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Volumn 67, Issue 5, 2015, Pages 664-676

High c-Met expression in stage I-II pancreatic adenocarcinoma: Proposal for an immunostaining scoring method and correlation with poor prognosis

Author keywords

Biomarker; Immunochemistry; Invasion; Pancreatic cancer; Survival

Indexed keywords

SCATTER FACTOR RECEPTOR; TUMOR MARKER;

EID: 84943359065     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12691     Document Type: Article
Times cited : (22)

References (46)
  • 2
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 2010; 127; 2893-2917.
    • (2010) Int. J. Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 3
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N. Engl. J. Med. 2010; 362; 1605-1617.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 4
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim AD, Mirek ET, Aiello NM et al. EMT and dissemination precede pancreatic tumor formation. Cell 2012; 148; 349-361.
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3
  • 5
    • 84864832834 scopus 로고    scopus 로고
    • The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
    • Erkan M, Hausmann S, Michalski CW et al. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat. Rev. Gastroenterol. Hepatol. 2012; 9; 454-467.
    • (2012) Nat. Rev. Gastroenterol. Hepatol. , vol.9 , pp. 454-467
    • Erkan, M.1    Hausmann, S.2    Michalski, C.W.3
  • 6
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • Neesse A, Michl P, Frese KK et al. Stromal biology and therapy in pancreatic cancer. Gut 2011; 60; 861-868.
    • (2011) Gut , vol.60 , pp. 861-868
    • Neesse, A.1    Michl, P.2    Frese, K.K.3
  • 7
    • 84872611820 scopus 로고    scopus 로고
    • Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
    • Provenzano PP, Hingorani SR. Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br. J. Cancer 2013; 108; 1-8.
    • (2013) Br. J. Cancer , vol.108 , pp. 1-8
    • Provenzano, P.P.1    Hingorani, S.R.2
  • 8
    • 84878015534 scopus 로고    scopus 로고
    • The role of pancreatic stellate cells in pancreatic cancer
    • Erkan M. The role of pancreatic stellate cells in pancreatic cancer. Pancreatology 2013; 13; 106-109.
    • (2013) Pancreatology , vol.13 , pp. 106-109
    • Erkan, M.1
  • 9
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat. Rev. Mol. Cell Biol. 2010; 11; 834-848.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 10
    • 0029149510 scopus 로고
    • Hepatocyte growth-factor and its receptor C-met regulate both cell-growth and invasion of human pancreatic-cancer
    • Hasegawa Y, Yamamoto M, Maeda S, Saitoh Y. Hepatocyte growth-factor and its receptor C-met regulate both cell-growth and invasion of human pancreatic-cancer. Int. J. Oncol. 1995; 7; 877-881.
    • (1995) Int. J. Oncol. , vol.7 , pp. 877-881
    • Hasegawa, Y.1    Yamamoto, M.2    Maeda, S.3    Saitoh, Y.4
  • 11
    • 0028941747 scopus 로고
    • Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer
    • Di Renzo MF, Poulsom R, Olivero M et al. Expression of the Met/hepatocyte growth factor receptor in human pancreatic cancer. Cancer Res. 1995; 55; 1129-1138.
    • (1995) Cancer Res. , vol.55 , pp. 1129-1138
    • Di Renzo, M.F.1    Poulsom, R.2    Olivero, M.3
  • 12
    • 0030657708 scopus 로고    scopus 로고
    • c-met expression in pancreatic cancer and effects of hepatocyte growth factor on pancreatic cancer cell growth
    • Kiehne K, Herzig KH, Folsch UR. c-met expression in pancreatic cancer and effects of hepatocyte growth factor on pancreatic cancer cell growth. Pancreas 1997; 15; 35-40.
    • (1997) Pancreas , vol.15 , pp. 35-40
    • Kiehne, K.1    Herzig, K.H.2    Folsch, U.R.3
  • 13
    • 0032856141 scopus 로고    scopus 로고
    • Hepatocyte growth factor stimulates cell growth and enhances the expression of transforming growth factor alpha mRNA in AsPC-1 human pancreatic cancer cells
