
Patel MB, Pothula SP, Xu Z, et al. The roleof the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer. Carcinogenesis. 2014;35(8):1891–900.
-
(2014)
Carcinogenesis
, vol.35
, Issue.8
, pp. 1891-1900
-
-
Patel, M.B.1
Pothula, S.P.2
Xu, Z.3
-
121
-
-
79955641985
-
Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6in pancreatic ductal adenocarcinoma
-
Zhu GH, Huang C, Qiu ZJ, et al. Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6in pancreatic ductal adenocarcinoma. Dig Dis Sci. 2011;56(4):1090–8.
-
(2011)
Dig Dis Sci
, vol.56
, Issue.4
, pp. 1090-1098
-
-
Zhu, G.H.1
Huang, C.2
Qiu, Z.J.3
-
122
-
-
81855194258
-
C-Met is a marker of pancreatic cancer stem cells and therapeutic target
-
Li C, Wu JJ, Hynes M, et al. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology. 2011;141(6):2218–27.e5.
-
(2011)
Gastroenterology
, vol.141
, Issue.6
, pp. 2218-2227
-
-
Li, C.1
Wu, J.J.2
Hynes, M.3
-
123
-
-
79955828776
-
Stromal biology and therapy in pancreatic cancer
-
Neesse A, Michl P, Frese KK, et al. Stromal biology and therapy in pancreatic cancer. Gut. 2011;60(6):861–8.
-
(2011)
Gut
, vol.60
, Issue.6
, pp. 861-868
-
-
Neesse, A.1
Michl, P.2
Frese, K.K.3
-
124
-
-
0035102323
-
Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo
-
Xin X, Yang S, Ingle G, et al. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am J Pathol. 2001;158(3):1111–20.
-
(2001)
Am J Pathol
, vol.158
, Issue.3
, pp. 1111-1120
-
-
Xin, X.1
Yang, S.2
Ingle, G.3
-
125
-
-
36349006961
-
Development and characterization of gemcitabine-resistant pancreatic tumor cells
-
Shah AN, Summy JM, Zhang J, et al. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol. 2007;14(12):3629–37.
-
(2007)
Ann Surg Oncol
, vol.14
, Issue.12
, pp. 3629-3637
-
-
Shah, A.N.1
Summy, J.M.2
Zhang, J.3
-
126
-
-
84876744809
-
Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer
-
Avan A, Quint K, Nicolini F, et al. Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940–50.
-
(2013)
Curr Pharm Des
, vol.19
, Issue.5
, pp. 940-950
-
-
Avan, A.1
Quint, K.2
Nicolini, F.3
-
127
-
-
84888347646
-
Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma
-
Avan A, Caretti V, Funel N, et al. Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma. Cancer Res. 2013;73(22):6745–56.
-
(2013)
Cancer Res
, vol.73
, Issue.22
, pp. 6745-6756
-
-
Avan, A.1
Caretti, V.2
Funel, N.3
-
128
-
-
84879372540
-
The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer
-
Hage C, Rausch V, Giese N, et al. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. Cell Death Dis. 2013 May 9;4:e627. doi: 10.1038/cddis.2013.158.
-
(2013)
Cell Death Dis
, vol.4
-
-
Hage, C.1
Rausch, V.2
Giese, N.3
-
129
-
-
84890571003
-
Cabozantinib in progressive medullary thyroid cancer
-
Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol. 2013;31(29):3639–46.
-
(2013)
J Clin Oncol
, vol.31
, Issue.29
, pp. 3639-3646
-
-
Elisei, R.1
Schlumberger, M.J.2
Müller, S.P.3
-
130
-
-
84928816153
-
YKL-40/c-Met Expression in Rectal Cancer Biopsies Predicts Tumor Regression following Neoadjuvant Chemoradiotherapy: A Multi-Institutional Study
-
Senetta R, Duregon E, Sonetto C, et al. YKL-40/c-Met Expression in Rectal Cancer Biopsies Predicts Tumor Regression following Neoadjuvant Chemoradiotherapy: A Multi-Institutional Study. PLoS One. 2015;10(4):e0123759.
-
(2015)
Plos One
, vol.10
, Issue.4
-
-
Senetta, R.1
Duregon, E.2
Sonetto, C.3
-
131
-
-
84926361705
-
Prognostic value of c-Metin colorectal cancer: A meta-analysis
-
Liu Y, Yu XF, Zou J, et al. Prognostic value of c-Metin colorectal cancer: A meta-analysis. World J Gastroenterol. 2015;21(12):3706–10.
-
(2015)
World J Gastroenterol
, vol.21
, Issue.12
, pp. 3706-3710
-
-
Liu, Y.1
Yu, X.F.2
Zou, J.3
-
132
-
-
84899030304
-
MET aberrations and c-MET inhibitorsin patients with gastric and esophageal cancers in a phase I unit
-
Jardim DL, de Melo Gagliato D, Falchook GS, et al. MET aberrations and c-MET inhibitorsin patients with gastric and esophageal cancers in a phase I unit. Oncotarget. 2014;5(7):1837–45.
