-
1
-
-
0036123185
-
Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
-
COI: 1:CAS:528:DC%2BD38XitVGltLs%3D, PID: 11872628
-
Ahmed N, Pansino F, Clyde R, Murthi P, Quinn MA, Rice GE, Agrez MV, Mok S, Baker MS (2002) Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade. Carcinogenesis 23:237–244
-
(2002)
Carcinogenesis
, vol.23
, pp. 237-244
-
-
Ahmed, N.1
Pansino, F.2
Clyde, R.3
Murthi, P.4
Quinn, M.A.5
Rice, G.E.6
Agrez, M.V.7
Mok, S.8
Baker, M.S.9
-
2
-
-
84892755518
-
Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of alphavbeta6 integrin in DCIS identifies high-risk patients and predicts recurrence
-
COI: 1:CAS:528:DC%2BC2cXhtFKrsrc%3D, PID: 24150233
-
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA, Dickinson S, Edwards DR, Pennington CJ, Sestak I, Cuzick J, Marshall JF, Hart IR, Jones JL (2014) Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of alphavbeta6 integrin in DCIS identifies high-risk patients and predicts recurrence. Clin Cancer Res 20:344–357
-
(2014)
Clin Cancer Res
, vol.20
, pp. 344-357
-
-
Allen, M.D.1
Thomas, G.J.2
Clark, S.3
Dawoud, M.M.4
Vallath, S.5
Payne, S.J.6
Gomm, J.J.7
Dreger, S.A.8
Dickinson, S.9
Edwards, D.R.10
Pennington, C.J.11
Sestak, I.12
Cuzick, J.13
Marshall, J.F.14
Hart, I.R.15
Jones, J.L.16
-
3
-
-
61949349656
-
Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
-
COI: 1:CAS:528:DC%2BD1MXit1Gqtb4%3D, PID: 19118215
-
Aluwihare P, Mu Z, Zhao Z, Yu D, Weinreb PH, Horan GS, Violette SM, Munger JS (2009) Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice. J Cell Sci 122:227–232
-
(2009)
J Cell Sci
, vol.122
, pp. 227-232
-
-
Aluwihare, P.1
Mu, Z.2
Zhao, Z.3
Yu, D.4
Weinreb, P.H.5
Horan, G.S.6
Violette, S.M.7
Munger, J.S.8
-
4
-
-
2942653435
-
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
-
COI: 1:CAS:528:DC%2BD2cXkslyqsb8%3D, PID: 15184403
-
Annes JP, Chen Y, Munger JS, Rifkin DB (2004) Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 165:723–734
-
(2004)
J Cell Biol
, vol.165
, pp. 723-734
-
-
Annes, J.P.1
Chen, Y.2
Munger, J.S.3
Rifkin, D.B.4
-
5
-
-
84856284021
-
Defective retinal vascular endothelial cell development as a consequence of impaired integrin alphaVbeta8-mediated activation of transforming growth factor-beta
-
COI: 1:CAS:528:DC%2BC38Xjt1CmsLk%3D, PID: 22279205
-
Arnold TD, Ferrero GM, Qiu H, Phan IT, Akhurst RJ, Huang EJ, Reichardt LF (2012) Defective retinal vascular endothelial cell development as a consequence of impaired integrin alphaVbeta8-mediated activation of transforming growth factor-beta. J Neurosci 32:1197–1206
-
(2012)
J Neurosci
, vol.32
, pp. 1197-1206
-
-
Arnold, T.D.1
Ferrero, G.M.2
Qiu, H.3
Phan, I.T.4
Akhurst, R.J.5
Huang, E.J.6
Reichardt, L.F.7
-
6
-
-
85035392112
-
Liver fibrosis
-
COI: 1:CAS:528:DC%2BD2MXhtFyjs70%3D, PID: 15690074
-
Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209–218
-
(2005)
J Clin Invest
, vol.115
, pp. 209-218
-
-
Bataller, R.1
Brenner, D.A.2
-
7
-
-
14944348752
-
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
-
COI: 1:CAS:528:DC%2BD2MXhtFyjsLc%3D, PID: 15668738
-
Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM (2005) Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 115:339–347
-
(2005)
J Clin Invest
, vol.115
, pp. 339-347
-
-
Bates, R.C.1
Bellovin, D.I.2
Brown, C.3
Maynard, E.4
Wu, B.5
Kawakatsu, H.6
Sheppard, D.7
Oettgen, P.8
Mercurio, A.M.9
-
8
-
-
23744432972
-
Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression
-
PID: 15970443
-
Beacham DA, Cukierman E (2005) Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression. Semin Cancer Biol 15:329–341
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 329-341
-
-
Beacham, D.A.1
Cukierman, E.2
-
9
-
-
15844420283
-
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
-
COI: 1:CAS:528:DyaK28Xjtlyls78%3D, PID: 8646777
-
Brooks PC, Stromblad S, Sanders LC, von Schalscha TL, Aimes RT, Stetler-Stevenson WG, Quigley JP, Cheresh DA (1996) Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85:683–693
-
(1996)
Cell
, vol.85
, pp. 683-693
-
-
Brooks, P.C.1
Stromblad, S.2
Sanders, L.C.3
von Schalscha, T.L.4
Aimes, R.T.5
Stetler-Stevenson, W.G.6
Quigley, J.P.7
Cheresh, D.A.8
-
10
-
-
19544368642
-
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch
-
COI: 1:CAS:528:DC%2BD2MXlsFynsL4%3D, PID: 15920172
-
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL (2005) Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol 166:1883–1894
-
(2005)
Am J Pathol
, vol.166
, pp. 1883-1894
-
-
Cambier, S.1
Gline, S.2
Mu, D.3
Collins, R.4
Araya, J.5
Dolganov, G.6
Einheber, S.7
Boudreau, N.8
Nishimura, S.L.9
-
11
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
COI: 1:CAS:528:DC%2BD3sXpvFaktLg%3D, PID: 14676299
-
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875–1886
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
McGrady, G.7
Wahl, S.M.8
-
12
-
-
84937041850
-
Association of OPN overexpression with tumor stage, differentiation, metastasis and tumor progression in human laryngeal squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BC28Xns1Ghs7Y%3D, PID: 26221249
-
Chen J, Zhu C, He Z, Geng M, Li G, Tao X, Zhang F (2015) Association of OPN overexpression with tumor stage, differentiation, metastasis and tumor progression in human laryngeal squamous cell carcinoma. Int J Clin Exp Med 8:7116–7124
-
(2015)
Int J Clin Exp Med
, vol.8
, pp. 7116-7124
-
-
Chen, J.1
Zhu, C.2
He, Z.3
Geng, M.4
Li, G.5
Tao, X.6
Zhang, F.7
-
13
-
-
80054012347
-
Developmental and pathological angiogenesis
-
COI: 1:CAS:528:DC%2BC3MXhsFyqtbfK, PID: 21756109
-
Chung AS, Ferrara N (2011) Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol 27:563–584
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 563-584
-
-
Chung, A.S.1
Ferrara, N.2
-
14
-
-
84900560121
-
Is osteopontin involved in cutaneous fibroblast activation? Its hypothetical role in scleroderma pathogenesis
-
COI: 1:CAS:528:DC%2BC2cXhs1eitrnN, PID: 24674683
-
Corallo C, Volpi N, Franci D, Montella A, Biagioli M, Mariotti G, D’Onofrio F, Gonnelli S, Nuti R, Giordano N (2014) Is osteopontin involved in cutaneous fibroblast activation? Its hypothetical role in scleroderma pathogenesis. Int J Immunopathol Pharmacol 27:97–102
-
(2014)
Int J Immunopathol Pharmacol
, vol.27
, pp. 97-102
-
-
Corallo, C.1
Volpi, N.2
Franci, D.3
Montella, A.4
Biagioli, M.5
Mariotti, G.6
D’Onofrio, F.7
Gonnelli, S.8
Nuti, R.9
Giordano, N.10
-
15
-
-
84925433508
-
LOX expression and functional analysis in astrocytomas and impact of IDH1 mutation
-
PID: 25790191
-
da Silva R, Uno M, Marie SK, Oba-Shinjo SM (2015) LOX expression and functional analysis in astrocytomas and impact of IDH1 mutation. PLoS One 10:e0119781
-
(2015)
PLoS One
, vol.10
-
-
da Silva, R.1
Uno, M.2
Marie, S.K.3
Oba-Shinjo, S.M.4
-
16
-
-
21444434608
-
Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1
-
COI: 1:CAS:528:DC%2BD2MXjvFekurw%3D, PID: 15677465
-
Dallas SL, Sivakumar P, Jones CJ, Chen Q, Peters DM, Mosher DF, Humphries MJ, Kielty CM (2005) Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem 280:18871–18880
-
(2005)
J Biol Chem
, vol.280
, pp. 18871-18880
-
-
Dallas, S.L.1
Sivakumar, P.2
Jones, C.J.3
Chen, Q.4
Peters, D.M.5
Mosher, D.F.6
Humphries, M.J.7
Kielty, C.M.8
-
17
-
-
34248193368
-
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands
-
COI: 1:CAS:528:DC%2BD2sXjtlCitbw%3D, PID: 17244604
-
DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF (2007) Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem 282:9657–9665
-
(2007)
J Biol Chem
, vol.282
, pp. 9657-9665
-
-
DiCara, D.1
Rapisarda, C.2
Sutcliffe, J.L.3
Violette, S.M.4
Weinreb, P.H.5
Hart, I.R.6
Howard, M.J.7
Marshall, J.F.8
-
18
-
-
84946854646
-
Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages
-
PID: 26497364
-
Ding L, Liang G, Yao Z, Zhang J, Liu R, Chen H, Zhou Y, Wu H, Yang B, He Q (2015) Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages. Oncotarget 6:36441–36455
-
(2015)
Oncotarget
, vol.6
, pp. 36441-36455
-
-
Ding, L.1
Liang, G.2
Yao, Z.3
Zhang, J.4
Liu, R.5
Chen, H.6
Zhou, Y.7
Wu, H.8
Yang, B.9
He, Q.10
-
19
-
-
84935036672
-
Alphavbeta6 integrin is required for TGFbeta1-mediated matrix metalloproteinase2 expression
-
COI: 1:CAS:528:DC%2BC2MXjvFygsbc%3D, PID: 25558779
-
Dutta A, Li J, Fedele C, Sayeed A, Singh A, Violette SM, Manes TD, Languino LR (2015) Alphavbeta6 integrin is required for TGFbeta1-mediated matrix metalloproteinase2 expression. Biochem J 466:525–536
-
(2015)
Biochem J
, vol.466
, pp. 525-536
-
-
Dutta, A.1
Li, J.2
Fedele, C.3
Sayeed, A.4
Singh, A.5
Violette, S.M.6
Manes, T.D.7
Languino, L.R.8
-
20
-
-
84884204893
-
A human monoclonal antibody 264RAD targeting alphavbeta6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
-
COI: 1:CAS:528:DC%2BC38XhsFyjsLjF, PID: 23108397
