메뉴 건너뛰기




Volumn 7, Issue 2, 2015, Pages 556-573

cMET in NSCLC: Can we cut off the head of the Hydra? From the pathway to the resistance

Author keywords

cMET; NSCLC; Targeted therapies

Indexed keywords

CARBOPLATIN; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FOCAL ADHESION KINASE; GEFITINIB; GEMCITABINE; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SEMA4D; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SEMAPHORIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5;

EID: 84925872286     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers7020556     Document Type: Review
Times cited : (37)

References (107)
  • 2
    • 33644887722 scopus 로고    scopus 로고
    • The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing
    • [CrossRef] [PubMed]
    • Conway, K.P.; Price, P.E.; Harding, K.G.; Jiang, W.G. The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing. Wound Repair Regen. 2006, 14, 2–10. [CrossRef] [PubMed]
    • (2006) Wound Repair Regen , vol.14 , pp. 2-10
    • Conway, K.P.1    Price, P.E.2    Harding, K.G.3    Jiang, W.G.4
  • 5
    • 0038115223 scopus 로고    scopus 로고
    • HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro
    • [CrossRef] [PubMed]
    • Ding, S.; Merkulova-rainon, T.; Han, Z.C. HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood 2003, 101, 4816–4822. [CrossRef] [PubMed]
    • (2003) Blood , vol.101 , pp. 4816-4822
    • Ding, S.1    Merkulova-Rainon, T.2    Han, Z.C.3
  • 6
    • 30544452034 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes lymphatic vessel formation and function
    • [CrossRef] [PubMed]
    • Kajiya, K.; Hirakawa, S.; Ma, B.; Drinnenberg, I.; Detmar, M. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005, 24, 2885–2895. [CrossRef] [PubMed]
    • (2005) EMBO J , vol.24 , pp. 2885-2895
    • Kajiya, K.1    Hirakawa, S.2    Ma, B.3    Drinnenberg, I.4    Detmar, M.5
  • 7
    • 0030237229 scopus 로고    scopus 로고
    • Roles of mesenchymal-epithelial interactions and hepatocyte growth factor-scatter factor (HGF-SF) in placental development
    • [CrossRef] [PubMed]
    • Stewart, F. Roles of mesenchymal-epithelial interactions and hepatocyte growth factor-scatter factor (HGF-SF) in placental development. Rev. Reprod. 1996, 1, 144–148. [CrossRef] [PubMed]
    • (1996) Rev. Reprod , vol.1 , pp. 144-148
    • Stewart, F.1
  • 8
    • 0028221326 scopus 로고
    • Involvement of hepatocyte growth factor in kidney development
    • [CrossRef] [PubMed]
    • Santos, O.; Barros, E.; Yang, X.-M.; Matsumoto, K.; Nakamura, T.; Park, M.; Nigam, S. Involvement of hepatocyte growth factor in kidney development. Dev. Biol. 1994, 163, 525–529. [CrossRef] [PubMed]
    • (1994) Dev. Biol , vol.163 , pp. 525-529
    • Santos, O.1    Barros, E.2    Yang, X.-M.3    Matsumoto, K.4    Nakamura, T.5    Park, M.6    Nigam, S.7
  • 9
    • 0027337146 scopus 로고
    • Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin
    • [CrossRef] [PubMed]
    • Komada, M.; Hatsuzawa, K.; Shibamoto, S.; Ito, F.; Nakayama, K.; Kitamura, N. Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin. FEBS Lett. 1993, 328, 25–29. [CrossRef] [PubMed]
    • (1993) FEBS Lett , vol.328 , pp. 25-29
    • Komada, M.1    Hatsuzawa, K.2    Shibamoto, S.3    Ito, F.4    Nakayama, K.5    Kitamura, N.6
  • 10
    • 0023790119 scopus 로고
    • Structure of the met protein and variation of met protein kinase activity among human tumour cell lines
    • [CrossRef] [PubMed]
    • Tempest, P.; Stratton, M.; Cooper, C. Structure of the met protein and variation of met protein kinase activity among human tumour cell lines. Br. J. Cancer 1988, 58, 3–7. [CrossRef] [PubMed]
    • (1988) Br. J. Cancer , vol.58 , pp. 3-7
    • Tempest, P.1    Stratton, M.2    Cooper, C.3
  • 11
    • 0023724679 scopus 로고
    • P145, a protein with associated tyrosine kinase activity in human gastric carcinoma cell line. Mol
    • [PubMed]
    • Giordano, S.; Flavia, M.; Renzo, D.I.; Ferracini, R.; Chiado-piat, L.; Comoglio, P.M. p145, a protein with associated tyrosine kinase activity in human gastric carcinoma cell line. Mol. Cell Biol. 1988, 8, 3510–3517. [PubMed]
    • (1988) Cell Biol , vol.8 , pp. 3510-3517
    • Giordano, S.1    Flavia, M.2    Renzo, D.I.3    Ferracini, R.4    Chiado-Piat, L.5    Comoglio, P.M.6
  • 12
    • 0142091400 scopus 로고    scopus 로고
    • Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor
    • [CrossRef] [PubMed]
    • Gherardi, E.; Youles, M.E.; Miguel, R.N.; Blundell, T.L.; Iamele, L.; Gough, J.; Bandyopadhyay, A.; Hartmann, G.; Butler, P.J.G. Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor. Proc. Natl. Acad. Sci. USA 2003, 100, 12039–12044. [CrossRef] [PubMed]
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12039-12044
    • Gherardi, E.1    Youles, M.E.2    Miguel, R.N.3    Blundell, T.L.4    Iamele, L.5    Gough, J.6    Bandyopadhyay, A.7    Hartmann, G.8    Butler, P.9
  • 13
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • [CrossRef] [PubMed]
    • Ponzetto, C.; Giordano, S.; Graxiani, A.; Panayotou, G.; Comoglio, P.M.Y.; Bardelli, A.; Zhen, Z.; Maina, F.; dalla Zonca, P.; Giordano, S. et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994, 77, 261–271. [CrossRef] [PubMed]
    • (1994) Cell , vol.77 , pp. 261-271
