Vitamin K2-induced cell growth inhibition via autophagy formation in cholangiocellular carcinoma cell lines

International Journal of Molecular Medicine

Volumn 20, Issue 6, 2007, Pages 801-808

  Enomoto, Masanobu ^a   Tsuchida, Akihiko ^a   Miyazawa, Keisuke ^a   Yokoyama, Tomohisa ^a   Kawakita, Hideaki ^a   Tokita, Hiromi ^a   Naito, Munekazu ^a   Itoh, Masahiro ^a   Ohyashiki, Kazuma ^a   Aoki, Tatsuya ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Autophagy; Chemoprevention; Cholangiocellular carcinoma; Vitamin K2

Indexed keywords

DRUG DERIVATIVE; FARNOQUINONE; PROTEIN BCL 2; VITAMIN;

ANIMAL; APOPTOSIS; ARTICLE; AUTOPHAGY; BILE DUCT CARCINOMA; BILE DUCT TUMOR; CELL CYCLE; CELL SHAPE; CELL STRAIN HL 60; HUMAN; INTRAHEPATIC BILE DUCT; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; AUTOPHAGY; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CELL CYCLE; CELL SHAPE; CHOLANGIOCARCINOMA; HL-60 CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; VITAMIN K 2; VITAMINS;

EID: 42149088983     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.20.6.801     Document Type: Article

References (35)