-
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, Ross SJ, Rooney C, Smith NR, Rinkenberger J, Cao A, Churchman A, Marshall JF, Weir HM, Bedian V, Blakey DC, Foltz IN, Barry ST (2013) A human monoclonal antibody 264RAD targeting alphavbeta6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo. Oncogene 32:4406–4416
-
(2013)
Oncogene
, vol.32
, pp. 4406-4416
-
-
Eberlein, C.1
Kendrew, J.2
McDaid, K.3
Alfred, A.4
Kang, J.S.5
Jacobs, V.N.6
Ross, S.J.7
Rooney, C.8
Smith, N.R.9
Rinkenberger, J.10
Cao, A.11
Churchman, A.12
Marshall, J.F.13
Weir, H.M.14
Bedian, V.15
Blakey, D.C.16
Foltz, I.N.17
Barry, S.T.18
-
21
-
-
85028196338
-
E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling
-
COI: 1:CAS:528:DC%2BC2cXhs12jsLw%3D
-
Eberlein C, Rooney C, Ross SJ, Farren M, Weir HM, Barry ST (2015) E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin αvβ6 and maintained through TGFβ signalling.Oncogene 34:704–716
-
(2015)
Oncogene
, vol.34
, pp. 704-716
-
-
Eberlein, C.1
Rooney, C.2
Ross, S.J.3
Farren, M.4
Weir, H.M.5
Barry, S.T.6
-
22
-
-
34250862163
-
A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
-
COI: 1:CAS:528:DC%2BD2sXmsFCqtrc%3D, PID: 17575158
-
Elayadi AN, Samli KN, Prudkin L, Liu YH, Bian A, Xie XJ, Wistuba II, Roth JA, McGuire MJ, Brown KC (2007) A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer. Cancer Res 67:5889–5895
-
(2007)
Cancer Res
, vol.67
, pp. 5889-5895
-
-
Elayadi, A.N.1
Samli, K.N.2
Prudkin, L.3
Liu, Y.H.4
Bian, A.5
Xie, X.J.6
Wistuba, I.I.7
Roth, J.A.8
McGuire, M.J.9
Brown, K.C.10
-
23
-
-
84922561479
-
Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial
-
COI: 1:STN:280:DC%2BC2M3gvFOqtw%3D%3D, PID: 25319061
-
Elez E, Kocakova I, Hohler T, Martens UM, Bokemeyer C, Van Cutsem E, Melichar B, Smakal M, Csoszi T, Topuzov E, Orlova R, Tjulandin S, Rivera F, Straub J, Bruns R, Quaratino S, Tabernero J (2015) Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial. Ann Oncol 26:132–40
-
(2015)
Ann Oncol
, vol.26
, pp. 132-140
-
-
Elez, E.1
Kocakova, I.2
Hohler, T.3
Martens, U.M.4
Bokemeyer, C.5
Van Cutsem, E.6
Melichar, B.7
Smakal, M.8
Csoszi, T.9
Topuzov, E.10
Orlova, R.11
Tjulandin, S.12
Rivera, F.13
Straub, J.14
Bruns, R.15
Quaratino, S.16
Tabernero, J.17
-
25
-
-
27744574700
-
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1
-
COI: 1:CAS:528:DC%2BD2MXht1eitbvN, PID: 16260650
-
Fontana L, Chen Y, Prijatelj P, Sakai T, Fassler R, Sakai LY, Rifkin DB (2005) Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J 19:1798–1808
-
(2005)
FASEB J
, vol.19
, pp. 1798-1808
-
-
Fontana, L.1
Chen, Y.2
Prijatelj, P.3
Sakai, T.4
Fassler, R.5
Sakai, L.Y.6
Rifkin, D.B.7
-
26
-
-
69249222379
-
Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN
-
COI: 1:CAS:528:DC%2BD1MXhsVChs7vN, PID: 19732719
-
Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, Worthen GS, Albelda SM (2009) Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN. Cancer Cell 16:183–194
-
(2009)
Cancer Cell
, vol.16
, pp. 183-194
-
-
Fridlender, Z.G.1
Sun, J.2
Kim, S.3
Kapoor, V.4
Cheng, G.5
Ling, L.6
Worthen, G.S.7
Albelda, S.M.8
-
27
-
-
0029610677
-
Definition of two angiogenic pathways by distinct alpha v integrins
-
COI: 1:CAS:528:DyaK2MXps12hs7k%3D, PID: 7491498
-
Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA (1995) Definition of two angiogenic pathways by distinct alpha v integrins. Science 270:1500–1502
-
(1995)
Science
, vol.270
, pp. 1500-1502
-
-
Friedlander, M.1
Brooks, P.C.2
Shaffer, R.W.3
Kincaid, C.M.4
Varner, J.A.5
Cheresh, D.A.6
-
28
-
-
84940237009
-
Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case–control study
-
Friesenhengst A, Pribitzer-Winner T, Schreiber M (2014) Association of the G473A polymorphism and expression of lysyl oxidase with breast cancer risk and survival in European women: a hospital-based case–control study. PLoS One 9:e105579
-
(2014)
PLoS One
, vol.9
-
-
Friesenhengst, A.1
Pribitzer-Winner, T.2
Schreiber, M.3
-
29
-
-
84939125072
-
Periostin is a key niche component for wound metastasis of melanoma
-
PID: 26083413
-
Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H (2015) Periostin is a key niche component for wound metastasis of melanoma. PLoS One 10:e0129704
-
(2015)
PLoS One
, vol.10
-
-
Fukuda, K.1
Sugihara, E.2
Ohta, S.3
Izuhara, K.4
Funakoshi, T.5
Amagai, M.6
Saya, H.7
-
30
-
-
84907618334
-
The contribution of collagen crosslinks to bone strength
-
PID: 24363926
-
Garnero P (2012) The contribution of collagen crosslinks to bone strength. Bonekey Rep 1:182
-
(2012)
Bonekey Rep
, vol.1
, pp. 182
-
-
Garnero, P.1
-
31
-
-
70449526719
-
Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility
-
COI: 1:CAS:528:DC%2BD1MXhtlCnu7rN, PID: 19838175
-
Giampieri S, Manning C, Hooper S, Jones L, Hill CS, Sahai E (2009) Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol 11:1287–1296
-
(2009)
Nat Cell Biol
, vol.11
, pp. 1287-1296
-
-
Giampieri, S.1
Manning, C.2
Hooper, S.3
Jones, L.4
Hill, C.S.5
Sahai, E.6
-
32
-
-
84862180623
-
TGFbeta signaling plays a critical role in promoting alternative macrophage activation
-
COI: 1:CAS:528:DC%2BC38XhslKjtLzP, PID: 22703233
-
Gong D, Shi W, Yi SJ, Chen H, Groffen J, Heisterkamp N (2012) TGFbeta signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol 13:31
-
(2012)
BMC Immunol
, vol.13
, pp. 31
-
-
Gong, D.1
Shi, W.2
Yi, S.J.3
Chen, H.4
Groffen, J.5
Heisterkamp, N.6
-
33
-
-
0037186502
-
Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins
-
COI: 1:CAS:528:DC%2BD38XotV2htg%3D%3D, PID: 11855984
-
Goodman SL, Holzemann G, Sulyok GA, Kessler H (2002) Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. J Med Chem 45:1045–1051
-
(2002)
J Med Chem
, vol.45
, pp. 1045-1051
-
-
Goodman, S.L.1
Holzemann, G.2
Sulyok, G.A.3
Kessler, H.4
-
34
-
-
0037007226
-
Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
-
COI: 1:CAS:528:DC%2BD38XjtVOgtL8%3D, PID: 11927558
-
Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P (2002) Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J 21:1743–1753
-
(2002)
EMBO J
, vol.21
, pp. 1743-1753
-
-
Goumans, M.J.1
Valdimarsdottir, G.2
Itoh, S.3
Rosendahl, A.4
Sideras, P.5
ten Dijke, P.6
-
35
-
-
0035877765
-
CYR61 stimulates human skin fibroblast migration through integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain
-
COI: 1:CAS:528:DC%2BD3MXksFGktrs%3D, PID: 11287419
-
Grzeszkiewicz TM, Kirschling DJ, Chen N, Lau LF (2001) CYR61 stimulates human skin fibroblast migration through integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. J Biol Chem 276:21943–21950
-
(2001)
J Biol Chem
, vol.276
, pp. 21943-21950
-
-
Grzeszkiewicz, T.M.1
Kirschling, D.J.2
Chen, N.3
Lau, L.F.4
-
36
-
-
84946866487
-
MicroRNAs, TGF-beta signaling, and the inflammatory microenvironment in cancer
-
COI: 1:CAS:528:DC%2BC2MXhvVyhs77E, PID: 26563372
-
Guo L, Zhang Y, Zhang L, Huang F, Li J, Wang S (2016) MicroRNAs, TGF-beta signaling, and the inflammatory microenvironment in cancer. Tumour Biol 37:115–125
-
(2016)
Tumour Biol
, vol.37
, pp. 115-125
-
-
Guo, L.1
Zhang, Y.2
Zhang, L.3
Huang, F.4
Li, J.5
Wang, S.6
-
37
-
-
0033870756
-
Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3
-
COI: 1:CAS:528:DC%2BD3cXmsVOmsbo%3D, PID: 10955784
-
Gutheil JC, Campbell TN, Pierce PR, Watkins JD, Huse WD, Bodkin DJ, Cheresh DA (2000) Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res 6:3056–3061
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3056-3061
-
-
Gutheil, J.C.1
Campbell, T.N.2
Pierce, P.R.3
Watkins, J.D.4
Huse, W.D.5
Bodkin, D.J.6
Cheresh, D.A.7
-
38
-
-
33645760428
-
Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype
-
COI: 1:CAS:528:DC%2BD28XjtV2gt7k%3D, PID: 16585599
-
Hagemann T, Wilson J, Burke F, Kulbe H, Li NF, Pluddemann A, Charles K, Gordon S, Balkwill FR (2006) Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype. J Immunol 176:5023–5032
-
(2006)
J Immunol
, vol.176
, pp. 5023-5032
-
-
Hagemann, T.1
Wilson, J.2
Burke, F.3
Kulbe, H.4
Li, N.F.5
Pluddemann, A.6
Charles, K.7
Gordon, S.8
Balkwill, F.R.9
-
39
-
-
33847009161
-
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse
-
COI: 1:CAS:528:DC%2BD2sXhsV2gurw%3D, PID: 17200187
-
Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF 3rd, Sheppard D, Gardner HA, Violette SM (2007) Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol 170:110–125
-
(2007)
Am J Pathol
, vol.170
, pp. 110-125
-
-
Hahm, K.1
Lukashev, M.E.2
Luo, Y.3
Yang, W.J.4
Dolinski, B.M.5
Weinreb, P.H.6
Simon, K.J.7
Chun Wang, L.8
Leone, D.R.9
Lobb, R.R.10
McCrann, D.J.11
Allaire, N.E.12
Horan, G.S.13
Fogo, A.14
Kalluri, R.15
Shield, C.F.16
Sheppard, D.17
Gardner, H.A.18
Violette, S.M.19
-
40
-
-
34347359740
-
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival
-
COI: 1:CAS:528:DC%2BD2sXosVyms7k%3D, PID: 17503414