    • Ponzetto, C.1    Giordano, S.2    Graxiani, A.3    Panayotou, G.4    Comoglio, P.5    Bardelli, A.6    Zhen, Z.7    Maina, F.8    Dalla Zonca, P.9    Giordano, S.10
  • 14
    • 0028308229 scopus 로고
    • Expression and functional interaction of hepatocyte growth factor—Scatter factor and its receptor
    • [CrossRef] [PubMed]
    • Jung, W.; Castren, E.; Odenthal, M.; vande Woude, G.F.; Ishii, T.; Dienes, H.P.; Lindholm, D.; Schirmacher, P. Expression and functional interaction of hepatocyte growth factor—Scatter factor and its receptor. J. Cell Biol. 1994, 126, 485–494. [CrossRef] [PubMed]
    • (1994) J. Cell Biol , vol.126 , pp. 485-494
    • Jung, W.1    Castren, E.2    Odenthal, M.3    Vande Woude, G.F.4    Ishii, T.5    Dienes, H.P.6    Lindholm, D.7    Schirmacher, P.8
  • 15
    • 0027437547 scopus 로고
    • C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development
    • [CrossRef] [PubMed]
    • Sonnenberg, E.; Meyer, D. Weidner, K.M. Birchmeier, C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J. Cell Biol. 1993, 123, 223–235. [CrossRef] [PubMed]
    • (1993) J. Cell Biol. , vol.123 , pp. 223-235
    • Sonnenberg, E.1    Meyer, D.W.2    Birchmeier, K.M.3
  • 16
    • 0027761342 scopus 로고
    • Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA
    • [PubMed]
    • Mars, W.M.; Zarnegar, R.; Michalopoulos, G.K. Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. Am. J. Pathol. 1993, 143, 949–958. [PubMed]
    • (1993) Am. J. Pathol , vol.143 , pp. 949-958
    • Mars, W.M.1    Zarnegar, R.2    Michalopoulos, G.K.3
  • 17
    • 76549122581 scopus 로고    scopus 로고
    • ; Ellis, V. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
    • [CrossRef] [PubMed]
    • Owen, K.A.; Qiu, D.; Alves, J.; Schumacher, A.M.; Kilpatrick, L.M.; Li, J.; Harris, J.L.; Ellis, V. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. Biochem. J. 2010, 426, 219–228. [CrossRef] [PubMed]
    • (2010) Biochem. J. , vol.426 , pp. 219-228
    • Owen, K.A.1    Qiu, D.2    Alves, J.3    Schumacher, A.M.4    Kilpatrick, L.M.5    Li, J.6    Harris, J.L.7
  • 18
    • 0028123481 scopus 로고
    • Hairpin loop and second kringle domain are essential sites heparin binding and biological activity of hepatocyte growth factor
    • [PubMed]
    • Mizuno, K.; Inoue, H.; Hagiya, M.; Shimizu, S.; Nose, T.; Shimohigasho, Y.; Nakamura, T. Hairpin loop and second kringle domain are essential sites heparin binding and biological activity of hepatocyte growth factor. J. Biol. Chem. 1994, 269, 1131–1136. [PubMed]
    • (1994) J. Biol. Chem , vol.269 , pp. 1131-1136
    • Mizuno, K.1    Inoue, H.2    Hagiya, M.3    Shimizu, S.4    Nose, T.5    Shimohigasho, Y.6    Nakamura, T.7
  • 19
    • 0031002920 scopus 로고    scopus 로고
    • Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms. Heparan Sulfate glycosaminoglycan requirement for met binding and signaling
    • [CrossRef] [PubMed]
    • Sakata, H.; Stahl, S.J.; Taylor, W.G.; Rosenberg, J.M.; Sakaguchi, K.; Wingfield, P.T.; Rubin, J.S. Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms. Heparan Sulfate glycosaminoglycan requirement for met binding and signaling. J. Biol. Chem. 1997, 272, 9457–9463. [CrossRef] [PubMed]
    • (1997) J. Biol. Chem , vol.272 , pp. 9457-9463
    • Sakata, H.1    Stahl, S.J.2    Taylor, W.G.3    Rosenberg, J.M.4    Sakaguchi, K.5    Wingfield, P.T.6    Rubin, J.S.7
  • 20
    • 17544371922 scopus 로고    scopus 로고
    • Pathways downstream of Shc and Grb2 are required for cell transformation by the Tpr-Met oncoprotein
    • [CrossRef] [PubMed]
    • Fixman, E.; Fournier, T.; Kamikura, D.; Naujokas, M.; Park, M. Pathways downstream of Shc and Grb2 are required for cell transformation by the Tpr-Met oncoprotein. J. Biol. Chem. 1996, 271, 13116–13122. [CrossRef] [PubMed]
    • (1996) J. Biol. Chem. , vol.271 , pp. 13116-13122
    • Fixman, E.1    Fournier, T.2    Kamikura, D.3    Naujokas, M.4    Park, M.5
  • 21
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
    • [CrossRef] [PubMed]
    • Weinder, K.M.; di Cesare, S.; Sachs, M.; Brinkmann, V.; Behrens, J.; Birchmeier, W. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 1996, 384, 173–176. [CrossRef] [PubMed]
    • (1996) Nature , vol.384 , pp. 173-176
    • Weinder, K.M.1    Di Cesare, S.2    Sachs, M.3    Brinkmann, V.4    Behrens, J.5    Birchmeier, W.6
  • 22
    • 0036896923 scopus 로고    scopus 로고
    • CD44 is required for two consecutive steps in HGF/c-Met signaling
    • [CrossRef] [PubMed]
    • Orian-rousseau, V.; Chen, L.; Sleeman, J.P.; Herrlich, P.; Ponta, H. CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev. 2002, 16, 3074–3086. [CrossRef] [PubMed]
    • (2002) Genes Dev , vol.16 , pp. 3074-3086
    • Orian-Rousseau, V.1    Chen, L.2    Sleeman, J.P.3    Herrlich, P.4    Ponta, H.5
  • 23
    • 33846077485 scopus 로고    scopus 로고
    • Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-Actin
    • [CrossRef] [PubMed]
    • Orian-Rousseau, V.; Morrison, H.; Matzke, A.; Kastilan, T.; Pace, G.; Herrlich, P.; Ponta, H. Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-Actin. Mol. Biol. Cell 2007, 18, 76–83. [CrossRef] [PubMed]
    • (2007) Mol. Biol. Cell , vol.18 , pp. 76-83
    • Orian-Rousseau, V.1    Morrison, H.2    Matzke, A.3    Kastilan, T.4    Pace, G.5    Herrlich, P.6    Ponta, H.7
  • 24
    • 14044272770 scopus 로고    scopus 로고
    • A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
