-
1
-
-
0038748968
-
-
World Health Organization, Accessed 15 December 2012
-
World Health Organization. Global cancer rates could increase by 50% to 15 million by 2020. Available from: http://www.who.int/mediacentre/news/releases/2003/pr27/en/ Accessed 15 December 2012.
-
Global cancer rates could increase by 50% to 15 million by 2020
-
-
-
2
-
-
33646568784
-
Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world
-
Kamangar F, Dores GM, Anderson WF, (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24: 2137-2150.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2137-2150
-
-
Kamangar, F.1
Dores, G.M.2
Anderson, W.F.3
-
3
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
-
4
-
-
77955174673
-
Advanced gastric cancer-slow but steady progress
-
Power DG, Kelsen DP, Shah MA, (2010) Advanced gastric cancer-slow but steady progress. Cancer Treat Rev 36: 384-392.
-
(2010)
Cancer Treat Rev
, vol.36
, pp. 384-392
-
-
Power, D.G.1
Kelsen, D.P.2
Shah, M.A.3
-
6
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, et al. (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376: 687-697.
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
Chung, H.C.4
Shen, L.5
-
7
-
-
1842428601
-
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
-
Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, et al. (2004) Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A 101: 4477-82.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4477-4482
-
-
Huh, C.G.1
Factor, V.M.2
Sanchez, A.3
Uchida, K.4
Conner, E.A.5
-
8
-
-
79954471845
-
Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target
-
Lee J, Seo JW, Jun HJ, Ki CS, Park SH, et al. (2011) Impact of MET amplification on gastric cancer: possible roles as a novel prognostic marker and a potential therapeutic target. Oncol Rep 25: 1517-1524.
-
(2011)
Oncol Rep
, vol.25
, pp. 1517-1524
-
-
Lee, J.1
Seo, J.W.2
Jun, H.J.3
Ki, C.S.4
Park, S.H.5
-
9
-
-
0031858312
-
Amplification of the c-met, c-erbB-2 and epidermal growth factor receptor gene in human gastric cancers: correlation to clinical features
-
Tsugawa K, Yonemura Y, Hirono Y, Fushida S, Kaji M, et al. (1998) Amplification of the c-met, c-erbB-2 and epidermal growth factor receptor gene in human gastric cancers: correlation to clinical features. Oncology 55: 475-481.
-
(1998)
Oncology
, vol.55
, pp. 475-481
-
-
Tsugawa, K.1
Yonemura, Y.2
Hirono, Y.3
Fushida, S.4
Kaji, M.5
-
10
-
-
0030668305
-
Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer
-
Tsujimoto H, Sugihara H, Hagiwara A, Hattori T, (1997) Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer. Virchows Arch 431: 383-9.
-
(1997)
Virchows Arch
, vol.431
, pp. 383-389
-
-
Tsujimoto, H.1
Sugihara, H.2
Hagiwara, A.3
Hattori, T.4
-
11
-
-
0027055114
-
Frequent amplification of the c-met gene in scirrhous type stomach cancer
-
Kuniyasu H, Yasui W, Kitadai Y, Yokozaki H, Ito H, et al. (1992) Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem Biophys Res Commun 189: 227-232.
-
(1992)
Biochem Biophys Res Commun
, vol.189
, pp. 227-232
-
-
Kuniyasu, H.1
Yasui, W.2
Kitadai, Y.3
Yokozaki, H.4
Ito, H.5
-
12
-
-
0031735293
-
Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, and ERBB2
-
Nessling M, Solinas-Toldo S, Wilgenbus KK, Borchard F, Lichter P, (1998) Mapping of chromosomal imbalances in gastric adenocarcinoma revealed amplified protooncogenes MYCN, MET, WNT2, and ERBB2. Genes Chromosomes Cancer 23: 307-316.
-
(1998)
Genes Chromosomes Cancer
, vol.23
, pp. 307-316
-
-
Nessling, M.1
Solinas-Toldo, S.2
Wilgenbus, K.K.3
Borchard, F.4
Lichter, P.5
-
13
-
-
0033012995
-
Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization
-
Sakakura C, Mori T, Sakabe T, Ariyama Y, Shinomiya T, et al. (1999) Gains, losses, and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization. Genes Chromosomes Cancer 24: 299-305.
-
(1999)
Genes Chromosomes Cancer
, vol.24
, pp. 299-305
-
-
Sakakura, C.1
Mori, T.2
Sakabe, T.3
Ariyama, Y.4
Shinomiya, T.5
-
14
-
-
79959897520
-
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma
-
Catenacci DV, Cervantes G, Yala S, Nelson EA, El-Hashani E, et al. (2011) RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. Cancer Biol Ther 12: 9-46.
