Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β

Journal of Biological Chemistry

Volumn 273, Issue 3, 1998, Pages 1288-1297

  Hehner, Steffen P ^a   Heinrich, Michael ^b   Bork, Peter M ^b   Vogt, Markus ^c   Ratter, Frank ^a   Lehmann, Volker ^a   Schulze Osthoff, Klaus ^c   Dröge, Wulf ^a   Schmitz, M Lienhard ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; PARTHENOLIDE; PHORBOL ESTER; PROTEIN TYROSINE KINASE; SANTONIN; SESQUITERPENE LACTONE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL KILLING; DEGRADATION; DNA BINDING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ANIMALS; DNA; DNA-BINDING PROTEINS; FREE RADICALS; GENE EXPRESSION; HELA CELLS; HUMANS; HYDROGEN PEROXIDE; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; JURKAT CELLS; LACTONES; MICE; NF-KAPPA B; PLANTS, MEDICINAL; SESQUITERPENES; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031915368     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.3.1288     Document Type: Article

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