-
1
-
-
33846474121
-
G-protein-coupled receptors and cancer
-
Dorsam, R. T. & Gutkind, J. S. G-protein-coupled receptors and cancer. Nat. Rev. Cancer 7, 79-94 (2007).
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 79-94
-
-
Dorsam, R.T.1
Gutkind, J.S.2
-
2
-
-
78650845707
-
G protein-coupled receptors: Novel targets for drug discovery in cancer
-
Lappano, R. & Maggiolini, M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat. Rev. Drug Discov. 10, 47-60 (2011).
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 47-60
-
-
Lappano, R.1
Maggiolini, M.2
-
3
-
-
84884594350
-
Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis
-
Feigin, M. E. Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis. FEBS J. 280, 4729-4738 (2013).
-
(2013)
FEBS J.
, vol.280
, pp. 4729-4738
-
-
Feigin, M.E.1
-
4
-
-
0037478671
-
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
-
Santos, R. A. et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl Acad. Sci. USA 100, 8258-8263 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 8258-8263
-
-
Santos, R.A.1
-
5
-
-
0242266916
-
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
-
Debnath, J., Walker, S. J. & Brugge, J. S. Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J. Cell Biol. 163, 315-326 (2003).
-
(2003)
J. Cell Biol.
, vol.163
, pp. 315-326
-
-
Debnath, J.1
Walker, S.J.2
Brugge, J.S.3
-
6
-
-
33746851956
-
Tumor metastasis: Mechanistic insights and clinical challenges
-
Steeg, P. S. Tumor metastasis: mechanistic insights and clinical challenges. Nat. Med. 12, 895-904 (2006).
-
(2006)
Nat. Med.
, vol.12
, pp. 895-904
-
-
Steeg, P.S.1
-
7
-
-
77950012622
-
The regulatory crosstalk between kinases and proteases in cancer
-
Lopez-Otin, C. & Hunter, T. The regulatory crosstalk between kinases and proteases in cancer. Nat. Rev. Cancer 10, 278-292 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 278-292
-
-
Lopez-Otin, C.1
Hunter, T.2
-
8
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin, S. R. Thrombin signalling and protease-activated receptors. Nature 407, 258-264 (2000).
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
9
-
-
0025784847
-
cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization
-
Rasmussen, U. B. et al. cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization. FEBS Lett. 288, 123-128 (1991).
-
(1991)
FEBS Lett.
, vol.288
, pp. 123-128
-
-
Rasmussen, U.B.1
-
10
-
-
0027933068
-
Molecular cloning of a potential proteinase activated receptor
-
Nystedt, S., Emilsson, K., Wahlestedt, C. & Sundelin, J. Molecular cloning of a potential proteinase activated receptor. Proc. Natl Acad. Sci. USA 91, 9208-9212 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 9208-9212
-
-
Nystedt, S.1
Emilsson, K.2
Wahlestedt, C.3
Sundelin, J.4
-
11
-
-
79955584619
-
Structure, function and pathophysiology of protease activated receptors
-
Adams, M. N. et al. Structure, function and pathophysiology of protease activated receptors. Pharmacol. Ther. 130, 248-282 (2011).
-
(2011)
Pharmacol. Ther.
, vol.130
, pp. 248-282
-
-
Adams, M.N.1
-
12
-
-
77951684623
-
Signal transduction by protease-activated receptors
-
Soh, U. J., Dores, M. R., Chen, B. & Trejo, J. Signal transduction by protease-activated receptors. Br. J. Pharmacol. 160, 191-203 (2010).
-
(2010)
Br. J. Pharmacol.
, vol.160
, pp. 191-203
-
-
Soh, U.J.1
Dores, M.R.2
Chen, B.3
Trejo, J.4
-
13
-
-
79959575294
-
PAR1 plays a role in epithelial malignancies: Transcriptional regulation and novel signaling pathway
-
Bar-Shavit, R. et al. PAR1 plays a role in epithelial malignancies: transcriptional regulation and novel signaling pathway. IUBMB Life 63, 397-402 (2011).