-
(2014)
Oncotarget
, vol.5
, Issue.7
, pp. 1837-1845
-
-
Jardim, D.L.1
De Melo Gagliato, D.2
Falchook, G.S.3
-
133
-
-
84922567957
-
Potent antitumor activity of cabozantinib, a c-METand VEGFR2inhibitor, in a colorectal cancer patient-derived tumor explant model
-
Song EK, Tai WM, Messersmith WA, et al. Potent antitumor activity of cabozantinib, a c-METand VEGFR2inhibitor, in a colorectal cancer patient-derived tumor explant model. Int J Cancer. 2015;136(8):1967–75.
-
(2015)
Int J Cancer
, vol.136
, Issue.8
, pp. 1967-1975
-
-
Song, E.K.1
Tai, W.M.2
Messersmith, W.A.3
-
134
-
-
84901747256
-
Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 andMET
-
Xiang Q, Chen W, Ren M, et al. Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 andMET. Clin Cancer Res. 2014;20(11):2959–70.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.11
, pp. 2959-2970
-
-
Xiang, Q.1
Chen, W.2
Ren, M.3
-
135
-
-
84908091776
-
Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistantprostate cancer
-
Eswaraka J, Giddabasappa A, Han G, et al. Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistantprostate cancer. BMC Cancer. 2014;14:742.
-
(2014)
BMC Cancer
, vol.14
, pp. 742
-
-
Eswaraka, J.1
Giddabasappa, A.2
Han, G.3
-
136
-
-
84874787799
-
Cabozantinib in patients with advanced prostate cancer: Results of a phase II randomized discontinuation trial
-
Smith DC, Smith MR, Sweeney C, et al. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. J Clin Oncol. 2013;31(4):412–9.
-
(2013)
J Clin Oncol
, vol.31
, Issue.4
, pp. 412-419
-
-
Smith, D.C.1
Smith, M.R.2
Sweeney, C.3
-
137
-
-
84926683147
-
MET Gene Copy Number Alterations and Expression of METand Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas
-
Schmitz K, Koeppen H, Binot E, et al. MET Gene Copy Number Alterations and Expression of METand Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas. PLoS One. 2015;10(4):e0120079.
-
(2015)
Plos One
, vol.10
, Issue.4
-
-
Schmitz, K.1
Koeppen, H.2
Binot, E.3
-
138
-
-
84902256995
-
Soft tissue sarcoma: An update on systemic treatment options for patients with advanced disease
-
Schöffski P, Cornillie J, Wozniak A, et al. Soft tissue sarcoma: an update on systemic treatment options for patients with advanced disease. Oncol Res Treat. 2014;37(6):355–62.
-
(2014)
Oncol Res Treat
, vol.37
, Issue.6
, pp. 355-362
-
-
Schöffski, P.1
Cornillie, J.2
Wozniak, A.3
-
139
-
-
84863728707
-
Autocrine activation of theMET receptor tyrosine kinase in acute myeloid leukemia
-
Kentsis A, Reed C, Rice KL, et al. Autocrine activation of theMET receptor tyrosine kinase in acute myeloid leukemia. Nat Med. 2012;18(7):1118–22.
-
(2012)
Nat Med
, vol.18
, Issue.7
, pp. 1118-1122
-
-
Kentsis, A.1
Reed, C.2
Rice, K.L.3
-
140
-
-
84930822320
-
-
NLM Identifier: NCT01697072
-
Amgen. A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled Study of Rilotumumab (AMG102) With Epirubicin, Cisplatin, and Capecitabine (ECX) as First-line Therapy in Advanced MET-Positive Gastric or Gastroesophageal Junction Adenocarcinoma. Available from: http://clinicaltrials.gov/show/NCT01697072. NLM Identifier: NCT01697072.
-
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled Study of Rilotumumab (AMG102) with Epirubicin, Cisplatin, and Capecitabine (ECX) as First-Line Therapy in Advanced Met-Positive Gastric Or Gastroesophageal Junction Adenocarcinoma
-
-
-
141
-
-
84872214179
-
Phase Ib study of ficlatuzumab (Formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC
-
Tan EP, Park K, Lim WT, et al. Phase Ib study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC. J Clin Oncol. (Meeting abstracts). 2011;29(15):7571.
-
(2011)
J Clin Oncol. (Meeting Abstracts).
