-
1
-
-
0037317520
-
The endothelin axis: Emerging role in cancer
-
Nelson, J., Bagnato, A., Battistini, B. & Nisen, P. The endothelin axis: emerging role in cancer. Nature Rev. Cancer 3, 110-116 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 110-116
-
-
Nelson, J.1
Bagnato, A.2
Battistini, B.3
Nisen, P.4
-
2
-
-
0029085123
-
Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
-
Nelson, J. B. et al. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nature Med. 1, 944-949 (1995).
-
(1995)
Nature Med
, vol.1
, pp. 944-949
-
-
Nelson, J.B.1
-
3
-
-
0028982331
-
Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells
-
Bagnato, A. et al. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells. Clin. Cancer Res. 1, 1059-1066 (1995).
-
(1995)
Clin. Cancer Res
, vol.1
, pp. 1059-1066
-
-
Bagnato, A.1
-
4
-
-
0023859136
-
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
-
Yanagisawa, M. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411-415 (1988).
-
(1988)
Nature
, vol.332
, pp. 411-415
-
-
Yanagisawa, M.1
-
5
-
-
84871603109
-
Endothelin-2 the forgotten isoform: Emerging role in the cardiovascular system, ovarian development, immunology and cancer
-
Ling, L., Maguire, J. J. & Davenport, A. P. Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer. Br. J. Pharmacol. 168, 283-295 (2013).
-
(2013)
Br. J. Pharmacol
, vol.168
, pp. 283-295
-
-
Ling, L.1
Maguire, J.J.2
Davenport, A.P.3
-
6
-
-
79251592532
-
Endothelin-1 gene regulation
-
Stow, L. R., Jacobs, M. E., Wingo, C. S., Cain, B. D. Endothelin-1 gene regulation. FASEB J. 25, 16-28 (2011).
-
(2011)
FASEB J
, vol.25
, pp. 16-28
-
-
Stow, L.R.1
Jacobs, M.E.2
Wingo, C.S.3
Cain, B.D.4
-
7
-
-
84879604260
-
Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism
-
Matteucci, E. et al. Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism. Exp. Cell Res. 319, 1865-1874(2013).
-
(2013)
Exp. Cell Res
, vol.319
, pp. 1865-1874
-
-
Matteucci, E.1
-
8
-
-
84862794595
-
The inhibitory effect of miRNA-1 on ET-1 gene expression
-
Li, D. et al. The inhibitory effect of miRNA-1 on ET-1 gene expression. FEBS Lett. 586, 1014-1021 (2012).
-
(2012)
FEBS Lett
, vol.586
, pp. 1014-1021
-
-
Li, D.1
-
9
-
-
84866349767
-
MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1
-
Li, D. et al. MicroRNA-1 inhibits proliferation of hepatocarcinoma cells by targeting endothelin-1. Life Sci. 91, 440-447 (2012).
-
(2012)
Life Sci
, vol.91
, pp. 440-447
-
-
Li, D.1
-
10
-
-
0033197939
-
Paracrine regulation of ovarian cancer by endothelin
-
Moraitis, S., Miller, W. R., Smyth, J. F. & Langdon, S. P. Paracrine regulation of ovarian cancer by endothelin. Eur. J. Cancer 35, 1381-1387 (1999).
-
(1999)
Eur. J. Cancer
, vol.35
, pp. 1381-1387
-
-
Moraitis, S.1
Miller, W.R.2
Smyth, J.F.3
Langdon, S.P.4
-
11
-
-
80052359992
-
Emerging paradigms of arrestin-dependent seven transmembrane receptor signaling
-
Shukla, A. K., Xiao, K. & Lefkowitz, R. J. Emerging paradigms of arrestin-dependent seven transmembrane receptor signaling. Trends Biochem. Sci. 36, 457-469 (2011).
-
(2011)
Trends Biochem. Sci
, vol.36
, pp. 457-469
-
-
Shukla, A.K.1
Xiao, K.2
Lefkowitz, R.J.3
-
12
-
-
84867581538
-
Comparison of human ETA and ETB receptor signalling via G-protein and arrestin pathways
-
Maguire, J. J. et al. Comparison of human ETA and ETB receptor signalling via G-protein and arrestin pathways. Life Sci. 91, 544-549 (2012).
-
(2012)
Life Sci
, vol.91
, pp. 544-549
-
-
Maguire, J.J.1
-
13
-
-
0030044360
-
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
-
Daub, H., Weiss, F. U., Wallasch, C. & Ullrich, A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379, 557-560 (1996).
-
(1996)
Nature
, vol.379
, pp. 557-560
-
-
Daub, H.1
Weiss, F.U.2
Wallasch, C.3
Ullrich, A.4
-
14
-
-
0034665584
-
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signalling in human ovarian carcinoma cells
-
Vacca, F., Bagnato, A., Catt, K. J. & Tecce, R. Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signalling in human ovarian carcinoma cells. Cancer Res. 60, 5310-5317 (2000).
-
(2000)
Cancer Res
, vol.60
, pp. 5310-5317
-
-
Vacca, F.1
Bagnato, A.2
Catt, K.J.3
Tecce, R.4
-
15
-
-
34447136110
-
Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity
-
Rosan-, L. et al. Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity. Cancer Res. 67, 6351-6359 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 6351-6359
-
-
Rosan, L.1
-
16
-
-
62449145673
-
ß-arrestin links endothelin A receptor to ß-catenin signalling to induce ovarian cancer cell invasion and metastasis
-
Rosan ó, L. et al. ß-arrestin links endothelin A receptor to ß-catenin signalling to induce ovarian cancer cell invasion and metastasis. Proc. Natl Acad. Sci. USA 106, 2806-2811 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2806-2811
-
-
Rosanó, L.1
-
17
-
-
84883164592
-
Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells
-
Spinella, F. et al. Endothelin-1 induces the transactivation of vascular endothelial growth factor receptor-3 and modulates cell migration and vasculogenic mimicry in melanoma cells. J. Mol. Med 91, 395-405 (2013).
-
(2013)
J. Mol. Med
, vol.91
, pp. 395-405
-
-
Spinella, F.1
-
18
-
-
80255129266
-
Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal-epithelial interactions
-
Hinsley, E. E., Hunt, S., Hunter, K. D., Whawell, S. A. & Lambert, D. W. Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal-epithelial interactions. Int. J. Cancer 130, 40-47 (2012).
