메뉴 건너뛰기




Volumn 10, Issue 1, 2010, Pages 47-57

Hepatocyte growth factor activation inhibitors - Therapeutic potential in cancer

Author keywords

HAI 1; HAI 2; Hepatocyte growth factor; HGF activator; HGF inhibitor; Matriptase; Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT; BLOOD CLOTTING FACTOR 11A; CYTOKINE RECEPTOR ANTAGONIST; HEPATOCYTE GROWTH FACTOR ACTIVATION INHIBITOR 1; HEPATOCYTE GROWTH FACTOR ACTIVATION INHIBITOR 2; HEPATOCYTE GROWTH FACTOR ACTIVATOR; HEPSIN; MATRIPTASE; MEMBRANE PROTEIN; PLASMIN; PRO HEPATOCYTE GROWTH FACTOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SERINE PROTEINASE; TISSUE KALLIKREIN; TRYPSIN; UNCLASSIFIED DRUG;

EID: 77950808485     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/1871520611009010047     Document Type: Review
Times cited : (26)

References (109)
  • 1
    • 0002695098 scopus 로고
    • Mendelson, J.; Howley, P.M.; Israel, M.A.; Liotta, L.A. Eds. WB Saunders Company: Philadelphia
    • Stracke, M.L.; Liotta, L.A The Molecular Basis of Cancer; Mendelson, J.; Howley, P.M.; Israel, M.A.; Liotta, L.A. Eds. WB Saunders Company: Philadelphia, 1995, pp. 233-247.
    • (1995) The Molecular Basis of Cancer , pp. 233-247
    • Stracke, M.L.1    Liotta, L.A.2
  • 3
    • 16244403039 scopus 로고    scopus 로고
    • Cancer incidence and mortality in Europe 2004
    • Boyle, P.; Ferlay, J. Cancer incidence and mortality in Europe, 2004. Ann. Oncol., 2005, 16(3), 481-488.
    • (2005) Ann. Oncol. , vol.16 , Issue.3 , pp. 481-488
    • Boyle, P.1    Ferlay, J.2
  • 4
    • 0021285134 scopus 로고
    • Partial purification and characterization of hepatocyte growth factor from serum of hepatomized rats
    • Nakamura, T.; Nawa, K.; Ichihara, A. Partial purification and characterization of hepatocyte growth factor from serum of hepatomized rats. Biochem. Biophys. Res. Commun., 1984, 122(30), 1450-1459.
    • (1984) Biochem. Biophys. Res. Commun. , vol.122 , Issue.30 , pp. 1450-1459
    • Nakamura, T.1    Nawa, K.2    Ichihara, A.3
  • 6
    • 33745465488 scopus 로고    scopus 로고
    • Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions
    • Matsumoto, K.; Nakamura, T. Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Int. J. Cancer, 2006, 119(3), 477-483.
    • (2006) Int. J. Cancer , vol.119 , Issue.3 , pp. 477-483
    • Matsumoto, K.1    Nakamura, T.2
  • 7
    • 33847390775 scopus 로고    scopus 로고
    • C-Met and hepatocyte growth factor: Potential as novel targets in cancer therapy
    • Sattler, M.; Salgia, R. c-Met and hepatocyte growth factor: potential as novel targets in cancer therapy. Curr. Oncol. Rep., 2007, 9(2),102-108.
    • (2007) Curr. Oncol. Rep. , vol.9 , Issue.2 , pp. 102-108
    • Sattler, M.1    Salgia, R.2
  • 8
    • 58149147368 scopus 로고    scopus 로고
    • Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer
    • Toschi, L.; Jänne, P.A. Single-agent and combination therapeutic strategies to inhibit hepatocyte growth factor/MET signaling in cancer. Clin. Cancer. Res., 2008, 14(19), 5941-5946.
    • (2008) Clin. Cancer. Res. , vol.14 , Issue.19 , pp. 5941-5946
    • Toschi, L.1    Jänne, P.A.2
  • 9
    • 67649595545 scopus 로고    scopus 로고
    • Inhibition of HGF/MET as therapy for malignancy
    • Naran, S.; Zhang, X.; Hughes, S.J. Inhibition of HGF/MET as therapy for malignancy. Expert. Opin. Ther. Targets, 2009, 13(5), 569-581.
    • (2009) Expert. Opin. Ther. Targets , vol.13 , Issue.5 , pp. 569-581
    • Naran, S.1    Zhang, X.2    Hughes, S.J.3
  • 10
    • 0024601997 scopus 로고
    • Purification of the migration stimulating factor produced by fetal and breast cancer patients fibroblasts
    • Grey, A.M.; Schlor, A.M.; Rushton, G.; Ellis, I.; Schlor, S.L. Purification of the migration stimulating factor produced by fetal and breast cancer patients fibroblasts. Proc. Natl. Acad. Sci. USA, 1989, 86(7), 2438-2442.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , Issue.7 , pp. 2438-2442
    • Grey, A.M.1    Schlor, A.M.2    Rushton, G.3    Ellis, I.4    Schlor, S.L.5
  • 12
    • 2342640981 scopus 로고    scopus 로고
    • Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions
    • DOI 10.1158/0008-5472.CAN-03-2464
    • Ohuchida, K.; Mizumoto, K.; Murakami, M.; Qian, L.W.; Sato, N.; Nagai, E.; Matsumoto, K.; Nakamura, T.; Tanaka, M. Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res., 2004, 64(9), 3215-3222. (Pubitemid 38581425)
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3215-3222
    • Ohuchida, K.1    Mizumoto, K.2    Murakami, M.3    Qian, L.-W.4    Sato, N.5    Nagai, E.6    Matsumoto, K.7    Nakamura, T.8    Tanaka, M.9
  • 13
    • 0026485023 scopus 로고
    • A functional domain in the heavychain of scatter factor hepatocyte growth-factor binds the c-met receptor and induces cell-dissociation but not mitogenesis
    • Hartmann, G.; Naldini, L.; Weidner, K.M.; Sachs, M.; Vigna, E.; Comoglio, P.M.; Birchmeier, W. A functional domain in the heavychain of scatter factor hepatocyte growth-factor binds the c-met receptor and induces cell-dissociation but not mitogenesis. Proc. Natl. Acad. Sci. USA, 1992, 89(23), 11574-11578.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , Issue.23 , pp. 11574-11578
    • Hartmann, G.1    Naldini, L.2    Weidner, K.M.3    Sachs, M.4    Vigna, E.5    Comoglio, P.M.6    Birchmeier, W.7
  • 14
    • 0026646946 scopus 로고
    • Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity
    • Gak, E.; Taylor, W.G.; Chan, A.M.; Rubin, J.S. Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity. FEBS Lett., 1992, 311(1), 17-21.