1. Miyazawa K, Yaguchi M, Funato K, Gotoh A, Kawanishi Y, Nishizawa Y, Yuo A and Ohyashiki K: Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells. Leukemia 15: 1111-1117, 2001. (Pubitemid 32717282)
2. Yokoyama T, Miyazawa K, Yoshida T and Ohyashiki K: Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines: Int J Oncol 26: 33-40, 2005.
3. Yoshida T, Miyazawa K, Kasuga I, Yokoyama T, Minemura K, Ustumi K, Aoshima M and Ohyashiki K: Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. Int J Oncol 23: 627-632, 2003.
4. Tokita H, Tsuchida A, Miyazawa K, Ohyashiki K, Katayanagi S, Sudo H, Enomoto M, Takagi Y and Aoki T: Vitamin K2-induced antitumor effects via cell-cycle arrest and apoptosis in gastric cancer cell lines. Int J Mol Med 17: 235-243, 2006.
5. Bouzahzah B, Nishikawa Y, Simon D and Carr BI: Growth control and gene expression in a new hepatocellular carcinoma cell line, Hep40: inhibitory actions of vitamin K. J Cell Physiol 165: 459-467, 1995.
6. Miyazawa K, Nishimaki J, Ohyashiki K, Enomoto S, Kuriya S, Fukuda R, Hotta T, Teramura M, Mizoguchi H, Uchiyama T and Omine M: Vitamin K2 therapy for myelodysplastic syndromes (MDS) and post-MDS acute myeloid leukemia: information through a questionnaire survey of multi-center pilot studies in Japan. Leukemia 14: 1156-1157, 2000.
7. Yaguchi M, Miyazawa K, Otawa M, Ito Y, Kawanishi Y and Toyama K: Vitamin K2 therapy for a patient with myelodysplastic syndrome. Leukemia 13: 144-145, 1999.
8. Mizuta T, Ozaki I, Eguchi Y, Yasutake T, Kawazoe S, Fujimoto K and Yamamoto K: The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer 106: 867-872, 2006.
9. Wu FY, Liao WC and Chang HM: Comparison of antitumor activity of vitamins K1, K2 and K3 on human tumor cells by two (MTT and SRB) cell viability assays. Life Sci 52: 1797-1804, 1993.
10. Parekh HK, Mansuri-Torshizi H, Srivastava TS and Chitnis MP: Circumvention of adriamycin resistance: effect of 2-methyl-1, 4-naphthoquinone (vitamin K3) on drug cytotoxicity in sensitive and MDR P388 leukemia cells. Cancer Lett 61: 147-156, 1992.
11. Orimo H, Shiraki M, Tomita A, Morii H, Fujita T and Ohata M: Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: a double-blind placebo-controlled study. J Bone Miner Metab 16: 106-112, 1998.
12. Kondo Y, Kanzawa T, Sawaya R and Kondo S: The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726-734, 2005.
13. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T and Mizushima N: The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036, 2004. (Pubitemid 40052234)
14. Tsukada M and Ohsumi Y: Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333: 169-174, 1993.
15. Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G and Levine B: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820, 2003.
16. Yue Z, Jin S, Yang C, Levine AJ and Heintz N: Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100: 15077-15082, 2003.
17. Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, Ghidoni R and Codogno P: Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 279: 18384-18391, 2004.
18. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH and Lenardo MJ: Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502, 2004.
19. Yaguchi M, Miyazawa K, Otawa M, Katagiri T, Nishimaki J, Uchida Y, Iwase O, Gotoh A, Kawanishi Y and Toyama K: Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody. Leukemia 12: 1392-1397, 1998.
20. Tsuchida A, Nagae I, Saitoh H, Ikeda T, Tanabe Y, Takahashi S, Aoki T and Itoi T: Clin Gastroenterol 21: 705-709, 2006.
21. Saijyo S, Kudo T, Suzuki M, Katayose Y, Shinoda M, Muto T, Fukuhara K, Suzuki T and Matsuno S: Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1. Tohoku J Exp Med 177: 61-71, 1995.
22. Yoshida K, Tomizawa H, Ota T, Nagashima T, Kikuchi H, Watanabe H, Hashizaki K and Yonaha A: Establishment and characterization of human cholaginocarcinoma, MEC, producing carbohydrate antigen 19-9. Hum Cell 3: 346-351, 1990.
23. Miyagiwa M, Ichida T, Tokiwa T, Sato J and Sasaki H: A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19-9 in serum-free medium. In Vitro Cell Dev Biol 25: 503-510, 1989.
24. Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D and Yahalom J: A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61: 439-444, 2001.
25. Traganos F and Darzynkiewicz Z: Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol 41: 185-194, 1994.
26. Stankiewicz M, Jonas W, Hadas E, Cabaj W and Douch PG: Supravital staining of eosinophils. Int J Parasitol 26: 445-446, 1996.
27. Nishimaki J, Miyazawa K, Yaguchi M, Katagiri T, Kawanishi Y, Toyama K, Ohyashiki K, Hashimoto S, Nakaya K and Takiguchi T: Vitamin K2 induces apoptosis of novel cell line established from a patient with myelodysplastic syndrome in blastic transformation. Leukemia 13: 1399-1405, 1999.
28. Wang Z, Wang M, Finn F and Carr BI: The growth inhibitory effects of vitamins K and their actions on gene expression. Hepatology 22: 876-882, 1995.
29. Kanzawa T, Kondo Y, Ito H, Kondo S and Germano I: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 63: 2103-2108, 2003. (Pubitemid 36538613)
30. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y and Kondo S: Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 11: 448-457, 2004. (Pubitemid 38489422)
31. Shao Y, Gao Z, Marks PA and Jiang X: Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc Natl Acad Sci USA 101: 18030-18035, 2004.
32. Shimizu S, Kanaseki T, Mizushima N, Arakawa-Kobayashi S, Mizuta T, Thompson CB and Tsujimoto Y: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6: 1221-1228, 2004.
33. Sano Y, Tadano K, Kaneko K, Kikuchi K and Yuzuriha T: Metabolic fate of menatetrenone in rats - absorption, distribution, metabolism and excretion after a single oral administration. Jpn Pharmacol Ther 23: 2659-2667, 1995.
34. Sano Y, Tadano K, Kikuchi K, Kaneko K, Yuzuriha T, Kimura T and Murayama Y: Metabolic fate of menaquinone-4 in dogs (I): Absorption, distribution, metabolism and excretion after a single oral administration. Drug Metab Pharmacokinet 12: 48-57, 1997.
35. Sano Y, Tadano K, Kikuchi K, Kaneko K, Yuzuriha T, Kimura T and Murayama Y: Metabolic fate of menaquinone-4 in dogs (II): Absorption, distribution, metabolism and excretion after a single oral administration. Drug Metab Pharmacokinet 12: 58-67, 1997.