-
(2012)
Int. J. Cancer
, vol.130
, pp. 40-47
-
-
Hinsley, E.E.1
Hunt, S.2
Hunter, K.D.3
Whawell, S.A.4
Lambert, D.W.5
-
19
-
-
13244284605
-
ß-catenin activates the growth factor endothelin-1 in colon cancer cells
-
Kim, T. H., Xiong, H., Zhang, Z. & Ren, B. ß-catenin activates the growth factor endothelin-1 in colon cancer cells. Oncogene 24, 597-604 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 597-604
-
-
Kim, T.H.1
Xiong, H.2
Zhang, Z.3
Ren, B.4
-
20
-
-
31044437778
-
Positive inter-regulation between ß-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells
-
Sun, P., Xiong, H., Kim, T. H., Ren, B. & Zhang, Z. Positive inter-regulation between ß-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells. Mol. Pharmacol. 69, 520-531 (2006).
-
(2006)
Mol. Pharmacol
, vol.69
, pp. 520-531
-
-
Sun, P.1
Xiong, H.2
Kim, T.H.3
Ren, B.4
Zhang, Z.5
-
21
-
-
84886100276
-
ß-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced ß-catenin signaling
-
doi.org/10.1038/onc.2012.527
-
Rosanó, L. et al. ß-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced ß-catenin signaling. Oncogene http://dx.doi. org/10.1038/onc.2012.527(2012).
-
(2012)
Oncogene
-
-
Rosanó, L.1
-
22
-
-
0037112435
-
Growth inhibition of cervix carcinoma cell in vivo by endothelin A receptor blockade
-
Bagnato, A. et al. Growth inhibition of cervix carcinoma cell in vivo by endothelin A receptor blockade. Cancer Res. 62, 6381-6384 (2002).
-
(2002)
Cancer Res
, vol.62
, pp. 6381-6384
-
-
Bagnato, A.1
-
23
-
-
34447128915
-
ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo
-
Rosanó, L. et al. ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo. Mol. Cancer Ther. 6, 2003-2011 (2007).
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 2003-2011
-
-
Rosanó, L.1
-
24
-
-
0037843596
-
Therapeutic targeting of the endothelin A receptor in human ovarian carcinoma
-
Rosanó, L. et al. Therapeutic targeting of the endothelin A receptor in human ovarian carcinoma. Cancer Res. 63, 2447-2453 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 2447-2453
-
-
Rosanó, L.1
-
25
-
-
34248584876
-
In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer
-
Banerjee, S. et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer. Cancer Res. 67, 3818-3826 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 3818-3826
-
-
Banerjee, S.1
-
26
-
-
0036176126
-
Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: Requirement for Akt activation
-
Del Bufalo, D. et al. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation. Mol. Pharmacol. 61, 524-532 (2002).
-
(2002)
Mol. Pharmacol
, vol.61
, pp. 524-532
-
-
Del Bufalo, D.1
-
27
-
-
23244454378
-
Endothelin-1 inhibits apoptosis in prostate cancer
-
Nelson, J. B., Udan, M. S., Guruli, G. & Pflug, B. R. Endothelin-1 inhibits apoptosis in prostate cancer. Neoplasia 7, 631-637 (2005).
-
(2005)
Neoplasia
, vol.7
, pp. 631-637
-
-
Nelson, J.B.1
Udan, M.S.2
Guruli, G.3
Pflug, B.R.4
-
28
-
-
0034126340
-
Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells
-
Eberl, L. P., Valdenaire, O., Saintgiorgio, V., Jeannin, J. F. & Juillerat-Jeanneret, L. Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells. Int. J. Cancer 86, 182-187 (2000).
-
(2000)
Int. J. Cancer
, vol.86
, pp. 182-187
-
-
Eberl, L.P.1
Valdenaire, O.2
Saintgiorgio, V.3
Jeannin, J.F.4
Juillerat-Jeanneret, L.5
-
29
-
-
33749045722
-
Endothelin receptor A blockade enhances taxane effects in prostate cancer
-
Akhavan, A. et al. Endothelin receptor A blockade enhances taxane effects in prostate cancer. Neoplasia 8, 725-732 (2006).
-
(2006)
Neoplasia
, vol.8
, pp. 725-732
-
-
Akhavan, A.1
-
30
-
-
79951501975
-
Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer
-
Kim, S. J. Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer. Neoplasia 13, 167-179 (2011).
-
(2011)
Neoplasia
, vol.13
, pp. 167-179
-
-
Kim S., .J.1
-
31
-
-
84862961320
-
Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist
-
Kim, S. J. et al. Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist. Transl. Oncol. 5, 39-47 (2012).
-
(2012)
Transl. Oncol
, vol.5
, pp. 39-47
-
-
Kim, S.J.1
-
32
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
-
Polyak, K. & Weinberg, R. A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nature Rev. Cancer 9, 265-273 (2009).
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
33
-
-
82655189563
-
Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes
-
Ha, N. et al. Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes. Cancer Res. 71, 7259-7269 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 7259-7269
-
-
Ha, N.1
-
34
-
-
0035890357
-
Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells
-
Rosanó, L. et al. Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells. Cancer Res. 61, 8340-8346 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 8340-8346
-
-
Rosanó, L.1
-
35
-
-
84860441391
-
Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways
-
Wu, M. H. et al. Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways. J. Cell. Phisiol. 227, 3016-3026 (2012).
-
(2012)
J. Cell. Phisiol
, vol.227
, pp. 3016-3026
-
-
Wu, M.H.1
-
36
-
-
0030903110
-
Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells
-
Bagnato, A., Tecce, R., Di Castro, V. & Catt, K. J. Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells. Cancer Res. 57, 1306-1311 (1997).
-
(1997)
Cancer Res
, vol.57
, pp. 1306-1311
-
-
Bagnato, A.1
Tecce, R.2
Di Castro, V.3
Catt, K.J.4
-
37
-
-
34447125096
-
Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization
-
Lange, K. et al. Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization. Cancer Res. 67, 6163-6173 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 6163-6173
-
-
Lange, K.1
-
38
-
-
33646576837
-
Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma
-
Rosanó, L. et al. Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma. Mol. Cancer Ther. 5, 833-842 (2006).
