Autophagy in the degenerating human intervertebral disc: In vivo molecular and morphological evidence, and induction of autophagy in cultured annulus cells exposed to proinflammatory cytokines-implications for disc degeneration

Spine

Volumn 40, Issue 11, 2015, Pages 773-782

  Gruber, Helen E ^a   Hoelscher, Gretchen L ^a   Ingram, Jane A ^a   Bethea, Synthia ^a   Hanley, Edward N ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Autophagy; Disc degeneration; IL 1 ; Intervertebral disc; p62 SQSTM1; PIM 2 oncogene; Proinflammatory cytokines; TNF ; WIPI49

Indexed keywords

AUTOPHAGY PROTEIN 3; AUTOPHAGY PROTEIN 4B; AUTOPHAGY PROTEIN 4C; AUTOPHAGY PROTEIN 7; AUTOPHAGY PROTEIN 8; BECLIN 1; CATHEPSIN D; INTERLEUKIN 1BETA; L3A PROTEIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 1; N ACETYLGALACTOSAMINE 4 SULFATASE; PARAFFIN; PROTEIN; PROTEIN P62; TUMOR NECROSIS FACTOR ALPHA; ULK 2 PROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; ATG3 PROTEIN, HUMAN; ATG4A PROTEIN, HUMAN; ATG4B PROTEIN, HUMAN; ATG7 PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; CARRIER PROTEIN; CATHEPSIN B; CYSTEINE PROTEINASE; DRAM1 PROTEIN, HUMAN; MAP1LC3A PROTEIN, HUMAN; MAP1LC3B PROTEIN, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; P62 PROTEIN, HUMAN; PIM2 PROTEIN, HUMAN; PRESENILIN 1; PROTEIN SERINE THREONINE KINASE; RNA BINDING PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; ULK2 PROTEIN, HUMAN; WIPI-1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VACUOLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTERVERTEBRAL DISK DEGENERATION; MALE; MIDDLE AGED; PRESCHOOL CHILD; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; UPREGULATION; YOUNG ADULT; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; INFANT; INTERVERTEBRAL DISK; LUMBAR VERTEBRA; METABOLISM; PATHOLOGY; SACRUM;

ADULT; AGED; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CARRIER PROTEINS; CATHEPSIN B; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; FEMALE; GENE EXPRESSION; HUMANS; INFANT; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LUMBAR VERTEBRAE; MALE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; PRESENILIN-1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; SACRUM; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES; UP-REGULATION; YOUNG ADULT;

EID: 84942596217     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0000000000000865     Document Type: Article

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