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Volumn 10, Issue 4, 2015, Pages 307-316

Understanding nucleus pulposus cell phenotype: A prerequisite for stem cell based therapies to treat intervertebral disc degeneration

Author keywords

Annulus fibrosus; Cell phenotype; Hypoxia; Intervertebral disc; Intervertebral disc degeneration; Nucleus pulposus; Stem cell therapy

Indexed keywords

NOTCH RECEPTOR;

EID: 84930517944     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574888X10666150113112149     Document Type: Article
Times cited : (61)

References (122)
  • 2
    • 57349105550 scopus 로고    scopus 로고
    • The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain
    • Oxford
    • Freemont AJ. The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain. Rheumatology (Oxford) 2009; 48(1): 5-10.
    • (2009) Rheumatology , vol.48 , Issue.1 , pp. 5-10
    • Freemont, A.J.1
  • 4
    • 39049097183 scopus 로고    scopus 로고
    • Expenditures and health status among adults with back and neck problems
    • Martin BI, Deyo RA, Mirza SK, et al. Expenditures and health status among adults with back and neck problems. JAMA 2008; 299(6): 656-64.
    • (2008) JAMA , vol.299 , Issue.6 , pp. 656-664
    • Martin, B.I.1    Deyo, R.A.2    Mirza, S.K.3
  • 5
    • 0036201942 scopus 로고    scopus 로고
    • Intervertebral disc degeneration adjacent to a lumbar fusion. An experimental rabbit model
    • Phillips FM, Reuben J, Wetzel FT. Intervertebral disc degeneration adjacent to a lumbar fusion. An experimental rabbit model. J Bone Joint Surg Br 2002; 84(2): 289-94.
    • (2002) J Bone Joint Surg Br , vol.84 , Issue.2 , pp. 289-294
    • Phillips, F.M.1    Reuben, J.2    Wetzel, F.T.3
  • 6
    • 0029813162 scopus 로고    scopus 로고
    • The human lumbar intervertebral disc: Evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration
    • Antoniou J, Steffen T, Nelson F, et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996; 98(4): 996-1003.
    • (1996) J Clin Invest , vol.98 , Issue.4 , pp. 996-1003
    • Antoniou, J.1    Steffen, T.2    Nelson, F.3
  • 7
    • 0029008944 scopus 로고
    • Aging and degeneration of the human intervertebral disc
    • Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine (Phila Pa 1976) 1995; 20(11): 1307-14.
    • (1995) Spine (Phila Pa 1976) , vol.20 , Issue.11 , pp. 1307-1314
    • Buckwalter, J.A.1
  • 8
    • 0021990523 scopus 로고
    • Water and electrolyte content of human intervertebral discs under variable load
    • Phila Pa 1976
    • Kraemer J, Kolditz D, Gowin R. Water and electrolyte content of human intervertebral discs under variable load. Spine (Phila Pa 1976) 1985; 10(1): 69-71.
    • (1985) Spine , vol.10 , Issue.1 , pp. 69-71
    • Kraemer, J.1    Kolditz, D.2    Gowin, R.3
  • 9
    • 0037109065 scopus 로고    scopus 로고
    • Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration
    • Phila Pa 1976
    • Cs-Szabo G, Ragasa-San Juan D, Turumella V, et al. Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration. Spine (Phila Pa 1976) 2002; 27(20): 2212-9.
    • (2002) Spine , vol.27 , Issue.20 , pp. 2212-2219
    • Cs-Szabo, G.1    Ragasa-San Juan, D.2    Turumella, V.3
  • 11
    • 0032527361 scopus 로고    scopus 로고
    • Percutaneous reinsertion of the nucleus pulposus. An experimental study
    • Phila Pa 1976, discussion 1539
    •  Nishimura K, Mochida J. Percutaneous reinsertion of the nucleus pulposus. An experimental study. Spine (Phila Pa 1976) 1998; 23(14): 1531-8; discussion 1539.
    • (1998) Spine , vol.23 , Issue.14 , pp. 1531-1538
    • Nishimura, K.1    Mochida, J.2
  • 13
    • 18244419494 scopus 로고    scopus 로고
    • Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes
    • Gorensek M, Jaksimović C, Kregar-Velikonja N, et al. Nucleus pulposus repair with cultured autologous elastic cartilage derived chondrocytes. Cell Mol Biol Lett 2004; 9(2): 363-73.
    • (2004) Cell Mol Biol Lett , vol.9 , Issue.2 , pp. 363-373
    • Gorensek, M.1    Jaksimović, C.2    Kregar-Velikonja, N.3
  • 14
    • 82355164086 scopus 로고    scopus 로고
    • Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells
    • Acosta FL, Metz L, Adkisson HD, et al. Porcine intervertebral disc repair using allogeneic juvenile articular chondrocytes or mesenchymal stem cells. Tissue Eng Part A 2011; 17(23-24): 3045-55.
    • (2011) Tissue Eng Part A , vol.17 , Issue.23-24 , pp. 3045-3055
    • Acosta, F.L.1    Metz, L.2    Adkisson, H.D.3
  • 15
    • 80052041972 scopus 로고    scopus 로고
    • Notochordal cells in the adult intervertebral disc: New perspective on an old question
    • Risbud MV, Shapiro IM. Notochordal cells in the adult intervertebral disc: new perspective on an old question. Crit Rev Eukaryot Gene Expr 2011; 21(1): 29-41.
    • (2011) Crit Rev Eukaryot Gene Expr , vol.21 , Issue.1 , pp. 29-41
    • Risbud, M.V.1    Shapiro, I.M.2
  • 17
    • 84923830954 scopus 로고    scopus 로고
    • Defining the Phenotype of Young Healthy Nucleus Pulposus Cells: Recommendations of the Spine Research Interest Group at the 2014 Annual ORS Meeting
    • Risbud MV, Schoepflin ZR, Mwale F, et al. Defining the Phenotype of Young Healthy Nucleus Pulposus Cells: Recommendations of the Spine Research Interest Group at the 2014 Annual ORS Meeting. J Orthop Res 2014; 33(3): 283-93.
    • (2014) J Orthop Res , vol.33 , Issue.3 , pp. 283-293
    • Risbud, M.V.1    Schoepflin, Z.R.2    Mwale, F.3
  • 18
    • 37249058369 scopus 로고    scopus 로고
    • Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs
    • Melrose J, Smith SM, Fuller ES, et al. Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. Eur Spine J 2007; 16(12): 2193-205.
    • (2007) Eur Spine J , vol.16 , Issue.12 , pp. 2193-2205
    • Melrose, J.1    Smith, S.M.2    Fuller, E.S.3
  • 19
    • 0001471994 scopus 로고
    • Experimental incision of the intervertebral disc
    •  Smith JW, Walmsley R. Experimental incision of the intervertebral disc. J Bone Joint Surg Br 1951; 33-B(4): 612-25.
