메뉴 건너뛰기




Volumn 13, Issue 2, 2012, Pages 222-229

NAD+ metabolism and NAD+-dependent enzymes: Promising therapeutic targets for neurological diseases

Author keywords

Calcium homeostasis; Cell death; NAD+; Neurological diseases; Oxidative stress

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; SIRTUIN;

EID: 84863116397     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012799201711     Document Type: Article
Times cited : (51)

References (89)
  • 1
    • 0029930021 scopus 로고    scopus 로고
    • Deleterious network hypothesis of Alzheimer's disease
    • Ying W. Deleterious network hypothesis of Alzheimer's disease. Med Hypotheses 1996; 46: 421-428.
    • (1996) Med Hypotheses , vol.46 , pp. 421-428
    • Ying, W.1
  • 2
    • 0029806859 scopus 로고    scopus 로고
    • A new hypothesis of neurodegenerative diseases: The deleterious network hypothesis
    • Ying W. A new hypothesis of neurodegenerative diseases: the deleterious network hypothesis. Med Hypotheses 1996; 47: 307-313.
    • (1996) Med Hypotheses , vol.47 , pp. 307-313
    • Ying, W.1
  • 3
    • 0030835921 scopus 로고    scopus 로고
    • Deleterious network: A testable pathogenetic concept of Alzheimer's disease
    • Ying W. Deleterious network: a testable pathogenetic concept of Alzheimer's disease. Gerontology 1997; 43: 242-253.
    • (1997) Gerontology , vol.43 , pp. 242-253
    • Ying, W.1
  • 4
    • 0029888311 scopus 로고    scopus 로고
    • Role of oxidants in ischemic brain damage
    • Chan PH. Role of oxidants in ischemic brain damage. Stroke 1996; 27: 1124-1149.
    • (1996) Stroke , vol.27 , pp. 1124-1149
    • Chan, P.H.1
  • 5
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21: 2-14.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 6
    • 3342910554 scopus 로고    scopus 로고
    • Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury
    • Starkov AA, Chinopoulos C, Fiskum G. Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium 2004; 36: 257-264.
    • (2004) Cell Calcium , vol.36 , pp. 257-264
    • Starkov, A.A.1    Chinopoulos, C.2    Fiskum, G.3
  • 7
    • 59349106603 scopus 로고    scopus 로고
    • Inflammation and the neurovascular unit in the setting of focal cerebral ischemia
    • del Zoppo GJ. Inflammation and the neurovascular unit in the setting of focal cerebral ischemia. Neuroscience 2009; 158: 972-982.
    • (2009) Neuroscience , vol.158 , pp. 972-982
    • del Zoppo, G.J.1
  • 8
    • 75649106812 scopus 로고    scopus 로고
    • Inflammation in Ischemic Brain Injury: Current Advances and Future Perspectives
    • Xia W, Han J, Huang G, Ying W. Inflammation in Ischemic Brain Injury: Current Advances and Future Perspectives. Clin Exp Pharmacol Physiol 2010; 37: 253-258.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 253-258
    • Xia, W.1    Han, J.2    Huang, G.3    Ying, W.4
  • 9
    • 0021997074 scopus 로고
    • Poly(ADP-ribose) in the cellular response to DNA damage
    • Berger NA. Poly(ADP-ribose) in the cellular response to DNA damage. Radiat Res 1985; 101: 4-15.
    • (1985) Radiat Res , vol.101 , pp. 4-15
    • Berger, N.A.1
  • 10
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
    • Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 2002; 54: 375-429.
    • (2002) Pharmacol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 11
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NFkappaB signaling
    • Chen J, Zhou Y, Mueller-Steiner S, et al. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NFkappaB signaling. J Biol Chem 2005; 280: 40364-40374.
    • (2005) J Biol Chem , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3
  • 12
    • 34547599329 scopus 로고    scopus 로고
    • Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    • Outeiro TF KE, Altmann SM, Kufareva I, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science 2007; 317: 516-519.