-
Hazelbag S, Kenter GG, Gorter A, Dreef EJ, Koopman LA, Violette SM, Weinreb PH, Fleuren GJ (2007) Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival. J Pathol 212:316–324
-
(2007)
J Pathol
, vol.212
, pp. 316-324
-
-
Hazelbag, S.1
Kenter, G.G.2
Gorter, A.3
Dreef, E.J.4
Koopman, L.A.5
Violette, S.M.6
Weinreb, P.H.7
Fleuren, G.J.8
-
41
-
-
84889886646
-
Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs
-
COI: 1:CAS:528:DC%2BC3sXhslCqsbjE, PID: 24216753
-
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D (2013) Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med 19:1617–1624
-
(2013)
Nat Med
, vol.19
, pp. 1617-1624
-
-
Henderson, N.C.1
Arnold, T.D.2
Katamura, Y.3
Giacomini, M.M.4
Rodriguez, J.D.5
McCarty, J.H.6
Pellicoro, A.7
Raschperger, E.8
Betsholtz, C.9
Ruminski, P.G.10
Griggs, D.W.11
Prinsen, M.J.12
Maher, J.J.13
Iredale, J.P.14
Lacy-Hulbert, A.15
Adams, R.H.16
Sheppard, D.17
-
42
-
-
77949394260
-
A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic melanoma
-
COI: 1:CAS:528:DC%2BC3cXktFGgsLk%3D, PID: 20108344
-
Hersey P, Sosman J, O’Day S, Richards J, Bedikian A, Gonzalez R, Sharfman W, Weber R, Logan T, Buzoianu M, Hammershaimb L, Kirkwood JM (2010) A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - dacarbazine in patients with stage IV metastatic melanoma. Cancer 116:1526–1534
-
(2010)
Cancer
, vol.116
, pp. 1526-1534
-
-
Hersey, P.1
Sosman, J.2
O’Day, S.3
Richards, J.4
Bedikian, A.5
Gonzalez, R.6
Sharfman, W.7
Weber, R.8
Logan, T.9
Buzoianu, M.10
Hammershaimb, L.11
Kirkwood, J.M.12
-
43
-
-
84866434918
-
TGF-beta and alphavbeta6 integrin act in a common pathway to suppress pancreatic cancer progression
-
COI: 1:CAS:528:DC%2BC38XhtlygtbnI, PID: 22787119
-
Hezel AF, Deshpande V, Zimmerman SM, Contino G, Alagesan B, O’Dell MR, Rivera LB, Harper J, Lonning S, Brekken RA, Bardeesy N (2012) TGF-beta and alphavbeta6 integrin act in a common pathway to suppress pancreatic cancer progression. Cancer Res 72:4840–4845
-
(2012)
Cancer Res
, vol.72
, pp. 4840-4845
-
-
Hezel, A.F.1
Deshpande, V.2
Zimmerman, S.M.3
Contino, G.4
Alagesan, B.5
O’Dell, M.R.6
Rivera, L.B.7
Harper, J.8
Lonning, S.9
Brekken, R.A.10
Bardeesy, N.11
-
44
-
-
84943369787
-
Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma
-
COI: 1:CAS:528:DC%2BC2MXntlWlt7k%3D, PID: 25824984
-
Hou X, Wu X, Huang P, Zhan J, Zhou T, Ma Y, Qin T, Luo R, Feng Y, Xu Y, Chen L, Zhang L (2015) Osteopontin is a useful predictor of bone metastasis and survival in patients with locally advanced nasopharyngeal carcinoma. Int J Cancer 137:1672–1678
-
(2015)
Int J Cancer
, vol.137
, pp. 1672-1678
-
-
Hou, X.1
Wu, X.2
Huang, P.3
Zhan, J.4
Zhou, T.5
Ma, Y.6
Qin, T.7
Luo, R.8
Feng, Y.9
Xu, Y.10
Chen, L.11
Zhang, L.12
-
45
-
-
84953296867
-
The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer
-
Hu H, Hang JJ, Han T, Zhuo M, Jiao F, Wang LW (2016) The M2 phenotype of tumor-associated macrophages in the stroma confers a poor prognosis in pancreatic cancer. Tumour Biol. doi:10.1007/s13277-015-4741-z
-
(2016)
Tumour Biol
-
-
Hu, H.1
Hang, J.J.2
Han, T.3
Zhuo, M.4
Jiao, F.5
Wang, L.W.6
-
46
-
-
84907218872
-
Effects of integrin ανβ3 on differentiation and collagen synthesis induced by connective tissue growth factor in human hypertrophic scar fibroblasts
-
COI: 1:CAS:528:DC%2BC2cXitVOht7jO, PID: 25174803
-
Hu X, Li N, Tao K, Fang X, Liu J, Wang Y, Wang H, Shi J, Wang Y, Ji P, Cai W, Bai X, Zhu X, Han J, Hu D (2014) Effects of integrin ανβ3 on differentiation and collagen synthesis induced by connective tissue growth factor in human hypertrophic scar fibroblasts. Int J Mol Med 34:1323–1334
-
(2014)
Int J Mol Med
, vol.34
, pp. 1323-1334
-
-
Hu, X.1
Li, N.2
Tao, K.3
Fang, X.4
Liu, J.5
Wang, Y.6
Wang, H.7
Shi, J.8
Wang, Y.9
Ji, P.10
Cai, W.11
Bai, X.12
Zhu, X.13
Han, J.14
Hu, D.15
-
47
-
-
15844376477
-
Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
-
COI: 1:CAS:528:DyaK28XjtF2kurs%3D, PID: 8666675
-
Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV Jr, Sheppard D (1996) Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol 133:921–928
-
(1996)
J Cell Biol
, vol.133
, pp. 921-928
-
-
Huang, X.Z.1
Wu, J.F.2
Cass, D.3
Erle, D.J.4
Corry, D.5
Young, S.G.6
Farese, R.V.7
Sheppard, D.8
-
48
-
-
67449095769
-
Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BD1MXksVSruro%3D, PID: 19288017
-
Huang X, Xiao DW, Xu LY, Zhong HJ, Liao LD, Xie ZF, Li EM (2009) Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma. Oncol Rep 21:1123–1129
-
(2009)
Oncol Rep
, vol.21
, pp. 1123-1129
-
-
Huang, X.1
Xiao, D.W.2
Xu, L.Y.3
Zhong, H.J.4
Liao, L.D.5
Xie, Z.F.6
Li, E.M.7
-
49
-
-
0033983168
-
Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study
-
COI: 1:STN:280:DC%2BD3c%2FosleitA%3D%3D, PID: 10619790
-
Hubbard R, Venn A, Lewis S, Britton J (2000) Lung cancer and cryptogenic fibrosing alveolitis. A population-based cohort study. Am J Respir Crit Care Med 161:5–8
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 5-8
-
-
Hubbard, R.1
Venn, A.2
Lewis, S.3
Britton, J.4
-
50
-
-
84941779973
-
Perivascular M2 macrophages stimulate tumor relapse after chemotherapy
-
COI: 1:CAS:528:DC%2BC2MXhsVWqtLnI, PID: 26269531
-
Hughes R, Qian BZ, Rowan C, Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW, Lewis CE (2015) Perivascular M2 macrophages stimulate tumor relapse after chemotherapy. Cancer Res 75:3479–3491
-
(2015)
Cancer Res
, vol.75
, pp. 3479-3491
-
-
Hughes, R.1
Qian, B.Z.2
Rowan, C.3
Muthana, M.4
Keklikoglou, I.5
Olson, O.C.6
Tazzyman, S.7
Danson, S.8
Addison, C.9
Clemons, M.10
Gonzalez-Angulo, A.M.11
Joyce, J.A.12
De Palma, M.13
Pollard, J.W.14
Lewis, C.E.15
-
51
-
-
79551647444
-
Switching TGFbeta from a tumor suppressor to a tumor promoter
-
COI: 1:CAS:528:DC%2BC3MXhvFKjurw%3D, PID: 21251810
-
Inman GJ (2011) Switching TGFbeta from a tumor suppressor to a tumor promoter. Curr Opin Genet Dev 21:93–99
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 93-99
-
-
Inman, G.J.1
-
52
-
-
43049146157
-
The role of proteases in transforming growth factor-beta activation
-
COI: 1:CAS:528:DC%2BD1cXlslGltb0%3D, PID: 18243766
-
Jenkins G (2008) The role of proteases in transforming growth factor-beta activation. Int J Biochem Cell Biol 40:1068–1078
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1068-1078
-
-
Jenkins, G.1
-
53
-
-
33846675282
-
Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis
-
COI: 1:CAS:528:DC%2BD2sXhs1Wkt7c%3D, PID: 17053163
-
Jeon SH, Chae BC, Kim HA, Seo GY, Seo DW, Chun GT, Kim NS, Yie SW, Byeon WH, Eom SH, Ha KS, Kim YM, Kim PH (2007) Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. J Leukoc Biol 81:557–566
-
(2007)
J Leukoc Biol
, vol.81
, pp. 557-566
-
-
Jeon, S.H.1
Chae, B.C.2
Kim, H.A.3
Seo, G.Y.4
Seo, D.W.5
Chun, G.T.6
Kim, N.S.7
Yie, S.W.8
Byeon, W.H.9
Eom, S.H.10
Ha, K.S.11
Kim, Y.M.12
Kim, P.H.13
-
54
-
-
79960808454
-
Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors
-
COI: 1:CAS:528:DC%2BC3cXhsFajsrzF
-
Jotzu C, Alt E, Welte G, Li J, Hennessy BT, Devarajan E, Krishnappa S, Pinilla S, Droll L, Song YH (2010) Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors. Anal Cell Pathol (Amst) 33:61-79
-
(2010)
Anal Cell Pathol (Amst)
, vol.33
, pp. 61-79
-
-
Jotzu, C.1
Alt, E.2
Welte, G.3
Li, J.4
Hennessy, B.T.5
Devarajan, E.6
Krishnappa, S.7
Pinilla, S.8
Droll, L.9
Song, Y.H.10
-
55
-
-
77954243065
-
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
-
COI: 1:CAS:528:DC%2BC3cXot1Wmur4%3D, PID: 20526329
-
Jun JI, Lau LF (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12:676–685
-
(2010)
Nat Cell Biol
, vol.12
, pp. 676-685
-
-
Jun, J.I.1
Lau, L.F.2
-
56
-
-
0028806184
-
Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
-
COI: 1:CAS:528:DyaK2MXpvVCksLk%3D, PID: 7493022
-
Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J (1995) Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 11:415–421
-
(1995)
Nat Genet
, vol.11
, pp. 415-421
-
-
Kaartinen, V.1
Voncken, J.W.2
Shuler, C.3
Warburton, D.4
Bu, D.5
Heisterkamp, N.6
Groffen, J.7
-
57
-
-
68549123472
-
New regulatory mechanisms of TGF-beta receptor function
-
COI: 1:CAS:528:DC%2BD1MXhtVSitLjF, PID: 19648010
-
Kang JS, Liu C, Derynck R (2009) New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol 19:385–394
-
(2009)
Trends Cell Biol
, vol.19
, pp. 385-394
-
-
Kang, J.S.1
Liu, C.2
Derynck, R.3
-
58
-
-
84959497239
-
Cilengitide with metronomic temozolomide, procarbazine, and standard radiotherapy in patients with glioblastoma and unmethylated MGMT gene promoter in ExCentric, an open-label phase II trial
-
COI: 1:CAS:528:DC%2BC28Xjslyisb4%3D
-