    • (1951) J Bone Joint Surg Br , vol.33-B , Issue.4 , pp. 612-625
    • Smith, J.W.1    Walmsley, R.2
  • 20
    • 40049109380 scopus 로고    scopus 로고
    • Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model
    • Phila Pa 1976
    • Korecki CL, Costi JJ, Iatridis JC. Needle puncture injury affects intervertebral disc mechanics and biology in an organ culture model. Spine (Phila Pa 1976) 2008; 33(3): 235-41.
    • (2008) Spine , vol.33 , Issue.3 , pp. 235-241
    • Korecki, C.L.1    Costi, J.J.2    Iatridis, J.C.3
  • 21
    • 35848940018 scopus 로고    scopus 로고
    • Evidence for skeletal progenitor cells in the degenerate human intervertebral disc
    • Phila Pa 1976
    • Risbud MV, Guttapalli A, Tsai T-T, et al. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine (Phila Pa 1976) 2007; 32(23): 2537-44.
    • (2007) Spine , vol.32 , Issue.23 , pp. 2537-2544
    • Risbud, M.V.1    Guttapalli, A.2    Tsai, T.-T.3
  • 22
    • 84874099730 scopus 로고    scopus 로고
    • The presence of local mesenchymal progenitor cells in human degenerated intervertebral discs and possibilities to influence these in vitro: A descriptive study in humans
    • Brisby H, Papadimitriou N, Brantsing C, et al. The presence of local mesenchymal progenitor cells in human degenerated intervertebral discs and possibilities to influence these in vitro: a descriptive study in humans. Stem Cells Dev 2013; 22(5): 804-14.
    • (2013) Stem Cells Dev , vol.22 , Issue.5 , pp. 804-814
    • Brisby, H.1    Papadimitriou, N.2    Brantsing, C.3
  • 23
    • 78650936677 scopus 로고    scopus 로고
    • Isolation and characterization of mesenchymal stromal cells from human degenerated nucleus pulposus: Comparison with bone marrow mesenchymal stromal cells from the same subjects
    • Phila Pa 1976
    • Blanco JF, Graciani IF, Sanchez-Guijo FM, et al. Isolation and characterization of mesenchymal stromal cells from human degenerated nucleus pulposus: comparison with bone marrow mesenchymal stromal cells from the same subjects. Spine (Phila Pa 1976) 2010; 35(26): 2259-65.
    • (2010) Spine , vol.35 , Issue.26 , pp. 2259-2265
    • Blanco, J.F.1    Graciani, I.F.2    Sanchez-Guijo, F.M.3
  • 24
    • 77950868519 scopus 로고    scopus 로고
    • Multipotential differentiation of human anulus fibrosus cells: An in vitro study
    • Feng G, Yang X, Shang H, et al. Multipotential differentiation of human anulus fibrosus cells: an in vitro study. J Bone Joint Surg Am 2010; 92(3): 675-85.
    • (2010) J Bone Joint Surg Am , vol.92 , Issue.3 , pp. 675-685
    • Feng, G.1    Yang, X.2    Shang, H.3
  • 25
    • 70349814406 scopus 로고    scopus 로고
    • Identification of cell proliferation zones, progenitor cells and a potential stem cell niche in the intervertebral disc region: A study in four species
    • Phila Pa 1976
    • Henriksson H, Thornemo M, Karlsson C, et al. Identification of cell proliferation zones, progenitor cells and a potential stem cell niche in the intervertebral disc region: a study in four species. Spine (Phila Pa 1976) 2009; 34(21): 2278-87.
    • (2009) Spine , vol.34 , Issue.21 , pp. 2278-2287
    • Henriksson, H.1    Thornemo, M.2    Karlsson, C.3
  • 26
    • 84860326883 scopus 로고    scopus 로고
    • Support of concept that migrating progenitor cells from stem cell niches contribute to normal regeneration of the adult mammal intervertebral disc: A descriptive study in the New Zealand white rabbit
    • Phila Pa 1976
    • Henriksson HB, Svala E, Skioldebrand E, Lindahl A, Brisby H. Support of concept that migrating progenitor cells from stem cell niches contribute to normal regeneration of the adult mammal intervertebral disc: a descriptive study in the New Zealand white rabbit. Spine (Phila Pa 1976) 2012; 37(9): 722-32.
    • (2012) Spine , vol.37 , Issue.9 , pp. 722-732
    • Henriksson, H.B.1    Svala, E.2    Skioldebrand, E.3    Lindahl, A.4    Brisby, H.5
  • 27
    • 84871794357 scopus 로고    scopus 로고
    • Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
    • Sakai D, Nakamura Y, Nakai T, et al. Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun 2012; 3: 1264.
    • (2012) Nat Commun , vol.3 , pp. 1264
    • Sakai, D.1    Nakamura, Y.2    Nakai, T.3
  • 28
    • 84879207385 scopus 로고    scopus 로고
    • Changes of number of cells expressing proliferation and progenitor cell markers with age in rabbit intervertebral discs
    • Yasen M, Fei Q, Hutton WC, et al. Changes of number of cells expressing proliferation and progenitor cell markers with age in rabbit intervertebral discs. Acta Biochim Biophys Sin (Shanghai) 2013; 45(5): 368-76.
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , Issue.5 , pp. 368-376
    • Yasen, M.1    Fei, Q.2    Hutton, W.C.3
  • 29
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8(4): 315-7.
    • (2006) Cytotherapy , vol.8 , Issue.4 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 30
    • 84884590994 scopus 로고    scopus 로고
    • The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: Spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc
    • Shu C, Hughes C, Smith SM, et al. The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconj J 2013; 30(7): 717-25.
    • (2013) Glycoconj J , vol.30 , Issue.7 , pp. 717-725
    • Shu, C.1    Hughes, C.2    Smith, S.M.3
  • 31
    • 79955567515 scopus 로고    scopus 로고
    • Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: Implications in degenerative disc disease
    • Hiyama A, Skubutyte R, Markova D, et al. Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease. Arthritis Rheum 2011; 63(5): 1355-64.
    • (2011) Arthritis Rheum , vol.63 , Issue.5 , pp. 1355-1364
    • Hiyama, A.1    Skubutyte, R.2    Markova, D.3
  • 32
    • 27644561755 scopus 로고    scopus 로고
    • Hypoxia requires notch signaling to maintain the undifferentiated cell state
    • Gustafsson M V, Zheng X, Pereira T, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005; 9(5): 617-28.
    • (2005) Dev Cell , vol.9 , Issue.5 , pp. 617-628
    • Gustafsson, M.V.1    Zheng, X.2    Pereira, T.3
  • 33
    • 84878767656 scopus 로고    scopus 로고
    • Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: Implications in intervertebral disc degeneration
    • Wang H, Tian Y, Wang J, et al. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem 2013; 288(23): 16761-74.