    • (2007) Science , vol.317 , pp. 516-519
    • Outeiro, T.F.K.E.1    Altmann, S.M.2    Kufareva, I.3
  • 13
    • 34248375793 scopus 로고    scopus 로고
    • + profoundly decreases brain injury in a rat model of transient focal ischemia
    • + profoundly decreases brain injury in a rat model of transient focal ischemia. Front Biosci 2007; 12: 2728-2734.
    • (2007) Front Biosci , vol.12 , pp. 2728-2734
    • Ying, W.1    Wei, G.2    Wang, D.3
  • 14
    • 0038061606 scopus 로고    scopus 로고
    • Nicotinamide: Necessary nutrient emerges as a novel cytoprotectant for the brain
    • Maiese K, Chong ZZ. Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol Sci 2003; 24: 228-232.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 228-232
    • Maiese, K.1    Chong, Z.Z.2
  • 15
    • 0033198919 scopus 로고    scopus 로고
    • Poly(ADPribosyl) ation reactions in the regulation of nuclear functions
    • D'Amours D, Desnoyers S, D'Silva I, Poirier GG. Poly(ADPribosyl) ation reactions in the regulation of nuclear functions. Biochem J 1999; 342 (Pt 2): 249-268.
    • (1999) Biochem J , vol.342 , Issue.Pt 2 , pp. 249-268
    • D'Amours, D.1    Desnoyers, S.2    D'Silva, I.3    Poirier, G.G.4
  • 16
    • 37549068090 scopus 로고    scopus 로고
    • +/NADH and NADP+/NADPH in cellular functions and cell death: Regulation and biological consequences
    • +/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal 2008; 10: 179-206.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 179-206
    • Ying, W.1
  • 17
    • 0041573041 scopus 로고    scopus 로고
    • + repletion prevents PARP- 1-induced glycolytic blockade and cell death in cultured mouse astrocytes
    • + repletion prevents PARP- 1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem Biophys Res Commun 2003; 308: 809-813.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 809-813
    • Ying, W.1    Garnier, P.2    Swanson, R.A.3
  • 18
    • 2442624618 scopus 로고    scopus 로고
    • + depletion and mitochondrial permeability transition
    • + depletion and mitochondrial permeability transition. J Biol Chem 2004; 279:18895-18902.
    • (2004) J Biol Chem , vol.279 , pp. 18895-18902
    • Alano, C.C.1    Ying, W.2    Swanson, R.A.3
  • 20
    • 0036488223 scopus 로고    scopus 로고
    • Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation
    • Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem 2002; 80: 531-538.
    • (2002) J Neurochem , vol.80 , pp. 531-538
    • Alano, C.C.1    Beutner, G.2    Dirksen, R.T.3    Gross, R.A.4    Sheu, S.S.5
  • 21
    • 84863134130 scopus 로고    scopus 로고
    • + can restore intracellular ATP levels and prevent PC12 cell death induced by oxidative stress
    • American Society for Neurosciences Annual Meeting Abstracts
    • + can restore intracellular ATP levels and prevent PC12 cell death induced by oxidative stress. FASEB Journal 2010: lb471 (American Society for Neurosciences Annual Meeting Abstracts).
    • (2010) FASEB Journal
    • Chen, H.1    Zhao, C.2    Shao, J.3    Chen, C.4    Xia, W.5    Ying, W.6
  • 22
    • 0034023238 scopus 로고    scopus 로고
    • New functions of a long-known molecule. Emerging roles of NAD in cellular signaling
    • Ziegler M. New functions of a long-known molecule. Emerging roles of NAD in cellular signaling. Eur J Biochem 2000; 267: 1550-1564.
    • (2000) Eur J Biochem , vol.267 , pp. 1550-1564
    • Ziegler, M.1
  • 23
    • 35349011726 scopus 로고    scopus 로고
    • Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
    • Kim EJ, Kho JH, Kang MR, Um SJ. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol Cell 2007; 28: 277-290.
    • (2007) Mol Cell , vol.28 , pp. 277-290
    • Kim, E.J.1    Kho, J.H.2    Kang, M.R.3    Um, S.J.4
  • 24
    • 53149100858 scopus 로고    scopus 로고
    • SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: Regulation of aging via NF-kappaB acetylation?
    • Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? Bioessays 2008; 30: 939-942.
    • (2008) Bioessays , vol.30 , pp. 939-942
    • Salminen, A.1    Kauppinen, A.2    Suuronen, T.3    Kaarniranta, K.4
  • 25
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease--a double-edged sword
    • Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease--a double-edged sword. Neuron 2002; 35: 419-432.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 26
    • 47749126515 scopus 로고    scopus 로고
    • Why neurodegenerative diseases are progressive: Uncontrolled inflammation drives disease progression
    • Gao HM, Hong JS. Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 2008; 29: 357-365.
    • (2008) Trends Immunol , vol.29 , pp. 357-365
    • Gao, H.M.1    Hong, J.S.2
  • 27
    • 0032863224 scopus 로고    scopus 로고
    • A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation
    • Hassa PO, Hottiger MO. A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation. Biol Chem 1999; 380: 953-959.
    • (1999) Biol Chem , vol.380 , pp. 953-959
    • Hassa, P.O.1    Hottiger, M.O.2
  • 28
    • 0034654055 scopus 로고    scopus 로고
    • Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase
    • Kameoka M, Ota K, Tetsuka T, et al. Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymerase. Biochem J 2000; 346 Pt 3: 641-649.
    • (2000) Biochem J , vol.346 , Issue.3 , pp. 641-649
    • Kameoka, M.1    Ota, K.2    Tetsuka, T.3
  • 29
    • 34547105307 scopus 로고    scopus 로고
    • Activation of poly(ADP)- ribose polymerase (PARP-1) induces release of the proinflammatory mediator HMGB1 from the nucleus
    • Ditsworth D, Zong WX, Thompson CB. Activation of poly(ADP)- ribose polymerase (PARP-1) induces release of the proinflammatory mediator HMGB1 from the nucleus. J Biol Chem 2007; 282: 17845-17854.
    • (2007) J Biol Chem , vol.282 , pp. 17845-17854
    • Ditsworth, D.1    Zong, W.X.2    Thompson, C.B.3
  • 31
    • 30444446344 scopus 로고    scopus 로고
    • Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion
    • Kovacs K, Toth A, Deres P, et al. Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion. Biochem Pharmacol 2006; 71: 441-452.
    • (2006) Biochem Pharmacol , vol.71 , pp. 441-452
    • Kovacs, K.1    Toth, A.2    Deres, P.3
  • 32
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 33
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and - independent control of neuronal survival by the PI3K-Akt signaling pathway
    • Brunet A, Datta SR, Greenberg ME. Transcription-dependent and - independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol 2001; 11: 297-305.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 34
    • 4644307600 scopus 로고    scopus 로고
    • TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase
    • Fonfria E, Marshall IC, Benham CD, et al. TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase. Br J Pharmacol 2004; 143: 186-192.
    • (2004) Br J Pharmacol , vol.143 , pp. 186-192
    • Fonfria, E.1    Marshall, I.C.2    Benham, C.D.3
  • 35
    • 33744462507 scopus 로고    scopus 로고
    • Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death
    • Yang KT, Chang WL, Yang PC, et al. Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ 2005; 13: 1815-1826.
    • (2005) Cell Death Differ , vol.13 , pp. 1815-1826
    • Yang, K.T.1    Chang, W.L.2    Yang, P.C.3
  • 36
    • 27644507847 scopus 로고    scopus 로고
    • Amyloid beta-peptide(1- 42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures
    • Fonfria E, Marshall IC, Boyfield I, et al. Amyloid beta-peptide(1- 42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem 2005; 95: 715-723.
    • (2005) J Neurochem , vol.95 , pp. 715-723
    • Fonfria, E.1    Marshall, I.C.2    Boyfield, I.3
  • 37
    • 0034193776 scopus 로고    scopus 로고
    • Sir2 links chromatin silencing, metabolism, and aging
    • Guarente L. Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 2000; 14: 1021-1026.
    • (2000) Genes Dev , vol.14 , pp. 1021-1026
    • Guarente, L.1
  • 39
    • 33744475759 scopus 로고    scopus 로고
    • Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
    • Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P. Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle 2006; 5: 873-877.