Khasraw M, Lee A, McCowatt S, Kerestes Z, Buyse ME, Back M, Kichenadasse G, Ackland S, Wheeler H (2016) Cilengitide with metronomic temozolomide, procarbazine, and standard radiotherapy in patients with glioblastoma and unmethylated MGMT gene promoter in ExCentric, an open-label phase II trial. J Neuro-Oncol 128:163–171
-
(2016)
J Neuro-Oncol
, vol.128
, pp. 163-171
-
-
Khasraw, M.1
Lee, A.2
McCowatt, S.3
Kerestes, Z.4
Buyse, M.E.5
Back, M.6
Kichenadasse, G.7
Ackland, S.8
Wheeler, H.9
-
59
-
-
84944279759
-
The role of osteopontin expression in melanoma progression
-
COI: 1:CAS:528:DC%2BC2MXhs12jtL7K, PID: 25944164
-
Kiss T, Ecsedi S, Vizkeleti L, Koroknai V, Emri G, Kovacs N, Adany R, Balazs M (2015) The role of osteopontin expression in melanoma progression. Tumour Biol 36:7841–7847
-
(2015)
Tumour Biol
, vol.36
, pp. 7841-7847
-
-
Kiss, T.1
Ecsedi, S.2
Vizkeleti, L.3
Koroknai, V.4
Emri, G.5
Kovacs, N.6
Adany, R.7
Balazs, M.8
-
60
-
-
84910601354
-
Prestress in the extracellular matrix sensitizes latent TGF-beta1 for activation
-
COI: 1:CAS:528:DC%2BC2cXhvVKrtLjJ, PID: 25332161
-
Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Genot E, Hinz B (2014) Prestress in the extracellular matrix sensitizes latent TGF-beta1 for activation. J Cell Biol 207:283–297
-
(2014)
J Cell Biol
, vol.207
, pp. 283-297
-
-
Klingberg, F.1
Chow, M.L.2
Koehler, A.3
Boo, S.4
Buscemi, L.5
Quinn, T.M.6
Costell, M.7
Alman, B.A.8
Genot, E.9
Hinz, B.10
-
61
-
-
85048751041
-
Osteopontin-A master regulator of epithelial-mesenchymal transition
-
Kothari AN, Arffa ML, Chang V, Blackwell RH, Syn WK, Zhang J, Mi Z, Kuo PC (2016) Osteopontin-A master regulator of epithelial-mesenchymal transition. J Clin Med 5:39
-
(2016)
J Clin Med
, vol.5
, pp. 39
-
-
Kothari, A.N.1
Arffa, M.L.2
Chang, V.3
Blackwell, R.H.4
Syn, W.K.5
Zhang, J.6
Mi, Z.7
Kuo, P.C.8
-
62
-
-
84902551497
-
Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment
-
COI: 1:CAS:528:DC%2BC2cXhtVSqs7zM, PID: 24674392
-
Kotobuki Y, Yang L, Serada S, Tanemura A, Yang F, Nomura S, Kudo A, Izuhara K, Murota H, Fujimoto M, Katayama I, Naka T (2014) Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment. Pigment Cell Melanoma Res 27:630–639
-
(2014)
Pigment Cell Melanoma Res
, vol.27
, pp. 630-639
-
-
Kotobuki, Y.1
Yang, L.2
Serada, S.3
Tanemura, A.4
Yang, F.5
Nomura, S.6
Kudo, A.7
Izuhara, K.8
Murota, H.9
Fujimoto, M.10
Katayama, I.11
Naka, T.12
-
63
-
-
84893858450
-
Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells
-
PID: 24578639
-
Krstic J, Santibanez JF (2014) Transforming growth factor-beta and matrix metalloproteinases: functional interactions in tumor stroma-infiltrating myeloid cells. ScientificWorldJournal 2014:521754
-
(2014)
ScientificWorldJournal
, vol.2014
, pp. 521754
-
-
Krstic, J.1
Santibanez, J.F.2
-
64
-
-
0027531528
-
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
-
COI: 1:CAS:528:DyaK3sXhtVShtrY%3D, PID: 8421714
-
Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, Roberts AB, Sporn MB, Ward JM, Karlsson S (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 90:770–774
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 770-774
-
-
Kulkarni, A.B.1
Huh, C.G.2
Becker, D.3
Geiser, A.4
Lyght, M.5
Flanders, K.C.6
Roberts, A.B.7
Sporn, M.B.8
Ward, J.M.9
Karlsson, S.10
-
65
-
-
84962799595
-
p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression
-
PID: 26930720
-
Landre V, Antonov A, Knight R, Melino G (2016) p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression. Oncotarget 7:11785–11802
-
(2016)
Oncotarget
, vol.7
, pp. 11785-11802
-
-
Landre, V.1
Antonov, A.2
Knight, R.3
Melino, G.4
-
66
-
-
80052925829
-
CCN1/CYR61: the very model of a modern matricellular protein
-
COI: 1:CAS:528:DC%2BC3MXhtFyjsrnP, PID: 21805345
-
Lau LF (2011) CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 68:3149–3163
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 3149-3163
-
-
Lau, L.F.1
-
67
-
-
84903942419
-
Integrin 1: a mechanosignaling sensor essential for connective tissue deposition by fibroblasts
-
Leask A (2013) Integrin 1: a mechanosignaling sensor essential for connective tissue deposition by fibroblasts. Adv Wound Care 2:160–166
-
(2013)
Adv Wound Care
, vol.2
, pp. 160-166
-
-
Leask, A.1
-
68
-
-
57349137178
-
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism
-
COI: 1:CAS:528:DC%2BD1cXhsVOgsLfO, PID: 18713838
-
Lee YH, Albig AR, Regner M, Schiemann BJ, Schiemann WP (2008) Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis 29:2243–2251
-
(2008)
Carcinogenesis
, vol.29
, pp. 2243-2251
-
-
Lee, Y.H.1
Albig, A.R.2
Regner, M.3
Schiemann, B.J.4
Schiemann, W.P.5
-
69
-
-
39449091122
-
Osteopontin expression is required for myofibroblast differentiation
-
COI: 1:CAS:528:DC%2BD1cXhslGku7s%3D, PID: 18079410
-
Lenga Y, Koh A, Perera AS, McCulloch CA, Sodek J, Zohar R (2008)Osteopontin expression is required for myofibroblast differentiation.Circ Res 102:319–327
-
(2008)
Circ Res
, vol.102
, pp. 319-327
-
-
Lenga, Y.1
Koh, A.2
Perera, A.S.3
McCulloch, C.A.4
Sodek, J.5
Zohar, R.6
-
70
-
-
24344483878
-
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
-
COI: 1:CAS:528:DC%2BD2MXhtVWisL3N, PID: 16135802
-
Levy L, Hill CS (2005) Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 25:8108–8125
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8108-8125
-
-
Levy, L.1
Hill, C.S.2
-
71
-
-
1642334157
-
Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
-
COI: 1:CAS:528:DC%2BD2cXht12iurY%3D, PID: 14970860
-
Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ (2004) Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br J Cancer 90:822–832
-
(2004)
Br J Cancer
, vol.90
, pp. 822-832
-
-
Lewis, M.P.1
Lygoe, K.A.2
Nystrom, M.L.3
Anderson, W.P.4
Speight, P.M.5
Marshall, J.F.6
Thomas, G.J.7
-
72
-
-
0035865163
-
Angiogenesis in breast cancer: the role of transforming growth factor beta and CD105
-
COI: 1:CAS:528:DC%2BD3MXhsl2jtro%3D, PID: 11170303
-
Li C, Guo B, Bernabeu C, Kumar S (2001) Angiogenesis in breast cancer: the role of transforming growth factor beta and CD105. Microsc Res Tech 52:437–449
-
(2001)
Microsc Res Tech
, vol.52
, pp. 437-449
-
-
Li, C.1
Guo, B.2
Bernabeu, C.3
Kumar, S.4
-
73
-
-
84954317176
-
Mechanistic basis and clinical relevance of the role of transforming growth factor-beta in cancer
-
PID: 26779375
-
Lin RL, Zhao LJ (2015) Mechanistic basis and clinical relevance of the role of transforming growth factor-beta in cancer. Cancer Biol Med 12:385–393
-
(2015)
Cancer Biol Med
, vol.12
, pp. 385-393
-
-
Lin, R.L.1
Zhao, L.J.2
-
74
-
-
24044481029
-
Characterization of integrin beta6 and thrombospondin-1 double-null mice
-
COI: 1:CAS:528:DC%2BD2sXlvFClu7s%3D, PID: 15963261
-
Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J (2005) Characterization of integrin beta6 and thrombospondin-1 double-null mice. J Cell Mol Med 9:421–437
-
(2005)
J Cell Mol Med
, vol.9
, pp. 421-437
-
-
Ludlow, A.1
Yee, K.O.2
Lipman, R.3
Bronson, R.4
Weinreb, P.5
Huang, X.6
Sheppard, D.7
Lawler, J.8
-
75
-
-
84939572294
-
Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer
-
COI: 1:CAS:528:DC%2BC2MXisFCisLk%3D, PID: 25708906
-
Malik R, Lelkes PI, Cukierman E (2015) Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends Biotechnol 33:230–236
-
(2015)
Trends Biotechnol
, vol.33
, pp. 230-236
-
-
Malik, R.1
Lelkes, P.I.2
Cukierman, E.3
-
76
-
-
84857613435
-
aV integrins and TGF-beta-induced EMT: a circle of regulation
-
COI: 1:CAS:528:DC%2BC38XltV2ku7s%3D, PID: 21883891
-
Mamuya FA, Duncan MK (2012) aV integrins and TGF-beta-induced EMT: a circle of regulation. J Cell Mol Med 16:445–455
-
(2012)
J Cell Mol Med
, vol.16
, pp. 445-455
-
-
Mamuya, F.A.1
Duncan, M.K.2
-
77
-
-
75949103899
-
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
-
COI: 1:CAS:528:DC%2BC3cXlvFGmuw%3D%3D, PID: 20075988
-
Margadant C, Sonnenberg A (2010) Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 11:97–105
-
(2010)
EMBO Rep
, vol.11
, pp. 97-105
-
-
Margadant, C.1
Sonnenberg, A.2
-
78
-
-
44849121993
-
Alpha vbeta 6 integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation
-
COI: 1:CAS:528:DC%2BD1cXltlSls78%3D
-
Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ (2008) Alpha vbeta 6 integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res 68:3295–3303
-
(2008)
Cancer Res
, vol.68
, pp. 3295-3303
-
-
Marsh, D.1
Dickinson, S.2
Neill, G.W.3
Marshall, J.F.4
Hart, I.R.5
Thomas, G.J.6
-
79
-
-
79551692337
-
Stromal features are predictive of disease mortality in oral cancer patients
-
COI: 1:CAS:528:DC%2BC3MXkt1Siu7g%3D, PID: 21294121
-
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N, Violette SM, Weinreb PH, Chester KA, Chana JS, Marshall JF, Hart IR, Hackshaw AK, Piper K, Thomas GJ (2011) Stromal features are predictive of disease mortality in oral cancer patients. J Pathol 223:470–481
-
(2011)
J Pathol
, vol.223
, pp. 470-481
-
-
Marsh, D.1