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 833-842
-
-
Rosanó, L.1
-
39
-
-
1242271205
-
Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression
-
Bagnato, A. et al. Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression. Cancer Res. 64, 1436-1443 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 1436-1443
-
-
Bagnato, A.1
-
40
-
-
0142135067
-
Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells
-
Spinella, F. et al. Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J. Biol. Chem. 278, 41294-41301 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41294-41301
-
-
Spinella, F.1
-
41
-
-
29144495415
-
Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
-
Rosanó, L. et al. Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res. 65, 11649-11657 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 11649-11657
-
-
Rosanó, L.1
-
42
-
-
84863038564
-
ROCK cooperated with ET-1 to induce epithelial to mesenchymal tranesition through SLUG in human ovarian cancer cells
-
Peng, J. et al. ROCK cooperated with ET-1 to induce epithelial to mesenchymal transition through SLUG in human ovarian cancer cells. Biosci. Biotechnol. Biochem.76, 42-47 (2012).
-
(2012)
Biosci. Biotechnol. Biochem.
, vol.76
, pp. 42-47
-
-
Peng, J.1
-
43
-
-
0036677416
-
UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells
-
Jamal, S. & Schneider, R. J. UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells. J. Clin. Invest. 110, 443-452 (2002).
-
(2002)
J. Clin. Invest
, vol.110
, pp. 443-452
-
-
Jamal, S.1
Schneider, R.J.2
-
44
-
-
33847737677
-
Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1 in human melanoma cells
-
Spinella, F. et al. Endothelin-1 and endothelin-3 promote invasive behavior via hypoxia-inducible factor-1 in human melanoma cells. Cancer Res. 67, 1725-1734 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 1725-1734
-
-
Spinella, F.1
-
45
-
-
0037008695
-
Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducibile factor-1 in ovarian carcinoma cells
-
Spinella, F., Rosanó, L., Di Castro, V., Natali, P. G. & Bagnato, A. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducibile factor-1 in ovarian carcinoma cells. J. Biol. Chem. 277, 27850-27855 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 27850-27855
-
-
Spinella, F.1
Rosanó, L.2
Di Castro, V.3
Natali, P.G.4
Bagnato, A.5
-
46
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
Mani, S. A. et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704-715 (2008).
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
-
47
-
-
84873465919
-
Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells
-
Coffman, L. et al. Endothelin receptor-A is required for the recruitment of antitumor T cells and modulates chemotherapy induction of cancer stem cells. Cancer Biol. Ther. 14, 184-192 (2013).
-
(2013)
Cancer Biol. Ther
, vol.14
, pp. 184-192
-
-
Coffman, L.1
-
48
-
-
66049159086
-
Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors
-
Liu, Q. et al. Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. J. Neurooncol. 94, 1-19 (2009).
-
(2009)
J. Neurooncol
, vol.94
, pp. 1-19
-
-
Liu, Q.1
-
49
-
-
84055182507
-
Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells
-
Liu, Y. et al. Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Mol. Cancer Res. 9, 1668-1685 (2011).
-
(2011)
Mol. Cancer Res
, vol.9
, pp. 1668-1685
-
-
Liu, Y.1
-
50
-
-
80052462125
-
Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells
-
Puglisi, M. A. et al. Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells. J. Pathol. 225, 305-314 (2011).
-
(2011)
J. Pathol
, vol.225
, pp. 305-314
-
-
Puglisi, M.A.1
-
51
-
-
74049135484
-
Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer
-
Wiesmann, F. Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer. Breast Cancer Res. 11, R34 (2009).
-
(2009)
Breast Cancer Res
, vol.11
-
-
Wiesmann, F.1
-
52
-
-
34250189204
-
Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells
-
Sun, de J. et al. Endothelin-3 growth factor levels decreased in cervical cancer compared with normal cervical epithelial cells. Hum. Pathol. 38, 1047-1056 (2007).
-
(2007)
Hum. Pathol
, vol.38
, pp. 1047-1056
-
-
Sun De, J.1
-
53
-
-
24344485096
-
Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers
-
Jazaeri, A. A. et al. Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers. Clin. Cancer Res. 11, 6300-6310 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 6300-6310
-
-
Jazaeri, A.A.1
-
54
-
-
77950188189
-
Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: The big picture
-
Helleman, J., Smid, M., Jansen, M. P., van der Burg, M. E. & Beins, E. M. Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture. Gynecol. Oncol. 117, 170-176 (2010).
-
(2010)
Gynecol. Oncol
, vol.117
, pp. 170-176
-
-
Helleman, J.1
Smid, M.2
Jansen, M.P.3
Van Der Burg, M.E.4
Beins, E.M.5
-
55
-
-
79954627096
-
Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells
-
Rosanó, L. et al. Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells. Clin. Cancer Res. 17, 2350-2360 (2011).
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 2350-2360
-
-
Rosanó, L.1
-
56
-
-
66249099232
-
Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells
-
Ghoul, A. et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res. 69, 4260-4269 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 4260-4269
-
-
Ghoul, A.1
-
57
-
-
84867125382
-
Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma
-
Cruz-Muz, W. et al. Roles for endothelin receptor B and BCL2A1 in spontaneous CNS metastasis of melanoma. Cancer Res. 72, 4909-4919 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 4909-4919
-
-
Cruz-Muz, W.1
-
58
-
-
23844468385
-
Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2
-
Titus, B. et al. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res. 65, 7320-7327 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 7320-7327
-
-
Titus, B.1
-
59
-
-
78650957612
-
Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer
-
Said, N., Smith, S., Sanchez-Carbayo, M. & Theodorescu, D. Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer. J. Clin. Invest. 121, 132-147 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 132-147
-
-
Said, N.1
Smith, S.2
Sanchez-Carbayo, M.3
Theodorescu, D.4
-
60
-
-
0141479984
-
A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastasis
-
Yin, J. J. et al. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastasis. Proc. Natl Acad. Sci. USA 100, 10954-10959 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 10954-10959
-
-
Yin, J.J.1
-
61
-
-
33750738067
-
Basic mechanisms responsible for osteolytic and osteoblastic bone metastases
-
Guise, T. A. et al. Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. Clin. Cancer Res.12, 6213-6216 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 6213-6216
-
-
Guise, T.A.1
-
62
-
-
33846624243
-
Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation
-
Clines, G. A. et al. Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation. Mol. Endocrinol. 21, 486-498 (2007).