    • (2013) J Biol Chem , vol.288 , Issue.23 , pp. 16761-16774
    • Wang, H.1    Tian, Y.2    Wang, J.3
  • 34
    • 84855169648 scopus 로고    scopus 로고
    • Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: Implications for the mechanisms of intervertebral disc degeneration
    • Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FWL. Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration. Arthritis Res Ther 2011; 13(6): R215.
    • (2011) Arthritis Res Ther , vol.13 , Issue.6
    • Erwin, W.M.1    Islam, D.2    Inman, R.D.3    Fehlings, M.G.4    Tsui, F.5
  • 35
    • 0037708391 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells embedded in Atelocollagen® gel to the intervertebral disc: A potential therapeutic model for disc degeneration
    • Sakai D, Mochida J, Yamamoto Y, et al. Transplantation of mesenchymal stem cells embedded in Atelocollagen® gel to the intervertebral disc: a potential therapeutic model for disc degeneration. Biomaterials 2003; 24(20): 3531-41.
    • (2003) Biomaterials , vol.24 , Issue.20 , pp. 3531-3541
    • Sakai, D.1    Mochida, J.2    Yamamoto, Y.3
  • 36
    • 26844531456 scopus 로고    scopus 로고
    • Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc
    • Sakai D, Mochida J, Iwashina T, et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials 2006; 27(3): 335-45.
    • (2006) Biomaterials , vol.27 , Issue.3 , pp. 335-345
    • Sakai, D.1    Mochida, J.2    Iwashina, T.3
  • 37
    • 27644541907 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: Potential and limitations for stem cell therapy in disc regeneration
    • Phila Pa 1976
    • Sakai D, Mochida J, Iwashina T, et al. Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration. Spine (Phila Pa 1976) 2005; 30(21): 2379-87.
    • (2005) Spine , vol.30 , Issue.21 , pp. 2379-2387
    • Sakai, D.1    Mochida, J.2    Iwashina, T.3
  • 38
    • 2942536282 scopus 로고    scopus 로고
    • Intervertebral disc cell therapy for regeneration: Mesenchymal stem cell implantation in rat intervertebral discs
    • Crevensten G, Walsh AJL, Ananthakrishnan D, et al. Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Ann Biomed Eng 2004; 32(3): 430-4.
    • (2004) Ann Biomed Eng , vol.32 , Issue.3 , pp. 430-434
    • Crevensten, G.1    Walsh, A.2    Ananthakrishnan, D.3
  • 39
    • 43649093152 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells in a canine disc degeneration model
    • Hiyama A, Mochida J, Iwashina T, et al. Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res 2008; 26(5): 589-600.
    • (2008) J Orthop Res , vol.26 , Issue.5 , pp. 589-600
    • Hiyama, A.1    Mochida, J.2    Iwashina, T.3
  • 40
    • 79952310565 scopus 로고    scopus 로고
    • Transplantation of goat bone marrow stromal cells to the degenerating intervertebral disc in a goat disc injury model
    • Phila Pa 1976
    • Zhang Y, Drapeau S, Howard SA, Thonar EJMA, Anderson DG. Transplantation of goat bone marrow stromal cells to the degenerating intervertebral disc in a goat disc injury model. Spine (Phila Pa 1976) 2011; 36(5): 372-7.
    • (2011) Spine , vol.36 , Issue.5 , pp. 372-377
    • Zhang, Y.1    Drapeau, S.2    Howard, S.A.3    Thonar, E.4    Erson, D.G.5
  • 41
    • 62249162950 scopus 로고    scopus 로고
    • The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs
    • Wei A, Tao H, Chung SA, et al. The fate of transplanted xenogeneic bone marrow-derived stem cells in rat intervertebral discs. J Orthop Res 2009; 27(3): 374-9.
    • (2009) J Orthop Res , vol.27 , Issue.3 , pp. 374-379
    • Wei, A.1    Tao, H.2    Chung, S.A.3
  • 42
    • 64049111281 scopus 로고    scopus 로고
    • Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model
    • Henriksson HB, Svanvik T, Jonsson M, et al. Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model. Spine (Phila Pa 1976) 2009; 34(2): 141-8.
    • (2009) Spine (Phila Pa 1976) , vol.34 , Issue.2 , pp. 141-148
    • Henriksson, H.B.1    Svanvik, T.2    Jonsson, M.3
  • 43
    • 15544381999 scopus 로고    scopus 로고
    • Induction of intervertebral disclike cells from adult mesenchymal stem cells
    • Steck E, Bertram H, Abel R, et al. Induction of intervertebral disclike cells from adult mesenchymal stem cells. Stem Cells 2005; 23(3): 403-11.
    • (2005) Stem Cells , vol.23 , Issue.3 , pp. 403-411
    • Steck, E.1    Bertram, H.2    Abel, R.3
  • 44
    • 77952409629 scopus 로고    scopus 로고
    • Intervertebral disc regeneration: Influence of growth factors on differentiation of human mesenchymal stem cells (hMSC)
    • Ehlicke F, Freimark D, Heil B, Dorresteijn A, Czermak P. Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (hMSC). Int J Artif Organs 2010; 33(4): 244-52.
    • (2010) Int J Artif Organs , vol.33 , Issue.4 , pp. 244-252
    • Ehlicke, F.1    Freimark, D.2    Heil, B.3    Dorresteijn, A.4    Czermak, P.5
  • 45
    • 33745002760 scopus 로고    scopus 로고
    • Intervertebral disc cell-mediated mesenchymal stem cell differentiation
    • Richardson SM, Walker R V, Parker S, et al. Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 2006; 24(3): 707-16.
    • (2006) Stem Cells , vol.24 , Issue.3 , pp. 707-716
    • Richardson, S.M.1    Walker, R.V.2    Parker, S.3
  • 46
    • 77957559989 scopus 로고    scopus 로고
    • Coculture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype
    •  Strassburg S, Richardson SM, Freemont AJ, Hoyland JA. Coculture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype. Regen Med 2010; 5(5): 701-11.
    • (2010) Regen Med , vol.5 , Issue.5 , pp. 701-711
    • Strassburg, S.1    Richardson, S.M.2    Freemont, A.J.3    Hoyland, J.A.4
  • 47
    • 78650903073 scopus 로고    scopus 로고
    • Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype
    • Korecki CL, Taboas JM, Tuan RS, Iatridis JC. Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem Cell Res Ther 2010; 1(2): 18.
    • (2010) Stem Cell Res Ther , vol.1 , Issue.2 , pp. 18
    • Korecki, C.L.1    Taboas, J.M.2    Tuan, R.S.3    Iatridis, J.C.4
  • 48
    • 79957658251 scopus 로고    scopus 로고
    • Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells
    • Purmessur D, Schek RM, Abbott RD, et al. Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells. Arthritis Res Ther 2011; 13(3): R81.