    • [CrossRef] [PubMed]
    • Montagner, A.; Yart, A.; Dance, M.; Perret, B.; Salles, J.-P.; Raynal, P. A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J. Biol. Chem. 2005, 280, 5350–5360. [CrossRef] [PubMed]
    • (2005) J. Biol. Chem. , vol.280 , pp. 5350-5360
    • Montagner, A.1    Yart, A.2    Dance, M.3    Perret, B.4    Salles, J.-P.5    Raynal, P.6
  • 25
    • 0027322529 scopus 로고
    • Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger
    • [PubMed]
    • Graziani, A.; Gramaglia, D.; dalla Zonca, P.; Comoglio, P.M. Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J. Biol. Chem. 1993, 268, 9165–9168. [PubMed]
    • (1993) J. Biol. Chem , vol.268 , pp. 9165-9168
    • Graziani, A.1    Gramaglia, D.2    Dalla Zonca, P.3    Comoglio, P.M.4
  • 26
    • 0035793091 scopus 로고    scopus 로고
    • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    • [CrossRef] [PubMed]
    • Xiao, G.H.; Jeffers, M.; Bellacosa, A.; Mitsuuchi, Y.; vande Woude, G.F.; Testa, J.R. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc. Natl. Acad. Sci. USA 2001, 98, 247–252. [CrossRef] [PubMed]
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3    Mitsuuchi, Y.4    Vande Woude, G.F.5    Testa, J.R.6
  • 27
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • [CrossRef]
    • Zoncu, R.; Sabatini, D.; Efeyan, A. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2012, 12, 21–35. [CrossRef]
    • (2012) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Sabatini, D.2    Efeyan, A.3
  • 28
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3 in cell survival and NF-kB activation
    • [CrossRef]
    • Hoeflich, K.P.; Luo, J.; Rubie, E.A.; Tsao, M.; Jin, O.; Woodgett, J.R. Requirement for glycogen synthase kinase-3 in cell survival and NF-kB activation. Nature 2000, 406, 2–6. [CrossRef]
    • (2000) Nature , vol.406 , pp. 2-6
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.4    Jin, O.5    Woodgett, J.R.6
  • 29
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-Induced phosphorylation of BAD through the protein kinase Akt
    • [CrossRef] [PubMed]
    • Del Peso, L.; Gonzalez-Garcia, M.; Page, C.; Herrera, R.; Nunez, G. Interleukin-3-Induced phosphorylation of BAD through the protein kinase Akt. Science 1997, 278, 687–689. [CrossRef] [PubMed]
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 30
    • 34248151416 scopus 로고    scopus 로고
    • Met acts on Mdm2 via mTOR to signal cell survival during development
    • [CrossRef] [PubMed]
    • Moumen, A.; Patané, S.; Porras, A.; Dono, R.; Maina, F. Met acts on Mdm2 via mTOR to signal cell survival during development. Development 2007, 134, 1443–1451. [CrossRef] [PubMed]
    • (2007) Development , vol.134 , pp. 1443-1451
    • Moumen, A.1    Patané, S.2    Porras, A.3    Dono, R.4    Maina, F.5
  • 31
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • [CrossRef] [PubMed]
    • Cardone, M.H. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998, 282, 1318–1321. [CrossRef] [PubMed]
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1
  • 32
    • 0037050212 scopus 로고    scopus 로고
    • Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
    • [CrossRef] [PubMed]
    • Zhang, Y.-W.; Wang, L.-M.; Jove, R.; vande Woude, G.F. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 2002, 21, 217–226. [CrossRef] [PubMed]
    • (2002) Oncogene , vol.21 , pp. 217-226
    • Zhang, Y.-W.1    Wang, L.-M.2    Jove, R.3    Vande Woude, G.F.4
  • 33
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • [CrossRef] [PubMed]
    • Yu, H.; Pardoll, D.; Jove, R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat. Rev. Cancer 2009, 9, 798–809. [CrossRef] [PubMed]
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 34
    • 0036007194 scopus 로고    scopus 로고
    • Activation of NF-kB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis
    • [CrossRef] [PubMed]
    • Müller, M.; Morotti, A.; Ponzetto, C. Activation of NF-kB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis. Mol. Cell. Biol. 2002, 22, 1060–1072. [CrossRef] [PubMed]
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1060-1072
    • Müller, M.1    Morotti, A.2    Ponzetto, C.3
  • 35
    • 14944348618 scopus 로고    scopus 로고
    • Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection
    • [CrossRef] [PubMed]
    • Fan, S.; Gao, M.; Meng, Q.; Laterra, J.J.; Symons, M.H.; Coniglio, S.; Pestell, R.G.; Goldberg, I.D.; Rosen, E.M. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene 2005, 24, 1749–1766. [CrossRef] [PubMed]
    • (2005) Oncogene , vol.24 , pp. 1749-1766
    • Fan, S.1    Gao, M.2    Meng, Q.3    Laterra, J.J.4    Symons, M.H.5    Coniglio, S.6    Pestell, R.G.7    Goldberg, I.D.8    Rosen, E.M.9
  • 36
    • 0029759716 scopus 로고    scopus 로고
    • Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor
    • [CrossRef] [PubMed]
    • Wang, R.; Kobayashi, R.; Bishop, J.M. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc. Natl. Acad. Sci. USA 1996, 93, 8425–8430. [CrossRef] [PubMed]
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8425-8430
    • Wang, R.1    Kobayashi, R.2    Bishop, J.M.3
  • 37
    • 36949005451 scopus 로고    scopus 로고
    • Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines
    • [CrossRef] [PubMed]