-
(2007)
Mol. Endocrinol
, vol.21
, pp. 486-498
-
-
Clines, G.A.1
-
63
-
-
33750075185
-
Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis
-
Dru, D. et al. Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis. Clin. Exp. Metastasis 23, 41-53 (2006).
-
(2006)
Clin. Exp. Metastasis
, vol.23
, pp. 41-53
-
-
Dru, D.1
-
64
-
-
0041888477
-
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
-
Khodorova, A. et al. Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury. Nature Med. 9, 1055-1061 (2003).
-
(2003)
Nature Med
, vol.9
, pp. 1055-1061
-
-
Khodorova, A.1
-
65
-
-
2642513829
-
Effects of selective endothelin ETA receptor antagonists on endothelin-1-induced potentiation of cancer pain
-
Yuyama, H. et al. Effects of selective endothelin ETA receptor antagonists on endothelin-1-induced potentiation of cancer pain. Eur. J. Pharmacol. 492, 177-182 (2004).
-
(2004)
Eur. J. Pharmacol
, vol.492
, pp. 177-182
-
-
Yuyama, H.1
-
66
-
-
77951767804
-
Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice
-
Quang, P. N. & Schmidt, B. L. Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice. Pain 149, 254-262 (2010).
-
(2010)
Pain
, vol.149
, pp. 254-262
-
-
Quang, P.N.1
Schmidt, B.L.2
-
67
-
-
65549118866
-
Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade
-
Spinella, F. et al. Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. Cancer Res. 69, 2669-2676 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 2669-2676
-
-
Spinella, F.1
-
68
-
-
0033724661
-
Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
-
Salani, D. et al. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am. J. Pathol. 157, 1703-1711 (2000).
-
(2000)
Am. J. Pathol
, vol.157
, pp. 1703-1711
-
-
Salani, D.1
-
69
-
-
84898016402
-
Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells
-
doi.org/10.1038/onc.2013.109
-
Wu, M. H. et al. Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells. Oncogene http://dx.doi. org/10.1038/onc.2013.109 (2013).
-
(2013)
Oncogene
-
-
Wu, M.H.1
-
70
-
-
0033724657
-
Role of endothelin-1 in neovascularization of ovarian carcinoma
-
Salani, D. et al. Role of endothelin-1 in neovascularization of ovarian carcinoma. Am. J. Pathol. 157, 1537-1547 (2000).
-
(2000)
Am. J. Pathol
, vol.157
, pp. 1537-1547
-
-
Salani, D.1
-
71
-
-
17144449019
-
Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up
-
Wfing, P. et al. Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up. Clin. Cancer Res. 9, 4125-4131 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 4125-4131
-
-
Wfing, P.1
-
72
-
-
19944368742
-
Expression patterns of angiogenic and lymphangiogenic factors in ductal breast carcinoma in situ
-
Wfing, P. et al. Expression patterns of angiogenic and lymphangiogenic factors in ductal breast carcinoma in situ. Br. J. Cancer 92, 1720-1728 (2005).
-
(2005)
Br. J. Cancer
, vol.92
, pp. 1720-1728
-
-
Wfing, P.1
-
73
-
-
54749126267
-
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
-
Clasper, S. et al. A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis. Cancer Res. 68, 7293-7303 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 7293-7303
-
-
Clasper, S.1
-
74
-
-
77957284078
-
Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin
-
Cueni, L. N. et al. Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am. J. Pathol. 177, 1004-1016 (2010).
-
(2010)
Am. J. Pathol
, vol.177
, pp. 1004-1016
-
-
Cueni, L.N.1
-
75
-
-
77955289816
-
Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1 in melanoma cells
-
Spinella, F. et al. Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1 in melanoma cells. PLoS ONE 5, e11241 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Spinella, F.1
-
76
-
-
33846229266
-
Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1
-
Wilson, J. L., Burchell, J. & Grimshaw, M. J. Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res. 66, 11802-11807 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 11802-11807
-
-
Wilson, J.L.1
Burchell, J.2
Grimshaw, M.J.3
-
77
-
-
34547729187
-
Endothelins and hypoxia-inducible factor in cancer
-
Grimshaw, M. J. Endothelins and hypoxia-inducible factor in cancer. Endocr. Relat. Cancer 14, 233-244 (2007).
-
(2007)
Endocr. Relat. Cancer
, vol.14
, pp. 233-244
-
-
Grimshaw, M.J.1
-
78
-
-
3242741855
-
Inhibition of cyclooxygenase-1 and-2 expression by targeting the endothelin A receptor in human ovarian carcinoma cells
-
Spinella, F. et al. Inhibition of cyclooxygenase-1 and-2 expression by targeting the endothelin A receptor in human ovarian carcinoma cells. Clin. Cancer Res. 10, 4670-4679 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 4670-4679
-
-
Spinella, F.1
-
79
-
-
84884204620
-
Mesenchymal stem cells promote growth and angiogenesis of tumors in mice
-
doi.org/10.1038/onc.2012.458
-
Huang, W. H. et al. Mesenchymal stem cells promote growth and angiogenesis of tumors in mice. Oncogene http://dx.doi.org/10.1038/onc.2012.458 (2012).
-
(2012)
Oncogene
-
-
Huang, W.H.1
-
80
-
-
0034601455
-
Molecular classification of cutaneous malignant melanoma by gene expression profiling
-
Bittner, M. et al. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536-540 (2000).
-
(2000)
Nature
, vol.406
, pp. 536-540
-
-
Bittner, M.1
-
81
-
-
84856110154
-
Endothelin-1 stimulates colon cancer adjacent fibroblasts
-
Knowles, J. P. et al. Endothelin-1 stimulates colon cancer adjacent fibroblasts. Int. J. Cancer 130, 1264-1272 (2012).
-
(2012)
Int. J. Cancer
, vol.130
, pp. 1264-1272
-
-
Knowles, J.P.1
-
82
-
-
84882264904
-
Efficacy of the specific endothelin A receptor antagonist zibotentan (ZD4054) in colorectal cancer: A preclinical study
-
30 May doi.org/10.1158/1535-7163. MCT-12-0975
-
Haque, S. U. et al. Efficacy of the specific endothelin A receptor antagonist zibotentan (ZD4054) in colorectal cancer: a preclinical study. Mol Cancer Ther. 30 May 2013 (http://dx.doi.org/10.1158/1535-7163. MCT-12-0975).