, vol.29
, Issue.15
-
-
Tan, E.P.1
Park, K.2
Lim, W.T.3
-
142
-
-
84871962904
-
Targeted MET inhibition in castration-resistant prostate cancer: A randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone
-
Ryan CJ, Rosenthal M, Ng S, et al. Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res. 2013;19(1):215–24.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.1
, pp. 215-224
-
-
Ryan, C.J.1
Rosenthal, M.2
Ng, S.3
-
143
-
-
80051991655
-
A phase II study of the efficacy and safety of AMG 102in patients with metastatic renal cell carcinoma
-
Schoffski P, Garcia JA, Stadler, et al. A phase II study of the efficacy and safety of AMG 102in patients with metastatic renal cell carcinoma. BJU Int. 2011;108(5):679–86.
-
(2011)
BJU Int
, vol.108
, Issue.5
, pp. 679-686
-
-
Schoffski, P.1
Garciastadler, J.A.2
-
144
-
-
79955766450
-
A phase II study evaluating the efficacy and safety of AMG 102 (Rilotumumab) in patients with recurrent glioblastoma
-
Wen PY, Schiff D, Cloughesy TF, et al. A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol. 2011;13(4):437–46.
-
(2011)
Neuro Oncol
, vol.13
, Issue.4
, pp. 437-446
-
-
Wen, P.Y.1
Schiff, D.2
Cloughesy, T.F.3
-
145
-
-
84879298407
-
HGF as a circulating biomarker of onartuzumab treatment in patients with advanced solid tumors
-
Penuel E, Li C, Parab V, et al. HGF as a circulating biomarker of onartuzumab treatment in patients with advanced solid tumors. Mol Cancer Ther. 2013;12:1122–30.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 1122-1130
-
-
Penuel, E.1
Li, C.2
Parab, V.3
-
146
-
-
84055212018
-
A phase I dose-escalation study of Tivantinib (ARQ 197) in adult patients with metastatic solid tumors
-
Rosen LS, Senzer N, Mekhail T, et al. A phase I dose-escalation study of Tivantinib (ARQ 197) in adult patients with metastatic solid tumors. Clin Cancer Res. 2011;17:7754–64.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7754-7764
-
-
Rosen, L.S.1
Senzer, N.2
Mekhail, T.3
-
147
-
-
84905028489
-
Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: An open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2study
-
Iveson T, Donehower RC, Davidenko I, et al. Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: An open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2study. Lancet Oncol. 2014;15:1007–18.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1007-1018
-
-
Iveson, T.1
Donehower, R.C.2
Davidenko, I.3
-
148
-
-
84940594027
-
Phase III, randomized, double-blind, multicenter, placebo (P)-controlled trial of rilotumumab (R) plus epirubicin, cisplatin and capecitabine (ECX) as first-line therapy in patients (pts) with advanced MET-positive (pos) gastric or gastroesophageal junction (G/GEJ) cancer: RILOMET-1 study
-
Cunningham D, Tebbutt NC, Davidenko I, et al. Phase III, randomized, double-blind, multicenter, placebo (P)-controlled trial of rilotumumab (R) plus epirubicin, cisplatin and capecitabine (ECX) as first-line therapy in patients (pts) with advanced MET-positive (pos) gastric or gastroesophageal junction (G/GEJ) cancer: RILOMET-1 study. J Clin Oncol. (Meeting abstracts). 2015;33:4000.
-
(2015)
J Clin Oncol. (Meeting Abstracts).
, vol.33
-
-
Cunningham, D.1
Tebbutt, N.C.2
Davidenko, I.3
-
149
-
-
83455209245
-
Exploratory biomarker analyses from OAM4558g: A placebo-controlled phase II study of erlotinib with or without MetMAb in patients with advanced non-small cell lung cancer (NSCLC)
-
Yu W, Pandita A, Penuel E, et al. Exploratory biomarker analyses from OAM4558g: A placebo-controlled phase II study of erlotinib with or without MetMAb in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. (Meeting abstracts). 2011;29:7529.
-
(2011)
J Clin Oncol. (Meeting Abstracts).
, vol.29
-
-
Yu, W.1
Pandita, A.2
Penuel, E.3
-
150
-
-
84924765300
-
Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth
-
Jung SK, Lee MH, Lim do Y, et al. Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. Mol Carcinog. 2015;54(4):322–31.
-
(2015)
Mol Carcinog
, vol.54
, Issue.4
, pp. 322-331
-
-
Jung, S.K.1
Lee, M.H.2
Lim Do, Y.3
-
151
-
-
84894208992
-
Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab
-
Mai E, Zheng Z, Chen Y, et al. Nonclinical evaluation of the serum pharmacodynamic biomarkers HGF and shed MET following dosing with the anti-MET monovalent monoclonal antibody onartuzumab. Mol Cancer Ther. 2014;13:540–52.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 540-552
-
-
Mai, E.1
Zheng, Z.2
Chen, Y.3
-
152
-
-
84871019676
-
Tivantinib (ARQ 197) versus placebo in patients (Pts) with hepatocellular carcinoma (HCC) who failed one systemic therapy: Results of a randomized controlled phase II trial (RCT)
-
Rimassa LPC, Borbath I, Daniele B, et al. Tivantinib (ARQ 197) versus placebo in patients (Pts) with hepatocellular carcinoma (HCC) who failed one systemic therapy: Results of a randomized controlled phase II trial (RCT). J Clin Oncol. (Meeting abstracts). 2012;4006.