    • (2006) Cell Cycle , vol.5 , pp. 873-877
    • Kolthur-Seetharam, U.1    Dantzer, F.2    McBurney, M.W.3    de Murcia, G.4    Sassone-Corsi, P.5
  • 40
    • 33750362174 scopus 로고    scopus 로고
    • Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway
    • Cai AL, Zipfel GJ, Sheline CT. Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway. Eur J Neurosci 2006; 24: 2169-2176.
    • (2006) Eur J Neurosci , vol.24 , pp. 2169-2176
    • Cai, A.L.1    Zipfel, G.J.2    Sheline, C.T.3
  • 41
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaBdependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, et al. Modulation of NF-kappaBdependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23: 2369-2380.
    • (2004) EMBO J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3
  • 42
    • 34447626095 scopus 로고    scopus 로고
    • SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    • Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 2007; 6: 505-514.
    • (2007) Aging Cell , vol.6 , pp. 505-514
    • Wang, F.1    Nguyen, M.2    Qin, F.X.3    Tong, Q.4
  • 43
    • 79954527563 scopus 로고    scopus 로고
    • Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells
    • Nie H, Chen H, Han J, et al. Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int J Physiol Pathophysiol Pharmacol 2011; 3: 65-70.
    • (2011) Int J Physiol Pathophysiol Pharmacol , vol.3 , pp. 65-70
    • Nie, H.1    Chen, H.2    Han, J.3
  • 44
    • 34548627517 scopus 로고    scopus 로고
    • + levels dictate cell survival
    • + levels dictate cell survival. Cell 2007; 130: 1095-1107.
    • (2007) Cell , vol.130 , pp. 1095-1107
    • Yang, H.1    Yang, T.2    Baur, J.A.3
  • 45
    • 2442624618 scopus 로고    scopus 로고
    • + depletion and mitochondrial permeability transition
    • + depletion and mitochondrial permeability transition. J Biol Chem 2004; 279: 18895-18902.
    • (2004) J Biol Chem , vol.279 , pp. 18895-18902
    • Alano, C.C.1    Ying, W.2    Swanson, R.A.3
  • 46
    • 52449091282 scopus 로고    scopus 로고
    • Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: Role of enhanced DNA repair
    • Wang S, Xing Z, Vosler PS, et al. Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair. Stroke 2008; 39: 2587-2595.
    • (2008) Stroke , vol.39 , pp. 2587-2595
    • Wang, S.1    Xing, Z.2    Vosler, P.S.3
  • 48
    • 79959666451 scopus 로고    scopus 로고
    • + blocks H2O2- induced HMGB1 translocation of PC12 cells and decreases survival of microglia
    • American Society for Neurosciences Annual Meeting Abstracts
    • + blocks H2O2- induced HMGB1 translocation of PC12 cells and decreases survival of microglia. FASEB Journal 2010: lb469 (American Society for Neurosciences Annual Meeting Abstracts).
    • (2010) FASEB Journal
    • Chen, H.1    Han, J.2    Shao, J.3    Xia, W.4    Ying, W.5
  • 49
    • 0030842946 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
    • Eliasson MJ, Sampei K, Mandir AS, et al. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 1997; 3: 1089-1095.
    • (1997) Nat Med , vol.3 , pp. 1089-1095
    • Eliasson, M.J.1    Sampei, K.2    Mandir, A.S.3
  • 51
    • 0036218940 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery
    • Goto S, Xue R, Sugo N, et al. Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. Stroke 2002; 33: 1101-1106.
    • (2002) Stroke , vol.33 , pp. 1101-1106
    • Goto, S.1    Xue, R.2    Sugo, N.3
  • 52
    • 0032924142 scopus 로고    scopus 로고
    • Neuronal accumulation of poly(ADP-ribose) after brain ischaemia
    • Love S, Barber R, Wilcock GK. Neuronal accumulation of poly(ADP-ribose) after brain ischaemia. Neuropathol Appl Neurobiol 1999; 25: 98-103.