-
(2013)
Mol Cancer Ther.
-
-
Haque, S.U.1
-
83
-
-
0026695638
-
Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells
-
Schrey, M. P., Patel, K. V. & Tezapsidis, N. Bombesin and glucocorticoids stimulate human breast cancer cells to produce endothelin, a paracrine mitogen for breast stromal cells. Cancer Res. 52, 1786-1790 (1992).
-
(1992)
Cancer Res
, vol.52
, pp. 1786-1790
-
-
Schrey, M.P.1
Patel, K.V.2
Tezapsidis, N.3
-
84
-
-
0031557119
-
Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: A possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2
-
Patel, K. V., Sheth, H. G. & Schrey, M. P. Stimulation or endothelin-1 secretion by human breast cancer cells through protein kinase A activation: a possible novel paracrine loop involving breast fibroblast-derived prostaglandin E2. Mol. Cell. Endocrinol. 126, 143-151 (1997).
-
(1997)
Mol. Cell. Endocrinol
, vol.126
, pp. 143-151
-
-
Patel, K.V.1
Sheth, H.G.2
Schrey, M.P.3
-
85
-
-
4644258403
-
Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops
-
Guruli, G. et al. Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops. Blood 104, 2107-2115 (2004).
-
(2004)
Blood
, vol.104
, pp. 2107-2115
-
-
Guruli, G.1
-
86
-
-
79952281752
-
Tumor immune surveillance and ovarian cancer: Lessons on immune mediated tumor rejection or tolerance
-
Kandalaft, L. E., Motz, G. T., Duraiswamy, J. & Coukos, G. Tumor immune surveillance and ovarian cancer: lessons on immune mediated tumor rejection or tolerance. Cancer Metastasis Rev. 30, 141-151 (2011).
-
(2011)
Cancer Metastasis Rev
, vol.30
, pp. 141-151
-
-
Kandalaft, L.E.1
Motz, G.T.2
Duraiswamy, J.3
Coukos, G.4
-
87
-
-
68049099399
-
Endothelin B receptor, a new target in cancer immune therapy
-
Kandalaft, L. E., Facciabene, A., Buckanovich, R. J. & Coukos, G. Endothelin B receptor, a new target in cancer immune therapy. Clin. Cancer Res. 15, 4521-4528 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4521-4528
-
-
Kandalaft, L.E.1
Facciabene, A.2
Buckanovich, R.J.3
Coukos, G.4
-
88
-
-
38049000452
-
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
-
Buckanovich, R. J. et al. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nature Med. 14, 28-36 (2008).
-
(2008)
Nature Med
, vol.14
, pp. 28-36
-
-
Buckanovich, R.J.1
-
89
-
-
0042845963
-
Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo
-
Rosanó, L. et al. Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo. Am. J. Pathol. 163, 753-762 (2003).
-
(2003)
Am. J. Pathol
, vol.163
, pp. 753-762
-
-
Rosanó, L.1
-
90
-
-
0033613134
-
An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
-
Lahav, R., Heffner, G. & Patterson, P. H. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc. Natl Acad. Sci. USA 96, 11496-11500 (1999).
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 11496-11500
-
-
Lahav, R.1
Heffner, G.2
Patterson, P.H.3
-
91
-
-
0033746814
-
Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: New potential targets for anticancer therapy
-
Venuti, A., Salani, D., Manni, V., Poggiali, F. & Bagnato, A. Expression of endothelin 1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy. FASEB J. 14, 2277-2283 (2000).
-
(2000)
FASEB J
, vol.14
, pp. 2277-2283
-
-
Venuti, A.1
Salani, D.2
Manni, V.3
Poggiali, F.4
Bagnato, A.5
-
92
-
-
0033637122
-
Modulation of human colon tumor-stromal interactions by the endothelin system
-
Egidy, G. et al. Modulation of human colon tumor-stromal interactions by the endothelin system. Am. J. Pathol.157, 1863-1874 (2000).
-
(2000)
Am. J. Pathol.157
, pp. 1863-1874
-
-
Egidy, G.1
-
93
-
-
84860769431
-
Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model
-
Li, Y. et al. Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. Mol. Med. Rep. 5, 1391-1395 (2012).
-
(2012)
Mol. Med. Rep
, vol.5
, pp. 1391-1395
-
-
Li, Y.1
-
94
-
-
84856491321
-
Targeting the endothelin axis with atrasentan, in combination with IFN-, in metastatic renal cell carcinoma
-
Groenewegen, G. et al. Targeting the endothelin axis with atrasentan, in combination with IFN-, in metastatic renal cell carcinoma. Br. J. Cancer 106, 284-289 (2012).
-
(2012)
Br. J. Cancer
, vol.106
, pp. 284-289
-
-
Groenewegen, G.1
-
95
-
-
84861313390
-
Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods
-
Bher, K. et al. Assessment of endothelin-A receptor expression in subcutaneous and orthotopic thyroid carcinoma xenografts in vivo employing optical imaging methods. Endocrinology 153, 2907-2918 (2012).
-
(2012)
Endocrinology
, vol.153
, pp. 2907-2918
-
-
Bher, K.1
-
96
-
-
84858641495
-
Role of endothelin receptor signalling in squamous cell carcinoma
-
Ishimoto, S. et al. Role of endothelin receptor signalling in squamous cell carcinoma. Int. J. Oncol. 40, 1011-1019 (2012).
-
(2012)
Int. J. Oncol
, vol.40
, pp. 1011-1019
-
-
Ishimoto, S.1
-
97
-
-
0028845350
-
Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth
-
Pagotto, U. et al. Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth. J. Clin. Invest. 96, 2017-2025 (1995).
-
(1995)
J. Clin. Invest
, vol.96
, pp. 2017-2025
-
-
Pagotto, U.1
-
98
-
-
79954456308
-
Role of the endothelin axis and its antagonists in the treatment of cancer
-
Bagnato, A. et al. Role of the endothelin axis and its antagonists in the treatment of cancer. Br. J. Pharmacol. 163, 220-233 (2011).
