SIRT2 mediates NADH-induced increases in Nrf2, GCL, and glutathione by modulating Akt phosphorylation in PC12 cells

FEBS Letters

Volumn , Issue , 2016, Pages 2241-2255

  Cao, Wei ^a   Hong, Yunyi ^a   Chen, Heyu ^a   Wu, Fan ^a   Wei, Xunbin ^a   Ying, Weihai ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Nrf2; SIRT2; nicotinamide adenine dinucleotide

Indexed keywords

CYTARABINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; OXIDOREDUCTASE; PROTEIN KINASE B; SIRTUIN 2; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ASTROCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; GENE SILENCING; LETTER; NONHUMAN; PC12 CELL LINE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84979587726     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1002/1873-3468.12236     Document Type: Article

References (53)

1. Nie H, Hong Y, Lu X, Zhang J, Chen H, Li Y, Ma Y and Ying W (2014) SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells. Neuroreport 25, 838–842.
2. Herskovits AZ and Guarente L (2013) Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res 23, 746–758.
3. Sayd S, Thirant C, El-Habr EA, Lipecka J, Dubois LG, Bogeas A, Tahiri-Jouti N, Chneiweiss H and Junier MP (2014) Sirtuin-2 activity is required for glioma stem cell proliferation arrest but not necrosis induced by resveratrol. Stem Cell Rev 10, 103–113.
4. Nie H, Li Y, Wang C, Chen X, Liu B, Wu D and Ying W (2014) SIRT2 plays a key role in both cell cycle regulation and cell survival of BV2 microglia. Int J Physiol Pathophysiol Pharmacol 6, 166–171.
5. Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K et al. (2015) The discovery of a highly selective 5,6,7,8-tetrahydrobenzo 4,5 thieno 2,3-d pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model. ChemMedChem 10, 69–82.
6. Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C et al. (2015) The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. PLoS One 10, e0116919.
7. Anderson G and Maes M (2014) Neurodegeneration in Parkinson's Disease: interactions of oxidative stress, tryptophan catabolites and depression with mitochondria and sirtuins. Mol Neurobiol 49, 771–783.
8. Patel VP and Chu CT (2014) Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. Exp Neurol 257, 170–181.
9. Smeyne M and Smeyne RJ (2013) Glutathione metabolism and Parkinson's disease. Free Radic Biol Med 62, 13–25.
10. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH and Burgering BM (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316–321.
11. Tan W-Q, Wang K, Lv D-Y and Li P-F (2008) Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem 283, 29730–29739.
12. Kleszczynski K, Ernst IM, Wagner AE, Kruse N, Zillikens D, Rimbach G and Fischer TW (2013) Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes. Pharmacol Res 78, 28–40.
13. Jacob MH, Janner Dda R, Araujo AS, Jahn MP, Kucharski LC, Moraes TB, Dutra Filho CS, Ribeiro MF and Bello-Klein A (2010) Redox imbalance influence in the myocardial Akt activation in aged rats treated with DHEA. Exp Gerontol 45, 957–963.
14. Liu L, Arun A, Ellis L, Peritore C and Donmez G (2012) Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating bim protein. J Biol Chem 287, 32307–32311.
15. Liu L, Arun A, Ellis L, Peritore C and Donmez G (2014) SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Front Aging Neurosci 6, 184.
16. Wang F, Nguyen M, Qin FX-F and Tong Q (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6, 505–514.
17. Li YN, Guo Y, Xi MM, Yang P, Zhou XY, Yin S, Hai CX, Li JG and Qin XJ (2014) Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways. Oxid Med Cell Longev 2014, 320513.
18. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY et al. (2014) Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J 33, 1304–1320.
19. Birkmayer JG, Vrecko C, Volc D and Birkmayer W (1993) Nicotinamide adenine dinucleotide (NADH) – a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application. Acta Neurol Scand Suppl 146, 32–35.
20. 2+ release via locally derived NADH. Proc Natl Acad Sci USA 102, 1357–1359.
21. +-dependent enzymes: promising therapeutic targets for neurological diseases. Curr Drug Targets 13, 222–229.
22. Zhu XH, Lu M, Lee BY, Ugurbil K and Chen W (2015) In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci USA 112, 2876–2881.