    • (1999) Neuropathol Appl Neurobiol , vol.25 , pp. 98-103
    • Love, S.1    Barber, R.2    Wilcock, G.K.3
  • 53
    • 12844251250 scopus 로고    scopus 로고
    • Adult or perinatal brain injury: Does sex matter?
    • Hurn PD, Vannucci SJ, Hagberg H. Adult or perinatal brain injury: does sex matter? Stroke 2005; 36: 193-195.
    • (2005) Stroke , vol.36 , pp. 193-195
    • Hurn, P.D.1    Vannucci, S.J.2    Hagberg, H.3
  • 54
    • 17044430692 scopus 로고    scopus 로고
    • Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: Male toxicity, female protection
    • McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD. Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab 2005; 25: 502-512.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 502-512
    • McCullough, L.D.1    Zeng, Z.2    Blizzard, K.K.3    Debchoudhury, I.4    Hurn, P.D.5
  • 55
    • 4444383142 scopus 로고    scopus 로고
    • PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury
    • Hagberg H, Wilson MA, Matsushita H, et al. PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury. J Neurochem 2004; 90: 1068-1075.
    • (2004) J Neurochem , vol.90 , pp. 1068-1075
    • Hagberg, H.1    Wilson, M.A.2    Matsushita, H.3
  • 56
    • 0034068520 scopus 로고    scopus 로고
    • Activation of poly(ADPribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia
    • Nagayama T, Simon RP, Chen D, et al. Activation of poly(ADPribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia. J Neurochem 2000; 74: 1636-1645.
    • (2000) J Neurochem , vol.74 , pp. 1636-1645
    • Nagayama, T.1    Simon, R.P.2    Chen, D.3
  • 57
    • 71649085421 scopus 로고    scopus 로고
    • Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia
    • Yang Y, Candelario-Jalil E, Thompson JF, et al. Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. J Neurochem; 112: 134-149.
    • J Neurochem , vol.112 , pp. 134-149
    • Yang, Y.1    Candelario-Jalil, E.2    Thompson, J.F.3
  • 59
    • 62249110887 scopus 로고    scopus 로고
    • Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
    • Della-Morte D, Dave KR, DeFazio RA, Bao YC, Raval AP, Perez-Pinzon MA. Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 2009; 159: 993-1002.
    • (2009) Neuroscience , vol.159 , pp. 993-1002
    • Della-Morte, D.1    Dave, K.R.2    Defazio, R.A.3    Bao, Y.C.4    Raval, A.P.5    Perez-Pinzon, M.A.6
  • 60
    • 68549085061 scopus 로고    scopus 로고
    • Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection
    • Kakefuda K, Fujita Y, Oyagi A, et al. Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. Biochem Biophys Res Commun 2009; 387: 784-788.
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 784-788
    • Kakefuda, K.1    Fujita, Y.2    Oyagi, A.3
  • 61
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol; 5: 253-295.
    • Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 62
    • 77952547233 scopus 로고    scopus 로고
    • Ten years of NAD-dependent SIR2 family deacetylases: Implications for metabolic diseases
    • Imai SI, Guarente L. Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci. 2010; 31:212-220.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 212-220
    • Imai, S.I.1    Guarente, L.2
  • 64
    • 79954458754 scopus 로고    scopus 로고
    • + treatment decreases tumor cell survival by inducing oxidative stress
    • + treatment decreases tumor cell survival by inducing oxidative stress. Front Biosci (Elite Ed); 3: 434-441.
    • Front Biosci (Elite Ed) , vol.3 , pp. 434-441
    • Zhao, C.1    Hong, Y.2    Han, J.3
  • 65
    • 80755130392 scopus 로고    scopus 로고
    • NAD(+) Treatment Induces Delayed Autophagy in Neuro2a Cells Partially by Increasing Oxidative Stress
    • Han J, Shi S, Min L, Wu T, Xia W, Ying W. NAD(+) Treatment Induces Delayed Autophagy in Neuro2a Cells Partially by Increasing Oxidative Stress. Neurochem Res 2011; 36: 2270-2277.