-
(2011)
IUBMB Life
, vol.63
, pp. 397-402
-
-
Bar-Shavit, R.1
-
14
-
-
1342325343
-
Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion
-
Booden, M. A., Eckert, L. B., Der, C. J. & Trejo, J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol. Cell Biol. 24, 1990-1999 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 1990-1999
-
-
Booden, M.A.1
Eckert, L.B.2
Der, C.J.3
Trejo, J.4
-
15
-
-
0031927754
-
Thrombin receptor overexpression in malignant and physiological invasion processes
-
Even-Ram, S. et al. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat. Med. 4, 909-914 (1998).
-
(1998)
Nat. Med.
, vol.4
, pp. 909-914
-
-
Even-Ram, S.1
-
16
-
-
52049124532
-
Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice
-
Versteeg, H. H. et al. Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res. 68, 7219-7227 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 7219-7227
-
-
Versteeg, H.H.1
-
17
-
-
0029952336
-
Ligand cross-reactivity within the protease-activated receptor family
-
Blackhart, B. D. et al. Ligand cross-reactivity within the protease-activated receptor family. J. Biol. Chem. 271, 16466-16471 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 16466-16471
-
-
Blackhart, B.D.1
-
18
-
-
0034608013
-
Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
-
O'Brien, P. J. et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. J. Biol. Chem. 275, 13502-13509 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 13502-13509
-
-
O'Brien, P.J.1
-
19
-
-
81755184108
-
Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia
-
Sevigny, L. M. et al. Protease-activated receptor-2 modulates protease-activated receptor-1-driven neointimal hyperplasia. Arterioscler. Thromb. Vasc. Biol. 31, e100-e106 (2011).
-
(2011)
Arterioscler. Thromb. Vasc. Biol.
, vol.31
, pp. e100-e106
-
-
Sevigny, L.M.1
-
20
-
-
84903318931
-
Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer
-
Jaber, M. et al. Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer. Cell Mol. Life Sci. 71, 2517-2533 (2014).
-
(2014)
Cell Mol. Life Sci.
, vol.71
, pp. 2517-2533
-
-
Jaber, M.1
-
21
-
-
0034663568
-
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
-
Lemmon, M. A. & Ferguson, K. M. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350(Pt 1): 1-18 (2000).
-
(2000)
Biochem. J.
, vol.350
, pp. 1-18
-
-
Lemmon, M.A.1
Ferguson, K.M.2
-
22
-
-
0031831780
-
Pleckstrin homology domains: A common fold with diverse functions
-
Rebecchi, M. J. & Scarlata, S. Pleckstrin homology domains: a common fold with diverse functions. Annu. Rev. Biophys. Biomol. Struct. 27, 503-528 (1998).
-
(1998)
Annu. Rev. Biophys. Biomol. Struct.
, vol.27
, pp. 503-528
-
-
Rebecchi, M.J.1
Scarlata, S.2
-
23
-
-
17144395975
-
The activation of Akt/PKB signaling pathway and cell survival
-
Song, G., Ouyang, G. & Bao, S. The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. 9, 59-71 (2005).
-
(2005)
J. Cell Mol. Med.
, vol.9
, pp. 59-71
-
-
Song, G.1
Ouyang, G.2
Bao, S.3
-
24
-
-
1542328927
-
Structure, regulation and function of PKB/AKT - A major therapeutic target
-
Hanada, M., Feng, J. & Hemmings, B. A. Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim. Biophys. Acta 1697, 3-16 (2004).
-
(2004)
Biochim. Biophys. Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
25
-
-
0030072570
-
Vertebrate non-receptor protein-tyrosine kinase families
-
Neet, K. & Hunter, T. Vertebrate non-receptor protein-tyrosine kinase families. Genes Cells 1, 147-169 (1996).