    • Nakamura, Y.; Matsubara, D.; Goto, A.; Ota, S.; Sachiko, O.; Ishikawa, S.; Aburatani, H.; Miyazawa, K.; Fukayama, M.; Niki, T. Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines. Cancer Sci. 2008, 99, 14–22. [CrossRef] [PubMed]
    • (2008) Cancer Sci , vol.99 , pp. 14-22
    • Nakamura, Y.1    Matsubara, D.2    Goto, A.3    Ota, S.4    Sachiko, O.5    Ishikawa, S.6    Aburatani, H.7    Miyazawa, K.8    Fukayama, M.9    Niki, T.10
  • 38
    • 79953220086 scopus 로고    scopus 로고
    • Ligand independent activation of c-Met by fibronectin and 5 1—Integrin regulates ovarian cancer invasion and metastasis
    • [CrossRef] [PubMed]
    • Mitra, A.; Sawada, K.; Tiwari, P.; Mui, K.; Gwin, K.; Lengyel, E. Ligand independent activation of c-Met by fibronectin and 5 1—Integrin regulates ovarian cancer invasion and metastasis. Oncogene 2011, 30, 1566–1576. [CrossRef] [PubMed]
    • (2011) Oncogene , vol.30 , pp. 1566-1576
    • Mitra, A.1    Sawada, K.2    Tiwari, P.3    Mui, K.4    Gwin, K.5    Lengyel, E.6
  • 39
    • 68049094943 scopus 로고    scopus 로고
    • Src and FAK mediate cell-matrix adhesion-dependent activation of Met during transformation of breast epithelial cells
    • [CrossRef] [PubMed]
    • Hui, A.Y.; Meens, J.A.; Schick, C.; Organ, S.L.; Qiao, H.; Tremblay, E.A.; Schaeffer, E.; Uniyal, S.; Chan, B.M.C.; Elliott, B.E. Src and FAK mediate cell-matrix adhesion-dependent activation of Met during transformation of breast epithelial cells. J. Cell. Biochem. 2009, 107, 1168–1181. [CrossRef] [PubMed]
    • (2009) J. Cell. Biochem , vol.107 , pp. 1168-1181
    • Hui, A.Y.1    Meens, J.A.2    Schick, C.3    Organ, S.L.4    Qiao, H.5    Tremblay, E.A.6    Schaeffer, E.7    Uniyal, S.8    Chan, B.9    Elliott, B.E.10
  • 40
    • 84906935511 scopus 로고    scopus 로고
    • FAK in cancer: Mechanistic findings and clinical applications. Nat
    • [CrossRef] [PubMed]
    • Sulzmaier, F.J.; Jean, C.; Schlaepfer, D.D. FAK in cancer: Mechanistic findings and clinical applications. Nat. Rev. Cancer 2014, 14, 598–610. [CrossRef] [PubMed]
    • (2014) Rev. Cancer , vol.14 , pp. 598-610
    • Sulzmaier, F.J.1    Jean, C.2    Schlaepfer, D.D.3
  • 41
    • 23344446919 scopus 로고    scopus 로고
    • Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway
    • [CrossRef] [PubMed]
    • Basile, J.R.; Afkhami, T.; Gutkind, J.S. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol. Cell. Biol. 2005, 25, 6889–6898. [CrossRef] [PubMed]
    • (2005) Mol. Cell. Biol , vol.25 , pp. 6889-6898
    • Basile, J.R.1    Afkhami, T.2    Gutkind, J.S.3
  • 43
    • 33745176581 scopus 로고    scopus 로고
    • Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc
    • [CrossRef] [PubMed]
    • Basile, J.R.; Castilho, R. M.; Williams, V.P.; Gutkind, J.S. Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA 2006, 103, 9017–9022. [CrossRef] [PubMed]
    • (2006) Natl. Acad. Sci. USA , vol.103 , pp. 9017-9022
    • Basile, J.R.1    Castilho, R.M.2    Williams, V.P.3    Gutkind, J.S.4
  • 44
    • 2442520826 scopus 로고    scopus 로고
    • Interplay between scatter factor receptors and B plexins controls invasive growth
    • [CrossRef] [PubMed]
    • Conrotto, P.; Corso, S.; Gamberini, S.; Comoglio, P.M.; Giordano, S. Interplay between scatter factor receptors and B plexins controls invasive growth. Oncogene 2004, 23, 5131–5137. [CrossRef] [PubMed]
    • (2004) Oncogene , vol.23 , pp. 5131-5137
    • Conrotto, P.1    Corso, S.2    Gamberini, S.3    Comoglio, P.M.4    Giordano, S.5
  • 46
    • 59149105217 scopus 로고    scopus 로고
    • Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers—Results of a large scale microarray analysis
    • [CrossRef] [PubMed]
    • Rody, A.; Karn, T.; Ruckhäberle, E.; Hanker, L.; Metzler, D.; Müller, V.; Solbach, C.; Ahr, A.; Gätje, R.; Holtrich, U. et al. Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers—Results of a large scale microarray analysis. Eur. J. Cancer 2009, 45, 405–413. [CrossRef] [PubMed]
    • (2009) Eur. J. Cancer , vol.45 , pp. 405-413
    • Rody, A.1    Karn, T.2    Ruckhäberle, E.3    Hanker, L.4    Metzler, D.5    Müller, V.6    Solbach, C.7    Ahr, A.8    Gätje, R.9    Holtrich, U.10
  • 47
    • 84858278408 scopus 로고    scopus 로고
    • Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth
    • [CrossRef] [PubMed]
    • Soong, J.; Chen, Y.; Shustef, E.M.; Scott, G.A. Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth. J. Investig. Dermatol. 2012, 132, 1230–1238. [CrossRef] [PubMed]
    • (2012) J. Investig. Dermatol , vol.132 , pp. 1230-1238
    • Soong, J.1    Chen, Y.2    Shustef, E.M.3    Scott, G.A.4
  • 48
    • 0035930341 scopus 로고    scopus 로고
    • Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
    • [CrossRef] [PubMed]
    • Peschard, P.; Fournier, T.M.; Lamorte, L.; Naujokas, M.A.; Band, H.; Langdon, W.Y.; Park, M. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol. Cell 2001, 8, 995–1004. [CrossRef] [PubMed]
    • (2001) Mol. Cell , vol.8 , pp. 995-1004
    • Peschard, P.1    Fournier, T.M.2    Lamorte, L.3    Naujokas, M.A.4    Band, H.5    Langdon, W.Y.6    Park, M.7
  • 49
    • 25444461165 scopus 로고    scopus 로고
    • Spatio-temporal decisions
    • [CrossRef] [PubMed]
    • Kermorgant, S.; Parker, J. c-MET signalling: Spatio-temporal decisions. Cell Cycle 2005, 4, 352–355. [CrossRef] [PubMed]
    • (2005) Cell Cycle , vol.4 , pp. 352-355
    • Kermorgant, S.1    Parker, J.2    Signalling, C.-M.3
  • 50