    • (2011) Neurochem Res , vol.36 , pp. 2270-2277
    • Han, J.1    Shi, S.2    Min, L.3    Wu, T.4    Xia, W.5    Ying, W.6
  • 66
    • 79954459786 scopus 로고    scopus 로고
    • Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival
    • Ma Y CH, Xia W, Ying W. Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival. Int J Physiol Pathophysiol Pharmacol 2011; 3: 21-28.
    • (2011) Int J Physiol Pathophysiol Pharmacol , vol.3 , pp. 21-28
    • Ma, Y.C.H.1    Xia, W.2    Ying, W.3
  • 67
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • Tentori L, Leonetti C, Scarsella M, et al. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin Cancer Res 2003; 9: 5370-5379.
    • (2003) Clin Cancer Res , vol.9 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3
  • 68
    • 0036793612 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells
    • Tentori L, Portarena I, Torino F, Scerrati M, Navarra P, Graziani G. Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. Glia 2002; 40: 44-54.
    • (2002) Glia , vol.40 , pp. 44-54
    • Tentori, L.1    Portarena, I.2    Torino, F.3    Scerrati, M.4    Navarra, P.5    Graziani, G.6
  • 69
    • 33644643513 scopus 로고    scopus 로고
    • FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2)
    • Voelter-Mahlknecht S, Ho AD, Mahlknecht U. FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2). Int J Oncol 2005; 27: 1187-1196.
    • (2005) Int J Oncol , vol.27 , pp. 1187-1196
    • Voelter-Mahlknecht, S.1    Ho, A.D.2    Mahlknecht, U.3
  • 70
    • 0041829415 scopus 로고    scopus 로고
    • Proteomics-based identification of differentially expressed genes in human gliomas: Down-regulation of SIRT2 gene
    • Hiratsuka M, Inoue T, Toda T, et al. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem Biophys Res Commun 2003; 309: 558-566.
    • (2003) Biochem Biophys Res Commun , vol.309 , pp. 558-566
    • Hiratsuka, M.1    Inoue, T.2    Toda, T.3
  • 71
    • 0031081488 scopus 로고    scopus 로고
    • Deleterious network hypothesis of aging
    • Ying W. Deleterious network hypothesis of aging. Med Hypotheses 1997; 48: 143-148.
    • (1997) Med Hypotheses , vol.48 , pp. 143-148
    • Ying, W.1
  • 72
    • 0036152892 scopus 로고    scopus 로고
    • Iron and Parkinson's disease
    • Wolozin B, Golts N. Iron and Parkinson's disease. Neuroscientist 2002; 8: 22-32.
    • (2002) Neuroscientist , vol.8 , pp. 22-32
    • Wolozin, B.1    Golts, N.2
  • 73
    • 10244246626 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment
    • Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembr 2004; 36: 381-386.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 381-386
    • Beal, M.F.1
  • 74
    • 0030581308 scopus 로고    scopus 로고
    • Poly(ADPribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice
    • Cosi C, Colpaert F, Koek W, Degryse A, Marien M. Poly(ADPribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice. Brain Res 1996; 729: 264-269.
    • (1996) Brain Res , vol.729 , pp. 264-269
    • Cosi, C.1    Colpaert, F.2    Koek, W.3    Degryse, A.4    Marien, M.5
  • 75
    • 0036788183 scopus 로고    scopus 로고
    • A novel in vivo post-translational modification of p53 by PARP-1 in MPTPinduced parkinsonism
    • Mandir AS, Simbulan-Rosenthal CM, Poitras MF, et al. A novel in vivo post-translational modification of p53 by PARP-1 in MPTPinduced parkinsonism. J Neurochem 2002; 83: 186-192.