    • Ohba N, Funatomi H, Seki T et al. Hepatocyte growth factor stimulates cell growth and enhances the expression of transforming growth factor alpha mRNA in AsPC-1 human pancreatic cancer cells. J. Gastroenterol. 1999; 34; 498-504.
    • (1999) J. Gastroenterol. , vol.34 , pp. 498-504
    • Ohba, N.1    Funatomi, H.2    Seki, T.3
  • 14
    • 0037428875 scopus 로고    scopus 로고
    • Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production
    • Qian LW, Mizumoto K, Maehara N et al. Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production. Cancer Lett. 2003; 190; 105-112.
    • (2003) Cancer Lett. , vol.190 , pp. 105-112
    • Qian, L.W.1    Mizumoto, K.2    Maehara, N.3
  • 15
    • 84876744809 scopus 로고    scopus 로고
    • Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer
    • Avan A, Quint K, Nicolini F et al. Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr. Pharm. Des. 2013; 19; 940-950.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 940-950
    • Avan, A.1    Quint, K.2    Nicolini, F.3
  • 16
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabine-resistant pancreatic tumor cells
    • Shah AN, Summy JM, Zhang J et al. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann. Surg. Oncol. 2007; 14; 3629-3637.
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3
  • 17
    • 0033965043 scopus 로고    scopus 로고
    • C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells
    • Otte JM, Kiehne K, Schmitz F et al. C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells. Scand. J. Gastroenterol. 2000; 35; 90-95.
    • (2000) Scand. J. Gastroenterol. , vol.35 , pp. 90-95
    • Otte, J.M.1    Kiehne, K.2    Schmitz, F.3
  • 18
    • 0027939437 scopus 로고
    • Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer
    • Ebert M, Yokoyama M, Friess H et al. Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer. Cancer Res. 1994; 54; 5775-5778.
    • (1994) Cancer Res. , vol.54 , pp. 5775-5778
    • Ebert, M.1    Yokoyama, M.2    Friess, H.3
  • 20
    • 84861733799 scopus 로고    scopus 로고
    • MET: a promising anticancer therapeutic target
    • Peters S, Adjei AA. MET: a promising anticancer therapeutic target. Nat. Rev. Clin. Oncol. 2012; 9; 314-326.
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 314-326
    • Peters, S.1    Adjei, A.A.2
  • 21
    • 84890108571 scopus 로고    scopus 로고
    • Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
    • Spigel DR, Ervin TJ, Ramlau RA et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 2013; 31; 4105-4114.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4105-4114
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.A.3
  • 22
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study
    • Santoro A, Rimassa L, Borbath I et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol. 2013; 14; 55-63.
    • (2013) Lancet Oncol. , vol.14 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 23
    • 24944452378 scopus 로고    scopus 로고
    • REporting recommendations for tumour MARKer prognostic studies (REMARK)
    • McShane LM, Altman DG, Sauerbrei W et al. REporting recommendations for tumour MARKer prognostic studies (REMARK). Br. J. Cancer 2005; 93; 387-391.
    • (2005) Br. J. Cancer , vol.93 , pp. 387-391
    • McShane, L.M.1    Altman, D.G.2    Sauerbrei, W.3
  • 24
    • 84905011727 scopus 로고    scopus 로고
    • Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib+/-onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit
    • Koeppen H, Yu W, Zha J et al. Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib+/-onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit. Clin. Cancer Res. 2014; 20; 4488-4498.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 4488-4498
    • Koeppen, H.1    Yu, W.2    Zha, J.3
  • 25
    • 84863542976 scopus 로고    scopus 로고
    • Contribution of CXCR4 and SMAD4 in predicting disease progression pattern and benefit from adjuvant chemotherapy in resected pancreatic adenocarcinoma
    • Bachet JB, Marechal R, Demetter P et al. Contribution of CXCR4 and SMAD4 in predicting disease progression pattern and benefit from adjuvant chemotherapy in resected pancreatic adenocarcinoma. Ann. Oncol. 2012; 23; 2327-2335.
