Characterization of the expression of PDZ-RhoGEF, LARG and Gα12/Gα13 proteins in the murine nervous system

European Journal of Neuroscience

Volumn 16, Issue 12, 2002, Pages 2333-2341

  Kuner, Rohini ^a   Swiercz, J M ^a   Zywietz, A ^a   Tappe, A ^a   Offermanns, S ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LEUKEMIA ASSOCIATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; NERVE PROTEIN; POLYCLONAL ANTIBODY; PROTEIN SUBUNIT; RHO FACTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL STRUCTURE; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAMMAL; MOUSE; NERVE CELL; NEUTROPHIL; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SOMATIC CELL;

ANIMALS; ANTIBODY SPECIFICITY; BRAIN; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GANGLIA, SPINAL; GENE EXPRESSION REGULATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HETEROTRIMERIC GTP-BINDING PROTEINS; IMMUNOHISTOCHEMISTRY; MICE; NERVOUS SYSTEM; NEURONS; NEURONS, AFFERENT; NOCICEPTORS; RECEPTORS, GLUTAMATE; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 0036925329     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02402.x     Document Type: Article

References (41)

1. Barr, A.J., Brass, L.F. & Manning, D.R. (1997) Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G-protein coupling. J. Biol. Chem., 272, 2223-2229.
2. Bateman, J. & Van Vactor, D. (2001) The Trio family of guanine-nucleotide exchange factors: Regulators of axon guidance. J. Cell Sci., 114, 1973-1980.
3. Brouns, M.R., Matheson, S.F. & Settleman, J. (2001) p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nature Cell Biol., 3, 361-367.
4. Buhl, A.M., Johnson, N.L., Dhanasekaran, N. & Johnson, G.L. (1995) Galpha12 and Galpha13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly. J. Biol. Chem., 270, 24631-24634.
5. Contos, J.J., Ishii, I. & Chun, J. (2000) Lysophosphatidic acid receptors. Mol. Pharmacol., 58, 1188-1196.
6. Dhanasekaran, N. & Dermott, J.M. (1996) Signaling by the G12 class of G proteins. Cell Signal, 8, 235-245.
7. Dickson, B.J. (2001) Rho GTPases in growth cone guidance. Curr. Opin. Neurobiol., 11, 103-110.
8. Fields, T.A. & Casey, P. (1997) Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. Biochem. J., 321, 561-571.
9. Fritsche, J., Reber, B.F., Schindelholz, B. & Bandtlow, C.E. (1999) Differential cytoskeletal changes during growth cone collapse in response to Sema III and thrombin. Mol. Cell Neurosci., 14, 398-418.
10. Fromm, C., Coso, O.A., Montaner, S., Xu, N. & Gutkind, J.S. (1997) The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. Proc. Natl. Acad. Sci. USA, 94, 10098-10103.
11. Fukuhara, S., Chikumi, H. & Gutkind, J.S. (2001) RGS-containing RhoGEFs: The missing link between transforming G proteins and Rho? Oncogene, 20, 1661-1668.
12. Fukuhara, S., Murga, C., Zohar, M., Igishi, T. & Gutkind, J.S. (1999) A novel PDZ. Domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J. Biol. Chem., 274, 5868-5879.
13. Fukushima, N., Ishii, I., Contos, J.J., Weiner, J.A. & Chun, J. (2001) Lysophospholipid receptors. Annu. Rev. Pharmacol. Toxicol., 41, 507-534.
14. Fukushima, N., Kimura, Y. & Chun, J. (1998) A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. Proc. Natl. Acad. Sci. USA, 95, 6151-6156.
15. Gao, H., Peng, B., Welch, W.J. & Wilcox, C.S. (1997) Central thromboxane receptors: mRNA expression and mediation of pressor responses. Am. J. Physiol., 272, R1493-R1500.
16. Girkontaite, I., Missy, K., Sakk, V., Harenberg, A., Tedford, K., Potzel, T., Pfeffer, K. & Fischer, K.D. (2001) Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nature Immunol., 2, 855-862.
17. Gohla, A., Offermanns, S., Wilkie, T. & Schultz, G. (1999) Differential involvement of G12 and G13 in receptor-mediated stress fiber formation. J. Biol. Chem., 274, 17901-17907.
18. Gratacap, M.P., Payrastre, B., Nieswandt, B. & Offermanns, S. (2001) Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J. Biol. Chem., 276, 47906-47913.
19. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science, 279, 50914.
20. Hart, M.J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W.D., Gilman, A.G., Sternweis, P.C. & Bollag, G. (1998) Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha 13. Science, 280, 2112-2114.
21. Jackson, M., Song, W., Liu, M.Y., Jin, L., Dykes-Hoberg, M., Lin, C.I., Bowers, W.J., Federoff, H.J., Sternweis, P.C. & Rothstein, J.D. (2001) Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature, 410, 89-93.
22. Jalink, K., Eichholtz, T., Postma, F.R., van Corven, E.J. & Moolenaar, W.H. (1993) Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: Similarity to thrombin action. Cell Growth Differ., 4, 247-255.
23. Jalink, K., van Corven, E.J., Hengeveld, T., Morii, N., Narumiya, S. & Moolenaar, W.H. (1994) Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol., 126, 801-810.
24. Katoh, H., Aoki, J., Yamaguchi, Y., Kitano, Y., Ichikawa, A. & Negishi, M. (1998) Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways. J. Biol. Chem., 273, 28700-28707.
25. Kourlas, P.J., Strout, M.P., Becknell, B., Veronese, M.L., Croce, C.M., Theil, K.S., Krahe, R., Ruutu, T., Knuutila, S., Bloomfield, C.D. & Caligiuri, M.A. (2000) Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia. Proc. Natl. Acad. Sci. USA, 97, 2145-2150.
26. Kranenburg, O., Poland, M., van Horck, F.P., Drechsel, D., Hall, A. & Moolenaar, W.H. (1999) Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: Induction of neurite retraction. Mol Biol. Cell, 10, 1851-1857.
27. Luo, L. (2000) Rho GTPases in neuronal morphogenesis. Nature Rev. Neurosci., 1, 173-180.
28. Moolenaar, W. (1999) Bioactive lysophospholipids and their G protein-coupled receptors. Exp. Cell Res., 253, 230-238.
29. Nakayama, A.Y. & Luo, L. (2000) Intracellular signaling pathways that regulate dendritic spine morphogenesis. Hippocampus, 10, 582-586.
30. Namgung, U. & Routtenber, A. (2000) Transcriptional and post-transcriptional regulation of brain growth protein: Regional differentiation and regeneration induction of GAP-43. Eur. J. Neurosci., 12, 3124-3136.
31. Postma, F.R., Jalink, K., Hengeveld, T., Offermanns, S. & Moolenaar, W.H. (2001) Galpha (13) mediates activation of a depolarizing chloride current that accompanies RhoA activation in both neuronal and nonneuronal cells. Curr. Biol., 11, 121-124.
32. Sah, V.P., Seasholtz, T.M., Sagi, S.A. & Brown, J.H. (2000) The role of Rho in G protein-coupled receptor signal transduction. Annu. Rev. Pharmacol. Toxicol., 40, 459-489.
33. Shamah, S.M., Lin, M.Z., Goldberg, J.L., Estrach, S., Sahin, M., Hu, L., Bazalakova, M., Neve, R.L., Corfas, G., Debant, A. & Greenberg, M.E. (2001) EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell, 105, 233-244.
34. Suidan, H.S., Stone, S.R., Hemmings, B.A. & Monard, D. (1992) Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors. Neuron, 8, 363-375.
35. Symons, M. & Settleman, J. (2000) Rho family GTPases: More than simple switches. Trends Cell Biol., 10, 415-419.
36. Tashiro, A., Minden, A. & Yuste, R. (2000) Regulation of dendritic spine morphology by the rho family of small GTPases: Antagonistic roles of Rac and Rho. Cereb. Cortex, 10, 927-938.
37. Tedford, K., Nitschke, L., Girkontaite, I., Charlesworth, A., Chan, G., Sakk, V., Barbacid, M. & Fischer, K.D. (2001) Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nature Immunonol., 2, 548-555.
38. Togashi, H., Nagata, K., Takagishi, M., Saitoh, N. & Inagaki, M. (2000) Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization. J. Biol. Chem., 275, 29570-29578.
39. Turgeon, V.L., Lloyd, E.D., Wang, S., Festoff, B.W. & Houenou, L.J. (1998) Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation. J. Neurosci., 18, 6882-6891.
40. Vergnolle, N., Wallace, J.L., Bunnett, N.W. & Hollenberg, M.D. (2001) Proteaseactivated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol. Sci., 22, 146-152.
41. Zheng, Y. (2001) Dbl family of guanine nucleotide exchange factors. Trends Biochem. Sci., 26, 724-732.