    • (2011) Arthritis Res Ther , vol.13 , Issue.3
    • Purmessur, D.1    Schek, R.M.2    Abbott, R.D.3
  • 49
    • 84896319244 scopus 로고    scopus 로고
    • Using notochordal cells of developmental origin to stimulate nucleus pulposus cells and bone marrow stromal cells for intervertebral disc regeneration
    • Potier E, Ito K. Using notochordal cells of developmental origin to stimulate nucleus pulposus cells and bone marrow stromal cells for intervertebral disc regeneration. Eur Spine J 2014; 23(3): 679-88.
    • (2014) Eur Spine J , vol.23 , Issue.3 , pp. 679-688
    • Potier, E.1    Ito, K.2
  • 50
    • 84924248021 scopus 로고    scopus 로고
    • Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia
    • Gantenbein B, Calandriello E, Wuertz-Kozak K, et al. Activation of intervertebral disc cells by co-culture with notochordal cells, conditioned medium and hypoxia. BMC Musculoskelet Disord 2014; 15(1): 422.
    • (2014) BMC Musculoskelet Disord , vol.15 , Issue.1 , pp. 422
    • Gantenbein, B.1    Calandriello, E.2    Wuertz-Kozak, K.3
  • 51
    • 14044269226 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: Implications for cell-based transplantation therapy
    • Risbud MV, Albert TJ, Guttapalli A, et al. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine (Phila Pa 1976) 2004; 29(23): 2627-32.
    • (2004) Spine (Phila Pa 1976) , vol.29 , Issue.23 , pp. 2627-2632
    • Risbud, M.V.1    Albert, T.J.2    Guttapalli, A.3
  • 52
    • 80053157000 scopus 로고    scopus 로고
    • Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells
    • Stoyanov J V, Gantenbein-Ritter B, Bertolo A, et al. Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells. Eur Cell Mater 2011; 21: 533-47.
    • (2011) Eur Cell Mater , vol.21 , pp. 533-547
    • Stoyanov, J.V.1    Gantenbein-Ritter, B.2    Bertolo, A.3
  • 53
    • 80052349703 scopus 로고    scopus 로고
    • Effects of hypoxias and scaffold architecture on rabbit mesenchymal stem cell differentiation towards a nucleus pulposus-like phenotype
    • Feng G, Jin X, Hu J, et al. Effects of hypoxias and scaffold architecture on rabbit mesenchymal stem cell differentiation towards a nucleus pulposus-like phenotype. Biomaterials 2011; 32(32): 8182-9.
    • (2011) Biomaterials , vol.32 , Issue.32 , pp. 8182-8189
    • Feng, G.1    Jin, X.2    Hu, J.3
  • 54
    • 77952406185 scopus 로고    scopus 로고
    • Transcriptional profiling of the nucleus pulposus: Say yes to notochord
    • Shapiro IM, Risbud MV. Transcriptional profiling of the nucleus pulposus: say yes to notochord. Arthritis Res Ther 2010; 12(3): 117.
    • (2010) Arthritis Res Ther , vol.12 , Issue.3 , pp. 117
    • Shapiro, I.M.1    Risbud, M.V.2
  • 55
    • 84907195495 scopus 로고    scopus 로고
    • Development of the annelid axochord: Insights into notochord evolution
    • Lauri A., Brunet T, Handberg-Thorsager M, et al. Development of the annelid axochord: Insights into notochord evolution. Science 2014; 345(6202): 1365-8.
    • (2014) Science , vol.345 , Issue.6202 , pp. 1365-1368
    • Lauri, A.1    Brunet, T.2    Handberg-Thorsager, M.3
  • 56
    • 84908430293 scopus 로고    scopus 로고
    • Loss of HIF-1a in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus
    •  Merceron C, Mangiavini L, Robling A, et al. Loss of HIF-1a in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus. PLoS One 2014; 9(10): e110768.
    • (2014) Plos One , vol.9 , Issue.10
    • Merceron, C.1    Mangiavini, L.2    Robling, A.3
  • 57
    • 0020461748 scopus 로고
    • Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus
    • Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat Rec 1982; 204(4): 307-14.
    • (1982) Anat Rec , vol.204 , Issue.4 , pp. 307-314
    • Trout, J.J.1    Buckwalter, J.A.2    Moore, K.C.3
  • 58
    • 33748564012 scopus 로고    scopus 로고
    • Molecular phenotypes of notochordal cells purified from immature nucleus pulposus
    • Chen J, Yan W, Setton LA. Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. Eur Spine J 2006; 15 Suppl 3: S303-11.
    • Eur Spine J 2006; 15 Suppl , vol.3
    • Chen, J.1    Yan, W.2    Setton, L.A.3
  • 59
    • 10344267546 scopus 로고    scopus 로고
    • Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: A species comparison
    • Hunter CJ, Matyas JR, Duncan NA. Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat 2004; 205(5): 357-62.
    • (2004) J Anat , vol.205 , Issue.5 , pp. 357-362
    • Hunter, C.J.1    Matyas, J.R.2    Duncan, N.A.3
  • 60
    • 0024690251 scopus 로고
    • Development and involution of the notochord in the human spine
    • Pazzaglia UE, Salisbury JR, Byers PD. Development and involution of the notochord in the human spine. J R Soc Med 1989; 82(7): 413-5.
    • (1989) J R Soc Med , vol.82 , Issue.7 , pp. 413-415
    • Pazzaglia, U.E.1    Salisbury, J.R.2    Byers, P.D.3
  • 61
    • 84904597285 scopus 로고    scopus 로고
    • Modulating notochordal differentiation of human induced pluripotent stem cells using natural nucleus pulposus tissue matrix
    •  Liu Y, Rahaman MN, Bal BS. Modulating notochordal differentiation of human induced pluripotent stem cells using natural nucleus pulposus tissue matrix. PLoS One 2014; 9(7): e100885.
    • (2014) Plos One , vol.9 , Issue.7
    • Liu, Y.1    Rahaman, M.N.2    Bal, B.S.3
  • 62
  • 63
    • 57149118250 scopus 로고    scopus 로고
    • Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation
    • Choi K-S, Cohn MJ, Harfe BD. Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn 2008; 237(12): 3953-8.
    • (2008) Dev Dyn , vol.237 , Issue.12 , pp. 3953-3958
    • Choi, K.-S.1    Cohn, M.J.2    Harfe, B.D.3
  • 64
    • 84860465584 scopus 로고    scopus 로고
    • Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc
    • Dahia CL, Mahoney E, Wylie C. Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One 2012; 7(4): e35944.
