Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-Related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 cancer cells

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 23, 2014, Pages 5390-5400

  Yuan, Li ^a   Wei, Shuping ^a   Wang, Jing ^a   Liu, Xuebo ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

apoptosis; autophagy; interplay; isoorientin; ROS

Indexed keywords

ACETYLCYSTEINE; AMINO ACIDS; CHEMICAL ACTIVATION; OXYGEN; PIGMENTS; SIGNALING; CELL DEATH; DISEASES;

APOPTOSIS INHIBITORS; AUTOPHAGY; INTERPLAY; ISOORIENTIN; POLY(ADP-RIBOSE) POLYMERASE; PYRROLIDINEDITHIOCARBAMIC ACID; REACTIVE OXYGEN SPECIES; ROS;

CELL DEATH; CELL SIGNALING;

ANTINEOPLASTIC AGENT; ISOORIENTIN; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TP53 PROTEIN, HUMAN;

APOPTOSIS; AUTOPHAGY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HEPG2 CELL LINE; HUMAN; LIVER NEOPLASMS; METABOLISM; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; LUTEOLIN; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; ONCOGENE PROTEIN V-AKT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84902255653     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf500903g     Document Type: Article

References (43)

1. Maiuri, M. C.; Zalckvar, E.; Kimchi, A.; Kroemer, G. Self-eating and self-killing: Crosstalk between autophagy and apoptosis Mol. Cell. Biol. 2007, 8, 741-745
2. Soldatenkov, V. A.; Smulson, M. Poly(ADP-ribose) polymerase in DNA damage-response pathway: implications for radiation oncology Int. J. Cancer 2000, 90, 59-67
3. Ghobrial, I. M.; Witzig, T. E.; Adjei, A. A. Targeting apoptosis pathways in cancer therapy Ca-Cancer J. Clin. 2005, 55, 178-194
4. Yokoyama, T.; Miyazawa, K.; Naito, M.; Toyotake, J.; Tauchi, T.; Itoh, M.; Yuo, A.; Hayashi, Y.; Georgescu, M. M.; Kondo, Y.; Kondo, S.; Ohyashiki, K. Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells Autophagy 2008, 4, 629-640
5. Bursch, W.; Ellinger, A.; Gerner, C.; Frohwein, U.; Schulte-Hermann, R. Programmed cell death (PCD). Apoptosis, autophagic PCD, or others? Ann. N. Y. Acad. Sci. 2000, 926, 1-12
6. Yang, C.; Kaushal, V.; Shah, S. V.; Kaushal, G. P. Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells Am. J. Physiol.: Renal, Fluid Electrolyte Physiol. 2008, 294, 777-787
7. Li, X.; Xu, H. L.; Liu, Y. X.; An, N.; Zhao, S.; Bao, J. K. Autophagy modulation as a target for anticancer drug discovery Acta Pharmacol. Sin. 2013, 34, 612-624
8. Gump, J. M.; Thorburn, A. Autophagy and apoptosis: What is the interplay? Trends Cell Biol. 2011, 21, 387-392
9. Yong-Chun, J.; Lin, Y.; Yuan, K. A novel high- performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China Pharmacogn. Mag. 2012, 8, 42-48
10. Prinz, S.; Ring, A.; Huefner, A.; Pemp, E.; Kopp, B. 4′′- Acetylvitexin-2′- O -rhamnoside, isoorientin, orientin, and 8-methoxykaempferol-3- O -glucoside as markers for the differentiation of Crataegus monogyna and Crataegus pentagyna from Crataegus laevigata Chem. Biodiversity 2007, 4, 2920-2931
11. Peng, J.; Fan, G.; Hong, Z.; Chai, Y.; Wu, Y. Preparative separation of isovitexin and isoorientin from Patrinia villosa Juss by high-speed counter-current chromatography J. Chromatogr. A 2005, 1074, 111-115
12. Mitsuru, W.; Miyuki, I. Changes in antioxidative activity and flavonoid composition of the extracts from aerial parts of buckwheat during growth period Nippon Shokuhin Kagaku Kogaku Kaishi 2002, 49, 119-125
13. Budzianowski, J.; Budzianowska, A.; Kromerb, K. Naphthalene glucoside and other phenolics from the shoot and callus cultures of Drosophyllum lusitanicum Phytochemistry 2002, 61, 421-425
14. Afifi, F. U.; Khalil, E.; Abdalla, S. Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs J. Ethnopharmacol. 1999, 65, 173-177
15. Ko, F. N.; Chu, C. C.; Lin, C. N.; Chang, C. C.; Teng, C. M. Isoorientin-6′- O -glucoside, a water-soluble antioxidant isolated from Gentiana arisanensis Biochim. Biophys. Acta 1998, 1389, 81-90
16. Harborne, J. B. The Flavonoids-Advances in Research since 1986; Chapman and Hall: London, U.K., 1994.
17. Pacifico, S.; Scognamiglio, M.; D'Abrosca, B.; Piccolella, S.; Tsafantakis, N.; Gallicchio, M.; Ricci, A.; Fiorentino, A. Spectroscopic characterization and antiproliferative activity on HepG2 human hepatoblastoma cells of flavonoid C -glycosides from Petrorhagia velutina J. Nat. Prod. 2010, 73, 1973-1978