    • (1992) FEBS Lett. , vol.311 , Issue.1 , pp. 17-21
    • Gak, E.1    Taylor, W.G.2    Chan, A.M.3    Rubin, J.S.4
  • 15
    • 0027289115 scopus 로고
    • And sequence-analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth-factor - Structural similarity of the protease precursor to blood-coagulation factor-xii
    • Miyazawa, K.; Shimomura, T.; Kitamura, A.; Kondo, J.; Morimoto, Y.; Kitamura, N. Molecular-cloning and sequence-analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth-factor - structural similarity of the protease precursor to blood-coagulation factor-xii. J. Biol. Chem., 1993, 268(14), 10024-10028.
    • (1993) J. Biol. Chem. , vol.268 , Issue.14 , pp. 10024-10028
    • Miyazawa, K.1    Shimomura, T.2    Kitamura, A.3    Kondo, J.4    Morimoto, Y.5    Molecular-Cloning, K.N.6
  • 16
    • 0035486691 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor/ scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells
    • Parr, C.; Jiang, W.G. Expression of hepatocyte growth factor/ scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. Int. J. Oncol., 2001, 19(4), 857-863.
    • (2001) Int. J. Oncol. , vol.19 , Issue.4 , pp. 857-863
    • Parr, C.1    Jiang, W.G.2
  • 17
    • 1642535487 scopus 로고    scopus 로고
    • The Hepatocyte Growth Factor Regulatory Factors in Human Breast Cancer
    • DOI 10.1158/1078-0432.CCR-0553-3
    • Parr, C.; Watkins, G.; Mansel, R.E.; Jiang, W.G. The hepatocyte growth factor regulatory factors and human breast cancer. Clin. Cancer. Res, 2004, 10(1), 202-211. (Pubitemid 38114181)
    • (2004) Clinical Cancer Research , vol.10 , Issue.1 , pp. 202-211
    • Parr, C.1    Watkins, G.2    Mansel, R.E.3    Jiang, W.G.4
  • 18
    • 0034711244 scopus 로고    scopus 로고
    • Activation of Hepatocyte growth factor and urokinase/plasminogen activator by matriptase an epithelial membrane serine protease
    • Lee, S.; Dickson, R.B.; Lin, C.Y. Activation of Hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease. J. Biol. Chem., 2000, 275(47), 36720-36725.
    • (2000) J. Biol. Chem. , vol.275 , Issue.47 , pp. 36720-36725
    • Lee, S.1    Dickson, R.B.2    Lin, C.Y.3
  • 19
    • 0028912590 scopus 로고
    • Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction
    • Naldini, L.; Vigna, E.; Bardelli, A.; Follenzi, A.; Galimi, F.; Comoglio, P.M. Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. J. Biol. Chem., 1995, 270(2), 603-611.
    • (1995) J. Biol. Chem. , vol.270 , Issue.2 , pp. 603-611
    • Naldini, L.1    Vigna, E.2    Bardelli, A.3    Follenzi, A.4    Galimi, F.5    Comoglio, P.M.6
  • 21
    • 0028598887 scopus 로고
    • Protease inhibitors: Role and potential therapeutic use in human cancer
    • Declerk, Y.A.; Imren, S. Protease inhibitors: role and potential therapeutic use in human cancer. Eur. J. Cancer, 1994, 30(14), 2170-2180.
    • (1994) Eur. J. Cancer , vol.30 , Issue.14 , pp. 2170-2180
    • Declerk, Y.A.1    Imren, S.2
  • 22
    • 0028851737 scopus 로고
    • Disruption of the function of tumor-suppressor gene p53 by the hepatitis-b virus x-protein and hepatocarcinogenesis
    • Takada, S.; Tsuchida, T.; Kobayashi, M.; Koike, K. Disruption of the function of tumor-suppressor gene p53 by the hepatitis-b virus x-protein and hepatocarcinogenesis. J. Cancer. Res. Clin. Oncol., 1995, 121(9), 593-601.
    • (1995) J. Cancer. Res. Clin. Oncol. , vol.121 , Issue.9 , pp. 593-601
    • Takada, S.1    Tsuchida, T.2    Kobayashi, M.3    Koike, K.4
  • 23
    • 0034327340 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma
    • Kataoka, H.; Hamasuna, R.; Itoh, H.; Kitamura, N.; Koono, M. Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma. Cancer Res., 2000, 60(21), 6148-6159.
    • (2000) Cancer Res. , vol.60 , Issue.21 , pp. 6148-6159
    • Kataoka, H.1    Hamasuna, R.2    Itoh, H.3    Kitamura, N.4    Koono, M.5
  • 24
    • 0347129545 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor types 1 and 2 are expressed by tubular epithelium in kidney and downregulated in renal cell carcinoma
    • Yamauchi, M.; Kataoka, H.; Itoh, H.; Seguchi, T.; Hasui, Y.; Osada, Y. Hepatocyte growth factor activator inhibitor types 1 and 2 are expressed by tubular epithelium in kidney and downregulated in renal cell carcinoma. J. Urol., 2004, 171(2), 890-896.
    • (2004) J. Urol. , vol.171 , Issue.2 , pp. 890-896
    • Yamauchi, M.1    Kataoka, H.2    Itoh, H.3    Seguchi, T.4    Hasui, Y.5    Osada, Y.6
  • 25
    • 30444437590 scopus 로고    scopus 로고
    • Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo
    • Uchinokura, S.; Miyata, S.; Fukushima, T.; Itoh, H.; Nakano, S.; Wakisaka, S.; Kataoka, H. Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo. Int. J. Cancer, 2006, 118(3), 583-592.