-
(2012)
J Clin Oncol. (Meeting Abstracts).
, pp. 4006
-
-
Rimassa, L.1
Borbath, I.2
Daniele, B.3
-
153
-
-
84871721240
-
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
-
Santoro A, Rimassa L, Borbath I, et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol. 2013;14(1):55–63.
-
(2013)
Lancet Oncol
, vol.14
, Issue.1
, pp. 55-63
-
-
Santoro, A.1
Rimassa, L.2
Borbath, I.3
-
154
-
-
84951187393
-
Relationship between tumor MET expression and clinical outcomes in cancer patients treated with tivantinib
-
Zahir H, Rodig S, Sequist L, et al. Relationship between tumor MET expression and clinical outcomes in cancer patients treated with tivantinib. EJC supplements. 2012;48(6):149.
-
(2012)
EJC Supplements
, vol.48
, Issue.6
-
-
Zahir, H.1
Rodig, S.2
Sequist, L.3
-
155
-
-
84982253975
-
An exploratory biomarker analysis evaluating the effect of the c-Met inhibitor tivantinib (ARQ 197) and erlotinib in NSCLC patients in a randomized, double-blinded phase 2study
-
Rodig S, Sequist L, Schiller JH, et al. An exploratory biomarker analysis evaluating the effect of the c-Met inhibitor tivantinib (ARQ 197) and erlotinib in NSCLC patients in a randomized, double-blinded phase 2study. Proceedings of the American Association of Cancer Res. 2012;72:1729.
-
(2012)
Proceedings of the American Association of Cancer Res
, vol.72
-
-
Rodig, S.1
Sequist, L.2
Schiller, J.H.3
-
156
-
-
84555190809
-
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
-
Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011;29(36):4803–10.
-
(2011)
J Clin Oncol
, vol.29
, Issue.36
, pp. 4803-4810
-
-
Lennerz, J.K.1
Kwak, E.L.2
Ackerman, A.3
-
157
-
-
80052969848
-
MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations
-
Tanizaki J, Okamoto I, Okamoto K, et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol. 2011;6(10):1624–31.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.10
, pp. 1624-1631
-
-
Tanizaki, J.1
Okamoto, I.2
Okamoto, K.3
-
158
-
-
79955458487
-
Activity of crizotinib (PF02341066), a dual mesenchymal–epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
-
Ou SH, Kwak EL, Siwak-Tapp C, et al. Activity of crizotinib (PF02341066), a dual mesenchymal–epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol.2011;6(5), 942–6.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.5
, pp. 942-946
-
-
Ou, S.H.1
Kwak, E.L.2
Siwak-Tapp, C.3
-
159
-
-
84896701281
-
MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients
-
Rocci A, Gambella M, Aschero S, et al. MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients. Br J Haematol. 2014;164, 841–50.
-
(2014)
Br J Haematol
, vol.164
, pp. 841-850
-
-
Rocci, A.1
Gambella, M.2
Aschero, S.3
-
160
-
-
77954236265
-
A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
-
Eder JP, Shapiro GI, Appleman LJ, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res. 2010;16(13), 3507–16.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.13
, pp. 3507-3516
-
-
Eder, J.P.1
Shapiro, G.I.2
Appleman, L.J.3
-
161
-
-
84861636803
-
Preclinical evaluation of biomarkers for response monitoring to the MET inhibitor BAY−853474
-
Klotz M, Schmid E, Steiner-Hahn K, et al. Preclinical evaluation of biomarkers for response monitoring to the MET inhibitor BAY−853474. Biomarkers. 2012;17(4):325–35.
-
(2012)
Biomarkers
, vol.17
, Issue.4
, pp. 325-335
-
-
Klotz, M.1
Schmid, E.2
Steiner-Hahn, K.3
-
162
-
-
84880923318
-
A phase 2multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors
-
Feldman DR, Einhorn LH, Quinn DI, et al. A phase 2multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors. Invest New Drugs. 2013;31(4):1016–22.
-
(2013)
Invest New Drugs
, vol.31
, Issue.4
, pp. 1016-1022
-
-
Feldman, D.R.1
Einhorn, L.H.2
Quinn, D.I.3
-
163
-
-
84902097343
-
HGF/MET-directed therapeutics in gastroesophageal cancer: A review of clinical and biomarker development
-
Hack SP, Bruey JM, Koeppen H. HGF/MET-directed therapeutics in gastroesophageal cancer: a review of clinical and biomarker development. Oncotarget. 2014;5(10):2866–80.