18. Yuan, L.; Wang, J.; Xiao, H. F.; Xiao, C. X.; Wang, Y. T.; Liu, X. B. Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signalling pathway in HepG2 cancer cells Toxicol. Appl. Pharmacol. 2012, 265, 83-92
19. Yuan, L.; Wang, J.; Xiao, H. F.; Xiao, C. X.; Wang, Y. T.; Liu, X. B. MAPK signalling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells Food. Chem. Toxicol. 2013, 53, 62-68
20. Syama, S.; Reshma, S. C.; Sreekanth, P. J.; Varma, H. K.; Mohanan, P. V. Effect of zinc oxide nanoparticles on cellular oxidative stress and antioxidant defense mechanisms in mouse liver Toxicol. Environ. Chem. 2013, 95, 495-503
21. Augustine, M. K.; Choi, M. D.; Stefan, W.; Ryter, P. D.; Levine, B. Autophagy in human health and disease New Engl. J. Med. 2013, 368, 651-662
22. Lorin, S.; Hamaï, A.; Mehrpour, M.; Codogno, P. Autophagy regulation and its role in ancer Semin. Cancer Biol. 2013, 23, 361-379
23. Nikoletopoulou, V.; Markaki, M.; Palikaras, K.; Tavernarakis, N. Crosstalk between apoptosis, necrosis and autophagy Biochim. Biophys. Acta 2013, 1833, 3448-3459
24. Chargui, A.; Zekri, S.; Jacquillet, G.; Rubera, I.; Ilie, M.; Belaid, A.; Duranton, C.; Tauc, M.; Hofman, P.; Poujeol, P.; El May, M. V.; Mograbi, B. Cadmium-induced autophagy in rat kidney: An early biomarker of subtoxic exposure Toxicol. Sci. 2011, 121, 31-42
25. Gozuacik, D.; Kimchi, A. Autophagy and cell death Curr. Top. Dev. Biol. 2007, 78, 217-245
26. Baehrecke, E. H. Autophagy: Dual roles in life and death? Nat. Rev. Mol. Cell Biol. 2005, 6, 505-510
27. Wang, Q.; Chen, Z.; Diao, X.; Huang, S. Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells Cancer Lett. 2011, 302, 29-36
28. Raza, H.; Annie, J.; Sheela, B. Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells Eur. J. Pharmacol. 2011, 668, 15-24
29. Ling, L. U.; Tan, K. B.; Lin, H.; Chiu, G. N. The role of reactive oxygen species and autophagy in safingol-induced cell death Cell Death Dis. 2011, 2, 129
30. Zhan, Y.; Gong, K.; Chen, C.; Wang, H.; Li, W. p38 MAP kinase functions as a switch in MS-275-induced reactive oxygen species-dependent autophagy and apoptosis in human colon cancer cells Free Radical Biol. Med. 2012, 53, 532-543
31. Fimia, G. M.; Piacentini, M. Regulation of autophagy in mammals and its interplay with apoptosis Cell. Mol. Life Sci. 2010, 67, 1581-1588
32. Takeuchi, H.; Kondo, Y.; Fujiwara, K.; Kanzawa, T.; Aoki, H.; Mills, G. B.; Kondo, S. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors Cancer Res. 2005, 65, 3336-3346
33. Liu, C. M.; Ma, J. Q.; Sun, Y. Z.; Liu, C. M. Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway Toxicol. Appl. Pharmacol. 2011, 258, 330-342
34. Franke, T. F.; Hornik, C. P.; Segev, L.; Shostak, G. A.; Sugimoto, C. PI3K/Akt and apoptosis: Size matters Oncogene 2003, 22, 8983-8998
35. Chen, Y. J.; Liu, W. H.; Kao, P. H.; Wang, J. J.; Chang, L. S. Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells Toxicon 2010, 55, 1306-1316
36. Xie, N.; Wang, C.; Lin, Y.; Li, H.; Chen, L.; Zhang, T.; Sun, Y.; Zhang, Y.; Yin, D.; Chi, Z. The role of p38 MAPK in valproic acid induced microglia apoptosis Neurosci. Lett. 2010, 482, 51-56
37. Wei, Y.; Sinha, S.; Levine, B. Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation Autophagy 2008, 4, 949-951
38. Tang, G.; Yue, Z.; Talloczy, Z.; Hagemann, T.; Cho, W.; Messing, A.; Sulzer, D. L.; Goldman, J. E. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways Hum. Mol. Genet. 2008, 17, 1540-1555
39. Oren, M. Decision making by p53: Life, death and cancer Cell Death Differ. 2003, 10, 431-442
40. Levine, A. J. p53, the cellular gatekeeper for growth and division Cell 1997, 88, 323-331
41. Mayo, M. W.; Baldwin, A. S. The transcription factor NF-κB: Control of oncogenesis and cancer therapy resistance Biochim. Biophys. Acta 2000, 1470, 55-62
42. Jiang, Y. Y.; Yang, R.; Wang, H. J.; Huang, H.; Wu, D.; Tashiro, S.; Onodera, S.; Ikejima, T. Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells Eur. J. Pharmacol. 2011, 659, 7-14
43. Naugler, W. E.; Karin, M. NF-κB and cancer-identifying targets and mechanisms Curr. Opin. Genet. Dev. 2008, 18, 19-26