    • (2006) Int. J. Cancer , vol.118 , Issue.3 , pp. 583-592
    • Uchinokura, S.1    Miyata, S.2    Fukushima, T.3    Itoh, H.4    Nakano, S.5    Wakisaka, S.6    Kataoka, H.7
  • 26
    • 24644447871 scopus 로고    scopus 로고
    • Serum hepatocyte growth factor activator (HGFA) in benign prostatic hyperplasia and prostate cancer
    • DOI 10.1016/j.eururo.2005.05.020, PII S030228380500360X
    • Nagakawa, O.; Yamagishi, T.; Fujiuchi, Y.; Junicho, A.; Akashi, T.; Nagaike, K.; Fuse, H. Serum hepatocyte growth factor activator (HGFA) in benign prostatic hyperplasia and prostate cancer. Eur. Urol., 2005, 48(4), 686-690. (Pubitemid 41278597)
    • (2005) European Urology , vol.48 , Issue.4 , pp. 686-690
    • Nagakawa, O.1    Yamagishi, T.2    Fujiuchi, Y.3    Junicho, A.4    Akashi, T.5    Nagaike, K.6    Fuse, H.7
  • 27
    • 54249125034 scopus 로고    scopus 로고
    • Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma
    • Wader, K.F.; Fagerli, U.M.; Holt, R.U.; Stordal, B.; Børset, M.; Sundan, A.; Waage, A. Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma. Eur. J. Haematol., 2008, 81(5):380-383.
    • (2008) Eur. J. Haematol. , vol.81 , Issue.5 , pp. 380-383
    • Wader, K.F.1    Fagerli, U.M.2    Holt, R.U.3    Stordal, B.4    Børset, M.5    Sundan, A.6    Waage, A.7
  • 29
    • 0036459128 scopus 로고    scopus 로고
    • Deregulated activation of matriptase in breast cancer cells
    • Benaud, C.M.; Oberst, M.; Dickson, R.B.; Lin, C.Y. Deregulated activation of matriptase in breast cancer cells. Clin. Exp. Metastasis, 2002, 19(7), 639-649.
    • (2002) Clin. Exp. Metastasis , vol.19 , Issue.7 , pp. 639-649
    • Benaud, C.M.1    Oberst, M.2    Dickson, R.B.3    Lin, C.Y.4
  • 30
    • 0037374303 scopus 로고    scopus 로고
    • Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer
    • Kang, J.Y.; Dolled-Filhart, M.; Ocal, I.T.; Singh, B.; Lin, C.Y.; Dickson, R.B.; Rimm, D.L.; Camp, R.L. Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer. Cancer Res., 2003, 63(5), 1101-1105.
    • (2003) Cancer Res. , vol.63 , Issue.5 , pp. 1101-1105
    • Kang, J.Y.1    Dolled-Filhart, M.2    Ocal, I.T.3    Singh, B.4    Lin, C.Y.5    Dickson, R.B.6    Rimm, D.L.7    Camp, R.L.8
  • 31
    • 33750485799 scopus 로고    scopus 로고
    • Expression of EMMPRIN and matriptase in esophageal squamous cell carcinoma: Correlation with clinicopathological parameters
    • Cheng, M.F.; Tzao, C.; Tsai, W.C.; Lee, W.H.; Chen, A.; Chiang, H.; Sheu, L.F.; Jin, J.S. Expression of EMMPRIN and matriptase in esophageal squamous cell carcinoma: Correlation with clinicopathological parameters. Dis. Esophagus, 2006, 19(6), 482-486.
    • (2006) Dis. Esophagus , vol.19 , Issue.6 , pp. 482-486
    • Cheng, M.F.1    Tzao, C.2    Tsai, W.C.3    Lee, W.H.4    Chen, A.5    Chiang, H.6    Sheu, L.F.7    Jin, J.S.8
  • 32
    • 33746604484 scopus 로고    scopus 로고
    • The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals
    • Vogel, L.K.; Saebo, M.; Skjelbred, C.F.; Abell, K.; Pedersen, E.D.; Vogel, U.; Kure, E.H. The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals. BMC Cancer, 2006, 6, 176.
    • (2006) BMC Cancer , vol.6 , pp. 176
    • Vogel, L.K.1    Saebo, M.2    Skjelbred, C.F.3    Abell, K.4    Pedersen, E.D.5    Vogel, U.6    Kure, E.H.7
  • 34
    • 32344451851 scopus 로고    scopus 로고
    • Expression of serine protease matriptase in renal cell carcinoma: Correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters
    • DOI 10.1016/j.neures.2006.01.006
    • Jin, J.S.; Chen, A.; Hsieh, D.S.; Yao, C.W.; Cheng, M.F.; Lin, Y.F. Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters. Int. J. Surg. Pathol., 2006, 14(1), 65-72. (Pubitemid 43221618)
    • (2006) International Journal of Surgical Pathology , vol.14 , Issue.1 , pp. 65-72
    • Jin, J.-S.1    Chen, A.2    Hsieh, D.-S.3    Yao, C.-W.4    Cheng, M.-F.5    Lin, Y.-F.6
  • 35
    • 14844304649 scopus 로고    scopus 로고
    • Transmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): Expression and prognostic value in ovarian cancer
    • Tanimoto, H.; Shigemasa, K.; Tian, X.; Gu, L.; Beard, J.B.; Sawasaki, T.; O'brien, T.J. Transmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer. Br. J. Cancer, 2004, 92(2), 278-283.
    • (2004) Br. J. Cancer , vol.92 , Issue.2 , pp. 278-283
    • Tanimoto, H.1    Shigemasa, K.2    Tian, X.3    Gu, L.4    Beard, J.B.5    Sawasaki, T.6    O'Brien, T.J.7
  • 36
    • 0035069846 scopus 로고    scopus 로고
    • Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo
    • Oberst, M.; Anders, J.; Xie, B.; Singh, B.; Ossandon, M.; Johnson, M.; Dickson, R.B.; Lin, C.Y. Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. Am. J. Pathol., 2001, 158(4), 1301-1311.
    • (2001) Am. J. Pathol. , vol.158 , Issue.4 , pp. 1301-1311
    • Oberst, M.1    Anders, J.2    Xie, B.3    Singh, B.4    Ossandon, M.5    Johnson, M.6    Dickson, R.B.7    Lin, C.Y.8
  • 37
    • 2442432225 scopus 로고    scopus 로고
    • Gene expression profilingidentifies matriptase overexpression in malignant mesothelioma
    • Hoang, C.D.; D'Cunha, J.; Kratzke, M.G.; Casmey, C.E.; Frizelle, S.P.; Maddaus, M.A.; Kratzke, R.A. Gene expression profilingidentifies matriptase overexpression in malignant mesothelioma. Chest, 2004, 125(5), 1843-1852.