-
(1996)
Genes Cells
, vol.1
, pp. 147-169
-
-
Neet, K.1
Hunter, T.2
-
26
-
-
0001584969
-
The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
-
Smith, C. I. et al. The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays 23, 436-446 (2001).
-
(2001)
Bioessays
, vol.23
, pp. 436-446
-
-
Smith, C.I.1
-
27
-
-
77955296482
-
Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: Signaling partners, hierarchy and physiological significance
-
Cohen, I. et al. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance. PLoS ONE 5, e11135 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Cohen, I.1
-
28
-
-
0034461581
-
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
-
Zeng, L. et al. Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Mol. Cell Biol. 20, 9212-9224 (2000).
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 9212-9224
-
-
Zeng, L.1
-
29
-
-
45949098871
-
Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer
-
Lee, K. et al. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer. BMC Cancer 8, 158 (2008).
-
(2008)
BMC Cancer
, vol.8
, pp. 158
-
-
Lee, K.1
-
30
-
-
84856955553
-
A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer
-
Rao, S. et al. A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer. Oncogene 31, 716-727 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 716-727
-
-
Rao, S.1
-
31
-
-
23144450821
-
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
-
Cote, J. F., Motoyama, A. B., Bush, J. A. & Vuori, K. A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat. Cell Biol. 7, 797-807 (2005).
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 797-807
-
-
Cote, J.F.1
Motoyama, A.B.2
Bush, J.A.3
Vuori, K.4
-
32
-
-
2942563750
-
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
-
McManus, E. J. et al. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J. 23, 2071-2082 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 2071-2082
-
-
McManus, E.J.1
-
33
-
-
84860439454
-
BMX and its role in inflammation, cardiovascular disease, and cancer
-
Cenni, B., Gutmann, S. & Gottar-Guillier, M. BMX and its role in inflammation, cardiovascular disease, and cancer. Int. Rev. Immunol. 31, 166-173 (2012).
-
(2012)
Int. Rev. Immunol.
, vol.31
, pp. 166-173
-
-
Cenni, B.1
Gutmann, S.2
Gottar-Guillier, M.3
-
34
-
-
79956223769
-
The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner
-
Gottar-Guillier, M. et al. The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. J. Immunol. 186, 6014-6023 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 6014-6023
-
-
Gottar-Guillier, M.1
-
35
-
-
4644359986
-
The human cytotrophoblastic cell, a mononuclear chameleon
-
Bischof, P. & Irminger-Finger, I. The human cytotrophoblastic cell, a mononuclear chameleon. Int. J. Biochem. Cell Biol. 37, 1-16 (2005).
-
(2005)
Int. J. Biochem. Cell Biol.
, vol.37
, pp. 1-16
-
-
Bischof, P.1
Irminger-Finger, I.2
-
36
-
-
0026447253
-
Villous culture of first trimester human placenta - model to study extravillous trophoblast (EVT) differentiation
-
Genbacev, O., Schubach, S. A. & Miller, R. K. Villous culture of first trimester human placenta - model to study extravillous trophoblast (EVT) differentiation. Placenta 13, 439-461 (1992).
-
(1992)
Placenta
, vol.13
, pp. 439-461
-
-
Genbacev, O.1
Schubach, S.A.2
Miller, R.K.3
-
37
-
-
58149401697
-
Protease activated receptor-1, PAR1, promotes placenta trophoblast invasion and beta-catenin stabilization
-
Grisaru-Granovsky, S. et al. Protease activated receptor-1, PAR1, promotes placenta trophoblast invasion and beta-catenin stabilization. J. Cell Physiol. 218, 512-521 (2009).
-
(2009)
J. Cell Physiol.
, vol.218
, pp. 512-521
-
-
Grisaru-Granovsky, S.1
-
38
-
-
0028670203
-
The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta
-
Konishi, H., Kuroda, S. & Kikkawa, U. The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta. Biochem. Biophys. Res. Commun. 205, 1770-1775 (1994).
