Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 17, 2016, Pages 3876-3886

  Tyagi, Vikas ^a   Alwaseem, Hanan ^a   O'Dwyer, Kristen M ^a   Ponder, Jessica ^b   Li, Qi Ying ^a   Jordan, Craig T ^b   Fasan, Rudi ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Anticancer activity; Chemoenzymatic synthesis; Enzymatic hydroxylation; Late stage C H functionalization; Leukemia; Parthenolide

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYL 2 [(6,9A DIMETHYL 3 METHYLENE 2 OXO 2,3,3A,4,5,8,9,9A,10A,10B DECAHYDROOXIRENO[20,30:9,10]CYCLODECA[1,2 B]FURAN 5 YL)OXY] 2 PHENYLACETATE; CARBENE; ETHYL 2 [(6,9A DIMETHYL 3 METHYLENE 2 OXO 2,3,3A,4,5,8,9,9A,10A,10B DECAHYDROOXIRENO[20,30:9,10]CYCLODECA[1,2 B]FURAN 5 YL)OXY] 2 [4 (TRIFLUOROMETHYL)PHENYL]ACETATE; PARTHENOLIDE; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BENZYL 2-((6,9ALPHA-DIMETHYL-3-METHYLENE-2-OXO-2,3,3ALPHA,4,5,8,9,9A,10ALPHA,10BETA-DECAHYDROOXIRENO (2',3':9,10)CYCLODECA(1,2-B)FURAN-5-YL)OXY)-2-PHENYLACETATE; CYTOCHROME P450; ETHYL 2-((6,9ALPHA-DIMETHYL-3-METHYLENE-2-OXO-2,3,3ALPHA,4,5,8,9,9ALPHA,10ALPHA,10BETA-DECAHYDROOXIRENO (2',3':9,10)CYCLODECA(1,2-B)FURAN-5-YL)OXY)-2-(4-(TRIFLUOROMETHYL) PHENYL)ACETATE; FLAVOCYTOCHROME P450 BM3 MONOXYGENASES; NAD PHOSPHITE OXIDOREDUCTASE; OXIDOREDUCTASE; PHENYLACETIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; SESQUITERPENE;

ACUTE MYELOBLASTIC LEUKEMIA; ACYLATION; ALKYLATION; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; LC50; LEUKEMIA CELL; BACILLUS MEGATERIUM; CHEMISTRY; ESCHERICHIA COLI; LEUKEMIA; METABOLISM; STEREOISOMERISM; SYNTHESIS; TUMOR CELL LINE;

ACYLATION; ANTINEOPLASTIC AGENTS; BACILLUS MEGATERIUM; BACTERIAL PROTEINS; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; HUMANS; LEUKEMIA; NADH, NADPH OXIDOREDUCTASES; NADPH-FERRIHEMOPROTEIN REDUCTASE; PHENYLACETATES; SESQUITERPENES; STEREOISOMERISM;

EID: 84979742022     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.06.028     Document Type: Article

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