    • (2004) Chest , vol.125 , Issue.5 , pp. 1843-1852
    • Hoang, C.D.1    D'Cunha, J.2    Kratzke, M.G.3    Casmey, C.E.4    Frizelle, S.P.5    Maddaus, M.A.6    Kratzke, R.A.7
  • 39
    • 0142243202 scopus 로고    scopus 로고
    • The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma
    • Santin, A.D.; Cane, S.; Bellone, S.; Bignotti, E.; Palmieri, M.; Las Casas, L.E.; Anfossi, S.; Roman, J.J.; O'Brien, T.; Pecorelli, S. The novel serine protease tumor-associated differentially expressed gene-15 (matriptase/MT-SP1) is highly overexpressed in cervical carcinoma. Cancer, 2003, 98(9), 1898-1904.
    • (2003) Cancer , vol.98 , Issue.9 , pp. 1898-1904
    • Santin, A.D.1    Cane, S.2    Bellone, S.3    Bignotti, E.4    Palmieri, M.5    Las Casas, L.E.6    Anfossi, S.7    Roman, J.J.8    O'Brien, T.9    Pecorelli, S.10
  • 41
    • 33644784579 scopus 로고    scopus 로고
    • A novel biomarker for staging human prostate adenocarcinoma: Overexpression of matriptase with concomitant loss of its inhibitor hepatocyte growth factor activator inhibitor-1
    • Saleem, M.; Adhami, V.M.; Zhong, W.; Longley, B.J.; Lin, C.Y.; Dickson, R.B.; Reagan-Shaw, S.; Jarrard, D.F.; Mukhtar, H. A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1. Cancer Epidemiol. Biomarkers Prev., 2006, 15(2), 217-227
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , Issue.2 , pp. 217-227
    • Saleem, M.1    Adhami, V.M.2    Zhong, W.3    Longley, B.J.4    Lin, C.Y.5    Dickson, R.B.6    Reagan-Shaw, S.7    Jarrard, D.F.8    Mukhtar, H.9
  • 44
    • 48549104703 scopus 로고    scopus 로고
    • Evaluating the function of matriptase and Nacetylglucosaminyltransferase v in prostate cancer metastasis
    • Tsui, K.H.; Chang, P.L.; Feng, T.H.; Chung, L.C.; Sung, H.C.; Juang. H.H. Evaluating the function of matriptase and Nacetylglucosaminyltransferase V in prostate cancer metastasis. Anticancer Res., 2008, 28(4), 1993-1999.
    • (2008) Anticancer Res. , vol.28 , Issue.4 , pp. 1993-1999
    • Tsui, K.H.1    Chang, P.L.2    Feng, T.H.3    Chung, L.C.4    Sung, H.C.5    Juang., H.H.6
  • 45
    • 48549085959 scopus 로고    scopus 로고
    • Down-regulation of matriptase by overexpression of bikunin attenuates cell invasion in prostate carcinoma cells.
    • Tsui, K.H.; Chang, P.L.; Feng, T.H.; Chung, L.C.; Hsu, S.Y.; Juang, H.H. Down-regulation of matriptase by overexpression of bikunin attenuates cell invasion in prostate carcinoma cells. Anticancer Res., 2008, 28(4), 1977-1983.
    • (2008) Anticancer Res. , vol.28 , Issue.4 , pp. 1977-1983
    • Tsui, K.H.1    Chang, P.L.2    Feng, T.H.3    Chung, L.C.4    Hsu, S.Y.5    Juang, H.H.6
  • 46
    • 46649116786 scopus 로고    scopus 로고
    • Decreased matriptase/HAI-1 ratio in advanced colorectal adenocarcinoma of Chinese patients
    • Tsai, W.C.; Sheu, L.F.; Chao, Y.C.; Chen, A.; Chiang, H.; Jin, J.S. Decreased matriptase/HAI-1 ratio in advanced colorectal adenocarcinoma of Chinese patients. Chin. J. Physiol., 2007, 50(5), 225-231.
    • (2007) Chin. J. Physiol. , vol.50 , Issue.5 , pp. 225-231
    • Tsai, W.C.1    Sheu, L.F.2    Chao, Y.C.3    Chen, A.4    Chiang, H.5    Jin, J.S.6
  • 47
    • 0030044647 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor, in the injured tissues, is mediated by hepatocyte growth factor activator
    • Miyazawa, K.; Shimomura, T.; Kitamura, N. Activation of hepatocyte growth factor, in the injured tissues, is mediated by hepatocyte growth factor activator. J. Biol. Chem., 1996, 271(7), 3615-3618.
    • (1996) J. Biol. Chem. , vol.271 , Issue.7 , pp. 3615-3618
    • Miyazawa, K.1    Shimomura, T.2    Kitamura, N.3
  • 49
    • 0035805597 scopus 로고    scopus 로고
    • Activation of hepatocyte growth factor (HGF) by endogenous HGF activator is required for metanephric kidney morphogenesis in vitro
    • Van Adelsberg, J.; Sehgal, S.; Kukes, A.; Brady, C.; Barasch, J.; Yang, J.; Huan, Y. Activation of hepatocyte growth factor (HGF) by endogenous HGF activator is required for metanephric kidney morphogenesis in vitro. J. Biol. Chem., 2001, 276(18), 15099-15106.
    • (2001) J. Biol. Chem. , vol.276 , Issue.18 , pp. 15099-15106
    • Van Adelsberg, J.1    Sehgal, S.2    Kukes, A.3    Brady, C.4    Barasch, J.5    Yang, J.6    Huan, Y.7
  • 51
    • 0030786268 scopus 로고    scopus 로고
    • Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor
    • DOI 10.1074/jbc.272.44.27558
    • Kawaguchi, T.; Qin, L.; Shimomura, T.; Kondo, J.; Matsumoto, K.; Denda, K.; Kitamura, N. Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. J. Biol. Chem., 1997, 272(44), 27558-27564. (Pubitemid 27473546)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.44 , pp. 27558-27564
    • Kawaguchi, T.1    Qin, L.2    Shimomura, T.3    Kondo, J.4    Matsumoto, K.5    Denda, K.6    Kitamura, N.7
  • 52
    • 0037134489 scopus 로고    scopus 로고
    • Functional characterisation of kunitz domains in hepatocyte growth factor activator inhibtor type-1
    • Denda, K.; Shimomura, T.; Kawaguchi, T.; Miyazawa, K.; Kitamura, N. Functional characterisation of kunitz domains in hepatocyte growth factor activator inhibtor type-1. J. Biol. Chem., 2002, 277(16), 14053-14059.
