Age-related increases of macroautophagy and chaperone-mediated autophagy in rat nucleus pulposus

Connective Tissue Research

Volumn 52, Issue 6, 2011, Pages 472-478

  Ye, Wei ^a   Xu, Kang ^a   Huang, Dongsheng ^a   Liang, Anjing ^a   Peng, Yan ^a   Zhu, Weirong ^a   Li, Chunhai ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Aging; Chaperone mediated autophagy; Intervertebral disc; Macroautophagy; Rat

Indexed keywords

CHAPERONE; HEAT SHOCK COGNATE PROTEIN 70; LC3 I PROTEIN; LC3 II PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2A; MESSENGER RNA; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2D; PROTEIN; UNCLASSIFIED DRUG;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL VACUOLE; CHAPERONE MEDIATED AUTOPHAGY; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEUS PULPOSUS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

AGING; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; FEMALE; GENE EXPRESSION REGULATION; HSC70 HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MICROTUBULE-ASSOCIATED PROTEINS; MOLECULAR CHAPERONES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; VACUOLES;

RATTUS;

EID: 80755188000     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2011.564336     Document Type: Article

References (39)

1. Waddell, G. (1991). Low back disability: A syndrome of western civilization. Neurosurg. Clin. North Am. 2(4):719-738.
2. Frymoyer, J.W., and Cats-Baril, W.L. (1991). An overview of the incidences and costs of low back pain. Orthop. Clin. North Am. 22(2):263-271.
3. Buckwalter, J.A. (1995). Aging and degeneration of the human intervertebral disc. Spine 20(12):1307-1314.
4. Roughley, P.J. (2004). Biology of intervertebral disc aging and degeneration: Involvement of the extracellular matrix. Spine 29(3):2691-2699. (Pubitemid 40353255)
5. Park, J.B., Park, I.C., Park, S.J., Jin, H.O., Lee, J.K., and Riew, K.D. (2006). Anti-apoptotic effects of caspase inhibitors on rat intervertebral disc cells. J. Bone. Joint. Surg. Am. 88(4):771-779.
6. Rannou, F., Lee, T.S., Zhou, R.H., Chin, J., Lotz, J.C., and Mayoux-Benhamou, M.A. (2004). Intervertebral disc degeneration: AGE the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload. Am. J. Pathol. 164(3):915-924. (Pubitemid 38235473)
7. Zhao, C.Q., Zhang, Y.H., Jiang, S.D., Jiang, L.S., and Dai, L.Y. (2010). Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordr.) 32(2):161-177.
8. Cuervo, A.M. (2004). Autophagy: In sickness and in health. Trends Cell. Biol. 14(2):70-77. (Pubitemid 38186640)
9. Klionsky, D.J., Cuervo, A.M., and Seglen, P.O. (2007). Methods for monitoring autophagy from yeast to human. Autophagy 3(3):181-206. (Pubitemid 46752679)
10. Dice, J.F. (2007). Chaperone-mediated autophagy. Autophagy 3(4):295-299. (Pubitemid 46986334)
11. Wang, X., She, H., and Mao, Z. (2009). Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis. J. Biol. Chem. 284(47):32,619-32,626.
12. Du, M., Perry, R.L., Nowacki, N.B., Gordon, J.W., Salma, J., Zhao, J., Aziz, A., Chan, J., Siu, K.W., and McDermott, J.C. (2008). Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D. Mol. Cell. Biol. 28(9):2952-2970. (Pubitemid 351556528)
13. Lam, B.Y., and Chawla, S. (2007). MEF2D expression increases during neuronal differentiation of neural progenitor cells and correlates with neurite length. Neurosci. Lett. 427(3):153-158. (Pubitemid 47633796)
14. Cuervo, A.M., and Dice, J.F. (2000). Age-related decline in chaperone mediated autophagy. J. Biol. Chem. 275(40):31,505-31,513.
15. Donati, A., Cavallini, G., Paradiso, C., Vittorini, S., Pollera, M., Gori, Z., and Bergamini, E. (2001). Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes. J. Gerontol. A Biol Sci Med Sci. 56(7):B288-B293. (Pubitemid 32645812)
16. Yorimitsu, T., and Klionsky, D.J. (2005). Autophagy: Molecular machinery for self-eating. Cell Death Differ. 12(Suppl. 2):1542-1552. (Pubitemid 41553991)
17. Wohlgemuth, S.E., Julian, D., Akin, D.E., Fried, J., Toscano, K., Leeuwenburgh, C., and Dunn, W.A., Jr. (2007). Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Res. 10(3):281-292. (Pubitemid 47378708)