Suchak, K.2
Moutasim, K.A.3
Vallath, S.4
Hopper, C.5
Jerjes, W.6
Upile, T.7
Kalavrezos, N.8
Violette, S.M.9
Weinreb, P.H.10
Chester, K.A.11
Chana, J.S.12
Marshall, J.F.13
Hart, I.R.14
Hackshaw, A.K.15
Piper, K.16
Thomas, G.J.17
-
80
-
-
84956574782
-
Suppression of TGFbeta and angiogenesis by type VII collagen in cutaneous SCC
-
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kahari VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O’Toole EA (2016) Suppression of TGFbeta and angiogenesis by type VII collagen in cutaneous SCC. J Natl Cancer Inst 108:djv293
-
(2016)
J Natl Cancer Inst
, vol.108
, pp. djv293
-
-
Martins, V.L.1
Caley, M.P.2
Moore, K.3
Szentpetery, Z.4
Marsh, S.T.5
Murrell, D.F.6
Kim, M.H.7
Avari, M.8
McGrath, J.A.9
Cerio, R.10
Kivisaari, A.11
Kahari, V.M.12
Hodivala-Dilke, K.13
Brennan, C.H.14
Chen, M.15
Marshall, J.F.16
O’Toole, E.A.17
-
81
-
-
77951235064
-
Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase
-
COI: 1:CAS:528:DC%2BC3cXkvVGisbc%3D, PID: 20181949
-
Maruhashi T, Kii I, Saito M, Kudo A (2010) Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase. J Biol Chem 285:13294–13303
-
(2010)
J Biol Chem
, vol.285
, pp. 13294-13303
-
-
Maruhashi, T.1
Kii, I.2
Saito, M.3
Kudo, A.4
-
82
-
-
79956296631
-
CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis
-
COI: 1:CAS:528:DC%2BC3MXmtFSrsbk%3D, PID: 21502514
-
McNally A, Hill GR, Sparwasser T, Thomas R, Steptoe RJ (2011) CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 108:7529–7534
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 7529-7534
-
-
McNally, A.1
Hill, G.R.2
Sparwasser, T.3
Thomas, R.4
Steptoe, R.J.5
-
83
-
-
33646596637
-
Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition
-
COI: 1:CAS:528:DC%2BD28XltlWjsL8%3D, PID: 16467384
-
Medici D, Hay ED, Goodenough DA (2006) Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell 17:1871–1879
-
(2006)
Mol Biol Cell
, vol.17
, pp. 1871-1879
-
-
Medici, D.1
Hay, E.D.2
Goodenough, D.A.3
-
84
-
-
84894565577
-
Insidious changes in stromal matrix fuel cancer progression
-
COI: 1:CAS:528:DC%2BC2cXksFygsLc%3D, PID: 24452359
-
Miles FL, Sikes RA (2014) Insidious changes in stromal matrix fuel cancer progression. Mol Cancer Res 12:297–312
-
(2014)
Mol Cancer Res
, vol.12
, pp. 297-312
-
-
Miles, F.L.1
Sikes, R.A.2
-
85
-
-
84938417863
-
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
-
COI: 1:CAS:528:DC%2BC2MXpvFamsr8%3D, PID: 26077591
-
Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Mol Med 7:1063–1076
-
(2015)
EMBO Mol Med
, vol.7
, pp. 1063-1076
-
-
Miller, B.W.1
Morton, J.P.2
Pinese, M.3
Saturno, G.4
Jamieson, N.B.5
McGhee, E.6
Timpson, P.7
Leach, J.8
McGarry, L.9
Shanks, E.10
Bailey, P.11
Chang, D.12
Oien, K.13
Karim, S.14
Au, A.15
Steele, C.16
Carter, C.R.17
McKay, C.18
Anderson, K.19
Evans, T.R.20
Marais, R.21
Springer, C.22
Biankin, A.23
Erler, J.T.24
Sansom, O.J.25
more..
-
86
-
-
33750621551
-
Organ-specific endoglin (CD105) expression in the angiogenesis of human cancers
-
COI: 1:CAS:528:DC%2BD2sXksFKmtA%3D%3D, PID: 17096728
-
Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, Tokunaga O (2006) Organ-specific endoglin (CD105) expression in the angiogenesis of human cancers. Pathol Int 56:717–723
-
(2006)
Pathol Int
, vol.56
, pp. 717-723
-
-
Minhajat, R.1
Mori, D.2
Yamasaki, F.3
Sugita, Y.4
Satoh, T.5
Tokunaga, O.6
-
87
-
-
84959105586
-
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-beta
-
COI: 1:CAS:528:DC%2BC28XivVKltLs%3D, PID: 26901152
-
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyarto BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH (2016) Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-beta. Nat Immunol 17:414–421
-
(2016)
Nat Immunol
, vol.17
, pp. 414-421
-
-
Mohammed, J.1
Beura, L.K.2
Bobr, A.3
Astry, B.4
Chicoine, B.5
Kashem, S.W.6
Welty, N.E.7
Igyarto, B.Z.8
Wijeyesinghe, S.9
Thompson, E.A.10
Matte, C.11
Bartholin, L.12
Kaplan, A.13
Sheppard, D.14
Bridges, A.G.15
Shlomchik, W.D.16
Masopust, D.17
Kaplan, D.H.18
-
88
-
-
84904908675
-
Therapeutic targeting of integrin alphavbeta6 in breast cancer
-
PID: 24974129
-
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb PH, Kendrew J, Barry ST, Hart IR, Jones JL, Marshall JF (2014) Therapeutic targeting of integrin alphavbeta6 in breast cancer. J Natl Cancer Inst 106:dju169
-
(2014)
J Natl Cancer Inst
, vol.106
, pp. dju169
-
-
Moore, K.M.1
Thomas, G.J.2
Duffy, S.W.3
Warwick, J.4
Gabe, R.5
Chou, P.6
Ellis, I.O.7
Green, A.R.8
Haider, S.9
Brouilette, K.10
Saha, A.11
Vallath, S.12
Bowen, R.13
Chelala, C.14
Eccles, D.15
Tapper, W.J.16
Thompson, A.M.17
Quinlan, P.18
Jordan, L.19
Gillett, C.20
Brentnall, A.21
Violette, S.22
Weinreb, P.H.23
Kendrew, J.24
Barry, S.T.25
Hart, I.R.26
Jones, J.L.27
Marshall, J.F.28
more..
-
89
-
-
84947442283
-
Enhanced expression of integrin alphavbeta3 induced by TGF-beta is required for the enhancing effect of fibroblast growth factor 1 (FGF1) in TGF-beta-induced epithelial-mesenchymal transition (EMT) in mammary epithelial cells
-
Mori S, Kodaira M, Ito A, Okazaki M, Kawaguchi N, Hamada Y, Takada Y, Matsuura N (2015) Enhanced expression of integrin alphavbeta3 induced by TGF-beta is required for the enhancing effect of fibroblast growth factor 1 (FGF1) in TGF-beta-induced epithelial-mesenchymal transition (EMT) in mammary epithelial cells. PLoS One 10:e0137486
-
(2015)
PLoS One
, vol.10
-
-
Mori, S.1
Kodaira, M.2
Ito, A.3
Okazaki, M.4
Kawaguchi, N.5
Hamada, Y.6
Takada, Y.7
Matsuura, N.8
-
90
-
-
0037435009
-
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
-
COI: 1:CAS:528:DC%2BD3sXhvFKgsr4%3D, PID: 12634787
-
Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D (2003) Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 422:169–173
-
(2003)
Nature
, vol.422
, pp. 169-173
-
-
Morris, D.G.1
Huang, X.2
Kaminski, N.3
Wang, Y.4
Shapiro, S.D.5
Dolganov, G.6
Glick, A.7
Sheppard, D.8
-
91
-
-
0037192933
-
The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
-
COI: 1:CAS:528:DC%2BD38XjtleltLk%3D, PID: 11970960
-
Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL (2002) The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol 157:493–507
-
(2002)
J Cell Biol
, vol.157
, pp. 493-507
-
-
Mu, D.1
Cambier, S.2
Fjellbirkeland, L.3
Baron, J.L.4
Munger, J.S.5
Kawakatsu, H.6
Sheppard, D.7
Broaddus, V.C.8
Nishimura, S.L.9
-
92
-
-
0033524949
-
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
-
COI: 1:CAS:528:DyaK1MXht1eqsrY%3D, PID: 10025398
-
Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D (1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96:319–328
-
(1999)
Cell
, vol.96
, pp. 319-328
-
-
Munger, J.S.1
Huang, X.2
Kawakatsu, H.3
Griffiths, M.J.4
Dalton, S.L.5
Wu, J.6
Pittet, J.F.7
Kaminski, N.8
Garat, C.9
Matthay, M.A.10
Rifkin, D.B.11
Sheppard, D.12
-
93
-
-
84878183437
-
Snail and Slug, key regulators of TGF-beta-induced EMT, are sufficient for the induction of single-cell invasion
-
COI: 1:CAS:528:DC%2BC3sXnslahtbk%3D, PID: 23618854
-
Naber HP, Drabsch Y, Snaar-Jagalska BE, ten Dijke P, van Laar T (2013) Snail and Slug, key regulators of TGF-beta-induced EMT, are sufficient for the induction of single-cell invasion. Biochem Biophys Res Commun 435:58–63
-
(2013)
Biochem Biophys Res Commun
, vol.435
, pp. 58-63
-
-
Naber, H.P.1
Drabsch, Y.2
Snaar-Jagalska, B.E.3
ten Dijke, P.4
van Laar, T.5
-
94
-
-
84870474547
-
Suppression, subversion and escape: the role of regulatory T cells in cancer progression
-
COI: 1:CAS:528:DC%2BC38XhslKrtLrM, PID: 23199321
-
Oleinika K, Nibbs RJ, Graham GJ, Fraser AR (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clin Exp Immunol 171:36–45
-
(2013)
Clin Exp Immunol
, vol.171
, pp. 36-45
-
-
Oleinika, K.1
Nibbs, R.J.2
Graham, G.J.3
Fraser, A.R.4
-
95
-
-
80053186583
-
Controlling angiogenesis by two unique TGF-beta type I receptor signaling pathways
-
COI: 1:CAS:528:DC%2BC3MXhtVOnt7rI
-
Orlova VV, Liu Z, Goumans MJ, ten Dijke P (2011) Controlling angiogenesis by two unique TGF-beta type I receptor signaling pathways. Histol Histopathol 26:1219–1230
-
(2011)
Histol Histopathol
, vol.26
, pp. 1219-1230
-
-
Orlova, V.V.1
Liu, Z.2
Goumans, M.J.3
ten Dijke, P.4
-
96
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
COI: 1:CAS:528:DC%2BC2cXosl2hsr0%3D, PID: 24856586
-
Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R (2014) Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25:719–734
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Ozdemir, B.C.1
Pentcheva-Hoang, T.2
Carstens, J.L.3
Zheng, X.4
Wu, C.C.5
Simpson, T.R.6
Laklai, H.7
Sugimoto, H.8
Kahlert, C.9
Novitskiy, S.V.10
De Jesus-Acosta, A.11
Sharma, P.12
Heidari, P.13
Mahmood, U.14
Chin, L.15
Moses, H.L.16
Weaver, V.M.17
Maitra, A.18
Allison, J.P.19
LeBleu, V.S.20
Kalluri, R.21
more..