    • (2002) J. Biol. Chem. , vol.277 , Issue.16 , pp. 14053-14059
    • Denda, K.1    Shimomura, T.2    Kawaguchi, T.3    Miyazawa, K.4    Kitamura, N.5
  • 53
    • 15544386767 scopus 로고    scopus 로고
    • Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2
    • Kirchhofer, D.; Peek, M.; Lipari, M.T.; Billeci, K.; Fan, B.; Moran, P. Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett., 2005, 579(9), 1945-1950.
    • (2005) FEBS Lett. , vol.579 , Issue.9 , pp. 1945-1950
    • Kirchhofer, D.1    Peek, M.2    Lipari, M.T.3    Billeci, K.4    Fan, B.5    Moran, P.6
  • 54
    • 13844296946 scopus 로고    scopus 로고
    • Conformational lability in serine protease active sites: Structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B
    • Shia, S.; Stamos, J.; Kirchhofer, D.; Fan, B.; Wu, J.; Corpuz, R.T.; Santell, L.; Lazarus, R.A.; Eigenbrot, C. Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. J. Mol. Biol., 2005, 346(5), 1335-1349.
    • (2005) J. Mol. Biol. , vol.346 , Issue.5 , pp. 1335-1349
    • Shia, S.1    Stamos, J.2    Kirchhofer, D.3    Fan, B.4    Wu, J.5    Corpuz, R.T.6    Santell, L.7    Lazarus, R.A.8    Eigenbrot, C.9
  • 55
    • 57649183234 scopus 로고    scopus 로고
    • Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity
    • Szabo, R.; Hobson, J.P.; List, K.; Molinolo, A.; Lin, C.Y.; Bugge, T.H. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J. Biol. Chem., 2008, 283(43), 29495-29504.
    • (2008) J. Biol. Chem. , vol.283 , Issue.43 , pp. 29495-29504
    • Szabo, R.1    Hobson, J.P.2    List, K.3    Molinolo, A.4    Lin, C.Y.5    Bugge, T.H.6
  • 56
    • 0034704164 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenviroenvironment
    • Kataoka, H.; Shimomura, T.; Kawaguchi, T.; Hamasuna, R.; Itoh, H.; Kitamura, N.; Miyazawa, K.; Koono, M. Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenviroenvironment. J. Biol. Chem., 2000, 275(51), 40453-40462
    • (2000) J. Biol. Chem. , vol.275 , Issue.51 , pp. 40453-40462
    • Kataoka, H.1    Shimomura, T.2    Kawaguchi, T.3    Hamasuna, R.4    Itoh, H.5    Kitamura, N.6    Miyazawa, K.7    Koono, M.8
  • 58
    • 15444372149 scopus 로고    scopus 로고
    • Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activationfoci in human mammary epithelial cells
    • Lee, M.S.; Kiyomiya, K.; Benaud, C.; Dickson, R.B.; Lin, C.Y. Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activationfoci in human mammary epithelial cells. Am. J. Physiol. Cell. Physiol., 2005, 288(4), 932-941.
    • (2005) Am. J. Physiol. Cell. Physiol. , vol.288 , Issue.4 , pp. 932-941
    • Lee, M.S.1    Kiyomiya, K.2    Benaud, C.3    Dickson, R.B.4    Lin, C.Y.5
  • 60
    • 41449107352 scopus 로고    scopus 로고
    • Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase
    • Kojima, K.; Tsuzuki, S.; Fushiki, T.; Inouye, K. Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase. J. Biol. Chem., 2008, 283(5), 2478-2487.
    • (2008) J. Biol. Chem. , vol.283 , Issue.5 , pp. 2478-2487
    • Kojima, K.1    Tsuzuki, S.2    Fushiki, T.3    Inouye, K.4
  • 61
    • 67651146418 scopus 로고    scopus 로고
    • Role of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type i
    • Kojima, K.; Tsuzuki, S.; Fushiki, T.; Inouye, K. Role of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I. J. Biochem., 2009, 145(6), 783-790.
    • (2009) J. Biochem. , vol.145 , Issue.6 , pp. 783-790
    • Kojima, K.1    Tsuzuki, S.2    Fushiki, T.3    Inouye, K.4
  • 62
    • 33846917477 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
    • Fan, B.; Brennan, J.; Grant, D.; Peale, F.; Rangell, L.; Kirchhofer, D. Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth. Dev. Biol., 2007, 303(1), 222-230.
    • (2007) Dev. Biol. , vol.303 , Issue.1 , pp. 222-230
    • Fan, B.1    Brennan, J.2    Grant, D.3    Peale, F.4    Rangell, L.5    Kirchhofer, D.6
  • 64
    • 69049092775 scopus 로고    scopus 로고
    • Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice
    • Szabo, R.; Hobson, J.P.; Christoph, K.; Kosa, P.; List, K.; Bugge, T.H. Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development, 2009, 136(15), 2653-2663.
    • (2009) Development , vol.136 , Issue.15 , pp. 2653-2663
    • Szabo, R.1    Hobson, J.P.2    Christoph, K.3    Kosa, P.4    List, K.5    Bugge, T.H.6
  • 65
    • 0031684612 scopus 로고    scopus 로고
    • White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues
    • Yamada, T.; Tsujioka, Y.; Taguchi, J.; Takahashi, M.; Tsuboi, Y.; Shimomura, T. White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues. Exp. Neurol., 1998, 153(1), 60-64.
    • (1998) Exp. Neurol. , vol.153 , Issue.1 , pp. 60-64
    • Yamada, T.1    Tsujioka, Y.2    Taguchi, J.3    Takahashi, M.4    Tsuboi, Y.5    Shimomura, T.6
  • 66
    • 0032546894 scopus 로고    scopus 로고
    • Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa
    • Kataoka, H.; Uchino, H.; Denda, K.; Kitamura, N.; Itoh, H.; Tsubouchi, H.; Nabeshima, K.; Koono, M. Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa. Cancer Lett., 1998, 128(2), 219-227.
    • (1998) Cancer Lett. , vol.128 , Issue.2 , pp. 219-227
    • Kataoka, H.1    Uchino, H.2    Denda, K.3    Kitamura, N.4    Itoh, H.5    Tsubouchi, H.6    Nabeshima, K.7    Koono, M.8
  • 67
    • 0032962252 scopus 로고    scopus 로고
    • Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues: Cellular surface localisation of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues
    • Kataoka, H.; Itoh, H.; Kitamura, N.; Nabeshima, K.; Koono, M. Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues: Cellular surface localisation of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. J. Histochem. Cytochem., 1999, 47(5), 673-682.
