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Volumn 122, Issue 2, 2009, Pages 227-232

Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice

Author keywords

Autoimmunity; Integrins; Langerhans cells; Palate fusion; TGFb

Indexed keywords

ALPHAVBETA6 INTEGRIN; ALPHAVBETA8 INTEGRIN; INTEGRIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; INTEGRIN ALPHAVBETA8; OLIGOPEPTIDE; TUMOR ANTIGEN;

EID: 61949349656     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.035246     Document Type: Article
Times cited : (186)

References (49)
  • 1
    • 0037196163 scopus 로고    scopus 로고
    • The integrin αVβ6 binds and activates latent TGFβ3
    • Annes, J. P., Rifkin, D. B. and Munger, J. S. (2002). The integrin αVβ6 binds and activates latent TGFβ3. FEBS Lett. 511, 65-68.
    • (2002) FEBS Lett , vol.511 , pp. 65-68
    • Annes, J.P.1    Rifkin, D.B.2    Munger, J.S.3
  • 2
    • 0037439630 scopus 로고    scopus 로고
    • Making sense of latent TGFβ activation
    • Annes, J. P., Munger, J. S. and Rifkin, D. B. (2003). Making sense of latent TGFβ activation. J. Cell Sci. 116, 217-224.
    • (2003) J. Cell Sci , vol.116 , pp. 217-224
    • Annes, J.P.1    Munger, J.S.2    Rifkin, D.B.3
  • 3
    • 33746602210 scopus 로고    scopus 로고
    • Integrin-mediated transforming growth factor β activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
    • Araya, J., Cambier, S., Morris, A., Finkbeiner, W. and Nishimura, S. L. (2006). Integrin-mediated transforming growth factor β activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am. J. Pathol. 169, 405-415.
    • (2006) Am. J. Pathol , vol.169 , pp. 405-415
    • Araya, J.1    Cambier, S.2    Morris, A.3    Finkbeiner, W.4    Nishimura, S.L.5
  • 5
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts
    • Asano, Y., Ihn, H., Yamane, K., Jinnin, M., Mimura, Y. and Tamaki, K. (2005a). Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-β signaling in scleroderma fibroblasts. J. Immunol. 175, 7708-7718.
    • (2005) J. Immunol , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 6
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts
    • Asano, Y., Ihn, H., Yamane, K., Jinnin, M., Mimura, Y. and Tamaki, K. (2005b). Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts. Arthritis Rheum. 52, 2897-2905.
    • (2005) Arthritis Rheum , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 7
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins
    • Bader, B. L., Rayburn, H., Crowley, D. and Hynes, R. O. (1998). Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell 95, 507-519.
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 8
    • 0030456368 scopus 로고    scopus 로고
    • A role for endogenous transforming growth factor β1 in langerhans cell biology: The skin of transforming growth factor β1 null mice is devoid of epidermal langerhans cells
    • Borkowski, T. A., Letterio, J. J., Farr, A. G. and Udey, M. C. (1996). A role for endogenous transforming growth factor β1 in langerhans cell biology: the skin of transforming growth factor β1 null mice is devoid of epidermal langerhans cells. J. Exp. Med. 184, 2417-2422.
    • (1996) J. Exp. Med , vol.184 , pp. 2417-2422
    • Borkowski, T.A.1    Letterio, J.J.2    Farr, A.G.3    Udey, M.C.4
  • 9
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y. (2003). Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330-336.
    • (2003) Nat. Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 10
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot, J. D., Dooley, J. L., Farr, A. G. and Rudensky, A. Y. (2005). Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 202, 901-906.
    • (2005) J. Exp. Med , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 13
    • 15844376477 scopus 로고    scopus 로고
    • Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
    • Huang, X. Z., Wu, J. F., Cass, D., Erle, D. J., Corry, D., Young, S. G., Farese, R. V. and Sheppard, D. (1996). Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 133, 921-928.
    • (1996) J. Cell Biol , vol.133 , pp. 921-928
    • Huang, X.Z.1    Wu, J.F.2    Cass, D.3    Erle, D.J.4    Corry, D.5    Young, S.G.6    Farese, R.V.7    Sheppard, D.8
  • 14
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 15
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen, V., Voncken, J. W., Shuler, C., Warburton, D., Bu, D., Heisterkamp, N. and Groffen, J. (1995). Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11, 415-421.