    • 79958214335 scopus 로고    scopus 로고
    • GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration
    • [CrossRef] [PubMed]
    • Parachoniak, C.A.; Luo, Y.; Abella, J.V.; Keen, J.H.; Park, M. GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev. Cell 2011, 20, 751–763. [CrossRef] [PubMed]
    • (2011) Dev. Cell , vol.20 , pp. 751-763
    • Parachoniak, C.A.1    Luo, Y.2    Abella, J.V.3    Keen, J.H.4    Park, M.5
  • 51
    • 0035901973 scopus 로고    scopus 로고
    • Down-regulation of MET, the receptor for hepatocyte growth factor
    • [CrossRef] [PubMed]
    • Hammond, D.E.; Urbe, S.; vande Woude, G.F.; Clague, M.J. Down-regulation of MET, the receptor for hepatocyte growth factor. Oncogene 2001, 20, 2761–2770. [CrossRef] [PubMed]
    • (2001) Oncogene , vol.20 , pp. 2761-2770
    • Hammond, D.E.1    Urbe, S.2    Vande Woude, G.F.3    Clague, M.J.4
  • 52
    • 0031806620 scopus 로고    scopus 로고
    • Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways
    • [PubMed]
    • Ceresa, B.P.; Kao, A.W.; Santeler, S.R.; Pessin, J.E. Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Mol. Cell. Biol. 1998, 18, 3862–3870. [PubMed]
    • (1998) Mol. Cell. Biol , vol.18 , pp. 3862-3870
    • Ceresa, B.P.1    Kao, A.W.2    Santeler, S.R.3    Pessin, J.E.4
  • 53
    • 51649130231 scopus 로고    scopus 로고
    • Receptor trafficking controls weak signal delivery: A strategy used by c-Met for STAT3 nuclear accumulation
    • [CrossRef] [PubMed]
    • Kermorgant, S.; Parker, P.J. Receptor trafficking controls weak signal delivery: A strategy used by c-Met for STAT3 nuclear accumulation. J. Cell Biol. 2008, 182, 855–863. [CrossRef] [PubMed]
    • (2008) J. Cell Biol , vol.182 , pp. 855-863
    • Kermorgant, S.1    Parker, P.J.2
  • 54
    • 84901020430 scopus 로고    scopus 로고
    • Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways
    • [PubMed]
    • Ménard, L.; Parker, P.J.; Kermorgant, S. Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways. Nat. Commun. 2014, 5, 3907. [PubMed]
    • (2014) Nat. Commun , vol.5 , pp. 3907
    • Ménard, L.1    Parker, P.J.2    Kermorgant, S.3
  • 55
    • 65649111648 scopus 로고    scopus 로고
    • Down-regulation of the Met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis
    • [CrossRef] [PubMed]
    • Foveau, B.; Ancot, F.; Leroy, C.; Petrelli, A.; Reiss, K.; Vingtdeux, V.; Giordano, S.; Fafeur, V.; Tulasne, D. Down-regulation of the Met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis. Mol. Biol. Cell 2009, 20, 2495–2507. [CrossRef] [PubMed]
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2495-2507
    • Foveau, B.1    Ancot, F.2    Leroy, C.3    Petrelli, A.4    Reiss, K.5    Vingtdeux, V.6    Giordano, S.7    Fafeur, V.8    Tulasne, D.9
  • 56
    • 34548749917 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling
    • [CrossRef] [PubMed]
    • Kopitz, C.; Gerg, M.; Bandapalli, O.R.; Ister, D.; Pennington, C.J.; Hauser, S.; Flechsig, C.; Krell, H.-W.; Antolovic, D.; Brew, K. et al. Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling. Cancer Res. 2007, 67, 8615–8623. [CrossRef] [PubMed]
    • (2007) Cancer Res , vol.67 , pp. 8615-8623
    • Kopitz, C.1    Gerg, M.2    Bandapalli, O.R.3    Ister, D.4    Pennington, C.J.5    Hauser, S.6    Flechsig, C.7    Krell, H.-W.8    Antolovic, D.9    Brew, K.10
  • 58
    • 0141988690 scopus 로고    scopus 로고
    • C-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
    • [PubMed]
    • Ma, P.C.; Kijima, T.; Maulik, G.; Fox, E.A.; Sattler, M.; Griffin, J.D.; Johnson, B.E.; Salgia, R. c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res. 2003, 63, 6272–6281. [PubMed]
    • (2003) Cancer Res , vol.63 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3    Fox, E.A.4    Sattler, M.5    Griffin, J.D.6    Johnson, B.E.7    Salgia, R.8
  • 59
    • 34447580912 scopus 로고    scopus 로고
    • Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells
    • [CrossRef] [PubMed]
    • Jagadeeswaran, R.; Jagadeeswaran, S.; Bindokas, V.P.; Salgia, R. Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 292, L1488–L1494. [CrossRef] [PubMed]
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.292 , pp. 1488-1494
    • Jagadeeswaran, R.1    Jagadeeswaran, S.2    Bindokas, V.P.3    Salgia, R.4
  • 63
    • 67049134253 scopus 로고    scopus 로고
    • Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors
    • [CrossRef] [PubMed]
    • Timofeevski, S.L.; McTigue, M.A.; Ryan, K.; Cui, J.; Zou, H.Y.; Zhu, J.X.; Chau, F.; Alton, G.; Karlicek, S.; Christensen, J.G. et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry 2009, 48, 5339–5349. [CrossRef] [PubMed]
    • (2009) Biochemistry , vol.48 , pp. 5339-5349
    • Timofeevski, S.L.1    McTigue, M.A.2    Ryan, K.3    Cui, J.4    Zou, H.Y.5    Zhu, J.X.6    Chau, F.7    Alton, G.8    Karlicek, S.9    Christensen, J.G.10
  • 65
    • 0033539042 scopus 로고    scopus 로고
    • Activating mutations in the Met receptor overcome the requirement for autophosphorylation of tyrosines crucial for wild type signaling
    • [CrossRef] [PubMed]
    • Jeffers, M.; vande Woude, G.F. Activating mutations in the Met receptor overcome the requirement for autophosphorylation of tyrosines crucial for wild type signaling. Oncogene 1999, 18, 5120–5125. [CrossRef] [PubMed]
    • (1999) Oncogene , vol.18 , pp. 5120-5125
    • Jeffers, M.1    Vande Woude, G.F.2