23. Kirsch M and De Groot H (2001) NAD(P)H, a directly operating antioxidant? FASEB J 15, 1569–1574.
24. Mazzio EA and Soliman KF (2003) Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. Neurochem Res 28, 733–741.
25. Olek RA, Ziolkowski W, Kaczor JJ, Greci L, Popinigis J and Antosiewicz J (2004) Antioxidant activity of NADH and its analogue–an in vitro study. J Biochem Mol Biol 37, 416–421.
26. Ma Y, Chen H, Xia W and Ying W (2011) Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival. Int J Physiol Pathophysiol Pharmacol 3, 21–28.
27. Antion MD, Pearl SM, Stanwood GD, Jaumotte JD, Kapatos G and Zigmond MJ (1998) NADH increases dopaminergic activity in nigrostriatal neurons: implications for Parkinson's disease. Soc Neurosci Abs 24, 1467.
28. Zhang Z, Li G, Szeto SS, Chong CM, Quan Q, Huang C, Cui W, Guo B, Wang Y, Han Y et al (2015) Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease. Free Radic Biol Med 84, 331–343.
29. Maioli M, Rinaldi S, Migheli R, Pigliaru G, Rocchitta G, Santaniello S, Basoli V, Castagna A, Fontani V, Ventura C et al. (2015) Neurological morphofunctional differentiation induced by REAC technology in PC12. A neuro protective model for Parkinson's disease. Sci Rep 5, 10439.
30. Ying W, Han SK, Miller JW and Swanson RA (1999) Acidosis potentiates oxidative neuronal death by multiple mechanisms. J Neurochem 73, 1549–1556.
31. Baker MA, Cerniglia GJ and Zaman A (1990) Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 190, 360–365.
32. Copple IM, Goldring CE, Kitteringham NR and Park BK (2008) The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicology 246, 24–33.
33. Jaiswal AK (2004) Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 36, 1199–1207.
34. Kobayashi M and Yamamoto M (2006) Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46, 113–140.
35. Meister A and Anderson ME (1983) Glutathione. Annu Rev Biochem 52, 711–760.
36. Hamilton D, Wu JH, Alaoui-Jamali M and Batist G (2003) A novel missense mutation in the γ-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production. Blood 102, 725–730.
37. Rizvi F, Shukla S and Kakkar P (2014) Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3beta/Fyn kinase axis during oxidative hepatocellular toxicity. Cell Death Dis 5, e1153.
38. Lim JH, Kim KM, Kim SW, Hwang O and Choi HJ (2008) Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage. Pharmacol Res 57, 325–331.
39. Buendia I, Michalska P, Navarro E, Gameiro I, Egea J and Leon R (2016) Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther 157, 84–104.
40. Kaspar JW, Niture SK and Jaiswal AK (2009) Nrf 2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 47, 1304–1309.
41. Nie H, Chen H, Han J, Hong Y, Ma Y, Xia W and Ying W (2011) Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int J Physiol Pathophysiol Pharmacol 3, 65–70.
42. Pastore A, Federici G, Bertini E and Piemonte F (2003) Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333, 19–39.
43. Dringen R (2000) Metabolism and functions of glutathione in brain. Prog Neurobiol 62, 649–671.
44. Rogers LK, Tipple TE, Britt RD and Welty SE (2010) Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice. Pediatr Res 67, 144–149.
45. Yao HW, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L et al. (2014) SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 306, L816–L828.
46. Tusskorn O, Senggunprai L, Prawan A, Kukongviriyapan U and Kukongviriyapan V (2013) Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells. BMC Cancer 13, 571.
47. +-dependent sirtuin deacylation activities to NADH. J Biol Chem 291, 7128–7141.
48. +/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal 10, 179–206.
49. Khallaghi B, Safarian F, Nasoohi S, Ahmadiani A and Dargahi L (2016) Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells. Life Sci 148, 286–292.
50. 2-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes. Am J Physiol Cell Physiol 295, C50–C63.
51. Sadidi M, Lentz SI and Feldman EL (2009) Hydrogen peroxide-induced Akt phosphorylation regulates Bax activation. Biochimie 91, 577–585.
52. Chan CH, Jo U, Kohrman A, Rezaeian AH, Chou PC, Logothetis C and Lin HK (2014) Posttranslational regulation of Akt in human cancer. Cell Biosci 4, 59.
53. Marinho HS, Real C, Cyrne L, Soares H and Antunes F (2014) Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol 2, 535–562.