    • (2002) J Neurochem , vol.83 , pp. 186-192
    • Mandir, A.S.1    Simbulan-Rosenthal, C.M.2    Poitras, M.F.3
  • 76
    • 0033545925 scopus 로고    scopus 로고
    • Poly(ADPribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6- tetrahydropyridine (MPTP)-induced parkinsonism
    • Mandir AS, Przedborski S, Jackson-Lewis V, et al. Poly(ADPribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6- tetrahydropyridine (MPTP)-induced parkinsonism. Proc Natl Acad Sci U S A 1999; 96: 5774-5779.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5774-5779
    • Mandir, A.S.1    Przedborski, S.2    Jackson-Lewis, V.3
  • 77
    • 2442638936 scopus 로고    scopus 로고
    • Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4- chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Iwashita A, Yamazaki S, Mihara K, et al. Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4- chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. J Pharmacol Exp Ther 2004; 309: 1067-1078.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1067-1078
    • Iwashita, A.1    Yamazaki, S.2    Mihara, K.3
  • 80
    • 2442662542 scopus 로고    scopus 로고
    • Early administration of nicotinamide prevents learning and memory impairment in mice induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
    • Yang J, He L, Wang J, Adams JD, Jr. Early administration of nicotinamide prevents learning and memory impairment in mice induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Pharmacol Biochem Behav 2004; 78: 179-183.
    • (2004) Pharmacol Biochem Behav , vol.78 , pp. 179-183
    • Yang, J.1    He, L.2    Wang, J.3    Adams Jr., J.D.4
  • 81
    • 0027221074 scopus 로고
    • Nicotinamide adenine dinucleotide (NADH)--a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application
    • Birkmayer JG, Vrecko C, Volc D, Birkmayer W. Nicotinamide adenine dinucleotide (NADH)--a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application. Acta Neurol Scand Suppl 1993; 146: 32-35.
    • (1993) Acta Neurol Scand Suppl , vol.146 , pp. 32-35
    • Birkmayer, J.G.1    Vrecko, C.2    Volc, D.3    Birkmayer, W.4
  • 82
    • 0029801686 scopus 로고    scopus 로고
    • Parenteral application of NADH in Parkinson's disease: Clinical improvement partially due to stimulation of endogenous levodopa biosynthesis
    • Kuhn W, Muller T, Winkel R, et al. Parenteral application of NADH in Parkinson's disease: clinical improvement partially due to stimulation of endogenous levodopa biosynthesis. J Neural Transm 1996; 103: 1187-1193.
    • (1996) J Neural Transm , vol.103 , pp. 1187-1193
    • Kuhn, W.1    Muller, T.2    Winkel, R.3
  • 83
    • 0031785692 scopus 로고    scopus 로고
    • Is NADH effective in the treatment of Parkinson's disease?
    • Swerdlow RH. Is NADH effective in the treatment of Parkinson's disease? Drugs Aging 1998; 13: 263-28.
    • (1998) Drugs Aging , vol.13 , pp. 263-268
    • Swerdlow, R.H.1
  • 84
    • 33746824192 scopus 로고    scopus 로고
    • Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer's disease amyloid neuropathology by calorie restriction
    • Qin W, Yang T, Ho L, et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer's disease amyloid neuropathology by calorie restriction. J Biol Chem 2006; 281: 21745-21754.
    • (2006) J Biol Chem , vol.281 , pp. 21745-21754
    • Qin, W.1    Yang, T.2    Ho, L.3
  • 85
    • 33644875954 scopus 로고    scopus 로고
    • Neuronal protection by sirtuins in Alzheimer's disease
    • Anekonda TS, Reddy PH. Neuronal protection by sirtuins in Alzheimer's disease. J Neurochem 2006; 96: 305-313.
    • (2006) J Neurochem , vol.96 , pp. 305-313
    • Anekonda, T.S.1    Reddy, P.H.2
  • 87
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: Commonality amid diversity
    • Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat Rev Neurosci 2005; 6: 889-898.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 889-898
    • Coleman, M.1
  • 88
    • 4043165678 scopus 로고    scopus 로고
    • Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
    • Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 2004; 305: 1010-1013.
    • (2004) Science , vol.305 , pp. 1010-1013
    • Araki, T.1    Sasaki, Y.2    Milbrandt, J.3
  • 89
    • 23744474976 scopus 로고    scopus 로고
    • A local mechanism mediates NADdependent protection of axon degeneration
    • Wang J, Zhai Q, Chen Y, et al. A local mechanism mediates NADdependent protection of axon degeneration. J Cell Biol 2005; 170: 349-355.
    • (2005) J Cell Biol , vol.170 , pp. 349-355
    • Wang, J.1    Zhai, Q.2    Chen, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.