    • (2012) Plos One , vol.7 , Issue.4
    • Dahia, C.L.1    Mahoney, E.2    Wylie, C.3
  • 65
    • 84902477979 scopus 로고    scopus 로고
    • Wnt signaling activates shh signaling in early postnatal intervertebral discs, and re-activates shh signaling in old discs in the mouse
    • Winkler T, Mahoney EJ, Sinner D, Wylie CC, Dahia CL. Wnt signaling activates shh signaling in early postnatal intervertebral discs, and re-activates shh signaling in old discs in the mouse. PLoS One 2014; 9(6): e98444.
    • (2014) Plos One , vol.9 , Issue.6
    • Winkler, T.1    Mahoney, E.J.2    Sinner, D.3    Wylie, C.C.4    Dahia, C.L.5
  • 66
    • 0028031460 scopus 로고
    • The T genes in embryogenesis
    • Herrmann BG, Kispert A. The T genes in embryogenesis. Trends Genet 1994; 10(8): 280-6.
    • (1994) Trends Genet , vol.10 , Issue.8 , pp. 280-286
    • Herrmann, B.G.1    Kispert, A.2
  • 67
    • 77949474632 scopus 로고    scopus 로고
    • Transcriptional profiling of bovine intervertebral disc cells: Implications for identification of normal and degenerate human intervertebral disc cell phenotypes
    • Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA. Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther 2010; 12(1): R22.
    • (2010) Arthritis Res Ther , vol.12 , Issue.1
    • Minogue, B.M.1    Richardson, S.M.2    Zeef, L.A.3    Freemont, A.J.4    Hoyland, J.A.5
  • 68
    • 84871270841 scopus 로고    scopus 로고
    • Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging
    • Tang X, Jing L, Chen J. Changes in the molecular phenotype of nucleus pulposus cells with intervertebral disc aging. PLoS One 2012; 7(12): e52020.
    • (2012) Plos One , vol.7 , Issue.12
    • Tang, X.1    Jing, L.2    Chen, J.3
  • 69
    • 65549151759 scopus 로고    scopus 로고
    • Postnatal growth, differentiation, and aging of the mouse intervertebral disc
    • Dahia CL, Mahoney EJ, Durrani AA, Wylie C. Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine (Phila Pa 1976) 2009; 34(5): 447-55.
    • (2009) Spine (Phila Pa 1976) , vol.34 , Issue.5 , pp. 447-455
    • Dahia, C.L.1    Mahoney, E.J.2    Durrani, A.A.3    Wylie, C.4
  • 70
    • 77952428710 scopus 로고    scopus 로고
    • Disc regeneration therapy using marrow mesenchymal cell transplantation: A report of two case studies
    • Yoshikawa T, Ueda Y, Miyazaki K, Koizumi M, Takakura Y. Disc regeneration therapy using marrow mesenchymal cell transplantation: a report of two case studies. Spine (Phila Pa 1976) 2010; 35(11): E475-80.
    • (2010) Spine (Phila Pa 1976) , vol.35 , Issue.11
    • Yoshikawa, T.1    Ueda, Y.2    Miyazaki, K.3    Koizumi, M.4    Takakura, Y.5
  • 71
    • 84919461157 scopus 로고    scopus 로고
    • Percutaneous injection of  autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months
    • Pettine KA, Murphy MB, Suzuki RK, Sand TT. Percutaneous injection of  autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months. Stem Cells 2015; 33(1): 146-56.
    • (2015) Stem Cells , vol.33 , Issue.1 , pp. 146-156
    • Pettine, K.A.1    Murphy, M.B.2    Suzuki, R.K.3    Sand, T.T.4
  • 72
    • 57249084243 scopus 로고    scopus 로고
    • Adipose stem cells for intervertebral disc regeneration: Current status and concepts for the future
    • Hoogendoorn RJW, Lu ZF, Kroeze RJ, et al. Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future. J Cell Mol Med 2008; 12(6A): 2205-16.
    • (2008) J Cell Mol Med , vol.12 , Issue.6A , pp. 2205-2216
    • Hoogendoorn, R.1    Lu, Z.F.2    Kroeze, R.J.3
  • 73
    • 70349845897 scopus 로고    scopus 로고
    • Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: Experiments in a canine model
    • Ganey T, Hutton WC, Moseley T, Hedrick M, Meisel H-J. Intervertebral disc repair using adipose tissue-derived stem and regenerative cells: experiments in a canine model. Spine (Phila Pa 1976) 2009; 34(21): 2297-304.
    • (2009) Spine (Phila Pa 1976) , vol.34 , Issue.21 , pp. 2297-2304
    • Ganey, T.1    Hutton, W.C.2    Moseley, T.3    Hedrick, M.4    Meisel, H.-J.5
  • 74
    • 84866627201 scopus 로고    scopus 로고
    • Transplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs
    • Chun H-J, Kim YS, Kim BK, et al. Transplantation of human adipose-derived stem cells in a rabbit model of traumatic degeneration of lumbar discs. World Neurosurg 2012; 78(3): 364-71.
    • (2012) World Neurosurg , vol.78 , Issue.3 , pp. 364-371
    • Chun, H.-J.1    Kim, Y.S.2    Kim, B.K.3
  • 75
    • 68549090542 scopus 로고    scopus 로고
    • Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma
    • Chen W-H, Liu H-Y, Lo W-C, et al. Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma. Biomaterials 2009; 30(29): 5523-33.
    • (2009) Biomaterials , vol.30 , Issue.29 , pp. 5523-5533
    • Chen, W.-H.1    Liu, H.-Y.2    Lo, W.-C.3
  • 76
    • 78049386105 scopus 로고    scopus 로고
    • Intradiscal  transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits
    • Miyamoto T, Muneta T, Tabuchi T, et al. Intradiscal  transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res Ther 2010; 12(6): R206.
    • (2010) Arthritis Res Ther , vol.12 , Issue.6
    • Miyamoto, T.1    Muneta, T.2    Tabuchi, T.3
  • 77
    • 48749093464 scopus 로고    scopus 로고
    • Adipose-derived stem cell therapy for intervertebral disc regeneration: An in vitro reconstructed tissue in alginate capsules
    • Gaetani P., Torre M. L., Klinger M., et al. Adipose-derived stem cell therapy for intervertebral disc regeneration: an in vitro reconstructed tissue in alginate capsules. Tissue Eng Part A 2008; 14(8): 1415-23.
    • (2008) Tissue Eng Part A , vol.14 , Issue.8 , pp. 1415-1423
    • Gaetani, P.1    Torre, M.L.2    Klinger, M.3
  • 78
    • 51349153924 scopus 로고    scopus 로고
    • Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam
    • Nesti L. J., Li W.J., Shanti R.M., et al. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A 2008; 14(9): 1527-37.
    • (2008) Tissue Eng Part A , vol.14 , Issue.9 , pp. 1527-1537
    • Nesti, L.J.1    Li, W.J.2    Shanti, R.M.3
  • 79
    • 81255149435 scopus 로고    scopus 로고
    • Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds
    • Driscoll TP, Nerurkar NL, Jacobs NT, Elliott DM, Mauck RL. Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds. J Mech Behav Biomed Mater 2011; 4(8): 1627-36.
