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Volumn 87, Issue 2, 2015, Pages 89-95

Management of crizotinib therapy for ALK-rearranged non-small cell lung carcinoma: An expert consensus

(14)  Cappuzzo, Federico a   Moro Sibilot, Denis b   Gautschi, Oliver c   Boleti, Ekaterini d   Felip, Enriqueta e   Groen, Harry J M f   Germonpré, Paul g   Meldgaard, Peter h   Arriola, Edurne i   Steele, Nicola j   Fox, Jesme k   Schnell, Patrick l   Engelsberg, Arne m   Wolf, Jürgen n  


Author keywords

Anaplastic lymphoma kinase (ALK) inhibitor; Crizotinib; Non small cell lung cancer (NSCLC); Safety profile; Therapy management; Treatment beyond progression

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CRIZOTINIB; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

EID: 84922571357     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2014.12.010     Document Type: Review
Times cited : (44)

References (42)
  • 1
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
    • Rikova K., Guo A., Zeng Q., et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007, 131:1190-1203.
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 2
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M., Choi Y.L., Enomoto M., et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007, 448:561-566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 3
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • Soda M., Takada S., Takeuchi K., et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci USA 2008, 105:19893-19897.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 4
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak E.L., Bang Y.J., Camidge D.R., et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010, 363:1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 5
    • 34249324494 scopus 로고    scopus 로고
    • An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
    • Zou H.Y., Li Q., Lee J.H., et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007, 67:4408-4417.
    • (2007) Cancer Res , vol.67 , pp. 4408-4417
    • Zou, H.Y.1    Li, Q.2    Lee, J.H.3
  • 6
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K., Shaw A.T., Ou S.H., et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol 2012, 30:863-870.
    • (2012) J Clin Oncol , vol.30 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 7
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen J.G., Zou H.Y., Arango M.E., et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 2007, 6:3314-3322.
    • (2007) Mol Cancer Ther , vol.6 , pp. 3314-3322
    • Christensen, J.G.1    Zou, H.Y.2    Arango, M.E.3
  • 8
    • 84910054316 scopus 로고    scopus 로고
    • Available from:, [accessed 23.04.14]
    • Pfizer Inc. EU Xalkori (crizotinib) summary of product characteristics 2014, Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002489/WC500134759.pdf [accessed 23.04.14].
    • (2014) EU Xalkori (crizotinib) summary of product characteristics
  • 9
    • 84911493241 scopus 로고    scopus 로고
    • Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Reck M., Popat S., Reinmuth N., et al. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014, 25(Suppl. 3):iii27-iii39.
    • (2014) Ann Oncol , vol.25 , pp. iii27-iii39
    • Reck, M.1    Popat, S.2    Reinmuth, N.3
  • 11
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
    • Camidge D.R., Bang Y., Kwak E.L., et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012, 13:1011-1019.
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.2    Kwak, E.L.3
  • 14
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • [and supplemental material]
    • Shaw A.T., Kim D.W., Nakagawa K., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013, 368:2385-2394. [and supplemental material].
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 15
    • 84906221716 scopus 로고    scopus 로고
    • First-line crizotinib versus pemetrexed-cisplatin or pemetrexed-carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014)
    • May
    • Mok T., Kim D.-W., Wu Y.-L., et al. First-line crizotinib versus pemetrexed-cisplatin or pemetrexed-carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014). J Clin Oncol 2014, 32(May (Suppl. 20)). [Abstract 8002].
    • (2014) J Clin Oncol , vol.32
    • Mok, T.1    Kim, D.-W.2    Wu, Y.-L.3
  • 16
    • 84930005738 scopus 로고    scopus 로고
    • Overall and intracranial (IC) efficacy results and time to symptom deterioration in PROFILE 1014: 1st-line crizotinib vs pemetrexed-platinum chemotherapy (PPC) in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC)
    • Solomon B., Felip E., Blackhall F.H., et al. Overall and intracranial (IC) efficacy results and time to symptom deterioration in PROFILE 1014: 1st-line crizotinib vs pemetrexed-platinum chemotherapy (PPC) in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC). Ann Oncol 2014, 25(Suppl. 4):iv427. [Abstract 1225O].