    • (1999) J. Histochem. Cytochem. , vol.47 , Issue.5 , pp. 673-682
    • Kataoka, H.1    Itoh, H.2    Kitamura, N.3    Nabeshima, K.4    Koono, M.5
  • 68
  • 69
    • 0036920624 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: Identification of a distinct transcription start site for the HAI-2 gene in testis
    • Yamauchi, M,; Itoh, H.; Naganuma, S.; Koono, M.; Hasui, Y.; Osada, Y.; Kataoka, H. Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis. Biol. Chem., 2002, 383(12),1953-1957.
    • (2002) Biol. Chem. , vol.383 , Issue.12 , pp. 1953-1957
    • Yamauchi, M.1    Itoh, H.2    Naganuma, S.3    Koono, M.4    Hasui, Y.5    Osada, Y.6    Kataoka, H.7
  • 70
    • 0034040693 scopus 로고    scopus 로고
    • Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes
    • DOI 10.1046/j.1432-1327.2000.01368.x
    • Itoh, H.; Yamauchi, M.; Kataoka, H.; Hamasuna, R.; Kitamura, N.; Koono, M. Genomic structure and chromosomal mapping of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes. Eur. J. Biochem., 2000, 267(11), 3351-3359. (Pubitemid 30341165)
    • (2000) European Journal of Biochemistry , vol.267 , Issue.11 , pp. 3351-3359
    • Itoh, H.1    Yamauchi, M.2    Kataoka, H.3    Hamasuna, R.4    Kitamura, N.5    Koono, M.6
  • 71
    • 33746355289 scopus 로고    scopus 로고
    • Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells
    • Parr, C.; Jiang, W.G. Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cells. Int. J. Cancer, 2006, 119(5),1176-1183.
    • (2006) Int. J. Cancer , vol.119 , Issue.5 , pp. 1176-1183
    • Parr, C.1    Jiang, W.G.2
  • 72
    • 34250777391 scopus 로고    scopus 로고
    • Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients
    • Parr, C.; Sanders, A.J.; Davies, G.; Martin, T.; Lane, J.; Mason, M.D.; Mansel, R.E.; Jiang, W.G. Matriptase-2 inhibits breast tumor growth and invasion and correlates with favorable prognosis for breast cancer patients. Clin. Cancer Res., 2007, 13(12), 3568-3576.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.12 , pp. 3568-3576
    • Parr, C.1    Sanders, A.J.2    Davies, G.3    Martin, T.4    Lane, J.5    Mason, M.D.6    Mansel, R.E.7    Jiang, W.G.8
  • 73
    • 52649098954 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses
    • Komaki, W.; Fukushima, T.; Tanaka, H.; Itoh.; H, Chosa, E.; Kataoka, H. Expression of hepatocyte growth factor activator inhibitor type 1 on the epithelial cell surface is regulated by hypoxic and oxidative stresses. Virchows Arch., 2008, 453(4), 347-357
    • (2008) Virchows Arch. , vol.453 , Issue.4 , pp. 347-357
    • Komaki, W.1    Fukushima, T.2    Tanaka, H.3    Itoh, H.4    Chosa, E.5    Kataoka, H.6
  • 75
    • 0036554846 scopus 로고    scopus 로고
    • Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: Correlation with clinical outcome and tumor clinicopathological parameters
    • Oberst, M.D.; Johnson, M.D.; Dickson, R.B.; Lin, C.Y.; Singh, B.; Stewart, M.; Williams, A.; al-Nafussi, A.; Smyth, J.F.; Gabra, H.; Sellar, G.C. Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters. Clin. Cancer Res., 2002, 8(4), 1101-1107.
    • (2002) Clin. Cancer Res. , vol.8 , Issue.4 , pp. 1101-1107
    • Oberst, M.D.1    Johnson, M.D.2    Dickson, R.B.3    Lin, C.Y.4    Singh, B.5    Stewart, M.6    Williams, A.7    Al-Nafussi, A.8    Smyth, J.F.9    Gabra, H.10    Sellar, G.C.11
  • 76
    • 62449253973 scopus 로고    scopus 로고
    • HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for antiinvasive functions
    • Tung, E.K.; Wong, C.M.; Yau, T.O.; Lee, J.M.; Ching, Y.P.; Ng, I.O. HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for antiinvasive functions. Int. J. Cancer, 2009, 124(8), 1811-1819.
    • (2009) Int. J. Cancer , vol.124 , Issue.8 , pp. 1811-1819
    • Tung, E.K.1    Wong, C.M.2    Yau, T.O.3    Lee, J.M.4    Ching, Y.P.5    Ng, I.O.6
  • 78
    • 30644459109 scopus 로고    scopus 로고
    • Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract
    • Zeng, L.; Cao, J.; Zhang, X. Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract. World J. Gastroenterol., 2005, 11(39), 6202-6207.
    • (2005) World J. Gastroenterol. , vol.11 , Issue.39 , pp. 6202-6207
    • Zeng, L.1    Cao, J.2    Zhang, X.3
  • 79
    • 64549159005 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) in ovarian cancer
    • Nakamura, K.; Abarzua, F.; Kodama, J.; Hongo, A.; Nasu, Y.; Kumon, H.; Hiramatsu, Y. Expression of hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2) in ovarian cancer. Int. J. Oncol., 2009, 34(2), 345-353.
    • (2009) Int. J. Oncol. , vol.34 , Issue.2 , pp. 345-353
    • Nakamura, K.1    Abarzua, F.2    Kodama, J.3    Hongo, A.4    Nasu, Y.5    Kumon, H.6    Hiramatsu, Y.7
  • 80
    • 0035426921 scopus 로고    scopus 로고
    • Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: Implication for anti-invasive role of HAI- 2/PB in glioblastoma cells
    • Hamasuna, R.; Kataoka, H.; Meng, J.Y.; Itoh, H.; Moriyama. T.; Wakisaka, S.; Koono, M. Reduced expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin (HAI-2/PB) in human glioblastomas: implication for anti-invasive role of HAI- 2/PB in glioblastoma cells. Int. J. Cancer, 2001, 93(3), 339-345.