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 9-46
-
-
Catenacci, D.V.1
Cervantes, G.2
Yala, S.3
Nelson, E.A.4
El-Hashani, E.5
-
15
-
-
33144462553
-
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
-
Smolen GA, Sordella R, Muir B, Mohapatra G, Barmettler A, et al. (2006) Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci U S A 103: 2316-2321.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2316-2321
-
-
Smolen, G.A.1
Sordella, R.2
Muir, B.3
Mohapatra, G.4
Barmettler, A.5
-
16
-
-
0034641890
-
A novel germ line juxtamembrane Met mutation in human gastric cancer
-
Lee JH, Han SU, Cho H, Jennings B, Gerrard B, et al. (2000) A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene 19: 4947-4953.
-
(2000)
Oncogene
, vol.19
, pp. 4947-4953
-
-
Lee, J.H.1
Han, S.U.2
Cho, H.3
Jennings, B.4
Gerrard, B.5
-
17
-
-
0034789096
-
Overexpression of the c-met protooncogene in human gastric carcinoma-correlation to clinical features
-
Huang TJ, Wang JY, Lin SR, Lian ST, Hsieh JS, (2001) Overexpression of the c-met protooncogene in human gastric carcinoma-correlation to clinical features. Acta Oncol 40: 638-643.
-
(2001)
Acta Oncol
, vol.40
, pp. 638-643
-
-
Huang, T.J.1
Wang, J.Y.2
Lin, S.R.3
Lian, S.T.4
Hsieh, J.S.5
-
18
-
-
0036966942
-
c-Met expression in gastric cancer with liver metastasis
-
Amemiya H, Kono K, Itakura J, Tang RF, Takahashi A, et al. (2002) c-Met expression in gastric cancer with liver metastasis. Oncology 63: 286-296.
-
(2002)
Oncology
, vol.63
, pp. 286-296
-
-
Amemiya, H.1
Kono, K.2
Itakura, J.3
Tang, R.F.4
Takahashi, A.5
-
19
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara N, Gerber HP, LeCouter J, (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676.
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
20
-
-
70350230210
-
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
-
Qian F, Engst S, Yamaguchi K, Yu P, Won KA, et al. (2009) Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res 69: 8009-8016.
-
(2009)
Cancer Res
, vol.69
, pp. 8009-8016
-
-
Qian, F.1
Engst, S.2
Yamaguchi, K.3
Yu, P.4
Won, K.A.5
-
21
-
-
70149109569
-
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL
-
Liu L, Greger J, Shi H, Liu Y, Greshock J, et al. (2009) Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res 69: 6871-6878.
-
(2009)
Cancer Res
, vol.69
, pp. 6871-6878
-
-
Liu, L.1
Greger, J.2
Shi, H.3
Liu, Y.4
Greshock, J.5
-
22
-
-
85081776763
-
Foretinib: a multikinase AXL/MET inhibitor
-
abstr 201N
-
Lui L, (2010) Foretinib: a multikinase AXL/MET inhibitor. J Thoracic Oncol 5 (Suppl 1; abstr 201N) (): S20.
-
(2010)
J Thoracic Oncol
, vol.5
, Issue.SUPPL. 1
-
-
Lui, L.1
-
23
-
-
77954236265
-
A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
-
Eder JP, Shapiro GI, Appleman LJ, Zhu AX, Miles D, et al. (2010) A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res 16: 3507-3516.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3507-3516
-
-
Eder, J.P.1
Shapiro, G.I.2
Appleman, L.J.3
Zhu, A.X.4
Miles, D.5
-
24
-
-
79956198581
-
Abstract A8: Final results of a phase I dose escalation study of the safety and pharmacokinetics of foretinib administered orally daily to patients with solid tumors
-
doi:10.1158/1535-7163.TARG-09-A8
-
LoRusso PM, Eder JP, Sherman L, McCallum S, Liu Y, et al. (2009) Abstract A8: Final results of a phase I dose escalation study of the safety and pharmacokinetics of foretinib administered orally daily to patients with solid tumors. Mol Cancer Ther 8 (Suppl 1) () doi:10.1158/1535-7163.TARG-09-A8.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.SUPPL. 1
-
-
LoRusso, P.M.1
Eder, J.P.2
Sherman, L.3
McCallum, S.4
Liu, Y.5
-
25
-
-
84865247984
-
A phase II and biomarker study (MET111644) of the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Final efficacy, safety, and PD results
-
abstr 355
-
Choueiri TK, Vaishampayan UN, Rosenberg JE, Logan TF, Harzstark AL, et al. (2012) A phase II and biomarker study (MET111644) of the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Final efficacy, safety, and PD results. J Clin Oncol 30 (suppl 5; abstr 355) ().