-
(2014)
Oncotarget
, vol.5
, Issue.10
, pp. 2866-2880
-
-
Hack, S.P.1
Bruey, J.M.2
Koeppen, H.3
-
164
-
-
84885836502
-
Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation
-
Giampieri R, Scartozzi M, Del PM, et al. Molecular biomarkers of resistance to anti-EGFR treatment in metastatic colorectal cancer, from classical to innovation. Crit Rev Oncol Hematol. 2013;88(2):272–83.
-
(2013)
Crit Rev Oncol Hematol
, vol.88
, Issue.2
, pp. 272-283
-
-
Giampieri, R.1
Scartozzi, M.2
Del, P.M.3
-
165
-
-
84878466503
-
MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met
-
Luo W, Huang B, Li Z, Li, et al. MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. PLoS One. 2013;8(5):e64759.
-
(2013)
Plos One
, vol.8
, Issue.5
-
-
Luo, W.1
Huang, B.2
Lili, Z.3
-
166
-
-
79959624589
-
MiR-340inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met
-
Wu ZS, Wu Q, Wang CQ, et al. miR-340inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met. Cancer. 2011;117(13):2842–52.
-
(2011)
Cancer
, vol.117
, Issue.13
, pp. 2842-2852
-
-
Wu, Z.S.1
Wu, Q.2
Wang, C.Q.3
-
167
-
-
84951086268
-
Identification of gene expression signature to predict anti-tumor efficacy of MET/VEGFR inhibitor, TAS-115
-
Itadani H, Hasako S, Yonekura K, et al. Identification of gene expression signature to predict anti-tumor efficacy of MET/VEGFR inhibitor, TAS-115. EJC supplements. 2012;48(6):136.
-
(2012)
EJC Supplements
, vol.48
, Issue.6
-
-
Itadani, H.1
Hasako, S.2
Yonekura, K.3
-
168
-
-
78751520901
-
Antitumor activity of SNX-2112, a synthetic heat shock protein-90inhibitor, in MET amplified tumor cells with or without resistance to selective MET Inhibition
-
Bachleitner-Hofmann T, Sun MY, Chen CT, et al. Antitumor activity of SNX-2112, a synthetic heat shock protein-90inhibitor, in MET amplified tumor cells with or without resistance to selective MET Inhibition. Clin Cancer Res. 2011;17(1):122–33.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.1
, pp. 122-133
-
-
Bachleitner-Hofmann, T.1
Sun, M.Y.2
Chen, C.T.3
-
169
-
-
1242296133
-
Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy
-
Stabile LP, Lyker JS, Huang L, et al. Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy. Gene Ther. 2004;11(3):325–35.
-
(2004)
Gene Ther
, vol.11
, Issue.3
, pp. 325-335
-
-
Stabile, L.P.1
Lyker, J.S.2
Huang, L.3
-
170
-
-
84884241108
-
A randomized phase 2study with exploratory biomarker analysis of ficlantuzumab a humanized hepatocyte growth factor inhibitory MAB in combination with gefitinib versus gefitinib in Asian patients with lung adenocarcinoma
-
Mok TSK, Park K, Geater SL, et al. A randomized phase 2study with exploratory biomarker analysis of ficlantuzumab a humanized hepatocyte growth factor inhibitory MAB in combination with gefitinib versus gefitinib in Asian patients with lung adenocarcinoma. Ann Oncol. (Meeting abstracts). 2012;23:1198P.
-
(2012)
Ann Oncol. (Meeting Abstracts)
, vol.23
-
-
Mok, T.1
Park, K.2
Geater, S.L.3
-
171
-
-
80051991655
-
A phase II study of the efficacy and safety of AMG 102in patients with metastatic renal cell carcinoma
-
Schoffski P, Garcia JA, Stadler WM, et al. A phase II study of the efficacy and safety of AMG 102in patients with metastatic renal cell carcinoma. BJU Int. 2011;108(5):679–86.
-
(2011)
BJU Int
, vol.108
, Issue.5
, pp. 679-686
-
-
Schoffski, P.1
Garcia, J.A.2
Stadler, W.M.3
-
172
-
-
84905175125
-
A phaseI studyof cabozantinib(XL184) in patients with renal cell cancer
-
Choueiri TK, Pal SK, McDermott DF, et al. A phaseI studyof cabozantinib(XL184) in patients with renal cell cancer. Ann Oncol. 2014;25(8):1603–8.