    • (2001) Int. J. Cancer , vol.93 , Issue.3 , pp. 339-345
    • Hamasuna, R.1    Kataoka, H.2    Meng, J.Y.3    Itoh, H.4    Moriyama., T.5    Wakisaka, S.6    Koono, M.7
  • 81
    • 58949095931 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor- 2 (HAI-2) is a favorable prognosis marker and inhibits cell growth through the apoptotic pathway in cervical cancer
    • Nakamura, K.; Abarzua, F.; Hongo, A.; Kodama, J.; Nasu, Y.; Kumon, H.; Hiramatsu, Y. Hepatocyte growth factor activator inhibitor- 2 (HAI-2) is a favorable prognosis marker and inhibits cell growth through the apoptotic pathway in cervical cancer. Ann. Oncol., 2009, 20(1), 63-70.
    • (2009) Ann. Oncol. , vol.20 , Issue.1 , pp. 63-70
    • Nakamura, K.1    Abarzua, F.2    Hongo, A.3    Kodama, J.4    Nasu, Y.5    Kumon, H.6    Hiramatsu, Y.7
  • 82
    • 21144447438 scopus 로고    scopus 로고
    • Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma
    • Morris, M.R.; Gentle, D.; Abdulrahman, M.; Maina, E.N.; Gupta, K.; Banks, R.E.; Wiesener, M.S.; Kishida, T.; Yao, M.; Teh, B.; Latif, F.; Maher, E.R. Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. Cancer Res., 2005, 65(11), 4598-4606.
    • (2005) Cancer Res. , vol.65 , Issue.11 , pp. 4598-4606
    • Morris, M.R.1    Gentle, D.2    Abdulrahman, M.3    Maina, E.N.4    Gupta, K.5    Banks, R.E.6    Wiesener, M.S.7    Kishida, T.8    Yao, M.9    Teh, B.10    Latif, F.11    Maher, E.R.12
  • 85
    • 38449085987 scopus 로고    scopus 로고
    • Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro
    • Sanders, A.J.; Parr, C.; Mason, M.D.; Jiang, W.G. Suppression of hepatocyte growth factor activator inhibitor-1 leads to a more aggressive phenotype of prostate cancer cells in vitro. Int. J. Mol. Med., 2007, 20(4), 613-619.
    • (2007) Int. J. Mol. Med. , vol.20 , Issue.4 , pp. 613-619
    • Sanders, A.J.1    Parr, C.2    Mason, M.D.3    Jiang, W.G.4
  • 88
    • 62449216355 scopus 로고    scopus 로고
    • Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases
    • Cheng, H.; Fukushima, T.; Takahashi, N.; Tanaka, H.; Kataoka, H. Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases. Cancer Res., 2009, 69(5), 1828-1835.
    • (2009) Cancer Res. , vol.69 , Issue.5 , pp. 1828-1835
    • Cheng, H.1    Fukushima, T.2    Takahashi, N.3    Tanaka, H.4    Kataoka, H.5
  • 89
    • 35448988591 scopus 로고    scopus 로고
    • Kunitz domain 1 is responsible for the antiinvasive effect HAI-1 in human glioblastoma cells lines
    • Miyata, S.; Fukushima, T.; Kohama, K.; Tanaka, H.; Takeshima, H.; Kataoka, H. Kunitz domain 1 is responsible for the antiinvasive effect HAI-1 in human glioblastoma cells lines. Hum. Cell., 2007, 20(4), 100-106.
    • (2007) Hum. Cell. , vol.20 , Issue.4 , pp. 100-106
    • Miyata, S.1    Fukushima, T.2    Kohama, K.3    Tanaka, H.4    Takeshima, H.5    Kataoka, H.6
  • 90
    • 0027971732 scopus 로고
    • Induction of hepatocyte growth-factor in human skin fibroblasts by epidermal growth-factor, platelet-derived growth-factor and fibroblast growth-factor
    • Gohda, E.; Matsunaga, T.; Kataoka, H.; Takebe, T.; Yamamoto, I. Induction of hepatocyte growth-factor in human skin fibroblasts by epidermal growth-factor, platelet-derived growth-factor and fibroblast growth-factor. Cytokine, 1994,. 6(6), 633-640.
    • (1994) Cytokine , vol.6 , Issue.6 , pp. 633-640
    • Gohda, E.1    Matsunaga, T.2    Kataoka, H.3    Takebe, T.4    Yamamoto, I.5
  • 92
    • 69449086849 scopus 로고    scopus 로고
    • The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer
    • Nakamura, K.; Abarzua, F.; Hongo, A.; Kodama, J.; Nasu, Y.; Kumon, H.; Hiramatsu, Y. The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer. Int. J. Oncol., 2009, 35(2), 239-248.
    • (2009) Int. J. Oncol. , vol.35 , Issue.2 , pp. 239-248
    • Nakamura, K.1    Abarzua, F.2    Hongo, A.3    Kodama, J.4    Nasu, Y.5    Kumon, H.6    Hiramatsu, Y.7
  • 93
    • 0034714379 scopus 로고    scopus 로고
    • Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and singlechain urokinase-type plasminogen activator as substrates
    • Takeuchi, T.; Harris, J.L.; Huang, W.; Yan, K.W.; Coughlin, S.R.; Craik, C.S. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and singlechain urokinase-type plasminogen activator as substrates. J. Biol. Chem., 2000, 275(34), 26333-26342.
    • (2000) J. Biol. Chem. , vol.275 , Issue.34 , pp. 26333-26342
    • Takeuchi, T.1    Harris, J.L.2    Huang, W.3    Yan, K.W.4    Coughlin, S.R.5    Craik, C.S.6
  • 95
    • 0036039046 scopus 로고    scopus 로고
    • Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependant cascade
    • Kobayashi, H.; Suzuki, M.; Kanayama, N.; Takashi, N.; Takigawa, M.; Terao, T. Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependant cascade. Eur. J. Biochem., 2002, 269(16), 3945-3957.
    • (2002) Eur. J. Biochem. , vol.269 , Issue.16 , pp. 3945-3957
    • Kobayashi, H.1    Suzuki, M.2    Kanayama, N.3    Takashi, N.4    Takigawa, M.5    Terao, T.6
  • 96
    • 4444267635 scopus 로고    scopus 로고
    • Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist NK4 suppresses peritoneal metastases of gastric cancer in nude mice
    • Ueda, K.; Iwahashi, M.; Matsuura, I.; Nakamori, M.; Nakamura, M.; Ojima, T.; Naka, T.; Ishida, K.; Matsumoto, K.; Nakamura, T.; Yamaue, H. Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice. Eur. J. Cancer, 2004, 40(14), 2135-2142.