    • (2011) J Mech Behav Biomed Mater , vol.4 , Issue.8 , pp. 1627-1636
    • Driscoll, T.P.1    Nerurkar, N.L.2    Jacobs, N.T.3    Elliott, D.M.4    Mauck, R.L.5
  • 80
    • 84863424431 scopus 로고    scopus 로고
    • Simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell sheets and silk scaffolds for annulus fibrosus regeneration
    • See EY-S, Toh SL, Goh JCH. Simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell sheets and silk scaffolds for annulus fibrosus regeneration. J Tissue Eng Regen Med 2012; 6(7): 528-35.
    • (2012) J Tissue Eng Regen Med , vol.6 , Issue.7 , pp. 528-535
    • See, E.-S.1    Toh, S.L.2    Goh, J.3
  • 81
    • 84859971736 scopus 로고    scopus 로고
    • Mesenchymal stem cells injection in degenerated intervertebral disc: Cell leakage may induce osteophyte formation
    • Vadalà G, Sowa G, Hubert M, et al. Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation. J Tissue Eng Regen Med 2012; 6(5): 348-55.
    • (2012) J Tissue Eng Regen Med , vol.6 , Issue.5 , pp. 348-355
    • Vadalà, G.1    Sowa, G.2    Hubert, M.3
  • 82
    • 33745954928 scopus 로고    scopus 로고
    • Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells
    • Zhu W, Chen J, Cong X, Hu S, Chen X. Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells 2006; 24(2): 416-25.
    • (2006) Stem Cells , vol.24 , Issue.2 , pp. 416-425
    • Zhu, W.1    Chen, J.2    Cong, X.3    Hu, S.4    Chen, X.5
  • 83
    • 14844342946 scopus 로고    scopus 로고
    • Nutrition of the intervertebral disc
    • Urban JPG, Smith S, Fairbank JCT. Nutrition of the intervertebral disc. Spine (Phila Pa 1976) 2004; 29(23): 2700-9.
    • (2004) Spine (Phila Pa 1976) , vol.29 , Issue.23 , pp. 2700-2709
    • Urban, J.1    Smith, S.2    Fairbank, J.3
  • 84
    • 0036216444 scopus 로고    scopus 로고
    • Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs
    • Sive JI, Baird P, Jeziorsk M, et al. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol 2002; 55(2): 91-7.
    • (2002) Mol Pathol , vol.55 , Issue.2 , pp. 91-97
    • Sive, J.I.1    Baird, P.2    Jeziorsk, M.3
  • 85
    • 78650060236 scopus 로고    scopus 로고
    • Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation
    • Minogue BM, Richardson SM, Zeef LAH, Freemont AJ, Hoyland JA. Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation. Arthritis Rheum 2010; 62(12): 3695-705.
    • (2010) Arthritis Rheum , vol.62 , Issue.12 , pp. 3695-3705
    • Minogue, B.M.1    Richardson, S.M.2    Zeef, L.3    Freemont, A.J.4    Hoyland, J.A.5
  • 86
    • 0031908754 scopus 로고    scopus 로고
    • Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain
    • discussion 8
    • Bartels EM, Fairbank JC, Winlove CP, Urban JP. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine (Phila Pa 1976) 1998; 23(1): 1-7; discussion 8.
    • (1998) Spine (Phila Pa 1976) , vol.23 , Issue.1 , pp. 1-7
    • Bartels, E.M.1    Fairbank, J.C.2    Winlove, C.P.3    Urban, J.P.4
  • 87
    • 0027466510 scopus 로고
    • Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitis
    • Rudert M, Tillmann B. Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitis. Acta Orthop Scand 1993; 64(1): 37-40.
    • (1993) Acta Orthop Scand , vol.64 , Issue.1 , pp. 37-40
    • Rudert, M.1    Tillmann, B.2
  • 88
    • 0031908705 scopus 로고    scopus 로고
    • Evolution of disc degeneration in lumbar spine: A comparative histological study between herniated and postmortem retrieved disc specimens
    • Repanti M, Korovessis PG, Stamatakis MV, Spastris P, Kosti P. Evolution of disc degeneration in lumbar spine: a comparative histological study between herniated and postmortem retrieved disc specimens. J Spinal Disord 1998; 11(1): 41-5.
    • (1998) J Spinal Disord , vol.11 , Issue.1 , pp. 41-45
    • Repanti, M.1    Korovessis, P.G.2    Stamatakis, M.V.3    Spastris, P.4    Kosti, P.5
  • 89
    • 84887075789 scopus 로고    scopus 로고
    • FasL on human nucleus pulposus cells prevents angiogenesis in the disc by inducing Fas-mediated apoptosis of vascular endothelial cells
    • Sun Z, Wan Z-Y, Guo Y-S, Wang H-Q, Luo Z-J. FasL on human nucleus pulposus cells prevents angiogenesis in the disc by inducing Fas-mediated apoptosis of vascular endothelial cells. Int J Clin Exp Pathol 2013; 6(11): 2376-85.
    • (2013) Int J Clin Exp Pathol , vol.6 , Issue.11 , pp. 2376-2385
    • Sun, Z.1    Wan, Z.-Y.2    Guo, Y.-S.3    Wang, H.-Q.4    Luo, Z.-J.5
  • 90
    • 84914173080 scopus 로고    scopus 로고
    • Oxygen sensing and metabolic homeostasis
    • Palmer BF, Clegg DJ. Oxygen sensing and metabolic homeostasis. Mol Cell Endocrinol 2014; 397(1): 51-8.
    • (2014) Mol Cell Endocrinol , vol.397 , Issue.1 , pp. 51-58
    • Palmer, B.F.1    Clegg, D.J.2
  • 91
    • 70449527373 scopus 로고    scopus 로고
    • Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
    • Webb JD, Coleman ML, Pugh CW. Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci 2009; 66(22): 3539-54.
    • (2009) Cell Mol Life Sci , vol.66 , Issue.22 , pp. 3539-3554
    • Webb, J.D.1    Coleman, M.L.2    Pugh, C.W.3
  • 92
    • 57349102342 scopus 로고    scopus 로고
    • Cited2 modulates hypoxiainducible factor-dependent expression of vascular endothelialgrowth factor in nucleus pulposus cells of the rat intervertebral disc
    • Agrawal A, Gajghate S, Smith H, et al. Cited2 modulates hypoxiainducible factor-dependent expression of vascular endothelialgrowth factor in nucleus pulposus cells of the rat intervertebral disc. Arthritis Rheum 2008; 58(12): 3798-808.