  • 66
    • 0042206421 scopus 로고    scopus 로고
    • Mutations in the met oncogene unveil a “dual switch” mechanism controlling tyrosine kinase activity
    • [CrossRef] [PubMed]
    • Chiara, F.; Michieli, P.; Pugliese, L.; Comoglio, P.M. Mutations in the met oncogene unveil a “dual switch” mechanism controlling tyrosine kinase activity. J. Biol. Chem. 2003, 278, 29352–29358. [CrossRef] [PubMed]
    • (2003) J. Biol. Chem , vol.278 , pp. 29352-29358
    • Chiara, F.1    Michieli, P.2    Pugliese, L.3    Comoglio, P.M.4
  • 67
    • 75049083402 scopus 로고    scopus 로고
    • Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitor-resistant Chinese non-small cell lung cancer
    • [CrossRef] [PubMed]
    • Chen, H.-J.; Mok, T.S.; Chen, Z.-H.; Guo, A.-L.; Zhang, X.-C.; Su, J.; Wu, Y.-L. Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitor-resistant Chinese non-small cell lung cancer. Pathol. Oncol. Res. 2009, 15, 651–658. [CrossRef] [PubMed]
    • (2009) Pathol. Oncol. Res , vol.15 , pp. 651-658
    • Chen, H.-J.1    Mok, T.S.2    Chen, Z.-H.3    Guo, A.-L.4    Zhang, X.-C.5    Su, J.6    Wu, Y.-L.7
  • 68
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • [CrossRef] [PubMed]
    • Bean, J.; Brennan, C.; Shih, J.-Y.; Riely, G.; Viale, A.; Wang, L.; Chitale, D.; Motoi, N.; Szoke, J.; Broderick, S. et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl. Acad. Sci. USA 2007, 104, 20932–20937. [CrossRef] [PubMed]
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.-Y.3    Riely, G.4    Viale, A.5    Wang, L.6    Chitale, D.7    Motoi, N.8    Szoke, J.9    Broderick, S.10
  • 70
    • 84863229341 scopus 로고    scopus 로고
    • High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients
    • [PubMed]
    • Park, S.; Choi, Y.; Sung, C.O.; An, J.; Seo, J.; Ahn, M.; Ahn, J.S.; Park, K.; Shin, Y.K.; Erkin, O.C. et al. High MET copy number and MET overexpression: Poor outcome in non-small cell lung cancer patients. Histol. Histopathol. 2012, 27, 197–207. [PubMed]
    • (2012) Histol. Histopathol , vol.27 , pp. 197-207
    • Park, S.1    Choi, Y.2    Sung, C.O.3    An, J.4    Seo, J.5    Ahn, M.6    Ahn, J.S.7    Park, K.8    Shin, Y.K.9    Erkin, O.C.10
  • 71
    • 84890264356 scopus 로고    scopus 로고
    • Prognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancer
    • [CrossRef] [PubMed]
    • Sun, W.; Song, L.; Ai, T.; Zhang, Y.; Gao, Y.; Cui, J. Prognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancer. J. Biomed. Res. 2013, 27, 220–230. [CrossRef] [PubMed]
    • (2013) J. Biomed. Res. , vol.27 , pp. 220-230
    • Sun, W.1    Song, L.2    Ai, T.3    Zhang, Y.4    Gao, Y.5    Cui, J.6
  • 74
    • 0035035599 scopus 로고    scopus 로고
    • Mechanisms regulating c-met overexpression in liver-metastatic B16-LS9 melanoma cells
    • [CrossRef] [PubMed]
    • Elia, G.; Ren, Y.; Lorenzoni, P.; Zarnegar, R.; Burger, M.M.; Rusciano, D. Mechanisms regulating c-met overexpression in liver-metastatic B16-LS9 melanoma cells. J. Cell. Biochem. 2001, 81, 477–487. [CrossRef] [PubMed]
    • (2001) J. Cell. Biochem , vol.81 , pp. 477-487
    • Elia, G.1    Ren, Y.2    Lorenzoni, P.3    Zarnegar, R.4    Burger, M.M.5    Rusciano, D.6
  • 75
    • 84878398940 scopus 로고    scopus 로고
    • Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma
    • [CrossRef]
    • Ogunwobi, O.O.; Puszyk, W.; Dong, H.J.; Liu, C. Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma. PLoS ONE 2013, 8, 1–12. [CrossRef]
    • (2013) Plos ONE , vol.8 , pp. 1-12
    • Ogunwobi, O.O.1    Puszyk, W.2    Dong, H.J.3    Liu, C.4
  • 76
    • 84855543629 scopus 로고    scopus 로고
    • Condorelli, G. Et al. EGFR and MET receptor tyrosine kinase—Altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers
    • [PubMed]
    • Garofalo, M.; Romano, G.; di Leva, G.; Nuovo, G.; Jeon, Y.; Ngankeu, A.; Sun, J.; Lovat, F.; Alder, H.; Condorelli, G. et al. EGFR and MET receptor tyrosine kinase—Altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat. Med. 2011, 18, 74–82. [PubMed]
    • (2011) Nat. Med , vol.18 , pp. 74-82
    • Garofalo, M.1    Romano, G.2    Di Leva, G.3    Nuovo, G.4    Jeon, Y.5    Ngankeu, A.6    Sun, J.7    Lovat, F.8    Alder, H.9
  • 78
    • 16644373363 scopus 로고    scopus 로고
    • Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors
    • [PubMed]
    • Trovato, M.; Vitarelli, E.; Grosso, M.; Alesci, S.; Benvenga, S.; Trimarchi, F.; Barresi, G. Immunohistochemical expression of HGF, c-MET and transcription factor STAT3 in colorectal tumors. Eur. J. Histochem. 2004, 48, 291–297. [PubMed]
    • (2004) Eur. J. Histochem , vol.48 , pp. 291-297
    • Trovato, M.1    Vitarelli, E.2    Grosso, M.3    Alesci, S.4    Benvenga, S.5    Trimarchi, F.6    Barresi, G.7
  • 79
    • 2442513981 scopus 로고    scopus 로고
    • The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    • [CrossRef] [PubMed]
    • Masuya, D.; Huang, C.; Liu, D.; Nakashima, T.; Kameyama, K.; Haba, R.; Ueno, M.; Yokomise, H. The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients. Br. J. Cancer 2004, 90, 1555–1562. [CrossRef] [PubMed]
    • (2004) Br. J. Cancer , vol.90 , pp. 1555-1562
    • Masuya, D.1    Huang, C.2    Liu, D.3    Nakashima, T.4    Kameyama, K.5    Haba, R.6    Ueno, M.7    Yokomise, H.8
  • 80
    • 81755185464 scopus 로고    scopus 로고
    • Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort
    • [CrossRef] [PubMed]
    • Yano, S.; Yamada, T.; Takeuchi, S.; Tachibana, K.; Minami, Y.; Yatabe, Y.; Mitsudomi, T.; Tanaka, H.; Kimura, T.; Kudoh, S. et al. Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort. J. Thorac. Oncol. 2011, 6, 2011–2017. [CrossRef] [PubMed]
    • (2011) J. Thorac. Oncol. , vol.6 , pp. 2011-2017
    • Yano, S.1    Yamada, T.2    Takeuchi, S.3    Tachibana, K.4    Minami, Y.5    Yatabe, Y.6    Mitsudomi, T.7    Tanaka, H.8    Kimura, T.9    Kudoh, S.10
  • 81
    • 84877578990 scopus 로고    scopus 로고
    • Modulation of c-Met signaling and cellular sensitivity to radiation: Potential implications for therapy
    • [CrossRef] [PubMed]
    • Bhardwaj, V.; Cascone, T.; Cortez, M.A.; Amini, A.; Evans, J.; Komaki, R.U.; Heymach, J.V.; Welsh, J.W. Modulation of c-Met signaling and cellular sensitivity to radiation: Potential implications for therapy. Cancer 2013, 119, 1768–1775. [CrossRef] [PubMed]
    • (2013) Cancer , vol.119 , pp. 1768-1775
    • Bhardwaj, V.1    Cascone, T.2    Cortez, M.A.3    Amini, A.4    Evans, J.5    Komaki, R.U.6    Heymach, J.V.7    Welsh, J.W.8
  • 82
    • 0037401065 scopus 로고    scopus 로고
    • Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells
    • [CrossRef] [PubMed]
    • Qian, L.-W.; Mizumoto, K.; Inadome, N.; Nagai, E.; Sato, N.; Matsumoto, K.; Nakamura, T.; Tanaka, M. Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. Int. J. Cancer 2003, 104, 542–549. [CrossRef] [PubMed]
    • (2003) Int. J. Cancer , vol.104 , pp. 542-549
    • Qian, L.-W.1    Mizumoto, K.2    Inadome, N.3    Nagai, E.4    Sato, N.5    Matsumoto, K.6    Nakamura, T.7    Tanaka, M.8
  • 84
    • 28544438548 scopus 로고    scopus 로고
    • Radiation and the microenvironment— Tumorigenesis and therapy
    • [CrossRef] [PubMed]
    • Barcellos-Hoff, M.H.; Park, C.; Wright, E.G. Radiation and the microenvironment— Tumorigenesis and therapy. Nat. Rev. Cancer 2005, 5, 867–875. [CrossRef] [PubMed]
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 867-875
    • Barcellos-Hoff, M.H.1    Park, C.2    Wright, E.G.3
  • 85
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • [CrossRef] [PubMed]
    • Thiery, J.P.; Sleeman, J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 2006, 7, 131–142. [CrossRef] [PubMed]
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 86
    • 84878616847 scopus 로고    scopus 로고
    • DNA double strand break repair: A radiation perspective
    • [CrossRef] [PubMed]
    • Kavanagh, J.N.; Redmond, K.M.; Schettino, G.; Prise, K.M. DNA double strand break repair: A radiation perspective. Antioxid. Redox Signal. 2013, 18, 2458–2472. [CrossRef] [PubMed]
    • (2013) Antioxid. Redox Signal , vol.18 , pp. 2458-2472
    • Kavanagh, J.N.1    Redmond, K.M.2    Schettino, G.3    Prise, K.M.4
  • 87
    • 82255163062 scopus 로고    scopus 로고
    • N in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks
    • [CrossRef] [PubMed]
    • Medová, M.; Aebersold, D.M.; Zimmer, Y. MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks. Int. J. Cancer 2012, 130, 728–734. [CrossRef] [PubMed]
    • (2012) MET Inhibitio , vol.130 , pp. 728-734
    • Medová, M.1    Aebersold, D.M.2    Zimmer, Y.3
  • 88
    • 36448945111 scopus 로고    scopus 로고
    • Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines. Surg
    • [CrossRef] [PubMed]
    • Sheng-Hua, C.; Yan-Bin, M.; Zhi-An, Z.; Hong, Z.; Dong-Fu, F.; Zhi-Qiang, L.; Xian-Hou, Y. Radiation-enhanced hepatocyte growth factor secretion in malignant glioma cell lines. Surg. Neurol. 2007, 68, 610–614. [CrossRef] [PubMed]
    • (2007) Neurol , vol.68 , pp. 610-614
    • Sheng-Hua, C.1    Yan-Bin, M.2    Zhi-An, Z.3    Hong, Z.4    Dong-Fu, F.5    Zhi-Qiang, L.6    Xian-Hou, Y.7
  • 89
    • 84904388519 scopus 로고    scopus 로고
    • C-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer
    • [CrossRef] [PubMed]
    • Delitto, D.; Vertes-George, E.; Hughes, S.J.; Behrns, K.E.; Trevino, J.G. c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer. World J. Gastroenterol. 2014, 20, 8458–8470. [CrossRef] [PubMed]
    • (2014) World J. Gastroenterol , vol.20 , pp. 8458-8470
    • Delitto, D.1    Vertes-George, E.2    Hughes, S.J.3    Behrns, K.E.4    Trevino, J.G.5
  • 90
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • [CrossRef] [PubMed]
    • Shah, A.N.; Summy, J.M.; Zhang, J.; Park, S.I.; Parikh, N.U.; Gallick, G.E. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann. Surg. Oncol. 2007, 14, 3629–3637. [CrossRef] [PubMed]
    • (2007) Ann. Surg. Oncol , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 91
    • 76749107447 scopus 로고    scopus 로고
    • C-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2
    • [PubMed]
    • Tang, M.K.S.; Zhou, H.Y.; Yam, J.W.P.; Wong, A.S.T. c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2. Neoplasia 2010, 12, 128–138. [PubMed]
    • (2010) Neoplasia , vol.12 , pp. 128-138
    • Tang, M.1    Zhou, H.Y.2    Yam, J.3    Wong, A.4
  • 94
    • 84925870095 scopus 로고    scopus 로고
    • C-Met inhibitor increases the chemosensitivity of cancer stem cells to the irinotecan in gastric carcinoma
    • Yashiro, M.; Nishii, T.; Hasegawa, T.; Matsuzaki, T.; Morisaki, T.; Fukuoka, T.; Hirakawa, K. A c-Met inhibitor increases the chemosensitivity of cancer stem cells to the irinotecan in gastric carcinoma. Br. J. Cancer 2013, 1, 1–10.
