Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

Journal of Medicinal Chemistry

Volumn 59, Issue 15, 2016, Pages 7223-7238

  Spanò, Virginia ^a   Pennati, Marzia ^b   Parrino, Barbara ^a   Carbone, Anna ^a   Montalbano, Alessandra ^a   Cilibrasi, Vincenzo ^a   Zuco, Valentina ^b   Lopergolo, Alessia ^b   Cominetti, Denis ^b   Diana, Patrizia ^a   Cirrincione, Girolamo ^a   Barraja, Paola ^a   Zaffaroni, Nadia ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 METHOXYBENZYL) 1 PHENYL 2,5,6,7 TETRAHYDRO 4H ISOINDOL 4 ONE; 2 (3 METHOXYBENZYL) 1 PHENYL 2,5,6,7 TETRAHYDRO 4H ISOINDOL 4 ONE; 2 METHOXY 5 [(6 PHENYL 4,5 DIHYDRO 7H [1,2]OXAZOLO[5,4 E]ISOINDOL 7 YL)METHYL]ANILINE; 2 METHOXY 5 [[6 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDRO 7H [1,2]OXAZOLO[5,4 E]ISOINDOL 7 YL]METHYL]ANILINE; 4 [(6 PHENYL 4,5 DIHYDRO 7H [1,2]OXAZOLO[5,4 E]ISOINDOL 7 YL)METHYL]PHENOL; 4 [7 (4 METHOXYBENZYL) 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOL 6 YL]PHENYL ACETATE; 4 [7 (4 METHOXYBENZYL) 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOL 6L]PHENOL; 7 (2 METHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (2,3 DIMETHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (2,5 DIMETHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO-4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (3 METHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (3,4 DIMETHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (3,4,5 TRIMETHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (3,5 DIMETHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXY 3 NITROBENZYL) 6 (3,4,5 TRIMETHOXYPHENYL) 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXY 3 NITROBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXYBENZYL) 4,4 DIMETHYL 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXYBENZYL) 6 (3,4,5 TRIMETHOXYPHENYL) 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXYBENZYL) 6 (4 METHOXYPHENYL) 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXYBENZYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 (4 METHOXYPHENYL) 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 BENZYL 4,4 DIMETHYL 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 BENZYL 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; 7 METHYL 6 PHENYL 5,7 DIHYDRO 4H [1,2]OXAZOLO[5,4 E]ISOINDOLE; ANTINEOPLASTIC AGENT; ISOINDOLE DERIVATIVE; NAVELBINE; PACLITAXEL; UNCLASSIFIED DRUG; UNINDEXED DRUG; [1,2]OXAZOLO[5,4 E]ISOINDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; CROSS COUPLING REACTION; CYCLIZATION; DEACETYLATION; DRUG ACETYLATION; DRUG SYNTHESIS; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PERITONEUM MESOTHELIOMA; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; ANIMAL; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; EXPERIMENTAL NEOPLASM; LUNG TUMOR; MESOTHELIOMA; NUDE MOUSE; PATHOLOGY; PERITONEUM TUMOR; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOINDOLES; LUNG NEOPLASMS; MESOTHELIOMA; MICE; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; PERITONEAL NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84982144079     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00777     Document Type: Article

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