-
97
-
-
68949143128
-
Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
-
COI: 1:CAS:528:DC%2BD1MXovFWrtrs%3D, PID: 19487690
-
Pedroja BS, Kang LE, Imas AO, Carmeliet P, Bernstein AM (2009) Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. J Biol Chem 284:20708–20717
-
(2009)
J Biol Chem
, vol.284
, pp. 20708-20717
-
-
Pedroja, B.S.1
Kang, L.E.2
Imas, A.O.3
Carmeliet, P.4
Bernstein, A.M.5
-
98
-
-
84946222780
-
Polarisation of tumor-associated macrophages toward M2 phenotype correlates with poor response to chemoradiation and reduced survival in patients with locally advanced cervical cancer
-
PID: 26335330
-
Petrillo M, Zannoni GF, Martinelli E, Pedone Anchora L, Ferrandina G, Tropeano G, Fagotti A, Scambia G (2015) Polarisation of tumor-associated macrophages toward M2 phenotype correlates with poor response to chemoradiation and reduced survival in patients with locally advanced cervical cancer. PLoS One 10:e0136654
-
(2015)
PLoS One
, vol.10
-
-
Petrillo, M.1
Zannoni, G.F.2
Martinelli, E.3
Pedone Anchora, L.4
Ferrandina, G.5
Tropeano, G.6
Fagotti, A.7
Scambia, G.8
-
99
-
-
84888639681
-
The roles of TGFbeta in the tumour microenvironment
-
COI: 1:CAS:528:DC%2BC3sXhs1ersb7F, PID: 24132110
-
Pickup M, Novitskiy S, Moses HL (2013) The roles of TGFbeta in the tumour microenvironment. Nat Rev Cancer 13:788–799
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 788-799
-
-
Pickup, M.1
Novitskiy, S.2
Moses, H.L.3
-
100
-
-
79960005608
-
The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites
-
COI: 1:CAS:528:DC%2BC3MXnsFWjsLY%3D, PID: 21609000
-
Platzer G, Schedlbauer A, Chemelli A, Ozdowy P, Coudevylle N, Auer R, Kontaxis G, Hartl M, Miles AJ, Wallace BA, Glatter O, Bister K, Konrat R (2011) The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites. Biochemistry 50:6113–6124
-
(2011)
Biochemistry
, vol.50
, pp. 6113-6124
-
-
Platzer, G.1
Schedlbauer, A.2
Chemelli, A.3
Ozdowy, P.4
Coudevylle, N.5
Auer, R.6
Kontaxis, G.7
Hartl, M.8
Miles, A.J.9
Wallace, B.A.10
Glatter, O.11
Bister, K.12
Konrat, R.13
-
101
-
-
0035706407
-
A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer
-
COI: 1:CAS:528:DC%2BD3MXktF2hu7k%3D, PID: 11385959
-
Posey JA, Khazaeli MB, DelGrosso A, Saleh MN, Lin CY, Huse W, LoBuglio AF (2001) A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer. Cancer Biother Radiopharm 16:125–132
-
(2001)
Cancer Biother Radiopharm
, vol.16
, pp. 125-132
-
-
Posey, J.A.1
Khazaeli, M.B.2
DelGrosso, A.3
Saleh, M.N.4
Lin, C.Y.5
Huse, W.6
LoBuglio, A.F.7
-
102
-
-
84969706136
-
TGFbeta signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis
-
Principe DR, DeCant B, Mascarinas E, Wayne E, Diaz A, Akagi N, Hwang RF, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, (in press)
-
Principe DR, DeCant B, Mascarinas E, Wayne E, Diaz A, Akagi N, Hwang RF, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ (2016) TGFbeta signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis. Cancer Res (in press)
-
(2016)
Cancer Res
-
-
-
103
-
-
33846782878
-
Collagen reorganization at the tumor-stromal interface facilitates local invasion
-
PID: 17190588
-
Provenzano PP, Eliceiri KW, Campbell JM, Inman DR, White JG, Keely PJ (2006) Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med 4:38
-
(2006)
BMC Med
, vol.4
, pp. 38
-
-
Provenzano, P.P.1
Eliceiri, K.W.2
Campbell, J.M.3
Inman, D.R.4
White, J.G.5
Keely, P.J.6
-
104
-
-
84957556829
-
TGFbeta3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis
-
COI: 1:CAS:528:DC%2BC28XisVait7s%3D
-
Qin X, Yan M, Zhang J, Wang X, Shen Z, Lv Z, Li Z, Wei W, Chen W (2016) TGFbeta3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis. Sci Rep 6:20587
-
(2016)
Sci Rep
, vol.6
, pp. 20587
-
-
Qin, X.1
Yan, M.2
Zhang, J.3
Wang, X.4
Shen, Z.5
Lv, Z.6
Li, Z.7
Wei, W.8
Chen, W.9
-
105
-
-
64149106522
-
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors
-
COI: 1:CAS:528:DC%2BD1MXjsVCqtb4%3D, PID: 19305413
-
Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med 15:392–400
-
(2009)
Nat Med
, vol.15
, pp. 392-400
-
-
Reynolds, A.R.1
Hart, I.R.2
Watson, A.R.3
Welti, J.C.4
Silva, R.G.5
Robinson, S.D.6
Da Violante, G.7
Gourlaouen, M.8
Salih, M.9
Jones, M.C.10
Jones, D.T.11
Saunders, G.12
Kostourou, V.13
Perron-Sierra, F.14
Norman, J.C.15
Tucker, G.C.16
Hodivala-Dilke, K.M.17
-
106
-
-
20044380507
-
Accelerated re-epithelialization in beta3-integrin-deficient-mice is associated with enhanced TGF-beta1 signaling
-
COI: 1:CAS:528:DC%2BD2MXpvF2ntA%3D%3D, PID: 15654327
-
Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A, Hodivala-Dilke K (2005) Accelerated re-epithelialization in beta3-integrin-deficient-mice is associated with enhanced TGF-beta1 signaling. Nat Med 11:167–174
-
(2005)
Nat Med
, vol.11
, pp. 167-174
-
-
Reynolds, L.E.1
Conti, F.J.2
Lucas, M.3
Grose, R.4
Robinson, S.5
Stone, M.6
Saunders, G.7
Dickson, C.8
Hynes, R.O.9
Lacy-Hulbert, A.10
Hodivala-Dilke, K.11
-
107
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
COI: 1:CAS:528:DC%2BC2cXoslyisbc%3D, PID: 24856585
-
Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ (2014) Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25:735–747
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
Oberstein, P.E.2
Thomas, D.H.3
Mirek, E.T.4
Palermo, C.F.5
Sastra, S.A.6
Dekleva, E.N.7
Saunders, T.8
Becerra, C.P.9
Tattersall, I.W.10
Westphalen, C.B.11
Kitajewski, J.12
Fernandez-Barrena, M.G.13
Fernandez-Zapico, M.E.14
Iacobuzio-Donahue, C.15
Olive, K.P.16
Stanger, B.Z.17
-
108
-
-
0042307513
-
The two faces of transforming growth factor beta in carcinogenesis
-
COI: 1:CAS:528:DC%2BD3sXlvVyisL8%3D, PID: 12861075
-
Roberts AB, Wakefield LM (2003) The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci U S A 100:8621–8623
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8621-8623
-
-
Roberts, A.B.1
Wakefield, L.M.2
-
109
-
-
84943664666
-
Latent TGF-beta-binding proteins
-
COI: 1:CAS:528:DC%2BC2MXos1entL0%3D, PID: 25960419
-
Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB (2015) Latent TGF-beta-binding proteins. Matrix Biol 47:44–53
-
(2015)
Matrix Biol
, vol.47
, pp. 44-53
-
-
Robertson, I.B.1
Horiguchi, M.2
Zilberberg, L.3
Dabovic, B.4
Hadjiolova, K.5
Rifkin, D.B.6
-
110
-
-
0042424548
-
Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
-
COI: 1:CAS:528:DC%2BD3sXmtlykurs%3D, PID: 12874388
-
Rolli M, Fransvea E, Pilch J, Saven A, Felding-Habermann B (2003) Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc Natl Acad Sci U S A 100:9482–9487
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9482-9487
-
-
Rolli, M.1
Fransvea, E.2
Pilch, J.3
Saven, A.4
Felding-Habermann, B.5
-
111
-
-
4344658425
-
Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer
-
COI: 1:CAS:528:DC%2BD2cXmsVOisrg%3D
-
Saad RS, Liu YL, Nathan G, Celebrezze J, Medich D, Silverman JF (2004) Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer. Modern Pathol 17:197–203
-
(2004)
Modern Pathol
, vol.17
, pp. 197-203
-
-
Saad, R.S.1
Liu, Y.L.2
Nathan, G.3
Celebrezze, J.4
Medich, D.5
Silverman, J.F.6
-
112
-
-
84922777488
-
Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer
-
COI: 1:CAS:528:DC%2BC2MXhsVars7w%3D, PID: 25620698
-
Sagiv JY, Michaeli J, Assi S, Mishalian I, Kisos H, Levy L, Damti P, Lumbroso D, Polyansky L, Sionov RV, Ariel A, Hovav AH, Henke E, Fridlender ZG, Granot Z (2015) Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer. Cell Rep 10:562–573
-
(2015)
Cell Rep
, vol.10
, pp. 562-573
-
-
Sagiv, J.Y.1
Michaeli, J.2
Assi, S.3
Mishalian, I.4
Kisos, H.5
Levy, L.6
Damti, P.7
Lumbroso, D.8
Polyansky, L.9
Sionov, R.V.10
Ariel, A.11
Hovav, A.H.12
Henke, E.13
Fridlender, Z.G.14
Granot, Z.15
-
113
-
-
0030609894
-
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
-
COI: 1:CAS:528:DyaK2sXks1artbk%3D, PID: 9217007
-
Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sariola H, Friedman R, Boivin GP, Cardell EL, Doetschman T (1997) TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development 124:2659–2670
-
(1997)
Development
, vol.124
, pp. 2659-2670
-
-
Sanford, L.P.1
Ormsby, I.2
Gittenberger-de Groot, A.C.3
Sariola, H.4
Friedman, R.5
Boivin, G.P.6
Cardell, E.L.7
Doetschman, T.8
-
114
-
-
84966470659
-
Human macrophages induce CD4Foxp3 regulatory T cells via binding and re-release of TGF-beta
-
Schmidt A, Zhang XM, Joshi RN, Iqbal S, Wahlund C, Gabrielsson S, Harris RA, Tegner J, (in press)
-
Schmidt A, Zhang XM, Joshi RN, Iqbal S, Wahlund C, Gabrielsson S, Harris RA, Tegner J (2016) Human macrophages induce CD4Foxp3 regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Biol (in press)
-
(2016)
Immunol Cell Biol
-
-
-
115
-
-
84944386317
-
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis
-
COI: 1:CAS:528:DC%2BC2MXhs1Kks7bE, PID: 26462617
-
Shang B, Liu Y, Jiang SJ (2015) Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis. Sci Rep 5:15179
-
(2015)
Sci Rep
, vol.5
, pp. 15179
-
-
Shang, B.1
Liu, Y.2
Jiang, S.J.3
-
116
-
-
84928724449
-
Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-beta activation by epithelial cells and fibroblasts
-
PID: 25830829
-
Sheppard D (2015) Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-beta activation by epithelial cells and fibroblasts. Ann Am Thorac Soc 12 (Suppl 1):S21–S23
-
(2015)
Ann Am Thorac Soc
, vol.12
, pp. S21-S23
-
-
Sheppard, D.1
-
117
-
-
84907485104
-
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
-
COI: 1:CAS:528:DC%2BC2cXhs1GmtLfO, PID: 25259922
-
Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O’Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM (2014) Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159:80–93
-
(2014)
Cell
, vol.159
, pp. 80-93
-
-
Sherman, M.H.1
Yu, R.T.2
Engle, D.D.3
Ding, N.4
Atkins, A.R.5
Tiriac, H.6
Collisson, E.A.7
Connor, F.8
Van Dyke, T.9
Kozlov, S.10
Martin, P.11
Tseng, T.W.12
Dawson, D.W.13
Donahue, T.R.14
Masamune, A.15
Shimosegawa, T.16
Apte, M.V.17
Wilson, J.S.18
Ng, B.19
Lau, S.L.20
Gunton, J.E.21
Wahl, G.M.22
Hunter, T.23
Drebin, J.A.24
O’Dwyer, P.J.25
Liddle, C.26
Tuveson, D.A.27
Downes, M.28
Evans, R.M.29
more..
