Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: Synthesis and structure-activity relationship studies

Journal of Medicinal Chemistry

Volumn 52, Issue 19, 2009, Pages 5916-5925

  Putey, Aurélien ^a   Popowycz, Florence ^a   Do, Quoc Tuan ^b   Bernard, Philippe ^b   Talapatra, Sandeep K ^c   Kozielski, Frank ^c   Galmarini, Carlos M ^d   Joseph, Benoît ^a  

^a UNIVERSITÉ LYON 1   (France)

^b GreenPharma SA   (France)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d Univ Claude Bernard   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5,6,7,10 TETRAHYDROINDOLO[2,3 F][4]BENZAZONIN 9(8H) ONE; 5,6,7,9 TETRAHYDRO 8H INDOLO[2,3 E][3]BENZAZOCIN 8 ONE; 5,6,7,9 TETRAHYDROINDOLO[2,3 E][3]BENZAZOCIN 8 ONE; 5,7 DIHYDROINDOLO[2,3 C]QUINOLIN 6 ONE; 7 METHYL 5,6,7,9 TETRAHYDROINDOLO[2,3 E][3]BENZAZOCIN 8 ONE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; FLUOROURACIL; INDOLE DERIVATIVE; NAVELBINE; PACLITAXEL; UNCLASSIFIED DRUG; VINBLASTINE;

ALKYLATION; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

EID: 70349644859     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900476c     Document Type: Article

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