    • (2012) Ann. Oncol. , vol.23 , pp. 2327-2335
    • Bachet, J.B.1    Marechal, R.2    Demetter, P.3
  • 26
    • 65549096660 scopus 로고    scopus 로고
    • High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma
    • Marechal R, Demetter P, Nagy N et al. High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma. Br. J. Cancer 2009; 100; 1444-1451.
    • (2009) Br. J. Cancer , vol.100 , pp. 1444-1451
    • Marechal, R.1    Demetter, P.2    Nagy, N.3
  • 27
    • 84925237877 scopus 로고    scopus 로고
    • Guidelines for time-to-event end-point definitions in trials for pancreatic cancer. Results of the DATECAN initiative (Definition for the Assessment of Time-to-event End-points in CANcer trials)
    • Bonnetain F, Bonsing B, Conroy T et al. Guidelines for time-to-event end-point definitions in trials for pancreatic cancer. Results of the DATECAN initiative (Definition for the Assessment of Time-to-event End-points in CANcer trials). Eur. J. Cancer 2014; 50; 2983-2993.
    • (2014) Eur. J. Cancer , vol.50 , pp. 2983-2993
    • Bonnetain, F.1    Bonsing, B.2    Conroy, T.3
  • 28
    • 0017360990 scopus 로고
    • The measurement of observer agreement for categorical data
    • Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics 1977; 33; 159-174.
    • (1977) Biometrics , vol.33 , pp. 159-174
    • Landis, J.R.1    Koch, G.G.2
  • 29
    • 0028801180 scopus 로고
    • Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis
    • Furukawa T, Duguid WP, Kobari M et al. Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis. Am. J. Pathol. 1995; 147; 889-895.
    • (1995) Am. J. Pathol. , vol.147 , pp. 889-895
    • Furukawa, T.1    Duguid, W.P.2    Kobari, M.3
  • 30
    • 34548578994 scopus 로고    scopus 로고
    • The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
    • Ide T, Kitajima Y, Miyoshi A et al. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann. Surg. Oncol. 2007; 14; 2600-2607.
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 2600-2607
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3
  • 31
    • 79955641985 scopus 로고    scopus 로고
    • Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma
    • Zhu GH, Huang C, Qiu ZJ et al. Expression and prognostic significance of CD151, c-Met, and integrin alpha3/alpha6 in pancreatic ductal adenocarcinoma. Dig. Dis. Sci. 2011; 56; 1090-1098.
    • (2011) Dig. Dis. Sci. , vol.56 , pp. 1090-1098
    • Zhu, G.H.1    Huang, C.2    Qiu, Z.J.3
  • 32
    • 84876141188 scopus 로고    scopus 로고
    • Analysis of pancreatic cancer microenvironment: role of macrophage infiltrates and growth factors expression
    • Gardian K, Janczewska S, Olszewski WL, Durlik M. Analysis of pancreatic cancer microenvironment: role of macrophage infiltrates and growth factors expression. J. Cancer 2012; 3; 285-291.
    • (2012) J. Cancer , vol.3 , pp. 285-291
    • Gardian, K.1    Janczewska, S.2    Olszewski, W.L.3    Durlik, M.4
  • 33
    • 84872149239 scopus 로고    scopus 로고
    • Microenvironment elements involved in the development of pancreatic cancer tumor
    • Gardian K, Janczewska S, Durlik M. Microenvironment elements involved in the development of pancreatic cancer tumor. Gastroenterol. Res. Pract. 2012; 2012; Article ID 585674 1-6.
    • (2012) Gastroenterol. Res. Pract. , vol.2012 , pp. 1-6
    • Gardian, K.1    Janczewska, S.2    Durlik, M.3
  • 34
    • 84864966996 scopus 로고    scopus 로고
    • Postoperative prognostic predictors of pancreatic ductal adenocarcinoma: clinical analysis and immunoprofile on tissue microarrays
    • Park JK, Kim MA, Ryu JK et al. Postoperative prognostic predictors of pancreatic ductal adenocarcinoma: clinical analysis and immunoprofile on tissue microarrays. Ann. Surg. Oncol. 2012; 19; 2664-2672.
    • (2012) Ann. Surg. Oncol. , vol.19 , pp. 2664-2672
    • Park, J.K.1    Kim, M.A.2    Ryu, J.K.3
  • 35