    • (2008) Arthritis Rheum , vol.58 , Issue.12 , pp. 3798-3808
    • Agrawal, A.1    Gajghate, S.2    Smith, H.3
  • 93
    • 33646010313 scopus 로고    scopus 로고
    • Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: A metabolic adaptation to the intervertebral disc microenvironment
    • Risbud MV, Guttapalli A, Stokes DG, et al. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem 2006; 98(1): 152-9.
    • (2006) J Cell Biochem , vol.98 , Issue.1 , pp. 152-159
    • Risbud, M.V.1    Guttapalli, A.2    Stokes, D.G.3
  • 94
    • 84856160786 scopus 로고    scopus 로고
    • HIF-1a and HIF-2a degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc
    • Fujita N, Chiba K, Shapiro IM, Risbud MV. HIF-1a and HIF-2a degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res 2012; 27(2): 401-12.
    • (2012) J Bone Miner Res , vol.27 , Issue.2 , pp. 401-412
    • Fujita, N.1    Chiba, K.2    Shapiro, I.M.3    Risbud, M.V.4
  • 95
    • 84860864145 scopus 로고    scopus 로고
    • Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: Distinct roles of PHD2 and PHD3 proteins in controlling HIF-1 activity in hypoxia
    • Fujita N, Markova D, Anderson DG, et al. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1 activity in hypoxia. J Biol Chem 2012; 287(20): 16975-86.
    • (2012) J Biol Chem , vol.287 , Issue.20 , pp. 16975-16986
    • Fujita, N.1    Markova, D.2    Erson, D.G.3
  • 96
    • 84859926202 scopus 로고    scopus 로고
    • Tonicity enhancer binding protein (TonEBP) and hypoxiainducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: Role of Hsp70 in HIF-1a degradation
    • Gogate SS, Fujita N, Skubutyte R, Shapiro IM, Risbud MV. Tonicity enhancer binding protein (TonEBP) and hypoxiainducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1a degradation. J Bone Miner Res 2012; 27(5): 1106-17.
    • (2012) J Bone Miner Res , vol.27 , Issue.5 , pp. 1106-1117
    • Gogate, S.S.1    Fujita, N.2    Skubutyte, R.3    Shapiro, I.M.4    Risbud, M.V.5
  • 97
    • 85039878838 scopus 로고    scopus 로고
    • HIF-1a is Essential for the Development of the Nucleus Pulposus
    •  Mangiavini L, Wilson TL, Robling A, et al. HIF-1a is Essential for the Development of the Nucleus Pulposus. J Bone Miner Res 2012; 27 (Suppl.)
    • (2012) J Bone Miner Res
    • Mangiavini, L.1    Wilson, T.L.2    Robling, A.3
  • 98
    • 34547763695 scopus 로고    scopus 로고
    • Normoxic stabilization of HIF-1a drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk
    • Agrawal A, Guttapalli A, Narayan S, et al. Normoxic stabilization of HIF-1a drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk. Am J Physiol Cell Physiol 2007; 293(2): C621-31.
    • (2007) Am J Physiol Cell Physiol , vol.293 , Issue.2
    • Agrawal, A.1    Guttapalli, A.2    Narayan, S.3
  • 99
    • 0035989142 scopus 로고    scopus 로고
    • Phenotypic characteristics of the nucleus pulposus: Expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2
    • Rajpurohit R, Risbud MV, Ducheyne P, Vresilovic EJ, Shapiro IM. Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2. Cell Tissue Res 2002; 308(3): 401-7.
    • (2002) Cell Tissue Res , vol.308 , Issue.3 , pp. 401-407
    • Rajpurohit, R.1    Risbud, M.V.2    Ducheyne, P.3    Vresilovic, E.J.4    Shapiro, I.M.5
  • 100
    • 79959843998 scopus 로고    scopus 로고
    • Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: Role of hypoxia-inducible factor proteins
    • Gogate SS, Nasser R, Shapiro IM, Risbud MV. Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Arthritis Rheum 2011; 63(7): 1950-60.
    • (2011) Arthritis Rheum , vol.63 , Issue.7 , pp. 1950-1960
    • Gogate, S.S.1    Nasser, R.2    Shapiro, I.M.3    Risbud, M.V.4
  • 101
    • 38749107818 scopus 로고    scopus 로고
    • HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc
    • Zeng Y, Danielson KG, Albert TJ, Shapiro IM, Risbud MV. HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc. J Bone Miner Res 2007; 22(12): 1851-61.
    • (2007) J Bone Miner Res , vol.22 , Issue.12 , pp. 1851-1861
    • Zeng, Y.1    Danielson, K.G.2    Albert, T.J.3    Shapiro, I.M.4    Risbud, M.V.5
  • 102
    • 82455163775 scopus 로고    scopus 로고
    • Identification of cell surface-specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase XII varies with age and degeneration
    • Power KA, Grad S, Rutges JPHJ, et al. Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration. Arthritis Rheum 2011; 63(12): 3876-86.
    • (2011) Arthritis Rheum , vol.63 , Issue.12 , pp. 3876-3886
    • Power, K.A.1    Grad, S.2    Rutges, J.3
  • 103
    • 78649659788 scopus 로고    scopus 로고
    • PH control mechanisms of tumor survival and growth
    • Parks SK, Chiche J, Pouyssegur J. pH control mechanisms of tumor survival and growth. J Cell Physiol 2011; 226(2): 299-308.
    • (2011) J Cell Physiol , vol.226 , Issue.2 , pp. 299-308
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 104
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferrière J, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009; 69(1): 358-68.
    • (2009) Cancer Res , vol.69 , Issue.1 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferrière, J.3
  • 105
    • 84900428749 scopus 로고    scopus 로고
    • Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation
    • Reibring C-G, El Shahawy M, Hallberg K, et al. Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS One 2014; 9(5): e96007.
    • (2014) Plos One , vol.9 , Issue.5
    • Reibring, C.-G.1    El Shahawy, M.2    Hallberg, K.3
  • 106
    • 0025968680 scopus 로고
    • Carbonic anhydrase III, an early mesodermal marker, is expressed in embryonic mouse skeletal muscle and notochord
    • Lyons GE, Buckingham ME, Tweedie S, Edwards YH. Carbonic anhydrase III, an early mesodermal marker, is expressed in embryonic mouse skeletal muscle and notochord. Development 1991; 111(1): 233-44.
    • (1991) Development , vol.111 , Issue.1 , pp. 233-244
    • Lyons, G.E.1    Buckingham, M.E.2    Tweedie, S.3    Edwards, Y.H.4
  • 107
    • 84930512824 scopus 로고    scopus 로고
    • Riihimäki H,Viikari- Juntura E, Ed. 6. Musculoskeletal System. Encyclopedia of Occupational Health and Safety, Geneva: International Labor Organization
    • Roberts S, Urban JP. Intervertebral Discs. In: Riihimäki H,Viikari- Juntura E, Ed. 6. Musculoskeletal System. Encyclopedia of Occupational Health and Safety. Geneva: International Labor Organization. 2011.