-
(2011)
Br. J. Pharmacol
, vol.163
, pp. 220-233
-
-
Bagnato, A.1
-
99
-
-
27944449731
-
Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats
-
Rajeshkumar, N. V., Rai, A. & Gulati, A. Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats. Breast Cancer Res. Treat. 94, 237-247 (2005).
-
(2005)
Breast Cancer Res. Treat
, vol.94
, pp. 237-247
-
-
Rajeshkumar, N.V.1
Rai, A.2
Gulati, A.3
-
100
-
-
84858729714
-
IRL-1620, an endothelin-B receptor agonist, enhanced radiation induced reduction in tumor volume in Dalton's Lymphoma Ascites tumor model
-
Gulati, A., Sunila, E. S. & Kuttan, G. IRL-1620, an endothelin-B receptor agonist, enhanced radiation induced reduction in tumor volume in Dalton's Lymphoma Ascites tumor model. Arzneimittelforschung 62, 14-17 (2012).
-
(2012)
Arzneimittelforschung
, vol.62
, pp. 14-17
-
-
Gulati, A.1
Sunila, E.S.2
Kuttan, G.3
-
101
-
-
33746038556
-
Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signalling pathways in ovarian carcinoma
-
Spinella, F. et al. Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signalling pathways in ovarian carcinoma. Mol. Cancer Ther. 5, 1483-1492 (2006).
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 1483-1492
-
-
Spinella, F.1
-
102
-
-
0035924359
-
Endothelin-1 synthesis reduced by red wine
-
Corder, R. et al. Endothelin-1 synthesis reduced by red wine. Nature 414, 863-864 (2001).
-
(2001)
Nature
, vol.414
, pp. 863-864
-
-
Corder, R.1
-
103
-
-
0031889217
-
Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression
-
Papandreou, C. N. et al. Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression. Nature Med. 4, 50-57 (1998).
-
(1998)
Nature Med
, vol.4
, pp. 50-57
-
-
Papandreou, C.N.1
-
104
-
-
16344379860
-
Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo
-
Kajiyama, H. et al. Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo. Clin. Cancer Res. 11, 1798-1808 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 1798-1808
-
-
Kajiyama, H.1
-
105
-
-
22044435149
-
Specific inhibition of the endothelin A receptor with ZD4054: Clinical and pre-clinical evidence
-
Morris, C. D. et al. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence. Br. J. Cancer 92, 2148-2152 (2005).
-
(2005)
Br. J. Cancer
, vol.92
, pp. 2148-2152
-
-
Morris, C.D.1
-
106
-
-
84882450996
-
Phase III, randomized, placebo-controlled study of once-daily oral zibotentan (ZD4054) in patients with non-metastatic castration-resistant prostate cancer
-
Miller, K. et al. Phase III, randomized, placebo-controlled study of once-daily oral zibotentan (ZD4054) in patients with non-metastatic castration-resistant prostate cancer. Prostate Cancer Prostatic Dis. 16,187-192 (2013).
-
(2013)
Prostate Cancer Prostatic Dis
, vol.16
, pp. 187-192
-
-
Miller, K.1
-
107
-
-
84862127924
-
Detection of previously unidentified metastatic disease as a leading cause of screening failure in a Phase III trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer
-
Yu, E. Y. et al. Detection of previously unidentified metastatic disease as a leading cause of screening failure in a Phase III trial of zibotentan versus placebo in patients with nonmetastatic, castration resistant prostate cancer. J. Urol.188, 103-109 (2012).
-
(2012)
J. Urol.
, vol.188
, pp. 103-109
-
-
Yu, E.Y.1
-
108
-
-
84879093917
-
A Phase II, randomized, double-blind study of zibotentan (ZD4054) in combination with carboplatin/paclitaxel versus placebo in combination with carboplatin/paclitaxel in patients with advanced ovarian cancer sensitive to platinum-based chemotherapy (AGO-OVAR 2.14)
-
Cognetti, F. et al. A Phase II, randomized, double-blind study of zibotentan (ZD4054) in combination with carboplatin/paclitaxel versus placebo in combination with carboplatin/paclitaxel in patients with advanced ovarian cancer sensitive to platinum-based chemotherapy (AGO-OVAR 2.14). Gynecol. Oncol. 130, 31-37 (2012).
-
(2012)
Gynecol. Oncol
, vol.130
, pp. 31-37
-
-
Cognetti, F.1
-
109
-
-
68749095004
-
TLR2 and TLR4 agonists induce production of the vasoactive peptide endothelin-1 by human dendritic cells
-
Spirig, R. et al. TLR2 and TLR4 agonists induce production of the vasoactive peptide endothelin-1 by human dendritic cells. Mol. Immunol. 46, 3178-3182 (2009).
-
(2009)
Mol. Immunol
, vol.46
, pp. 3178-3182
-
-
Spirig, R.1
-
110
-
-
77954449908
-
Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells
-
Fischgre, J. et al. Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells. Int. J. Cancer 127, 696-706 (2010).
-
(2010)
Int. J. Cancer
, vol.127
, pp. 696-706
-
-
Fischgre, J.1
-
111
-
-
84878584063
-
Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice
-
Chang, I. et al. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J. Clin. Invest. 123, 2643-2653 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 2643-2653
-
-
Chang, I.1
-
112
-
-
0038380366
-
Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells
-
Grimshaw, M. J., Naylor, S. & Balkwill, F. R. Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells. Mol. Cancer. Ther. 1, 1273-1281 (2002).
-
(2002)
Mol. Cancer. Ther
, vol.1
, pp. 1273-1281
-
-
Grimshaw, M.J.1
Naylor, S.2
Balkwill, F.R.3
-
113
-
-
1942538390
-
A role for endothelin-2 and its receptors in breast tumor cell invasion
-
Grimshaw, M. J. et al. A role for endothelin-2 and its receptors in breast tumor cell invasion. Cancer Res. 64, 2461-2468 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 2461-2468
-
-
Grimshaw, M.J.1
-
114
-
-
3342904989
-
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF- dependent up-regulation of matrix metalloproteases
-
Hagemann, T. et al. Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF- dependent up-regulation of matrix metalloproteases. Carcinogenesis 25, 1543-1549 (2004).