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.205
, pp. 1770-1775
-
-
Konishi, H.1
Kuroda, S.2
Kikkawa, U.3
-
39
-
-
0028564915
-
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C
-
Yao, L., Kawakami, Y. & Kawakami, T. The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C. Proc. Natl Acad. Sci. USA 91, 9175-9179 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 9175-9179
-
-
Yao, L.1
Kawakami, Y.2
Kawakami, T.3
-
40
-
-
0036788788
-
The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation
-
Farhang-Fallah, J. et al. The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation. Mol. Cell Biol. 22, 7325-7336 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 7325-7336
-
-
Farhang-Fallah, J.1
-
41
-
-
0029020217
-
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling
-
Myers, Jr. M. G. et al. The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. J. Biol. Chem. 270, 11715-11718 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11715-11718
-
-
Myers, M.G.1
-
42
-
-
0029039613
-
Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid
-
Pitcher, J. A., Touhara, K., Payne, E. S. & Lefkowitz, R. J. Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. J. Biol. Chem. 270, 11707-11710 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11707-11710
-
-
Pitcher, J.A.1
Touhara, K.2
Payne, E.S.3
Lefkowitz, R.J.4
-
43
-
-
84864607612
-
Pleckstrin homology (PH) like domains - Versatile modules in protein-protein interaction platforms
-
Scheffzek, K. & Welti, S. Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms. FEBS Lett. 586, 2662-2673 (2012).
-
(2012)
FEBS Lett.
, vol.586
, pp. 2662-2673
-
-
Scheffzek, K.1
Welti, S.2
-
44
-
-
0029783037
-
The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting
-
Zheng, Y., Zangrilli, D., Cerione, R. A. & Eva, A. The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. J. Biol. Chem. 271, 19017-19020 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19017-19020
-
-
Zheng, Y.1
Zangrilli, D.2
Cerione, R.A.3
Eva, A.4
-
45
-
-
77954238441
-
Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation
-
Chen, Z. et al. Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation. J. Biol. Chem. 285, 21070-21081 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 21070-21081
-
-
Chen, Z.1
-
46
-
-
34250313651
-
Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains
-
Cohen, L. A. et al. Active Arf6 recruits ARNO/cytohesin GEFs to the PM by binding their PH domains. Mol. Biol. Cell 18, 2244-2253 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 2244-2253
-
-
Cohen, L.A.1
-
47
-
-
35948968634
-
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs
-
Lutz, S. et al. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science 318, 1923-1927 (2007).
-
(2007)
Science
, vol.318
, pp. 1923-1927
-
-
Lutz, S.1
-
48
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco, I. & Sawyers, C. L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
49
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
Stocker, H. et al. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295, 2088-2091 (2002).
-
(2002)
Science
, vol.295
, pp. 2088-2091
-
-
Stocker, H.1
-
50
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke, T. F. et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736 (1995).
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
-
51
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten, J. D. et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448, 439-444 (2007).
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
-
52
-
-
34548743454
-
Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils
-
Jia, Y. et al. Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity 27, 453-467 (2007).
-
(2007)
Immunity
, vol.27
, pp. 453-467
-
-
Jia, Y.1
-
53
-
-
51849134586
-
Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate
-
Jia, Y., Schurmans, S. & Luo, H. R. Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate. Cell Cycle 7, 2803-2808 (2008).
-
(2008)
Cell Cycle
, vol.7
, pp. 2803-2808
-
-
Jia, Y.1
Schurmans, S.2
Luo, H.R.3
-
54
-
-
0027305921
-
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
-
Rawlings, D. J. et al. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 261, 358-361 (1993).
-
(1993)
Science
, vol.261
, pp. 358-361
-
-
Rawlings, D.J.1
-
55
-
-
0035003136
-
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
-
Chen, R. et al. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 3, 439-444 (2001).