-
118
-
-
0026799402
-
Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
-
COI: 1:CAS:528:DyaK3sXjslSqtw%3D%3D, PID: 1436033
-
Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, Allen R, Sidman C, Proetzel G, Calvin D, Annunziata N, Doetschman T (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359:693–699
-
(1992)
Nature
, vol.359
, pp. 693-699
-
-
Shull, M.M.1
Ormsby, I.2
Kier, A.B.3
Pawlowski, S.4
Diebold, R.J.5
Yin, M.6
Allen, R.7
Sidman, C.8
Proetzel, G.9
Calvin, D.10
Annunziata, N.11
Doetschman, T.12
-
119
-
-
53449086315
-
Integrins: the keys to unlocking angiogenesis
-
COI: 1:CAS:528:DC%2BD1cXhtFSmsrfE, PID: 18658045
-
Silva R, D’Amico G, Hodivala-Dilke KM, Reynolds LE (2008) Integrins: the keys to unlocking angiogenesis. Arterioscler Thromb Vasc Biol 28:1703–1713
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1703-1713
-
-
Silva, R.1
D’Amico, G.2
Hodivala-Dilke, K.M.3
Reynolds, L.E.4
-
120
-
-
84955198521
-
The multifaceted roles neutrophils play in the tumor microenvironment
-
COI: 1:CAS:528:DC%2BC2cXpsFelsbY%3D, PID: 24895166
-
Sionov RV, Fridlender ZG, Granot Z (2015) The multifaceted roles neutrophils play in the tumor microenvironment. Cancer Microenviron 8:125–158
-
(2015)
Cancer Microenviron
, vol.8
, pp. 125-158
-
-
Sionov, R.V.1
Fridlender, Z.G.2
Granot, Z.3
-
121
-
-
4644324446
-
Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro
-
COI: 1:STN:280:DC%2BD2cvisF2itw%3D%3D, PID: 15330800
-
Sipos B, Hahn D, Carceller A, Piulats J, Hedderich J, Kalthoff H, Goodman SL, Kosmahl M, Kloppel G (2004) Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro. Histopathology 45:226–236
-
(2004)
Histopathology
, vol.45
, pp. 226-236
-
-
Sipos, B.1
Hahn, D.2
Carceller, A.3
Piulats, J.4
Hedderich, J.5
Kalthoff, H.6
Goodman, S.L.7
Kosmahl, M.8
Kloppel, G.9
-
122
-
-
84953792223
-
Pharmacological characterization of the alphavbeta6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2
-
COI: 1:CAS:528:DC%2BC28Xjt1ymsbw%3D, PID: 26734728
-
Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC (2016) Pharmacological characterization of the alphavbeta6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2. Pharmacology 97:114–125
-
(2016)
Pharmacology
, vol.97
, pp. 114-125
-
-
Slack, R.J.1
Hafeji, M.2
Rogers, R.3
Ludbrook, S.B.4
Marshall, J.F.5
Flint, D.J.6
Pyne, S.7
Denyer, J.C.8
-
123
-
-
55949115356
-
Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells
-
COI: 1:CAS:528:DC%2BD1cXhtlGrur3F, PID: 18941464
-
Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D (2008) Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells. Br J Cancer 99:1656–1667
-
(2008)
Br J Cancer
, vol.99
, pp. 1656-1667
-
-
Sun, Z.J.1
Wang, Y.2
Cai, Z.3
Chen, P.P.4
Tong, X.J.5
Xie, D.6
-
124
-
-
84958025713
-
Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma
-
PID: 26716408
-
Sung PL, Jan YH, Lin SC, Huang CC, Lin H, Wen KC, Chao KC, Lai CR, Wang PH, Chuang CM, Wu HH, Twu NF, Yen MS, Hsiao M, Huang CY (2016) Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma. Oncotarget 7:4036–4047
-
(2016)
Oncotarget
, vol.7
, pp. 4036-4047
-
-
Sung, P.L.1
Jan, Y.H.2
Lin, S.C.3
Huang, C.C.4
Lin, H.5
Wen, K.C.6
Chao, K.C.7
Lai, C.R.8
Wang, P.H.9
Chuang, C.M.10
Wu, H.H.11
Twu, N.F.12
Yen, M.S.13
Hsiao, M.14
Huang, C.Y.15
-
125
-
-
77955472749
-
A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis
-
COI: 1:CAS:528:DC%2BC3cXntVSrtbc%3D, PID: 20531304
-
Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH (2010) A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Oncogene 29:4460–4472
-
(2010)
Oncogene
, vol.29
, pp. 4460-4472
-
-
Tchaicha, J.H.1
Mobley, A.K.2
Hossain, M.G.3
Aldape, K.D.4
McCarty, J.H.5
-
126
-
-
80054044019
-
Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by beta8 integrin
-
COI: 1:CAS:528:DC%2BC3MXhtlSltLvL, PID: 21859829
-
Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (2011) Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by beta8 integrin. Cancer Res 71:6371–6381
-
(2011)
Cancer Res
, vol.71
, pp. 6371-6381
-
-
Tchaicha, J.H.1
Reyes, S.B.2
Shin, J.3
Hossain, M.G.4
Lang, F.F.5
McCarty, J.H.6
-
127
-
-
84867101901
-
Endoglin mediates fibronectin/alpha5beta1 integrin and TGF-beta pathway crosstalk in endothelial cells
-
COI: 1:CAS:528:DC%2BC38Xht1ynt7nO, PID: 22940691
-
Tian H, Mythreye K, Golzio C, Katsanis N, Blobe GC (2012) Endoglin mediates fibronectin/alpha5beta1 integrin and TGF-beta pathway crosstalk in endothelial cells. EMBO J 31:3885–3900
-
(2012)
EMBO J
, vol.31
, pp. 3885-3900
-
-
Tian, H.1
Mythreye, K.2
Golzio, C.3
Katsanis, N.4
Blobe, G.C.5
-
128
-
-
84896973126
-
TGF-beta activation and function in immunity
-
COI: 1:CAS:528:DC%2BC2cXovVemtrs%3D, PID: 24313777
-
Travis MA, Sheppard D (2014) TGF-beta activation and function in immunity. Annu Rev Immunol 32:51–82
-
(2014)
Annu Rev Immunol
, vol.32
, pp. 51-82
-
-
Travis, M.A.1
Sheppard, D.2
-
129
-
-
34548208943
-
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
-
COI: 1:CAS:528:DC%2BD2sXhtVKiu7jL, PID: 17694047
-
Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D (2007) Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449:361–365
-
(2007)
Nature
, vol.449
, pp. 361-365
-
-
Travis, M.A.1
Reizis, B.2
Melton, A.C.3
Masteller, E.4
Tang, Q.5
Proctor, J.M.6
Wang, Y.7
Bernstein, X.8
Huang, X.9
Reichardt, L.F.10
Bluestone, J.A.11
Sheppard, D.12
-
130
-
-
84894429827
-
Beta1 integrin inhibition elicits a prometastatic switch through the TGFbeta-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer
-
PID: 24518294
-
Truong HH, Xiong J, Ghotra VP, Nirmala E, Haazen L, Le Devedec SE, Balcioglu HE, He S, Snaar-Jagalska BE, Vreugdenhil E, Meerman JH, van de Water B, Danen EH (2014) Beta1 integrin inhibition elicits a prometastatic switch through the TGFbeta-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer. Sci Signal 7:ra15
-
(2014)
Sci Signal
, vol.7
, pp. ra15
-
-
Truong, H.H.1
Xiong, J.2
Ghotra, V.P.3
Nirmala, E.4
Haazen, L.5
Le Devedec, S.E.6
Balcioglu, H.E.7
He, S.8
Snaar-Jagalska, B.E.9
Vreugdenhil, E.10
Meerman, J.H.11
van de Water, B.12
Danen, E.H.13
-
131
-
-
84920722444
-
Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma
-
COI: 1:CAS:528:DC%2BC2MXlt1Gksw%3D%3D, PID: 25345775
-
Underwood TJ, Hayden AL, Derouet M, Garcia E, Noble F, White MJ, Thirdborough S, Mead A, Clemons N, Mellone M, Uzoho C, Primrose JN, Blaydes JP, Thomas GJ (2015) Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma. J Pathol 235:466–477
-
(2015)
J Pathol
, vol.235
, pp. 466-477
-
-
Underwood, T.J.1
Hayden, A.L.2
Derouet, M.3
Garcia, E.4
Noble, F.5
White, M.J.6
Thirdborough, S.7
Mead, A.8
Clemons, N.9
Mellone, M.10
Uzoho, C.11
Primrose, J.N.12
Blaydes, J.P.13
Thomas, G.J.14
-
132
-
-
39049098274
-
Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism
-
PID: 18199553
-
Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM (2008) Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res 68:561–570
-
(2008)
Cancer Res
, vol.68
, pp. 561-570
-
-
Van Aarsen, L.A.1
Leone, D.R.2
Ho, S.3
Dolinski, B.M.4
McCoon, P.E.5
LePage, D.J.6
Kelly, R.7
Heaney, G.8
Rayhorn, P.9
Reid, C.10
Simon, K.J.11
Horan, G.S.12
Tao, N.13
Gardner, H.A.14
Skelly, M.M.15
Gown, A.M.16
Thomas, G.J.17
Weinreb, P.H.18
Fawell, S.E.19
Violette, S.M.20
more..