    • (1995) Nat. Genet , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 16
    • 0027419881 scopus 로고
    • Requirement for transglutaminase in the activation of latent transforming growth factor-β in bovine endothelial cells
    • Kojima, S., Nara, K. and Rifkin, D. B. (1993). Requirement for transglutaminase in the activation of latent transforming growth factor-β in bovine endothelial cells. J. Cell Biol. 121, 439-448.
    • (1993) J. Cell Biol , vol.121 , pp. 439-448
    • Kojima, S.1    Nara, K.2    Rifkin, D.B.3
  • 19
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li, M. O., Sanjabi, S. and Flavell, R. A. (2006). Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25, 455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 20
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGFβ signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    • Liu, Y., Zhang, P., Li, J., Kulkarni, A. B., Perruche, S. and Chen, W. (2008). A critical function for TGFβ signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat. Immunol. 9, 632-640.
    • (2008) Nat. Immunol , vol.9 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 22
    • 0037437369 scopus 로고    scopus 로고
    • The integrin αvβ3 is a receptor for the latency-associated peptides of transforming growth factors β1 and β3
    • Ludbrook, S. B., Barry, S. T., Delves, C. J. and Horgan, C. M. (2003). The integrin αvβ3 is a receptor for the latency-associated peptides of transforming growth factors β1 and β3. Biochem. J. 369, 311-318.
    • (2003) Biochem. J , vol.369 , pp. 311-318
    • Ludbrook, S.B.1    Barry, S.T.2    Delves, C.J.3    Horgan, C.M.4
  • 23
    • 17144400393 scopus 로고    scopus 로고
    • TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • Marie, J. C., Letterio, J. J., Gavin, M. and Rudensky, A. Y. (2005). TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J. Exp. Med. 201, 1061-1067.
    • (2005) J. Exp. Med , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 24
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor
    • Marie, J. C., Liggitt, D. and Rudensky, A. Y. (2006). Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25, 441-454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 25
    • 13444249941 scopus 로고    scopus 로고
    • Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    • McCarty, J. H., Lacy-Hulbert, A., Charest, A., Bronson, R. T., Crowley, D., Housman, D., Savill, J., Roes, J. and Hynes, R. O. (2005). Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132, 165-176.
    • (2005) Development , vol.132 , pp. 165-176
    • McCarty, J.H.1    Lacy-Hulbert, A.2    Charest, A.3    Bronson, R.T.4    Crowley, D.5    Housman, D.6    Savill, J.7    Roes, J.8    Hynes, R.O.9
  • 28
    • 41949090936 scopus 로고    scopus 로고
    • TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis
    • Mu, Z., Yang, Z., Yu, D., Zhao, Z. and Munger, J. S. (2008). TGFβ1 and TGFβ3 are partially redundant effectors in brain vascular morphogenesis. Mech. Dev. 125, 508-516.
    • (2008) Mech. Dev , vol.125 , pp. 508-516
    • Mu, Z.1    Yang, Z.2    Yu, D.3    Zhao, Z.4    Munger, J.S.5
  • 29
    • 0031670654 scopus 로고    scopus 로고
    • Interactions between growth factors and integrins: Latent forms of transforming growth factor-β are ligands for the integrin αvβ1
    • Munger, J. S., Harpel, J. G., Giancotti, F. G. and Rifkin, D. B. (1998). Interactions between growth factors and integrins: latent forms of transforming growth factor-β are ligands for the integrin αvβ1. Mol. Biol. Cell 9, 2627-2638.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 2627-2638
    • Munger, J.S.1    Harpel, J.G.2    Giancotti, F.G.3    Rifkin, D.B.4
  • 31
    • 0032571765 scopus 로고    scopus 로고
    • Synaptic and glial localization of the integrin αvβ8 in mouse and rat brain
    • Nishimura, S. L., Boylen, K. P., Einheber, S., Milner, T. A., Ramos, D. M. and Pytela, R. (1998). Synaptic and glial localization of the integrin αvβ8 in mouse and rat brain. Brain Res. 791, 271-282.
    • (1998) Brain Res , vol.791 , pp. 271-282
    • Nishimura, S.L.1    Boylen, K.P.2    Einheber, S.3    Milner, T.A.4    Ramos, D.M.5    Pytela, R.6
  • 32
    • 27344444684 scopus 로고    scopus 로고
    • Vascular development of the brain requires β8 integrin expression in the neuroepithelium
    • Proctor, J. M., Zang, K., Wang, D., Wang, R. and Reichardt, L. F. (2005). Vascular development of the brain requires β8 integrin expression in the neuroepithelium. J. Neurosci. 25, 9940-9948.
    • (2005) J. Neurosci , vol.25 , pp. 9940-9948