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL. 5
-
-
Choueiri, T.K.1
Vaishampayan, U.N.2
Rosenberg, J.E.3
Logan, T.F.4
Harzstark, A.L.5
-
26
-
-
84865276119
-
Correlation of germline MET mutation with response to the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Results from a multicenter phase II study (MET111644)
-
abstr 372
-
Srinivasan R, Bottaro D, Choueiri TK, Vaishampayan UN, Rosenberg JE, et al. (2012) Correlation of germline MET mutation with response to the dual Met/VEGFR-2 inhibitor foretinib in patients with sporadic and hereditary papillary renal cell carcinoma: Results from a multicenter phase II study (MET111644). J Clin Oncol 30 (suppl 5; abstr 372) ().
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL. 5
-
-
Srinivasan, R.1
Bottaro, D.2
Choueiri, T.K.3
Vaishampayan, U.N.4
Rosenberg, J.E.5
-
27
-
-
84875030795
-
A Phase I/II Study Of Foretinib, An Oral Multikinase Inhibitor Targeting MET, RON, AXL, TIE-2 AND VEGFR In Advanced Hepatocellular Carcinoma (HCC)
-
abstr 665
-
Yau T, Yen C-J, Chen P-J, Chau Y, Lencioni R, et al. (2011) A Phase I/II Study Of Foretinib, An Oral Multikinase Inhibitor Targeting MET, RON, AXL, TIE-2 AND VEGFR In Advanced Hepatocellular Carcinoma (HCC). J Hepatol 54: S268, abstr 665.
-
(2011)
J Hepatol
, vol.54
-
-
Yau, T.1
Yen, C.-J.2
Chen, P.-J.3
Chau, Y.4
Lencioni, R.5
-
28
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, et al. (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92: 205-216.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
-
29
-
-
79955774755
-
MET expression and amplification in patients with localized gastric cancer
-
Janjigian YY, Tang LH, Coit DG, Kelsen DP, Francone TD, et al. (2011) MET expression and amplification in patients with localized gastric cancer. Cancer Epidemiol Biomarkers Prev 20: 1021-1027.
-
(2011)
Cancer Epidemiol Biomarkers Prev
, vol.20
, pp. 1021-1027
-
-
Janjigian, Y.Y.1
Tang, L.H.2
Coit, D.G.3
Kelsen, D.P.4
Francone, T.D.5
-
30
-
-
55349093866
-
A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma (PRC)
-
May 20, abstr 5103
-
Srinivasan R, Choueiri TK, Vaishampayan UN, Rosenberg JE, Stein MN, et al. (2008) A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma (PRC). J Clin Oncol 26 115S (May 20 Supplement) (): abstr 5103.
-
(2008)
J Clin Oncol
, vol.26
, Issue.115 SUPPL.
-
-
Srinivasan, R.1
Choueiri, T.K.2
Vaishampayan, U.N.3
Rosenberg, J.E.4
Stein, M.N.5
-
31
-
-
34547779489
-
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
-
Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, et al. (2007) Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med 5: 32.
-
(2007)
J Transl Med
, vol.5
, pp. 32
-
-
Deprimo, S.E.1
Bello, C.L.2
Smeraglia, J.3
Baum, C.M.4
Spinella, D.5
-
32
-
-
39049165334
-
Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
-
Ebos JM, Lee CR, Bogdanovic E, Alami J, Van Slyke P, et al. (2008) Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth. Cancer Res 68: 521-529.
-
(2008)
Cancer Res
, vol.68
, pp. 521-529
-
-
Ebos, J.M.1
Lee, C.R.2
Bogdanovic, E.3
Alami, J.4
Van Slyke, P.5
-
33
-
-
36749052895
-
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
-
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS, (2007) Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci U S A 104: 17069-17074.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17069-17074
-
-
Ebos, J.M.1
Lee, C.R.2
Christensen, J.G.3
Mutsaers, A.J.4
Kerbel, R.S.5
-
34
-
-
56249137901
-
HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells
-
Bachleitner-Hofmann T, Sun MY, Chen CT, Tang L, Song L, et al. (2008) HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. Mol Cancer Ther 7: 3499-3508.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3499-3508
-
-
Bachleitner-Hofmann, T.1
Sun, M.Y.2
Chen, C.T.3
Tang, L.4
Song, L.5
-
35
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, Riely G, Viale A, et al. (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104: 20932-20937.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
Riely, G.4
Viale, A.5
-
36
-
-
77957328515
-
MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors
-
Cepero V, Sierra JR, Corso S, Ghiso E, Casorzo L, et al. (2010) MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors. Cancer Res 70: 7580-7590.
-
(2010)
Cancer Res
, vol.70
, pp. 7580-7590
-
-
Cepero, V.1
Sierra, J.R.2
Corso, S.3
Ghiso, E.4
Casorzo, L.5
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