18. Backer, J., Bourret, L., and Dice, J. (1983). Regulation of catabolism of microinjected ribonuclease A requires the amino terminal twenty amino acids. Proc. Natl. Acad. Sci. U.S.A. 80(8):2166-2170. (Pubitemid 13097156)
19. Cuervo, A.M., and Dice, J.F. (1996). A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273(5274):501-503. (Pubitemid 26286451)
20. Cuervo, A.M., and Dice, J.F. (2000). Unique properties of lamp2a compared to other lamp2 isoforms. J. Cell. Sci. 113(24):4441-4450. (Pubitemid 32117905)
21. Sooparb, S., Price, S.R., Shaoguang, J., and Franch, H.A. (2004). Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus. Kidney Int. 65(6):2135-2144. (Pubitemid 38669999)
22. Majeski, A.E., and Dice, J.F. (2004). Mechanisms of chaperone- mediated autophagy. Int. J. Biochem. Cell Biol. 36(12):2435-2444.
23. Shi, Y., and Thomas, J.O. (1992). The transport of proteins into the nucleus requires the 70 kilodalton heat shock protein or its cytosolic cognate. Mol. Cell. Biol. 12(5):2186-2192.
24. Lowe, D.G., and Moran, L.A. (1984). Proteins related to the mouse L-cell major heat shock protein are synthesized in the absence of heat shock gene expression. Proc. Natl. Acad. Sci. U.S.A. 81(8):2317-2321. (Pubitemid 14148253)
25. Freeman, B.C., and Morimoto, R.I. (1996). The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a nonnative protein and protein refolding. EMBO J. 15(12):2969-2979.
26. Chiang, H.L., Terlecky, S.R., Plant, C.P., and Dice, J.F. (1989). A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 246(4928):382-385.
27. Pelham, H.R.B. (1986). Speculations on the function of the major heat shock and glucose regulated proteins. Cell 46(7):959-961. (Pubitemid 17182721)
28. Ekimova, I.V., Nitsinskaya, L.E., Romanova, I.V., Pastukhov, Y.F., Margulis, B.A., and Guzhova, I.V. (2010). Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures. J. Neurochem. 115(4):1035-1044.
29. Braun, R.D., Linsenmeier, R.A., and Goldstick, T.K. (1995). Oxygen consumption in the inner and outer retina of the cat. Invest. Ophthalmol. Vis. Sci. 36(3):542-554.
30. Bernstein, S.L., Liu, A.M., Hansen, B.C., and Somiari, R.I. (2000). Heat shock cognate-70 gene expression declines during normal aging of the primate retina. Invest. Ophthalmol. Vis. Sci. 41(10):2857-2862.
31. Martin, J.F., Miano, J.M., Hustad, C.M., Copeland, N.G., Jenkins, N.A., and Olson, E.N. (1994). A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol. Cell. Biol. 14(3):1647-1656. (Pubitemid 24074560)
32. Molkentin, J.D., Firulli, A.B., Black, B.L., Martin, J.F., Hustad, C.M., Copeland, N., Jenkins, N., Lyons, G., and Olson, E.N. (1996). MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol. 16(7):3814-3824. (Pubitemid 26199902)
33. Edmondson, D.G., Lyons, G.E., Martin, J.F., and Olson, E.N. (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120(5):1251-1263. (Pubitemid 24150050)
34. Pereira, A.H., Clemente, C.F., Cardoso, A.C., Theizen, T.H., Rocco, S.A., Judice, C.C., Guido, M.C., Pascoal, V.D., Lopes- Cendes, I., Souza, J.R., and Franchini, K.G. (2009). MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice. PLoS One 4(12):e8472.
35. Kim, Y., Phan, D., van Rooij, E., Wang, D.Z., McAnally, J., Qi, X., Richardson, J.A., Hill, J.A., Bassel-Duby, R., and Olson, E.N. (2008). The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J. Clin. Invest. 118(1):124-132.
36. Xu, J., Gong, N.L., Bodi, I., Aronow, B.J., Backx, P.H., and Molkentin, J.D. (2006). Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J. Biol. Chem. 281(14):9152-9162. (Pubitemid 43864629)
37. Naya, F.J., and Olson, E. (1999). MEF2: A transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation. Curr. Opin. Cell. Biol. 11(6): 683-688.
38. Li, H., Radford, J.C., Ragusa, M.J., Shea, K.L., McKercher, S.R., Zaremba, J.D., Soussou, W., Nie, Z., Kang, Y.J., Nakanishi, N., Okamoto, S., Roberts, A.J., Schwarz, J.J., and Lipton, S.A. (2008). Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105(27):9397-9402.
39. Yang, Q., She, H., Gearing, M., Colla, E., Lee, M., Shacka, J.J., and Mao, Z. (2009). Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323(5910):124-127.