    • (2013) Br. J. Cancer , vol.1 , pp. 1-10
    • Yashiro, M.1    Nishii, T.2    Hasegawa, T.3    Matsuzaki, T.4    Morisaki, T.5    Fukuoka, T.6    Hirakawa, K.A.7
  • 95
    • 33751569391 scopus 로고    scopus 로고
    • Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    • [CrossRef] [PubMed]
    • Ide, T.; Kitajima, Y.; Miyoshi, A.; Ohtsuka, T.; Mitsuno, M.; Ohtaka, K.; Koga, Y.; Miyazaki, K. Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int. J. Cancer 2006, 119, 2750–2759. [CrossRef] [PubMed]
    • (2006) Int. J. Cancer , vol.119 , pp. 2750-2759
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6    Koga, Y.7    Miyazaki, K.8
  • 96
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • [CrossRef] [PubMed]
    • Pennacchietti, S.; Michieli, P.; Galluzzo, M.; Mazzone, M.; Giordano, S.; Comoglio, P.M. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003, 3, 347–361. [CrossRef] [PubMed]
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3    Mazzone, M.4    Giordano, S.5    Comoglio, P.M.6
  • 97
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • [CrossRef] [PubMed]
    • Taron, M.; Ichinose, Y.; Rosell, R.; Mok, T.; Massuti, B.; Zamora, L.; Mate, J.L.; Manegold, C.; Ono, M.; Queralt, C. et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin. Cancer Res. 2005, 11, 5878–5885. [CrossRef] [PubMed]
    • (2005) Clin. Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3    Mok, T.4    Massuti, B.5    Zamora, L.6    Mate, J.L.7    Manegold, C.8    Ono, M.9    Queralt, C.10
  • 98
    • 68949201629 scopus 로고    scopus 로고
    • Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
    • [CrossRef] [PubMed]
    • Gazdar, A.F. Activating and resistance mutations of EGFR in non-small-cell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009, 28, S24–S31. [CrossRef] [PubMed]
    • (2009) Oncogene , vol.28 , pp. 24-31
    • Gazdar, A.F.1
  • 99
    • 77954586493 scopus 로고    scopus 로고
    • Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis
    • [CrossRef] [PubMed]
    • Benedettini, E.; Sholl, L.M.; Peyton, M.; Reilly, J.; Ware, C.; Davis, L.; Vena, N.; Bailey, D.; Yeap, B.Y.; Fiorentino, M. et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am. J. Pathol. 2010, 177, 415–423. [CrossRef] [PubMed]
    • (2010) Am. J. Pathol. , vol.177 , pp. 415-423
    • Benedettini, E.1    Sholl, L.M.2    Peyton, M.3    Reilly, J.4    Ware, C.5    Davis, L.6    Vena, N.7    Bailey, D.8    Yeap, B.Y.9    Fiorentino, M.10
  • 102
    • 84867406340 scopus 로고    scopus 로고
    • Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer
    • [CrossRef] [PubMed]
    • Nakagawa, T.; Takeuchi, S.; Yamada, T.; Nanjo, S.; Ishikawa, D.; Sano, T.; Kita, K.; Nakamura, T.; Matsumoto, K.; Suda, K. et al. Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer. Mol. Cancer Ther. 2012, 11, 2149–2157. [CrossRef] [PubMed]
    • (2012) Mol. Cancer Ther , vol.11 , pp. 2149-2157
    • Nakagawa, T.1    Takeuchi, S.2    Yamada, T.3    Nanjo, S.4    Ishikawa, D.5    Sano, T.6    Kita, K.7    Nakamura, T.8    Matsumoto, K.9    Suda, K.10
  • 103
    • 84885379849 scopus 로고    scopus 로고
    • Crizotinib overcomes hepatocyte growth factor-mediated resistance to gefitinib in EGFR-mutant non-small-cell lung cancer cells
    • [CrossRef] [PubMed]
    • Chen, X.; Zhou, J.-Y.; Zhao, J.; Chen, J.-J.; Ma, S.-N.; Zhou, J.-Y. Crizotinib overcomes hepatocyte growth factor-mediated resistance to gefitinib in EGFR-mutant non-small-cell lung cancer cells. Anticancer Drugs 2013, 24, 1039–1046. [CrossRef] [PubMed]
    • (2013) Anticancer Drugs , vol.24 , pp. 1039-1046
    • Chen, X.1    Zhou, J.-Y.2    Zhao, J.3    Chen, J.-J.4    Ma, S.-N.5    Zhou, J.-Y.6
  • 104
    • 84892724318 scopus 로고    scopus 로고
    • MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to to EGFR kinase inhibitors due to MET or AXL activation
    • [CrossRef] [PubMed]
    • Rho, J.K.; Choi, Y.J.; Kim, S.Y.; Kim, T.W.; Choi, E.K.; Yoon, S.-J.; Park, B.M.; Park, E.; Bae, J.H.; Choi, C.-M. et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to to EGFR kinase inhibitors due to MET or AXL activation. Cancer Res. 2014, 74, 253–262. [CrossRef] [PubMed]
    • (2014) Cancer Res , vol.74 , pp. 253-262
    • Rho, J.K.1    Choi, Y.J.2    Kim, S.Y.3    Kim, T.W.4    Choi, E.K.5    Yoon, S.-J.6    Park, B.M.7    Park, E.8    Bae, J.H.9    Choi, C.-M.10
  • 105
    • 84899046290 scopus 로고    scopus 로고
    • MET expression plays differing roles in non-small-cell lung cancer patients with or without EGFR mutation
    • [CrossRef] [PubMed]
    • Huang, L.; An, S.J.; Chen, Z.H.; Su, J.; Yan, H. H.; Wu, Y.L. MET expression plays differing roles in non-small-cell lung cancer patients with or without EGFR mutation. J. Thorac. Oncol. 2014, 9, 725–728. [CrossRef] [PubMed]
    • (2014) J. Thorac. Oncol. , vol.9 , pp. 725-728
    • Huang, L.1    An, S.J.2    Chen, Z.H.3    Su, J.4    Yan, H.H.5    Wu, Y.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.