-
1
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74.
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
2
-
-
70349782389
-
An overview of small-molecule inhibitors of VEGFR signaling
-
Ivy SP, Wick JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009;6:569-79.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 569-579
-
-
Ivy, S.P.1
Wick, J.Y.2
Kaufman, B.M.3
-
3
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8:299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
4
-
-
36849013036
-
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
-
Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 2007;450:825-31.
-
(2007)
Nature
, vol.450
, pp. 825-831
-
-
Shojaei, F.1
Wu, X.2
Zhong, C.3
Yu, L.4
Liang, X.H.5
Yao, J.6
-
5
-
-
35548982639
-
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
-
Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell 2007;131:463-75.
-
(2007)
Cell
, vol.131
, pp. 463-475
-
-
Fischer, C.1
Jonckx, B.2
Mazzone, M.3
Zacchigna, S.4
Loges, S.5
Pattarini, L.6
-
6
-
-
58149346173
-
The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis
-
You WK, McDonald DM. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep 2008;41:833-9.
-
(2008)
BMB Rep
, vol.41
, pp. 833-839
-
-
You, W.K.1
McDonald, D.M.2
-
7
-
-
33745697763
-
Targeting the c-Met signaling pathway in cancer
-
DOI 10.1158/1078-0432.CCR-06-0818
-
Peruzzi B, Bottaro DP. Targeting the c-Met signaling pathway in cancer. Clin Cancer Res 2006;12:3657-60. (Pubitemid 44000247)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.12
, pp. 3657-3660
-
-
Peruzzi, B.1
Bottaro, D.P.2
-
8
-
-
44449151030
-
Drug development of MET inhibitors: Targeting oncogene addiction and expedience
-
Comoglio PM, Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov 2008;7:504-16.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 504-516
-
-
Comoglio, P.M.1
Giordano, S.2
Trusolino, L.3
-
9
-
-
0036006814
-
Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition
-
Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R. Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine Growth Factor Rev 2002;13:41-59.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 41-59
-
-
Maulik, G.1
Shrikhande, A.2
Kijima, T.3
Ma, P.C.4
Morrison, P.T.5
Salgia, R.6
-
10
-
-
0345601083
-
Met, metastasis, motility and more
-
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. Met, metastasis, motility and more. Nat Rev Mol Cell Biol 2003;4:915-25.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande Woude, G.F.4
-
11
-
-
0026722243
-
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
-
Bussolino F, Di Renzo MF, Ziche M, Bocchietto E, Olivero M, Naldini L, et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992;119:629-41.
-
(1992)
J Cell Biol
, vol.119
, pp. 629-641
-
-
Bussolino, F.1
Di Renzo, M.F.2
Ziche, M.3
Bocchietto, E.4
Olivero, M.5
Naldini, L.6
-
12
-
-
35648962884
-
CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin
-
Singleton PA, Salgia R, Moreno-Vinasco L, Moitra J, Sammani S, Mirzapoiazova T, et al. CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. J Biol Chem 2007;282:30643-57.
-
(2007)
J Biol Chem
, vol.282
, pp. 30643-30657
-
-
Singleton, P.A.1
Salgia, R.2
Moreno-Vinasco, L.3
Moitra, J.4
Sammani, S.5
Mirzapoiazova, T.6
-
13
-
-
0242331653
-
Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
-
Zhang YW, Su Y, Volpert OV, Vande Woude GF. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation. Proc Natl Acad Sci U S A 2003;100:12718-23.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12718-12723
-
-
Zhang, Y.W.1
Su, Y.2
Volpert, O.V.3
Vande Woude, G.F.4
-
14
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
DOI 10.1016/S1535-6108(03)00085-0, PII S1535610803000850
-
Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003;3:347-61. (Pubitemid 38340304)
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
15
-
-
0027427588
-
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
-
Wang GL, Semenza GL. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 1993;268:21513-8.
-
(1993)
J Biol Chem
, vol.268
, pp. 21513-21518
-
-
Wang, G.L.1
Semenza, G.L.2
-
16
-
-
27644543354
-
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
-
Abounader R, Laterra J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro-Oncology 2005;7:436-51.