    • (2014) Ann Oncol , vol.25 , pp. iv427
    • Solomon, B.1    Felip, E.2    Blackhall, F.H.3
  • 17
    • 84878015837 scopus 로고    scopus 로고
    • Heart rate decrease during crizotinib treatment and potential correlation to clinical response
    • Ou S.H., Tong W.P., Azada M., et al. Heart rate decrease during crizotinib treatment and potential correlation to clinical response. Cancer 2013, 119:1969-1975.
    • (2013) Cancer , vol.119 , pp. 1969-1975
    • Ou, S.H.1    Tong, W.P.2    Azada, M.3
  • 19
    • 84867864355 scopus 로고    scopus 로고
    • Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer
    • Weickhardt A.J., Rothman M.S., Salian-Mehta S., et al. Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. Cancer 2012, 118:5302-5309.
    • (2012) Cancer , vol.118 , pp. 5302-5309
    • Weickhardt, A.J.1    Rothman, M.S.2    Salian-Mehta, S.3
  • 20
    • 84859507778 scopus 로고    scopus 로고
    • Preliminary characterization of visual events reported by patients receiving crizotinib for the treatment of advanced ALK-positive non-small cell lung cancer
    • Solomon B., Chiappori A., Lamb A., et al. Preliminary characterization of visual events reported by patients receiving crizotinib for the treatment of advanced ALK-positive non-small cell lung cancer. Poster presented at the European multidisciplinary cancer congress 2011, [Abstract 3030].
    • (2011) Poster presented at the European multidisciplinary cancer congress
    • Solomon, B.1    Chiappori, A.2    Lamb, A.3
  • 21
    • 84923004551 scopus 로고    scopus 로고
    • Visual disturbances in patients (pts) with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) treated with crizotinib
    • Besse B., Salgia R., Solomon B., et al. Visual disturbances in patients (pts) with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) treated with crizotinib. Poster presentation at the European society of medical oncology (ESMO) annual meeting 2012, [Abstract 1268P].
    • (2012) Poster presentation at the European society of medical oncology (ESMO) annual meeting
    • Besse, B.1    Salgia, R.2    Solomon, B.3
  • 23
    • 79952095377 scopus 로고    scopus 로고
    • Cardiotoxicity associated with targeting kinase pathways in cancer
    • Mellor H.R., Bell A.R., Valentin J.P., et al. Cardiotoxicity associated with targeting kinase pathways in cancer. Toxicol Sci 2011, 120:14-32.
    • (2011) Toxicol Sci , vol.120 , pp. 14-32
    • Mellor, H.R.1    Bell, A.R.2    Valentin, J.P.3
  • 24
    • 84905644636 scopus 로고    scopus 로고
    • US Food and Drug Administration, Available from, [accessed 5.02.14]
    • Pfizer Inc. Xalkori prescribing information November 2013, US Food and Drug Administration, Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202570s000lbl.pdf [accessed 5.02.14].
    • (2013) Xalkori prescribing information
  • 26
    • 84879086307 scopus 로고    scopus 로고
    • Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients
    • Weickhardt A.J., Doebele R.C., Purcell W.T., et al. Symptomatic reduction in free testosterone levels secondary to crizotinib use in male cancer patients. Cancer 2013, 119:2383-2390.
    • (2013) Cancer , vol.119 , pp. 2383-2390
    • Weickhardt, A.J.1    Doebele, R.C.2    Purcell, W.T.3
  • 27
    • 84887056433 scopus 로고    scopus 로고
    • Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels
    • Vigen R., O'Donnell C.I., Baron A.E., et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 2013, 310:1829-1836.
    • (2013) JAMA , vol.310 , pp. 1829-1836
    • Vigen, R.1    O'Donnell, C.I.2    Baron, A.E.3
  • 28
    • 84896718907 scopus 로고    scopus 로고
    • Drug-induced reduction in estimated glomerular filtration rate in patients with ALK-positive non-small cell lung cancer treated with the ALK inhibitor crizotinib
    • Brosnan E.M., Weickhardt A.J., Lu X., et al. Drug-induced reduction in estimated glomerular filtration rate in patients with ALK-positive non-small cell lung cancer treated with the ALK inhibitor crizotinib. Cancer 2014, 120:664-674.
    • (2014) Cancer , vol.120 , pp. 664-674
    • Brosnan, E.M.1    Weickhardt, A.J.2    Lu, X.3
  • 29
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • Doebele R.C., Pilling A.B., Aisner D.L., et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res 2012, 18:1472-1482.
    • (2012) Clin Cancer Res , vol.18 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3
  • 30
    • 84856999699 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers
    • Katayama R., Shaw A.T., Khan T.M., et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung cancers. Sci Transl Med 2012, 4:120ra17.
    • (2012) Sci Transl Med , vol.4
    • Katayama, R.1    Shaw, A.T.2    Khan, T.M.3
  • 31
    • 84875396927 scopus 로고    scopus 로고
    • Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer
    • Kim S., Kim T.M., Kim D.W., et al. Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer. J Thorac Oncol 2013, 8:415-422.
    • (2013) J Thorac Oncol , vol.8 , pp. 415-422
    • Kim, S.1    Kim, T.M.2    Kim, D.W.3
  • 32
    • 81355124049 scopus 로고    scopus 로고
    • Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen
    • Zhang S., Wang F., Keats J., et al. Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des 2011, 78:999-1005.
    • (2011) Chem Biol Drug Des , vol.78 , pp. 999-1005
    • Zhang, S.1    Wang, F.2    Keats, J.3
  • 33
    • 80053531654 scopus 로고    scopus 로고
    • Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: implications for clinical trial design
    • Chaft J.E., Oxnard G.R., Sima C.S., et al. Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: implications for clinical trial design. Clin Cancer Res 2011, 17:6298-6303.
    • (2011) Clin Cancer Res , vol.17 , pp. 6298-6303
    • Chaft, J.E.1    Oxnard, G.R.2    Sima, C.S.3
  • 34
    • 84863827626 scopus 로고    scopus 로고
    • Disease flare after treatment discontinuation in a patient with EML4-ALK lung cancer and acquired resistance to crizotinib
    • Pop O., Pirvu A., Toffart A.-C., et al. Disease flare after treatment discontinuation in a patient with EML4-ALK lung cancer and acquired resistance to crizotinib. J Thorac Oncol 2012, 7:e1-e2.
    • (2012) J Thorac Oncol , vol.7 , pp. e1-e2
    • Pop, O.1    Pirvu, A.2    Toffart, A.-C.3
  • 35
    • 84885636436 scopus 로고    scopus 로고
    • Disease flare after discontinuation of crizotinib in anaplastic lymphoma kinase-positive lung cancer
    • Kuriyama Y., Kim Y.H., Nagai H., et al. Disease flare after discontinuation of crizotinib in anaplastic lymphoma kinase-positive lung cancer. Case Rep Oncol 2013, 6:430-433.
    • (2013) Case Rep Oncol , vol.6 , pp. 430-433
    • Kuriyama, Y.1    Kim, Y.H.2    Nagai, H.3
  • 36
    • 84896737519 scopus 로고    scopus 로고
    • Stereotactic radiation therapy can safely and durably control sites of extra-central nervous system oligoprogressive disease in anaplastic lymphoma kinase-positive lung cancer patients receiving crizotinib
    • Gan G.N., Weickhardt A.J., Scheier B., et al. Stereotactic radiation therapy can safely and durably control sites of extra-central nervous system oligoprogressive disease in anaplastic lymphoma kinase-positive lung cancer patients receiving crizotinib. Int J Radiat Oncol Biol Phys 2014, 88:892-898.
    • (2014) Int J Radiat Oncol Biol Phys , vol.88 , pp. 892-898
    • Gan, G.N.1    Weickhardt, A.J.2    Scheier, B.3
  • 37
    • 84870317390 scopus 로고    scopus 로고
    • Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
    • Weickhardt A.J., Scheier B., Burke J.M., et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol 2012, 7:1807-1814.
    • (2012) J Thorac Oncol , vol.7 , pp. 1807-1814
    • Weickhardt, A.J.1    Scheier, B.2    Burke, J.M.3
  • 38
    • 84893399587 scopus 로고    scopus 로고
    • Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC
    • Ou S.H., Janne P.A., Bartlett C.H., et al. Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC. Ann Oncol 2014, 25:415-422.
    • (2014) Ann Oncol , vol.25 , pp. 415-422
    • Ou, S.H.1    Janne, P.A.2    Bartlett, C.H.3
  • 39
    • 84876354373 scopus 로고    scopus 로고
    • Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement
    • Takeda M., Okamoto I., Nakagawa K. Clinical impact of continued crizotinib administration after isolated central nervous system progression in patients with lung cancer positive for ALK rearrangement. J Thorac Oncol 2013, 8:654-657.
    • (2013) J Thorac Oncol , vol.8 , pp. 654-657
    • Takeda, M.1    Okamoto, I.2    Nakagawa, K.3
  • 40
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • Shaw A.T., Kim D.W., Mehra R., et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med 2014, 370:1189-1197.
    • (2014) N Engl J Med , vol.370 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.W.2    Mehra, R.3
  • 41
    • 84908569219 scopus 로고    scopus 로고
    • Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study
    • Gadgeel S.M., Gandhi L., Riely G.J., et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol 2014, 15:1119-1128.
    • (2014) Lancet Oncol , vol.15 , pp. 1119-1128
    • Gadgeel, S.M.1    Gandhi, L.2    Riely, G.J.3
  • 42
    • 84874045943 scopus 로고    scopus 로고
    • Response to crizotinib rechallenge after initial progression and intervening chemotherapy
    • Browning E.T., Weickhardt A.J., Camidge D.R. Response to crizotinib rechallenge after initial progression and intervening chemotherapy. J Thorac Oncol 2013, 8:e21.
    • (2013) J Thorac Oncol , vol.8 , pp. e21
    • Browning, E.T.1    Weickhardt, A.J.2    Camidge, D.R.3


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