    • Intervertebral Discs , pp. 2011
    • Roberts, S.1    Urban, J.P.2
  • 108
    • 0031975180 scopus 로고    scopus 로고
    • Quantitative analysis of diurnal variation in volume and water content of lumbar intervertebral discs
    • Roberts N, Hogg D, Whitehouse GH, Dangerfield P. Quantitative analysis of diurnal variation in volume and water content of lumbar intervertebral discs. Clin Anat 1998; 11(1): 1-8.
    • (1998) Clin Anat , vol.11 , Issue.1 , pp. 1-8
    • Roberts, N.1    Hogg, D.2    Whitehouse, G.H.3    Dangerfield, P.4
  • 109
    • 0028062112 scopus 로고
    • The chondrocyte: A cell under pressure
    • Urban JP. The chondrocyte: a cell under pressure. Br J Rheumatol 1994; 33(10): 901-8.
    • (1994) Br J Rheumatol , vol.33 , Issue.10 , pp. 901-908
    • Urban, J.P.1
  • 110
    • 0030952489 scopus 로고    scopus 로고
    • Proteoglycan synthesis in the intervertebral disk nucleus: The role of extracellular osmolality
    • Ishihara H, Warensjo K, Roberts S, Urban JP. Proteoglycan synthesis in the intervertebral disk nucleus: the role of extracellular osmolality. Am J Physiol 1997; 272(5 Pt 1): C1499-506.
    • (1997) Am J Physiol , vol.272 , Issue.5
    • Ishihara, H.1    Warensjo, K.2    Roberts, S.3    Urban, J.P.4
  • 111
    • 80455124093 scopus 로고    scopus 로고
    • Culturing bovine nucleus pulposus explants by balancing medium osmolarity
    • Van Dijk B, Potier E, Ito K. Culturing bovine nucleus pulposus explants by balancing medium osmolarity. Tissue Eng Part C Methods 2011; 17(11): 1089-96.
    • (2011) Tissue Eng Part C Methods , vol.17 , Issue.11 , pp. 1089-1096
    • Van Dijk, B.1    Potier, E.2    Ito, K.3
  • 112
    • 84918554285 scopus 로고    scopus 로고
    • Extracellular Osmolarity Regulates Matrix Homeostasis in the Intervertebral Disc and Articular Cartilage: Evolving role of TonEBP
    • Johnson ZI, Shapiro IM, Risbud MV. Extracellular Osmolarity Regulates Matrix Homeostasis in the Intervertebral Disc and Articular Cartilage: Evolving role of TonEBP. Matrix Biol 2014; 40:10-6.
    • (2014) Matrix Biol , vol.40 , pp. 10-16
    • Johnson, Z.I.1    Shapiro, I.M.2    Risbud, M.V.3
  • 113
    • 33748756124 scopus 로고    scopus 로고
    • TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc
    • Tsai T-T, Danielson KG, Guttapalli A, et al. TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. J Biol Chem 2006; 281(35): 25416-24.
    • (2006) J Biol Chem , vol.281 , Issue.35 , pp. 25416-25424
    • Tsai, T.-T.1    Danielson, K.G.2    Guttapalli, A.3
  • 114
    • 84876734648 scopus 로고    scopus 로고
    • NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance
    • Cheung CY, Ko BC. NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance. J Mol Signal 2013; 8(1): 5.
    • (2013) J Mol Signal , vol.8 , Issue.1 , pp. 5
    • Cheung, C.Y.1    Ko, B.C.2
  • 115
    • 0025934347 scopus 로고
    • Renal medullary organic osmolytes
    • Available from
    •  Garcia-Perez A, Burg MB. Renal medullary organic osmolytes. Physiol Rev 1991; 71(4): 1081-115. Available from: http://www.ncbi.nlm.nih.gov/pubmed/1924548
    • (1991) Physiol Rev , vol.71 , Issue.4 , pp. 1081-1115
    • Garcia-Perez, A.1    Burg, M.B.2
  • 116
    • 0020336190 scopus 로고
    • Living with water stress: Evolution of osmolyte systems
    • Yancey PH, Clark ME, Hand SC, Bowlus RD, Somero GN. Living with water stress: evolution of osmolyte systems. Science 1982; 217(4566): 1214-22.
    • (1982) Science , vol.217 , Issue.4566 , pp. 1214-1222
    • Yancey, P.H.1    Clark, M.E.2    Hand, S.C.3    Bowlus, R.D.4    Somero, G.N.5
  • 117
    • 34548546827 scopus 로고    scopus 로고
    • MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP
    • Tsai T-T, Guttapalli A, Agrawal A, et al. MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP. J Bone Miner Res 2007; 22(7): 965-74.
    • (2007) J Bone Miner Res , vol.22 , Issue.7 , pp. 965-974
    • Tsai, T.-T.1    Guttapalli, A.2    Agrawal, A.3
  • 118
    • 65649120732 scopus 로고    scopus 로고
    • Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc
    • Hiyama A, Gajghate S, Sakai D, et al. Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. J Biol Chem 2009; 284(15): 9824-34.
    • (2009) J Biol Chem , vol.284 , Issue.15 , pp. 9824-9834
    • Hiyama, A.1    Gajghate, S.2    Sakai, D.3
  • 119
    • 66349113470 scopus 로고    scopus 로고
    • Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc
    • Gajghate S, Hiyama A, Shah M, et al. Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res 2009; 24(6): 992-1001.
    • (2009) J Bone Miner Res , vol.24 , Issue.6 , pp. 992-1001
    • Gajghate, S.1    Hiyama, A.2    Shah, M.3
  • 120
    • 12344260899 scopus 로고    scopus 로고
    • Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: A requisite for tissue engineering of intervertebral disc
    • discussion 63-4
    •  Mwale F, Roughley P, Antoniou J. Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc. Eur Cell Mater 2004; 8: 58-63; discussion 63-4.
    • (2004) Eur Cell Mater , vol.8 , pp. 58-63
    • Mwale, F.1    Roughley, P.2    Antoniou, J.3
  • 121
    • 70350772321 scopus 로고    scopus 로고
    • Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc
    • Chen J, Jing L, Gilchrist CL, et al. Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc. Connect Tissue Res 2009; 50(5): 294-306.
    • (2009) Connect Tissue Res , vol.50 , Issue.5 , pp. 294-306
    • Chen, J.1    Jing, L.2    Gilchrist, C.L.3
  • 122
    • 84882906811 scopus 로고    scopus 로고
    • Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc
    • Bridgen DT, Gilchrist CL, Richardson WJ, et al. Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. J Orthop Res 2013; 31(10): 1661-7.
    • (2013) J Orthop Res , vol.31 , Issue.10 , pp. 1661-1667
    • Bridgen, D.T.1    Gilchrist, C.L.2    Richardson, W.J.3


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