-
133
-
-
0034791087
-
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling
-
COI: 1:CAS:528:DC%2BD3MXns1Wjt74%3D, PID: 11585905
-
Vinals F, Pouyssegur J (2001) Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling. Mol Cell Biol 21:7218–7230
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7218-7230
-
-
Vinals, F.1
Pouyssegur, J.2
-
134
-
-
84876817355
-
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer
-
COI: 1:CAS:528:DC%2BC3sXmsVaqtLc%3D, PID: 23612460
-
Wakefield LM, Hill CS (2013) Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer. Nat Rev Cancer 13:328–341
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 328-341
-
-
Wakefield, L.M.1
Hill, C.S.2
-
135
-
-
84941316326
-
Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer
-
COI: 1:CAS:528:DC%2BC2cXitFKksr7F, PID: 25531323
-
Weber CE, Kothari AN, Wai PY, Li NY, Driver J, Zapf MA, Franzen CA, Gupta GN, Osipo C, Zlobin A, Syn WK, Zhang J, Kuo PC, Mi Z (2015) Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer. Oncogene 34:4821–4833
-
(2015)
Oncogene
, vol.34
, pp. 4821-4833
-
-
Weber, C.E.1
Kothari, A.N.2
Wai, P.Y.3
Li, N.Y.4
Driver, J.5
Zapf, M.A.6
Franzen, C.A.7
Gupta, G.N.8
Osipo, C.9
Zlobin, A.10
Syn, W.K.11
Zhang, J.12
Kuo, P.C.13
Mi, Z.14
-
137
-
-
49049110677
-
Integrins and the activation of latent transforming growth factor beta1—an intimate relationship
-
COI: 1:CAS:528:DC%2BD1cXht1Ciu7fN, PID: 18342983
-
Wipff PJ, Hinz B (2008) Integrins and the activation of latent transforming growth factor beta1—an intimate relationship. Eur J Cell Biol 87:601–615
-
(2008)
Eur J Cell Biol
, vol.87
, pp. 601-615
-
-
Wipff, P.J.1
Hinz, B.2
-
138
-
-
37249044357
-
Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix
-
COI: 1:CAS:528:DC%2BD2sXhsVOgtL%2FL, PID: 18086923
-
Wipff PJ, Rifkin DB, Meister JJ, Hinz B (2007) Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol 179:1311–1323
-
(2007)
J Cell Biol
, vol.179
, pp. 1311-1323
-
-
Wipff, P.J.1
Rifkin, D.B.2
Meister, J.J.3
Hinz, B.4
-
139
-
-
84922180322
-
Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread
-
COI: 1:CAS:528:DC%2BC2MXntVKnsw%3D%3D, PID: 25584895
-
Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MR, Scudamore CL, Cereser B, Crnogorac-Jurcevic T, McDonald S, Elia G, Hagemann T, Kocher HM, Hodivala-Dilke KM (2015) Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread. Cancer Cell 27:123–137
-
(2015)
Cancer Cell
, vol.27
, pp. 123-137
-
-
Wong, P.P.1
Demircioglu, F.2
Ghazaly, E.3
Alrawashdeh, W.4
Stratford, M.R.5
Scudamore, C.L.6
Cereser, B.7
Crnogorac-Jurcevic, T.8
McDonald, S.9
Elia, G.10
Hagemann, T.11
Kocher, H.M.12
Hodivala-Dilke, K.M.13
-
140
-
-
84951188327
-
Paeoniflorin inhibits macrophage-mediated lung cancer metastasis
-
PID: 26721711
-
Wu Q, Chen GL, Li YJ, Chen Y, Lin FZ (2015) Paeoniflorin inhibits macrophage-mediated lung cancer metastasis. Chin J Nat Med 13:925–932
-
(2015)
Chin J Nat Med
, vol.13
, pp. 925-932
-
-
Wu, Q.1
Chen, G.L.2
Li, Y.J.3
Chen, Y.4
Lin, F.Z.5
-
141
-
-
84985877690
-
Periostin expression in intra-tumoral stromal cells is prognostic and predictive for colorectal carcinoma via creating a cancer-supportive niche
-
PID: 26556874
-
Xu X, Chang W, Yuan J, Han X, Tan X, Ding Y, Luo Y, Cai H, Liu Y, Gao X, Liu Q, Yu Y, Du Y, Wang H, Ma L, Wang J, Chen K, Fu C, Cao G (2016) Periostin expression in intra-tumoral stromal cells is prognostic and predictive for colorectal carcinoma via creating a cancer-supportive niche. Oncotarget 7:798–813
-
(2016)
Oncotarget
, vol.7
, pp. 798-813
-
-
Xu, X.1
Chang, W.2
Yuan, J.3
Han, X.4
Tan, X.5
Ding, Y.6
Luo, Y.7
Cai, H.8
Liu, Y.9
Gao, X.10
Liu, Q.11
Yu, Y.12
Du, Y.13
Wang, H.14
Ma, L.15
Wang, J.16
Chen, K.17
Fu, C.18
Cao, G.19
-
142
-
-
84979040695
-
Prognostic value of osteopontin expression in breast cancer: a meta-analysis
-
PID: 25798267
-
Xu YY, Zhang YY, Lu WF, Mi YJ, Chen YQ (2015) Prognostic value of osteopontin expression in breast cancer: a meta-analysis. Mol Clin Oncol 3:357–362
-
(2015)
Mol Clin Oncol
, vol.3
, pp. 357-362
-
-
Xu, Y.Y.1
Zhang, Y.Y.2
Lu, W.F.3
Mi, Y.J.4
Chen, Y.Q.5
-
143
-
-
84948969110
-
Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination
-
Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T, (in press)
-
Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T (2015) Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination. Gastric Cancer (in press)
-
(2015)
Gastric Cancer
-
-
-
144
-
-
72449168333
-
Fibulin-5, an integrin-binding matricellular protein: its function in development and disease
-
PID: 19798595
-
Yanagisawa H, Schluterman MK, Brekken RA (2009) Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J Cell Commun Signal 3:337–347
-
(2009)
J Cell Commun Signal
, vol.3
, pp. 337-347
-
-
Yanagisawa, H.1
Schluterman, M.K.2
Brekken, R.A.3
-
145
-
-
56449127197
-
Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?
-
COI: 1:CAS:528:DC%2BD1cXhtlOmt7zP, PID: 19010878
-
Yang L, Moses HL (2008) Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer? Cancer Res 68:9107–9111
-
(2008)
Cancer Res
, vol.68
, pp. 9107-9111
-
-
Yang, L.1
Moses, H.L.2
-
146
-
-
84989967720
-
ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis
-
COI: 1:CAS:528:DC%2BC2MXhtFOjt73L, PID: 26068788
-
Yang M, Liu J, Piao C, Shao J, Du J (2015) ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis. Cell Death Dis 6:e1780
-
(2015)
Cell Death Dis
, vol.6
-
-
Yang, M.1
Liu, J.2
Piao, C.3
Shao, J.4
Du, J.5
-
147
-
-
33947265169
-
Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice
-
COI: 1:CAS:528:DC%2BD2sXjt1GitLw%3D, PID: 17353357
-
Yang Z, Mu Z, Dabovic B, Jurukovski V, Yu D, Sung J, Xiong X, Munger JS (2007) Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol 176:787–793
-
(2007)
J Cell Biol
, vol.176
, pp. 787-793
-
-
Yang, Z.1
Mu, Z.2
Dabovic, B.3
Jurukovski, V.4
Yu, D.5
Sung, J.6
Xiong, X.7
Munger, J.S.8
-
148
-
-
0035984003
-
Beta8 integrins are required for vascular morphogenesis in mouse embryos
-
COI: 1:CAS:528:DC%2BD38XlsVyqtbY%3D, PID: 12050137
-
Zhu J, Motejlek K, Wang D, Zang K, Schmidt A, Reichardt LF (2002) Beta8 integrins are required for vascular morphogenesis in mouse embryos. Development 129:2891–2903
-
(2002)
Development
, vol.129
, pp. 2891-2903
-
-
Zhu, J.1
Motejlek, K.2
Wang, D.3
Zang, K.4
Schmidt, A.5
Reichardt, L.F.6
-
149
-
-
84942197713
-
Lysyl oxidase is predictive of unfavorable outcomes and essential for regulation of vascular endothelial growth factor in hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BC2MXhtVerurjL, PID: 26048020
-
Zhu J, Huang S, Wu G, Huang C, Li X, Chen Z, Zhao L, Zhao Y (2015a) Lysyl oxidase is predictive of unfavorable outcomes and essential for regulation of vascular endothelial growth factor in hepatocellular carcinoma. Dig Dis Sci 60:3019–3031
-
(2015)
Dig Dis Sci
, vol.60
, pp. 3019-3031
-
-
Zhu, J.1
Huang, S.2
Wu, G.3
Huang, C.4
Li, X.5
Chen, Z.6
Zhao, L.7
Zhao, Y.8
-
150
-
-
84944463294
-
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition
-
PID: 26318291
-
Zhu X, Zhong J, Zhao Z, Sheng J, Wang J, Liu J, Cui K, Chang J, Zhao H, Wong S (2015b) Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition. Oncotarget 6:25320–25338
-
(2015)
Oncotarget
, vol.6
, pp. 25320-25338
-
-
Zhu, X.1
Zhong, J.2
Zhao, Z.3
Sheng, J.4
Wang, J.5
Liu, J.6
Cui, K.7
Chang, J.8
Zhao, H.9
Wong, S.10
|