    • Proctor, J.M.1    Zang, K.2    Wang, D.3    Wang, R.4    Reichardt, L.F.5
  • 35
    • 34249678653 scopus 로고    scopus 로고
    • TGFβ signalling in control of T-cell-mediated self-reactivity
    • Rubtsov, Y. P. and Rudensky, A. Y. (2007). TGFβ signalling in control of T-cell-mediated self-reactivity. Nat. Rev. Immunol. 7, 443-453.
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 443-453
    • Rubtsov, Y.P.1    Rudensky, A.Y.2
  • 36
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S. (2004). Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22, 531-562.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 38
    • 27644538315 scopus 로고    scopus 로고
    • Integrin-mediated activation of latent transforming growth factor β
    • Sheppard, D. (2005). Integrin-mediated activation of latent transforming growth factor β. Cancer Metastasis Rev. 24, 395-402.
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 395-402
    • Sheppard, D.1
  • 39
    • 0035185411 scopus 로고    scopus 로고
    • Control of T cell activation by CD4+CD25+ suppressor T cells
    • Shevach, E. M., McHugh, R. S., Piccirillo, C. A. and Thornton, A. M. (2001). Control of T cell activation by CD4+CD25+ suppressor T cells. Immunol Rev. 182, 58-67.
    • (2001) Immunol Rev , vol.182 , pp. 58-67
    • Shevach, E.M.1    McHugh, R.S.2    Piccirillo, C.A.3    Thornton, A.M.4
  • 41
    • 0035670921 scopus 로고    scopus 로고
    • Appearance of langerhans cells in the epidermis of Tgfβ1(-/-) SCID mice: Paracrine and autocrine effects of transforming growth factor-β1 and -β2(1)
    • Thomas, R. M., Belsito, D. V., Huang, C., Chen, L. Z., Ormsby, I., Simmons, W. J., Cowin, P., Shaw, J., Doetschman, T. and Thorbecke, G. J. (2001). Appearance of langerhans cells in the epidermis of Tgfβ1(-/-) SCID mice: paracrine and autocrine effects of transforming growth factor-β1 and -β2(1). J. Invest. Dermatol. 117, 1574-1580.
    • (2001) J. Invest. Dermatol , vol.117 , pp. 1574-1580
    • Thomas, R.M.1    Belsito, D.V.2    Huang, C.3    Chen, L.Z.4    Ormsby, I.5    Simmons, W.J.6    Cowin, P.7    Shaw, J.8    Doetschman, T.9    Thorbecke, G.J.10
  • 43
    • 35748966479 scopus 로고    scopus 로고
    • Yin-yang' functions of transforming growth factor-β and T regulatory cells in immune regulation
    • Wan, Y. Y. and Flavell, R. A. (2007). 'Yin-yang' functions of transforming growth factor-β and T regulatory cells in immune regulation. Immunol. Rev. 220, 199-213.
    • (2007) Immunol. Rev , vol.220 , pp. 199-213
    • Wan, Y.Y.1    Flavell, R.A.2
  • 45
    • 37249044357 scopus 로고    scopus 로고
    • Myofibroblast contraction activates latent TGFβ1 from the extracellular matrix
    • Wipff, P. J., Rifkin, D. B., Meister, J. J. and Hinz, B. (2008). Myofibroblast contraction activates latent TGFβ1 from the extracellular matrix. J. Cell Biol. 179, 1311-1323.
    • (2008) J. Cell Biol , vol.179 , pp. 1311-1323
    • Wipff, P.J.1    Rifkin, D.B.2    Meister, J.J.3    Hinz, B.4
  • 46
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    • Yang, X., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., Roberts, A. B. and Deng, C. (1999). Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 18, 1280-1291.
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 47
    • 33947265169 scopus 로고    scopus 로고
    • Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice
    • Yang, Z., Mu, Z., Dabovic, B., Jurukovski, V., Yu, D., Sung, J., Xiong, X. and Munger, J. S. (2007). Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice. J. Cell Biol. 176, 787-793.
    • (2007) J. Cell Biol , vol.176 , pp. 787-793
    • Yang, Z.1    Mu, Z.2    Dabovic, B.3    Jurukovski, V.4    Yu, D.5    Sung, J.6    Xiong, X.7    Munger, J.S.8
  • 48
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
    • Yu, Q. and Stamenkovic, I. (2000). Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis. Genes Dev. 14, 163-176.
    • (2000) Genes Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 49
    • 0035984003 scopus 로고    scopus 로고
    • β8 integrins are required for vascular morphogenesis in mouse embryos
    • Zhu, J., Motejlek, K., Wang, D., Zang, K., Schmidt, A. and Reichardt, L. F. (2002). β8 integrins are required for vascular morphogenesis in mouse embryos. Development 129, 2891-2903.
    • (2002) Development , vol.129 , pp. 2891-2903
    • Zhu, J.1    Motejlek, K.2    Wang, D.3    Zang, K.4    Schmidt, A.5    Reichardt, L.F.6


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