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • Pennacchietti S, Michieli P, Galluzzo M et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003; 3; 347-361.
    • (2003) Cancer Cell , vol.3 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3
  • 36
    • 44449113872 scopus 로고    scopus 로고
    • Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    • Kitajima Y, Ide T, Ohtsuka T, Miyazaki K. Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. Cancer Sci. 2008; 99; 1341-1347.
    • (2008) Cancer Sci. , vol.99 , pp. 1341-1347
    • Kitajima, Y.1    Ide, T.2    Ohtsuka, T.3    Miyazaki, K.4
  • 37
    • 78650160949 scopus 로고    scopus 로고
    • Altered down regulation of the receptor tyrosine kinase met in pancreatic adenocarcinoma cells
    • Hill KS, Lorinczi M, Elferink LA. Altered down regulation of the receptor tyrosine kinase met in pancreatic adenocarcinoma cells. J. Exp. Ther. Oncol. 2010; 8; 297-312.
    • (2010) J. Exp. Ther. Oncol. , vol.8 , pp. 297-312
    • Hill, K.S.1    Lorinczi, M.2    Elferink, L.A.3
  • 38
    • 84864007949 scopus 로고    scopus 로고
    • Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer
    • Hill KS, Gaziova I, Harrigal L et al. Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer. PLoS ONE 2012; 7; e40420.
    • (2012) PLoS ONE , vol.7 , pp. e40420
    • Hill, K.S.1    Gaziova, I.2    Harrigal, L.3
  • 39
    • 33748310896 scopus 로고    scopus 로고
    • Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells
    • Bauer TW, Somcio RJ, Fan F et al. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol. Cancer Ther. 2006; 5; 1676-1682.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1676-1682
    • Bauer, T.W.1    Somcio, R.J.2    Fan, F.3
  • 40
    • 84879372540 scopus 로고    scopus 로고
    • The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer
    • e627
    • Hage C, Rausch V, Giese N et al. The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer. Cell Death Dis. 2013; 4; e627; 1-10.
    • (2013) Cell Death Dis. , vol.4 , pp. 1-10
    • Hage, C.1    Rausch, V.2    Giese, N.3
  • 41
    • 0035937364 scopus 로고    scopus 로고
    • NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
    • Maehara N, Matsumoto K, Kuba K et al. NK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells. Br. J. Cancer 2001; 84; 864-873.
    • (2001) Br. J. Cancer , vol.84 , pp. 864-873
    • Maehara, N.1    Matsumoto, K.2    Kuba, K.3
  • 42
    • 84888347646 scopus 로고    scopus 로고
    • Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma
    • Avan A, Caretti V, Funel N et al. Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma. Cancer Res. 2013; 73; 6745-6756.
    • (2013) Cancer Res. , vol.73 , pp. 6745-6756
    • Avan, A.1    Caretti, V.2    Funel, N.3
  • 43
    • 81855194258 scopus 로고    scopus 로고
    • c-Met is a marker of pancreatic cancer stem cells and therapeutic target
    • Li C, Wu JJ, Hynes M et al. c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology 2011; 141; 2218-2227.
    • (2011) Gastroenterology , vol.141 , pp. 2218-2227
    • Li, C.1    Wu, J.J.2    Hynes, M.3
  • 44
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth
    • Zhang YW, Staal B, Essenburg C et al. MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res. 2010; 70; 6880-6890.
    • (2010) Cancer Res. , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1    Staal, B.2    Essenburg, C.3
  • 45
    • 49249100382 scopus 로고    scopus 로고
    • MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
    • Jin H, Yang R, Zheng Z et al. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res. 2008; 68; 4360-4368.
    • (2008) Cancer Res. , vol.68 , pp. 4360-4368
    • Jin, H.1    Yang, R.2    Zheng, Z.3
  • 46
    • 0035887435 scopus 로고    scopus 로고
    • Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model
    • Tomioka D, Maehara N, Kuba K et al. Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model. Cancer Res. 2001; 61; 7518-7524.
    • (2001) Cancer Res. , vol.61 , pp. 7518-7524
    • Tomioka, D.1    Maehara, N.2    Kuba, K.3


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