    • (2004) Eur. J. Cancer , vol.40 , Issue.14 , pp. 2135-2142
    • Ueda, K.1    Iwahashi, M.2    Matsuura, I.3    Nakamori, M.4    Nakamura, M.5    Ojima, T.6    Naka, T.7    Ishida, K.8    Matsumoto, K.9    Nakamura, T.10    Yamaue, H.11
  • 97
  • 98
    • 2942555478 scopus 로고    scopus 로고
    • Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
    • Wen, J.; Matsumoto, K.; Taniura, N.; Tomioka, D.; Nakamura, T. Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Ther., 2004, 11(6), 419-430.
    • (2004) Cancer Gene Ther. , vol.11 , Issue.6 , pp. 419-430
    • Wen, J.1    Matsumoto, K.2    Taniura, N.3    Tomioka, D.4    Nakamura, T.5
  • 99
    • 0141925943 scopus 로고    scopus 로고
    • Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4
    • Brockmann, M.A.; Papadimitriou, A.; Brandt, M.; Fillbrandt, R.; Westphal, M.; Lamszus, K. Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor/hepatocyte growth factor-antagonist NK4. Clin. Cancer Res., 2003, 9(12), 4578-4585.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.12 , pp. 4578-4585
    • Brockmann, M.A.1    Papadimitriou, A.2    Brandt, M.3    Fillbrandt, R.4    Westphal, M.5    Lamszus, K.6
  • 100
  • 101
    • 0041887145 scopus 로고    scopus 로고
    • Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.
    • Martin, T.A.; Parr, C.; Davies, G.; Watkins, G.; Lane, J.; Matsumoto, K.; Nakamura, T.; Mansel, R.E.; Jiang, W.G. Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis, 2003, 24(8), 1317-1323.
    • (2003) Carcinogenesis , vol.24 , Issue.8 , pp. 1317-1323
    • Martin, T.A.1    Parr, C.2    Davies, G.3    Watkins, G.4    Lane, J.5    Matsumoto, K.6    Nakamura, T.7    Mansel, R.E.8    Jiang, W.G.9
  • 102
    • 0034806873 scopus 로고    scopus 로고
    • The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant
    • Parr, C.; Davies, G.; Nakamura, T.; Matsumoto, K.; Mason, M.D.; Jiang, W.G. The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variant. Biochem. Biophys. Res. Commun., 2001, 285(5), 1330-1337.
    • (2001) Biochem. Biophys. Res. Commun. , vol.285 , Issue.5 , pp. 1330-1337
    • Parr, C.1    Davies, G.2    Nakamura, T.3    Matsumoto, K.4    Mason, M.D.5    Jiang, W.G.6
  • 103
    • 0033971446 scopus 로고    scopus 로고
    • Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells
    • Parr, C.; Hiscox, S.; Nakamura, T.; Matsumoto, K.; Jiang, W.G. Nk4, a new HGF/SF variant, is an antagonist to the influence of HGF/SF on the motility and invasion of colon cancer cells. Int. J. Cancer, 2000, 85(4), 563-570.
    • (2000) Int. J. Cancer , vol.85 , Issue.4 , pp. 563-570
    • Parr, C.1    Hiscox, S.2    Nakamura, T.3    Matsumoto, K.4    Jiang, W.G.5
  • 104
    • 0032713122 scopus 로고    scopus 로고
    • Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in. vitro angiogenesis of human vascular endothelial cells
    • Jiang, W.G.; Hiscox, S.E.; Parr, C.; Martin, T.A.; Matsumoto, K.; Nakamura, T.; Mansel, R.E. Antagonistic effect of NK4, a novel hepatocyte growth factor variant, on in. vitro angiogenesis of human vascular endothelial cells. Clin. Cancer Res., 1999, 5(11), 3695-3703.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.11 , pp. 3695-3703
    • Jiang, W.G.1    Hiscox, S.E.2    Parr, C.3    Martin, T.A.4    Matsumoto, K.5    Nakamura, T.6    Mansel, R.E.7
  • 105
    • 50449087162 scopus 로고    scopus 로고
    • Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4
    • Matsumoto, K.; Nakamura, T.; Sakai, K.; Nakamura, T. Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4. Proteomics, 2008, 8(16), 3360-3370.
    • (2008) Proteomics , vol.8 , Issue.16 , pp. 3360-3370
    • Matsumoto, K.1    Nakamura, T.2    Sakai, K.3    Nakamura, T.4
  • 106
    • 38449111543 scopus 로고    scopus 로고
    • NK4 gene therapy targeting HGFMet and angiogenesis
    • Matsumoto, K.; Nakamura, T. NK4 gene therapy targeting HGFMet and angiogenesis. Front. Biosci., 2008, 13, 1943-1951.
    • (2008) Front. Biosci. , vol.13 , pp. 1943-1951
    • Matsumoto, K.1    Nakamura, T.2
  • 108
    • 22744454871 scopus 로고    scopus 로고
    • Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo
    • Miyata, S.; Uchinokura, S.; Fukushima, T.; Hamasuna, R.; Itoh, H.; Akiyama, Y.; Nakano, S.; Wakisaka, S.; Kataoka H. Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo. Cancer Lett., 2005, 227(1), 83-93.
    • (2005) Cancer Lett. , vol.227 , Issue.1 , pp. 83-93
    • Miyata, S.1    Uchinokura, S.2    Fukushima, T.3    Hamasuna, R.4    Itoh, H.5    Akiyama, Y.6    Nakano, S.7    Wakisaka, S.8    Kataoka, H.9
  • 109
    • 34147123126 scopus 로고    scopus 로고
    • Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma
    • DOI 10.1111/j.1349-7006.2007.00412.x
    • Betsunoh, H.; Mukai, S.; Akiyama, Y.; Fukushima, T.; Minamiguchi, N.; Hasui, Y.; Osada, Y.; Kataoka, H. Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma. Cancer Sci., 2007, 98(4), 491-498. (Pubitemid 46562738)
    • (2007) Cancer Science , vol.98 , Issue.4 , pp. 491-498
    • Betsunoh, H.1    Mukai, S.2    Akiyama, Y.3    Fukushima, T.4    Minamiguchi, N.5    Hasui, Y.6    Osada, Y.7    Kataoka, H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.