Semisynthetic derivatives of sesquiterpene lactones by palladium-catalyzed arylation of the α-methylene-γ-lactone substructure

Journal of Organic Chemistry

Volumn 74, Issue 18, 2009, Pages 7176-7179

  Han, Changho ^a   Barrios, Francis J ^b   Riofski, Mark V ^a   Colby, David A ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE; BIOLOGICAL EVALUATION; CHEMICAL EQUATIONS; COUPLING PRODUCT; E-OLEFIN; HELA CELL; INITIAL STRUCTURES; PALLADIUM-CATALYZED ARYLATION; SEMI-SYNTHETIC DERIVATIVES; SESQUITERPENE LACTONES;

CHEMICAL REACTIONS; OLEFINS; PALLADIUM;

AROMATIC COMPOUNDS;

ALKENE DERIVATIVE; ANTINEOPLASTIC AGENT; CARBENE; GAMMA LACTONE DERIVATIVE; LACTONE DERIVATIVE; PALLADIUM; SESQUITERPENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ARYLATION; CATALYSIS; CELL PROLIFERATION; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; HECK REACTION; HELA CELL; HUMAN; HUMAN CELL; QUANTUM YIELD; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALKENES; ANTINEOPLASTIC AGENTS; CATALYSIS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; PALLADIUM; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70249121509     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901533e     Document Type: Article

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