-
(2004)
Carcinogenesis
, vol.25
, pp. 1543-1549
-
-
Hagemann, T.1
-
115
-
-
72949095648
-
Endothelin-2 is upregulated in basal cell carcinoma under control of Hedgehog signaling pathway
-
Tanese, K., Fukuma, M., Ishiko, A. & Sakamoto, M. Endothelin-2 is upregulated in basal cell carcinoma under control of Hedgehog signaling pathway. Biochem. Biophys. Res. Commun. 391, 486-491 (2010).
-
(2010)
Biochem. Biophys. Res. Commun
, vol.391
, pp. 486-491
-
-
Tanese, K.1
Fukuma, M.2
Ishiko, A.3
Sakamoto, M.4
-
116
-
-
84874674052
-
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche
-
Chang, C. Y. et al. NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 495, 98-102 (2013).
-
(2013)
Nature
, vol.495
, pp. 98-102
-
-
Chang, C.Y.1
-
117
-
-
0028639196
-
Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
-
Hosoda, K. et al. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 79, 1267-1276 (1994).
-
(1994)
Cell
, vol.79
, pp. 1267-1276
-
-
Hosoda, K.1
-
118
-
-
46749136931
-
Endothelin-3 is produced by metastatic melanoma cells and promotes melanoma cell survival
-
Tang, L. et al. Endothelin-3 is produced by metastatic melanoma cells and promotes melanoma cell survival. J. Cutan. Med. Surg. 12, 64-70 (2008).
-
(2008)
J. Cutan. Med. Surg
, vol.12
, pp. 64-70
-
-
Tang, L.1
-
119
-
-
33644779655
-
Endothelin-3 production by human rhabdomyosarcoma: A possible new marker with a paracrine role
-
Palladini, A. et al. Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role. Eur. J. Cancer. 42, 680-687 (2006).
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 680-687
-
-
Palladini, A.1
-
120
-
-
84871583767
-
Early progress in epigenetic regulation of endothelin pathway genes
-
Welch, A., Jacobs, M., Wingo, C. & Cain, B. Early progress in epigenetic regulation of endothelin pathway genes. Br. J. Pharmacol. 168, 327-334 (2013).
-
(2013)
Br. J. Pharmacol
, vol.168
, pp. 327-334
-
-
Welch, A.1
Jacobs, M.2
Wingo, C.3
Cain, B.4
-
121
-
-
84872847300
-
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer
-
Wang, R. et al. Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int. J. Cancer 132, 1004-1012 (2013).
-
(2013)
Int. J. Cancer
, vol.132
, pp. 1004-1012
-
-
Wang, R.1
-
122
-
-
70349271342
-
Expression of the endothelin axis in noninvasive and superficially invasive bladder cancer: Relation to clinicopathologic and molecular prognostic parameters
-
Eltze, E. et al. Expression of the endothelin axis in noninvasive and superficially invasive bladder cancer: relation to clinicopathologic and molecular prognostic parameters. Eur. Urol. 56, 837-845 (2009).
-
(2009)
Eur. Urol
, vol.56
, pp. 837-845
-
-
Eltze, E.1
-
123
-
-
20244377662
-
The endothelin system in human glioblastoma
-
Egidy, G. et al. The endothelin system in human glioblastoma. Lab. Invest. 80, 1681-1689 (2000).
-
(2000)
Lab. Invest
, vol.80
, pp. 1681-1689
-
-
Egidy, G.1
-
124
-
-
20444370995
-
Functional endothelin et B receptors are selectively expressed in human oligodendrogliomas
-
Anguelova, E. et al. Functional endothelin ET B receptors are selectively expressed in human oligodendrogliomas. Brain Res. Mol. Brain Res. 137, 77-88 (2005).
-
(2005)
Brain Res. Mol. Brain Res
, vol.137
, pp. 77-88
-
-
Anguelova, E.1
-
125
-
-
1842531107
-
Endothelin-1, Endothelin-A and Endothelin-B-receptor expression is correlated with VEGF expression and angiogenesis in breast cancer
-
Wfing, P. et al. Endothelin-1, Endothelin-A and Endothelin-B-receptor expression is correlated with VEGF expression and angiogenesis in breast cancer. Clin. Cancer Res. 10, 2393-2400 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 2393-2400
-
-
Wfing, P.1
-
126
-
-
34547962065
-
Altered endothelin receptor subtypes in colorectal cancer
-
Hoosein, M. M. et al. Altered endothelin receptor subtypes in colorectal cancer. Eur. J. Gastroenterol. Hepatol. 19, 775-782 (2007).
-
(2007)
Eur. J. Gastroenterol. Hepatol
, vol.19
, pp. 775-782
-
-
Hoosein, M.M.1
-
127
-
-
84859925476
-
Expression patterns of endothelin-1 and its receptors in colorectal cancer
-
Liakou, P. et al. Expression patterns of endothelin-1 and its receptors in colorectal cancer. J. Surg. Oncol. 105, 643-649 (2012).
-
(2012)
J. Surg. Oncol
, vol.105
, pp. 643-649
-
-
Liakou, P.1
-
128
-
-
33744475913
-
Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan
-
Hsu, L. S. et al. Aberrant methylation of EDNRB and p16 genes in hepatocellular carcinoma (HCC) in Taiwan. Oncol. Rep. 15, 507-511 (2006).
-
(2006)
Oncol. Rep
, vol.15
, pp. 507-511
-
-
Hsu, L.S.1
-
129
-
-
34250768913
-
Inhibitory effect of endothelin A receptor blockade on tumor growth and liver metastasis of a human gastric cancer cell line
-
Fukui, R. et al. Inhibitory effect of endothelin A receptor blockade on tumor growth and liver metastasis of a human gastric cancer cell line. Gastr. Cancer 10, 123-128 (2007).
-
(2007)
Gastr. Cancer
, vol.10
, pp. 123-128
-
-
Fukui, R.1
-
130
-
-
84864069479
-
Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer
-
Tao, K. et al. Quantitative analysis of promoter methylation of the EDNRB gene in gastric cancer. Med. Oncol. 29, 107-112 (2012).
-
(2012)
Med. Oncol
, vol.29
, pp. 107-112
-
-
Tao, K.1
-
131
-
-
79954613624
-
Polymorphisms in the endothelin-1 and endothelin A receptor genes and survival in patients with locoregionally advanced nasopharyngeal carcinoma
-
Wen, Y. F. et al. Polymorphisms in the endothelin-1 and endothelin A receptor genes and survival in patients with locoregionally advanced nasopharyngeal carcinoma. Clin. Cancer Res. 17, 2451-2458 (2011).