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 439-444
-
-
Chen, R.1
-
56
-
-
0032696592
-
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins
-
Movilla, N. & Bustelo, X. R. Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol. Cell Biol. 19, 7870-7885 (1999).
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 7870-7885
-
-
Movilla, N.1
Bustelo, X.R.2
-
57
-
-
0030429765
-
The VAV family of signal transduction molecules
-
Bustelo, X. R. The VAV family of signal transduction molecules. Crit. Rev. Oncog. 7, 65-88 (1996).
-
(1996)
Crit. Rev. Oncog.
, vol.7
, pp. 65-88
-
-
Bustelo, X.R.1
-
58
-
-
84895156496
-
Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease
-
Hollenberg, M. D. et al. Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease. Br. J. Pharmacol. 171, 1180-1194 (2014).
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 1180-1194
-
-
Hollenberg, M.D.1
-
59
-
-
84905447408
-
Biased signaling of protease-activated receptors
-
Zhao, P., Metcalf, M. & Bunnett, N. W. Biased signaling of protease-activated receptors. Front. Endocrinol. (Lausanne) 5, 67, 1-16 (2014).
-
(2014)
Front. Endocrinol. (Lausanne)
, vol.5
, Issue.67
, pp. 1-16
-
-
Zhao, P.1
Metcalf, M.2
Bunnett, N.W.3
-
60
-
-
84887852110
-
Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1)
-
Mihara, K., Ramachandran, R., Renaux, B., Saifeddine, M. & Hollenberg, M. D. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J. Biol. Chem. 288, 32979-32990 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 32979-32990
-
-
Mihara, K.1
Ramachandran, R.2
Renaux, B.3
Saifeddine, M.4
Hollenberg, M.D.5
-
61
-
-
79960114650
-
Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
-
Ramachandran, R. et al. Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2). J. Biol. Chem. 286, 24638-24648 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 24638-24648
-
-
Ramachandran, R.1
-
62
-
-
84930619167
-
Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain
-
Zhao, P. et al. Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain. J. Biol. Chem. 290, 13875-13887 (2015).
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 13875-13887
-
-
Zhao, P.1
-
63
-
-
0242352509
-
The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity
-
Seatter, M. J. et al. The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity. Cell Signal. 16, 21-29 (2004).
-
(2004)
Cell Signal.
, vol.16
, pp. 21-29
-
-
Seatter, M.J.1
-
64
-
-
54049117260
-
Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: A novel paradigm for receptor cooperativity
-
Rallabhandi, P. et al. Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J. Biol. Chem. 283, 24314-24325 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24314-24325
-
-
Rallabhandi, P.1
-
65
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski, K. et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745 (2000).
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
-
66
-
-
0037452868
-
Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin
-
Mirzadegan, T., Benko, G., Filipek, S. & Palczewski, K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 42, 2759-2767 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 2759-2767
-
-
Mirzadegan, T.1
Benko, G.2
Filipek, S.3
Palczewski, K.4
-
67
-
-
0032541084
-
G protein-coupled receptors. II. Mechanism of agonist activation
-
Gether, U. & Kobilka, B. K. G protein-coupled receptors. II. Mechanism of agonist activation. J. Biol. Chem. 273, 17979-17982 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 17979-17982
-
-
Gether, U.1
Kobilka, B.K.2
-
68
-
-
33645223519
-
Role of the PAR1 receptor 8th helix in signaling: The 7-8-1 receptor activation mechanism
-
Swift, S. et al. Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism. J. Biol. Chem. 281, 4109-4116 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 4109-4116
-
-
Swift, S.1
-
69
-
-
82255161850
-
The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2
-
Adams, M. N., Christensen, M. E., He, Y., Waterhouse, N. J. & Hooper, J. D. The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. PLoS ONE 6, e28018 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Adams, M.N.1
Christensen, M.E.2
He, Y.3
Waterhouse, N.J.4
Hooper, J.D.5
|