-
(2005)
Neuro-Oncology
, vol.7
, pp. 436-451
-
-
Abounader, R.1
Laterra, J.2
-
17
-
-
34248191183
-
Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype
-
Garcia S, Dales JP, Charafe-Jauffret E, Carpentier-Meunier S, Andrac-Meyer L, Jacquemier J, et al. Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype. Hum Pathol 2007;38:830-41.
-
(2007)
Hum Pathol
, vol.38
, pp. 830-841
-
-
Garcia, S.1
Dales, J.P.2
Charafe-Jauffret, E.3
Carpentier-Meunier, S.4
Andrac-Meyer, L.5
Jacquemier, J.6
-
18
-
-
0035992387
-
Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability
-
Peghini PL, Iwamoto M, Raffeld M, Chen YJ, Goebel SU, Serrano J, et al. Overexpression of epidermal growth factor and hepatocyte growth factor receptors in a proportion of gastrinomas correlates with aggressive growth and lower curability. Clin Cancer Res 2002;8:2273-85. (Pubitemid 34753601)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.7
, pp. 2273-2285
-
-
Peghini, P.L.1
Iwamoto, M.2
Raffeld, M.3
Chen, Y.-J.4
Goebel, S.U.5
Serrano, J.6
Jensen, R.T.7
-
19
-
-
67049134253
-
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors
-
Mosc
-
Timofeevski SL, McTigue MA, Ryan K, Cui J, Zou HY, Zhu JX, et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry (Mosc) 2009;48:5339-49.
-
(2009)
Biochemistry
, vol.48
, pp. 5339-5349
-
-
Timofeevski, S.L.1
McTigue, M.A.2
Ryan, K.3
Cui, J.4
Zou, H.Y.5
Zhu, J.X.6
-
20
-
-
78650350791
-
-
Americat Tissue Type Collection Available from
-
Americat Tissue Type Collection. Available from: 2008 http://www.atcc.org/
-
(2008)
-
-
-
21
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007;67:4408-17.
-
(2007)
Cancer Res
, vol.67
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
Arango, M.E.4
McDonnell, S.R.5
Yamazaki, S.6
-
22
-
-
10744228765
-
A selective small molecule inhibitor of c-Met kinase inhibits c- Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo
-
Christensen JG, Schreck R, Burrows J, Kuruganti P, Chan E, Le P, et al. A selective small molecule inhibitor of c-Met kinase inhibits c- Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res 2003;63:7345-55.
-
(2003)
Cancer Res
, vol.63
, pp. 7345-7355
-
-
Christensen, J.G.1
Schreck, R.2
Burrows, J.3
Kuruganti, P.4
Le P, C.E.5
-
24
-
-
66149092730
-
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
-
Shojaei F, Wu X, Qu X, Kowanetz M, Yu L, Tan M, et al. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci U S A 2009;106:6742-7.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6742-6747
-
-
Shojaei, F.1
Wu, X.2
Qu, X.3
Kowanetz, M.4
Yu, L.5
Tan, M.6
-
25
-
-
0037468875
-
Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]- 2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl) amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
-
Sun L, Liang C, Shirazian S, Zhou Y, Miller T, Cui J, et al. Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]- 2,4-dimethyl-1H- pyrrole-3-carboxylic acid (2-diethylaminoethyl) amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003;46:1116-9.
-
(2003)
J Med Chem
, vol.46
, pp. 1116-1119
-
-
Sun, L.1
Liang, C.2
Shirazian, S.3
Zhou, Y.4
Miller, T.5
Cui, J.6
-
26
-
-
58149337448
-
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
-
Hu-Lowe DD, Zou HY, Grazzini ML, Hallin ME, Wickman GR, Amundson K, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 2008;14:7272-83.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7272-7283
-
-
Hu-Lowe, D.D.1
Zou, H.Y.2
Grazzini, M.L.3
Hallin, M.E.4
Wickman, G.R.5
Amundson, K.6
-
27
-
-
78650368766
-
-
U.S. National Institute of Health. Available from
-
U.S. National Institute of Health. Available from: 2010 http://clinicaltrials.gov/
-
(2010)
-
-
-
28
-
-
33747162725
-
Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment
-
Kobayashi H, DeBusk LM, Babichev YO, Dumont DJ, Lin PC. Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment. Blood 2006;108:1260-6.