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 2451-2458
-
-
Wen, Y.F.1
-
132
-
-
28244483379
-
Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma
-
Boldrini, L. et al. Expression of endothelin-1 is related to poor prognosis in non-small cell lung carcinoma. Eur. J. Cancer. 41, 2828-2835 (2005).
-
(2005)
Eur. J. Cancer
, vol.41
, pp. 2828-2835
-
-
Boldrini, L.1
-
133
-
-
76649098572
-
Expression of endothelin receptor subtypes in bronchial tumors
-
Blouquit-Laye, S. et al. Expression of endothelin receptor subtypes in bronchial tumors. Oncol. Rep. 23, 457-463 (2010).
-
(2010)
Oncol. Rep
, vol.23
, pp. 457-463
-
-
Blouquit-Laye, S.1
-
134
-
-
0035041835
-
Expression of the endothelin-B receptor in pigment cell lesions of the skin. Evidence for its role as tumor progression marker in malignant melanoma
-
Demunter, A., De Wolf-Peeters, C., Degreef, H., Stas, M. & van den Oord, J. J. Expression of the endothelin-B receptor in pigment cell lesions of the skin. Evidence for its role as tumor progression marker in malignant melanoma. Virchows Arch. 438, 485-491 (2001).
-
(2001)
Virchows Arch
, vol.438
, pp. 485-491
-
-
Demunter, A.1
De Wolf-Peeters, C.2
Degreef, H.3
Stas, M.4
Van Den Oord, J.J.5
-
135
-
-
0037132333
-
Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival
-
Smith, S. L. et al. Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival. Br. J. Cancer 87, 1308-1313 (2002).
-
(2002)
Br. J. Cancer
, vol.87
, pp. 1308-1313
-
-
Smith, S.L.1
-
136
-
-
0033083191
-
Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: Evidence for an autocrine role in tumor growth
-
Bagnato, A. et al. Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth. Cancer Res. 59, 720-727 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 720-727
-
-
Bagnato, A.1
-
137
-
-
34447513701
-
Distinct patterns of endothelin axis expression in primary prostate cancer
-
Godara, G. et al. Distinct patterns of endothelin axis expression in primary prostate cancer. Urology 70, 209-215 (2007).
-
(2007)
Urology
, vol.70
, pp. 209-215
-
-
Godara, G.1
-
138
-
-
0037364732
-
Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan
-
Nelson, J. B. et al. Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan. J. Urol. 169, 1143-1149 (2003).
-
(2003)
J. Urol
, vol.169
, pp. 1143-1149
-
-
Nelson, J.B.1
-
139
-
-
33947718424
-
Expression of the endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis
-
Herrmann, E. et al. Expression of the endothelin-axis in the different histologic subtypes of renal cell carcinoma: a tissue microarray analysis. Oncol. Rep. 17, 275-280 (2007).
-
(2007)
Oncol. Rep
, vol.17
, pp. 275-280
-
-
Herrmann, E.1
-
140
-
-
84863218985
-
CD31 EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases
-
Wuttig, D. et al. CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. Int. J. Cancer 131, e693-e704 (2012).
-
(2012)
Int. J. Cancer
, vol.131
-
-
Wuttig, D.1
-
141
-
-
2342594490
-
Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinoma
-
Douglas, M. L., Richardson, M. M. & Nicol, D. L. Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinoma. Cancer 100, 2118-2124 (2004).
-
(2004)
Cancer
, vol.100
, pp. 2118-2124
-
-
Douglas, M.L.1
Richardson, M.M.2
Nicol, D.L.3
-
142
-
-
47249164780
-
A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma
-
Yao, M. et al. A three-gene expression signature model to predict clinical outcome of clear cell renal carcinoma. Int. J. Cancer 123, 1126-1132 (2008).
-
(2008)
Int. J. Cancer
, vol.123
, pp. 1126-1132
-
-
Yao, M.1
-
143
-
-
34548528871
-
Expression and prognostic relevance of endothelin-B receptor in vulvar cancer
-
Eltze, E. et al. Expression and prognostic relevance of endothelin-B receptor in vulvar cancer. Oncol. Rep. 18, 305-311 (2007).
-
(2007)
Oncol. Rep
, vol.18
, pp. 305-311
-
-
Eltze, E.1
-
144
-
-
84868200731
-
Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone
-
Nelson, J. B. et al. Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone. Cancer 118, 5709-5718 (2012).
-
(2012)
Cancer
, vol.118
, pp. 5709-5718
-
-
Nelson, J.B.1
-
145
-
-
79955565641
-
A phase ii randomized, multicenter study to assess the efficacy, safety, and tolerability of zibotentan (ZD4054) in combination with pemetrexed in patients with advanced non-small cell lung cancer
-
Chouaid, C., Nathan, F., Pemberton, K. & Morris, T. A Phase II, randomized, multicenter study to assess the efficacy, safety, and tolerability of zibotentan (ZD4054) in combination with pemetrexed in patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol. 67, 1203-1208 (2011).
-
(2011)
Cancer Chemother. Pharmacol
, vol.67
, pp. 1203-1208
-
-
Chouaid, C.1
Nathan, F.2
Pemberton, K.3
Morris, T.4
-
146
-
-
55549112219
-
Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer
-
Nelson, J. B. et al. Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer. Cancer 113, 2478-2487 (2008).
-
(2008)
Cancer
, vol.113
, pp. 2478-2487
-
-
Nelson, J.B.1
-
147
-
-
35648968713
-
A Phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
-
Carducci, M. A. et al. A Phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 110, 1959-1966 (2007).
-
(2007)
Cancer
, vol.110
, pp. 1959-1966
-
-
Carducci, M.A.1
-
148
-
-
34248667859
-
A Phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma
-
Kefford, R. et al. A Phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma. Invest. New Drugs 25, 247-252 (2007).
-
(2007)
Invest. New Drugs
, vol.25
, pp. 247-252
-
-
Kefford, R.1
-
149
-
-
77950414996
-
A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy
-
Kefford, R. F. et al. A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy. Mol. Cancer 9, 69 (2010).]
-
(2010)
Mol. Cancer
, vol.9
, pp. 69
-
-
Kefford, R.F.1
|