-
(2014)
Ann Oncol
, vol.25
, Issue.8
, pp. 1603-1608
-
-
Choueiri, T.K.1
Pal, S.K.2
McDermott, D.F.3
-
173
-
-
84867827863
-
Activity of cabozantinib (XL184) in patients (pts) with metastatic, refractory renal cell carcinoma (RCC)
-
Choueiri TK, Pal SK, McDermott DF, et al. Activity of cabozantinib (XL184) in patients (pts) with metastatic, refractory renal cell carcinoma (RCC). J Clin Oncol. 2012;30(5):364.
-
(2012)
J Clin Oncol
, vol.30
, Issue.5
, pp. 364
-
-
Choueiri, T.K.1
Pal, S.K.2
McDermott, D.F.3
-
174
-
-
84931840038
-
Final analysis of COMET-1: Cabozantinib (Cabo) versus prednisone (Pred) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) previously treated with docetaxel (D) and abiraterone (A) and/or enzalutamide (E)
-
Smith MR, De Bono JS, Sternberg CN, et al. Final analysis of COMET-1: Cabozantinib (Cabo) versus prednisone (Pred) in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) previously treated with docetaxel (D) and abiraterone (A) and/or enzalutamide (E). J Clin Oncol. 2015;33(7):139.
-
(2015)
J Clin Oncol
, vol.33
, Issue.7
-
-
Smith, M.R.1
De Bono, J.S.2
Sternberg, C.N.3
-
175
-
-
84871962904
-
Targeted MET inhibition in castration-resistant prostate cancer: A randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone
-
Ryan CJ, Rosenthal M, Ng S, et al. Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res. 2013;19(1):215–24.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.1
, pp. 215-224
-
-
Ryan, C.J.1
Rosenthal, M.2
Ng, S.3
-
176
-
-
84883643499
-
A randomized, placebo-controlled, phaseI/II study of tivantinib (ARQ 197) in combination with cetuximab and irinotecan in patients (pts) with KRAS wild-type (WT) metastatic colorectal cancer (CRC) who had received previous front-line systemic therapy
-
Eng C, Hart LL, Severtsev A, et al. A randomized, placebo-controlled, phaseI/II study of tivantinib (ARQ 197) in combination with cetuximab and irinotecan in patients (pts) with KRAS wild-type (WT) metastatic colorectal cancer (CRC) who had received previous front-line systemic therapy. J Clin Oncol. 2013;31:3508.
-
(2013)
J Clin Oncol
, vol.31
-
-
Eng, C.1
Hart, L.L.2
Severtsev, A.3
-
177
-
-
80054746340
-
A randomized, phase Ib/II trial of rilotumumab (AMG 102; ril) or ganitumab (AMG 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wildtype (WT) KRAS metastatic colorectal cancer (mCRC): Primary and biomarker analyses
-
Eng C, Van Cutsem E, Nowara E, et al. A randomized, phase Ib/II trial of rilotumumab (AMG 102; ril) or ganitumab (AMG 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wildtype (WT) KRAS metastatic colorectal cancer (mCRC): Primary and biomarker analyses. J Clin Oncol. 2011;29:3500.
-
(2011)
J Clin Oncol
, vol.29
-
-
Eng, C.1
Van Cutsem, E.2
Nowara, E.3
-
178
-
-
84870511276
-
Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer
-
Oliner KS, Tang R, Anderson A, et al. Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer. J Clin Oncol. 2012;30:4005.
-
(2012)
J Clin Oncol
, vol.30
-
-
Oliner, K.S.1
Tang, R.2
Erson, A.3
-
179
-
-
84875035582
-
Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2inhibitor, in patients with metastatic gastric cancer
-
Shah MA, Wainberg ZA, Catenacci DV, et al. Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2inhibitor, in patients with metastatic gastric cancer. PLoS One. 2013;8(3):e54014.
-
(2013)
Plos One
, vol.8
, Issue.3
-
-
Shah, M.A.1
Wainberg, Z.A.2
Catenacci, D.V.3
-
180
-
-
84872549428
-
Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT)
-
Verslype C, Cohn AL, Kelley RK, et al. Activity of cabozantinib (XL184) in hepatocellular carcinoma: results from a phase II randomized discontinuation trial (RDT). J Clin Oncol. 2012;30:4007.
-
(2012)
J Clin Oncol
, vol.30
-
-
Verslype, C.1
Cohn, A.L.2
Kelley, R.K.3
-
181
-
-
84875025156
-
A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC)
-
Yau TC, Sukeepaisarnjaroen W, Chao Y, et al. A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2012;30:4108.
-
(2012)
J Clin Oncol
, vol.30
-
-
Yau, T.C.1
Sukeepaisarnjaroen, W.2
Chao, Y.3
-
182
-
-
84880709088
-
Activity of cabozantinib in metastatic uveal melanoma: Updated results from a phase II randomized discontinuation trial (RDT)
-
Daud A, Kluger HM, Edelman G, et al. Activity of cabozantinib in metastatic uveal melanoma: updated results from a phase II randomized discontinuation trial (RDT). J Clin Oncol. (Meeting abstracts). 2013;31(15):9094.