-
(2006)
Blood
, vol.108
, pp. 1260-1266
-
-
Kobayashi, H.1
DeBusk, L.M.2
Babichev, Y.O.3
Dumont, D.J.4
Lin, P.C.5
-
29
-
-
0141566669
-
Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
-
Jiang WG, Grimshaw D, Martin TA, Davies G, Parr C, Watkins G, et al. Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET. Clin Cancer Res 2003;9:4274-81. (Pubitemid 37204049)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.11
, pp. 4274-4281
-
-
Jiang, W.G.1
Grimshaw, D.2
Martin, T.A.3
Davies, G.4
Parr, C.5
Watkins, G.6
Lane, J.7
Abounader, R.8
Laterra, J.9
Mansel, R.E.10
-
30
-
-
34250321214
-
Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis
-
DOI 10.1158/0008-5472.CAN-06-3381
-
Cheng N, Chytil A, Shyr Y, Joly A, Moses HL. Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis. Cancer Res 2007;67:4869-77. (Pubitemid 46910195)
-
(2007)
Cancer Research
, vol.67
, Issue.10
, pp. 4869-4877
-
-
Cheng, N.1
Chytil, A.2
Shyr, Y.3
Joly, A.4
Moses, H.L.5
-
31
-
-
34548578994
-
The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
-
Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, Ohtaka K, et al. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol 2007;14:2600-7.
-
(2007)
Ann Surg Oncol
, vol.14
, pp. 2600-2607
-
-
Ide, T.1
Kitajima, Y.2
Miyoshi, A.3
Ohtsuka, T.4
Mitsuno, M.5
Ohtaka, K.6
-
32
-
-
0034551670
-
Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
-
Bronte V, Apolloni E, Cabrelle A, Ronca R, Serafini P, Zamboni P, et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 2000;96:3838-46.
-
(2000)
Blood
, vol.96
, pp. 3838-3846
-
-
Bronte, V.1
Apolloni, E.2
Cabrelle, A.3
Ronca, R.4
Serafini, P.5
Zamboni, P.6
-
33
-
-
48649107126
-
Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells
-
Shojaei F, Ferrara N. Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells. Cancer Res 2008;68:5501-4.
-
(2008)
Cancer Res
, vol.68
, pp. 5501-5504
-
-
Shojaei, F.1
Ferrara, N.2
-
34
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008;8:592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
35
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15:232-9.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
36
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-31.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
-
37
-
-
1442305186
-
Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy
-
Smith JK, Mamoon NM, Duhe RJ. Emerging roles of targeted small molecule protein-tyrosine kinase inhibitors in cancer therapy. Oncol Res 2004;14:175-225.
-
(2004)
Oncol Res
, vol.14
, pp. 175-225
-
-
Smith, J.K.1
Mamoon, N.M.2
Duhe, R.J.3
-
38
-
-
42249091688
-
Sunitinib for treatment of advanced renal cell cancer: Primary tumor response
-
Van Der Veldt AA, Meijerink MR, Van Den Eertwegh AJ, Bex A, de Gast G, Haanen JB, et al. Sunitinib for treatment of advanced renal cell cancer: primary tumor response. Clin Cancer Res 2008;14:2431-6.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2431-2436
-
-
Van Der Veldt, A.A.1
Meijerink, M.R.2
Van Den Eertwegh, A.J.3
Bex, A.4
De Gast, G.5
Haanen, J.B.6
-
39
-
-
40649104348
-
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
-
Shojaei F, Singh M, Thompson JD, Ferrara N. Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci U S A 2008;105:2640-5.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2640-2645
-
-
Shojaei, F.1
Singh, M.2
Thompson, J.D.3
Ferrara, N.4
-
40
-
-
57849106330
-
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
-
Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009;15:21-34.
-
(2009)
Cancer Cell
, vol.15
, pp. 21-34
-
-
Crawford, Y.1
Kasman, I.2
Yu, L.3
Zhong, C.4
Wu, X.5
Modrusan, Z.6
|