CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 18, 2011, Pages 7529-7534

  McNally, Alice ^a   Hill, Geoffrey R ^b   Sparwasser, Tim ^c   Thomas, Ranjeny ^a   Steptoe, Raymond J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ARTICLE; BIOAVAILABILITY; CD4+ CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; EFFECTOR CELL; FLOW CYTOMETRY; LYMPHOCYTE DIFFERENTIATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 79956296631     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1103782108     Document Type: Article

References (34)

1. Asano M, Toda M, Sakaguchi N, Sakaguchi S (1996) Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 184:387-396. (Pubitemid 26324092)
2. Kim JM, Rasmussen JP, Rudensky AY (2007) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8:191-197. (Pubitemid 46152650)
3. Lahl K, et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204:57-63. (Pubitemid 46148756)
4. Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT (2003) CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198:889-901. (Pubitemid 37152926)
5. Onizuka S, et al. (1999) Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody. Cancer Res 59:3128-3133. (Pubitemid 29316012)
6. Tang Q, et al. (2006) Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol 7:83-92. (Pubitemid 41823872)
7. Chen Z, Herman AE, Matos M, Mathis D, Benoist C (2005) Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med 202:1387-1397. (Pubitemid 41668741)
8. Chen ML, et al. (2005) Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci USA 102:419-424.
9. Mempel TR, et al. (2006) Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25:129-141. (Pubitemid 44066829)
10. Toka FN, Suvas S, Rouse BT (2004) CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol 78:13082-13089. (Pubitemid 39507816)
11. Vignali DA, Collison LW, Workman CJ (2008) How regulatory T cells work. Nat Rev Immunol 8:523-532.
12. Tang Q, Bluestone JA (2008) The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nat Immunol 9:239-244. (Pubitemid 351267321)
13. Thornton AM, Shevach EM (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188:287-296. (Pubitemid 28357757)
14. Pandiyan P, Zheng L, Ishihara S, Reed JC, Lenardo MJ (2007) CD4+CD25+Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 8:1353-1362. (Pubitemid 350131172)
15. Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J (2006) Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311:1924-1927.
16. Brandenburg S, et al. (2008) IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3 (+) regulatory T cells. Eur J Immunol 38:1643-1653.
17. Setoguchi R, Hori S, Takahashi T, Sakaguchi S (2005) Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201:723-735. (Pubitemid 40395118)
18. Yamanouchi J, et al. (2007) Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet 39:329-337. (Pubitemid 46328484)
19. Tang Q, et al. (2008) Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28:687-697.
20. Humrich JY, et al. (2010) Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci USA 107:204-209.
21. Schildknecht A, et al. (2010) FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci USA 107:199-203.
22. Steptoe RJ, et al. (2007) Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells. J Immunol 178:2094-2103. (Pubitemid 46233406)
23. Yamaguchi T, et al. (2007) Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity 27:145-159. (Pubitemid 47089022)
24. Chappert P, et al. (2010) Antigen-specific Treg impair CD8(+) T-cell priming by blocking early T-cell expansion. Eur J Immunol 40:339-350.
25. Heit A, et al. (2008) Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 38:1585-1597.
26. Cheng LE, Greenberg PD (2002) Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol 169:4990-4997. (Pubitemid 35217166)
27. Ahmadzadeh M, Rosenberg SA (2006) IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood 107:2409-2414. (Pubitemid 43345561)
28. Webster KE, et al. (2009) In vivo expansion of T reg cells with IL-2-mAb complexes: Induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 206:751-760.
29. Belghith M, et al. (2003) TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9:1202-1208. (Pubitemid 37173706)
30. Filippi CM, Estes EA, Oldham JE, von Herrath MG (2009) Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. J Clin Invest 119:1515-1523.
31. Grinberg-Bleyer Y, et al. (2010) IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med 207:1871-1878.
32. Hogquist KA, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76:17-27. (Pubitemid 24035278)
33. Mueller SN, Heath WR, McLain JD, Carbone FR, Jones CM (2002) Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol Cell Biol 80:156-163. (Pubitemid 34298088)
34. Reeves JP, Reeves PA, Chin LT (1991) Survival surgery: removal of the spleen or thymus. Current Protocols in Immunology, eds Coliga JE, Bierer BE, Margulies DH, Shevach EA, Strober W (John Wiley and Sons, Hoboken, NJ), Vol 1, Unit 1.10.