-
(2013)
J Clin Oncol. (Meeting Abstracts).
, vol.31
, Issue.15
-
-
Daud, A.1
Kluger, H.M.2
Edelman, G.3
-
183
-
-
84865089099
-
Activity of cabozantinib (XL184) in metastatic melanoma: Results from a phase II randomized discontinuation trial (RDT)
-
Gordon MS, Kluger HM, Shapiro G, et al. Activity of cabozantinib (XL184) in metastatic melanoma: Results from a phase II randomized discontinuation trial (RDT) J Clin Oncol. (Meeting abstracts). 2012;30:8531.
-
(2012)
J Clin Oncol. (Meeting Abstracts).
, vol.30
-
-
Gordon, M.S.1
Kluger, H.M.2
Shapiro, G.3
-
184
-
-
84873835254
-
Activity of cabozantinib (XL184) in metastatic breast cancer (MBC): Results from a phase II randomized discontinuation trial (RDT)
-
Winer EP, Tolaney S, Nechushtan H, et al. Activity of cabozantinib (XL184) in metastatic breast cancer (MBC): Results from a phase II randomized discontinuation trial (RDT) J Clin Oncol. (Meeting abstracts). 2012;30:535.
-
(2012)
J Clin Oncol. (Meeting Abstracts).
, vol.30
-
-
Winer, E.P.1
Tolaney, S.2
Nechushtan, H.3
-
185
-
-
84898901045
-
A phase II study of the efficacy and safety of foretinib, a novel receptor tyrosine kinase inhibitor, given on an intermittent 5-days-on/9-days-off (5/9) schedule in patients with recurrent or metastatic squamous cell cancer of the head and neck
-
Seiwert T, Swann S, Kurz H, et al. (2009). A phase II study of the efficacy and safety of foretinib, a novel receptor tyrosine kinase inhibitor, given on an intermittent 5-days-on/9-days-off (5/9) schedule in patients with recurrent or metastatic squamous cell cancer of the head and neck. Mol Cancer Ther. 2009;8:12(1):B6.
-
(2009)
Mol Cancer Ther
, vol.8:12
, Issue.1
-
-
Seiwert, T.1
Swann, S.2
Kurz, H.3
-
186
-
-
84880923318
-
A phase 2multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors
-
Feldman DR, Einhorn LH, Quinn DI, et al. A phase 2multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors. Invest New Drugs. 2013;31(4):1016–22.
-
(2013)
Invest New Drugs
, vol.31
, Issue.4
, pp. 1016-1022
-
-
Feldman, D.R.1
Einhorn, L.H.2
Quinn, D.I.3
-
187
-
-
84982251956
-
Activity of crizotinib (C) in patients (pts) with clear cell sarcoma (CCSA) in EORTC phase II trial 90101 “CREATE”. J Clin Oncol
-
Schoffski P, Wozniak A, Stacchiotti S, et al. Activity of crizotinib (C) in patients (pts) with clear cell sarcoma (CCSA) in EORTC phase II trial 90101 “CREATE”. J Clin Oncol. (Meeting abstracts). 2015;33:10542.
-
(2015)
(Meeting Abstracts).
, vol.33
-
-
Schoffski, P.1
Wozniak, A.2
Stacchiotti, S.3
-
188
-
-
84890571003
-
Cabozantinibin progressive medullary thyroid cancer
-
Elisei R, Schlumberger MJ, Müller SP, et al. Cabozantinibin progressive medullary thyroid cancer. J Clin Oncol. 2013;31(29):3639–46.
-
(2013)
J Clin Oncol
, vol.31
, Issue.29
, pp. 3639-3646
-
-
Elisei, R.1
Schlumberger, M.J.2
Müller, S.P.3
-
189
-
-
84862294110
-
Optimization of patient selection for EGFR-TKIs in advanced non-small cell lung cancer by combined analysis of KRAS, PIK3CA, MET, and non-sensitizing EGFR mutations
-
Ludovini V, Bianconi F, Pistola L, et al. Optimization of patient selection for EGFR-TKIs in advanced non-small cell lung cancer by combined analysis of KRAS, PIK3CA, MET, and non-sensitizing EGFR mutations. Cancer Chemother Pharmacol. 2012;69(5):1289–99.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, Issue.5
, pp. 1289-1299
-
-
Ludovini, V.1
Bianconi, F.2
Pistola, L.3
-
190
-
-
63849163410
-
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
-
Cappuzzo F, Marchetti A, Skokan M, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol. 2009;27(10):1667–74.
-
(2009)
J Clin Oncol
, vol.27
, Issue.10
, pp. 1667-1674
-
-
Cappuzzo, F.1
Marchetti, A.2
Skokan, M.3
-
191
-
-
84863229341
-
High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients
-
Park S, Choi YL, Sung CO, et al. High MET copy number and MET overexpression: poor outcome in non-small cell lung cancer patients. Histol Histopathol. 2012;27(2):197–207
-
(2012)
Histol Histopathol
, vol.27
, Issue.2
, pp. 197-207
-
-
Park, S.1
Choi, Y.L.2
Sung, C.O.3
-
192
-
-
55449116539
-
Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
-
Okuda K, Sasaki H, Yukiue H, et al. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci. 2012;99(11): 2280–5.
-
(2012)
Cancer Sci
, vol.99
, Issue.11
, pp. 2280-2285
-
-
Okuda, K.1
Sasaki, H.2
Yukiue, H.3
-
193
-
-
84903843228
-
MET is a potential target across all papillary renal cell carcinomas: Result from a large molecular study of pRCC with CGH array and matching gene expression array
-
Albiges L, Guegan J, Le Formal A, et al. MET is a potential target across all papillary renal cell carcinomas: result from a large molecular study of pRCC with CGH array and matching gene expression array. Clin Cancer Res. 2014;20(13):3411–21.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.13
, pp. 3411-3421
-
-
Albiges, L.1
Guegan, J.2
Le Formal, A.3
-
194
-
-
84892549017
-
Met as a therapeutic target in HCC: Facts and hopes
-
Giordano S, Columbano A. Met as a therapeutic target in HCC: facts and hopes. J Hepatol. 2014;60(2):442–52.
-
(2014)
J Hepatol
, vol.60
, Issue.2
, pp. 442-452
-
-
Giordano, S.1
Columbano, A.2
-
195
-
-
19544389146
-
C-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention
-
Christensen JG, Burrows J, Salgia R. c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett. 2005;225(1):1–26.
-
(2005)
Cancer Lett
, vol.225
, Issue.1
, pp. 1-26
-
-
Christensen, J.G.1
Burrows, J.2
Salgia, R.3
-
196
-
-
0028946604
-
Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
-
Di Renzo MF, Olivero M, Giacomini A, et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin Cancer Res. 1995;1(2):147–54
-
(1995)
Clin Cancer Res
, vol.1
, Issue.2
, pp. 147-154
-
-
Di Renzo, M.F.1
Olivero, M.2
Giacomini, A.3
-
197
-
-
66149135285
-
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
-
Seiwert TY, Jagadeeswaran R, Faoro L, et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 2009;69(7):3021–31.
-
(2009)
Cancer Res
, vol.69
, Issue.7
, pp. 3021-3031
-
-
Seiwert, T.Y.1
Jagadeeswaran, R.2
Faoro, L.3
-
198
-
-
84878862323
-
Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
-
Bardelli A, Corso S, Bertotti A, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 2013;3(6): 658–73.
-
(2013)
Cancer Discov
, vol.3
, Issue.6
, pp. 658-673
-
-
Bardelli, A.1
Corso, S.2
Bertotti, A.3
-
199
-
-
80052971224
-
Head neck squamous cell carcinoma c-Met+ cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis
-
Sun S, Wang Z. Head neck squamous cell carcinoma c-Met+ cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis. Int J Cancer. 2011;129(10):2337–48.
-
(2011)
Int J Cancer
, vol.129
, Issue.10
, pp. 2337-2348
-
-
Sun, S.1
Wang, Z.2
-
200
-
-
84871987996
-
PDGF alpha receptor is a mediator for Cisplatin-induced Met expression
-
Kina S, Phonaphonh T, Liang F, et al. PDGF alpha receptor is a mediator for Cisplatin-induced Met expression. Eur J Pharmacol. 2013;699(1–3): 227–32.
-
(2013)
Eur J Pharmacol
, vol.699
, Issue.13
, pp. 227-232
-
-
Kina, S.1
Phonaphonh, T.2
Liang, F.3
-
201
-
-
84880554542
-
Downregulation of miRNA-31induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET
-
Mitamura T, Watari H, Wang L, et al. Downregulation of miRNA-31induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET. Oncogenesis. 2013;2:e40.
-
(2013)
Oncogenesis
, vol.2
-
-
Mitamura, T.1
Watari, H.2
Wang, L.3
-
202
-
-
48649092035
-
Coupling of mutated Met variants to DNA repair via Abl and Rad51
-
Ganapathipillai SS, Medova M, Aebersold DM, et al. Coupling of mutated Met variants to DNA repair via Abl and Rad51. Cancer Res. 2008;68(14):5769–77.
-
(2008)
Cancer Res
, vol.68
, Issue.14
, pp. 5769-5777
-
-
Ganapathipillai, S.S.1
Medova, M.2
Aebersold, D.M.3
|