메뉴 건너뛰기




Volumn 112, Issue 9, 2015, Pages 2876-2881

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

Author keywords

Aging; Human brain; In vivo 31P MR spectroscopy; NAD; Redox state

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 84924352123     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417921112     Document Type: Article
Times cited : (356)

References (47)
  • 1
    • 0038119517 scopus 로고
    • The alcoholic ferment of yeast-juice
    • Harden A, Young WJ (1906) The alcoholic ferment of yeast-juice. Proc R Soc Lond B Biol Sci 77(519):405-420
    • (1906) Proc R Soc Lond B Biol Sci , vol.77 , Issue.519 , pp. 405-420
    • Harden, A.1    Young, W.J.2
  • 2
    • 33845786680 scopus 로고
    • Control of endogenous adenosine triphosphatase activity by energy-linked pyridine nucleotide reduction in mitochondria
    • Chance B, Ito T (1962) Control of endogenous adenosine triphosphatase activity by energy-linked pyridine nucleotide reduction in mitochondria. Nature 195:150-153
    • (1962) Nature , vol.195 , pp. 150-153
    • Chance, B.1    Ito, T.2
  • 4
    • 77953631698 scopus 로고    scopus 로고
    • The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways
    • Houtkooper RH, Cantó C, Wanders RJ, Auwerx J (2010) The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr Rev 31(2):194-223
    • (2010) Endocr Rev , vol.31 , Issue.2 , pp. 194-223
    • Houtkooper, R.H.1    Cantó, C.2    Wanders, R.J.3    Auwerx, J.4
  • 5
    • 0037376665 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
    • Lin SJ, Guarente L (2003) Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol 15(2):241-246
    • (2003) Curr Opin Cell Biol , vol.15 , Issue.2 , pp. 241-246
    • Lin, S.J.1    Guarente, L.2
  • 6
    • 84862022077 scopus 로고    scopus 로고
    • The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
    • Cantó C, et al. (2012) The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab 15(6): 838-847
    • (2012) Cell Metab , vol.15 , Issue.6 , pp. 838-847
    • Cantó, C.1
  • 7
    • 84869121812 scopus 로고    scopus 로고
    • Exploring the therapeutic space around NAD+
    • Houtkooper RH, Auwerx J (2012) Exploring the therapeutic space around NAD+. J Cell Biol 199(2):205-209
    • (2012) J Cell Biol , vol.199 , Issue.2 , pp. 205-209
    • Houtkooper, R.H.1    Auwerx, J.2
  • 8
    • 84880517634 scopus 로고    scopus 로고
    • The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
    • Mouchiroud L, et al. (2013) The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154(2):430-441
    • (2013) Cell , vol.154 , Issue.2 , pp. 430-441
    • Mouchiroud, L.1
  • 9
    • 84865525580 scopus 로고    scopus 로고
    • Regulation of cell survival and death by pyridine nucleotides
    • Oka S, Hsu CP, Sadoshima J (2012) Regulation of cell survival and death by pyridine nucleotides. Circ Res 111(5):611-627
    • (2012) Circ Res , vol.111 , Issue.5 , pp. 611-627
    • Oka, S.1    Hsu, C.P.2    Sadoshima, J.3
  • 10
    • 81555203042 scopus 로고    scopus 로고
    • Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis
    • Pittelli M, et al. (2011) Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis. Mol Pharmacol 80(6):1136-1146
    • (2011) Mol Pharmacol , vol.80 , Issue.6 , pp. 1136-1146
    • Pittelli, M.1
  • 11
    • 52449091282 scopus 로고    scopus 로고
    • Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: Role of enhanced DNA repair
    • Wang S, et al. (2008) Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: Role of enhanced DNA repair. Stroke 39(9):2587-2595
    • (2008) Stroke , vol.39 , Issue.9 , pp. 2587-2595
    • Wang, S.1
  • 12
    • 84903313716 scopus 로고    scopus 로고
    • NAD+ controls neural stem cell fate in the aging brain
    • Wiley C., Campisi J.(2014) NAD+ controls neural stem cell fate in the aging brain. EMBO J, 33:(12);1289-1291
    • (2014) EMBO J , vol.33 , Issue.12 , pp. 1289-1291
    • Wiley, C.1    Campisi, J.2
  • 13
    • 10144236677 scopus 로고
    • Localized fluorometry of oxidationreduction states of intracellular pyridine nucleotide in brain and kidney cortex of the anesthetized rat
    • Chance B, Cohen P, Jobsis F, Schoener B (1962) Localized fluorometry of oxidationreduction states of intracellular pyridine nucleotide in brain and kidney cortex of the anesthetized rat. Science 136(3513):325
    • (1962) Science , vol.136 , Issue.3513 , pp. 325
    • Chance, B.1    Cohen, P.2    Jobsis, F.3    Schoener, B.4
  • 14
    • 73049133557 scopus 로고
    • The measurement of pyridine nucleotides by enzymatic cycling
    • Lowry OH, Passonneau JV, Schulz DW, Rock MK (1961) The measurement of pyridine nucleotides by enzymatic cycling. J Biol Chem 236:2746-2755
    • (1961) J Biol Chem , vol.236 , pp. 2746-2755
    • Lowry, O.H.1    Passonneau, J.V.2    Schulz, D.W.3    Rock, M.K.4
  • 16
    • 0001244868 scopus 로고
    • Fluorescence of pyridine nucleotides in mitochondria
    • Avi-Dor Y, Olson JM, Doherty MD, Kaplan NO (1962) Fluorescence of pyridine nucleotides in mitochondria. J Biol Chem 237(7):2377-2383
    • (1962) J Biol Chem , vol.237 , Issue.7 , pp. 2377-2383
    • Avi-Dor, Y.1    Olson, J.M.2    Doherty, M.D.3    Kaplan, N.O.4
  • 17
    • 84900816363 scopus 로고    scopus 로고
    • Intracellular redox state revealed by in vivo 31P MRS measurement of NAD+ and NADH contents in brains
    • Lu M, Zhu XH, Zhang Y, ChenW(2014) Intracellular redox state revealed by in vivo 31P MRS measurement of NAD+ and NADH contents in brains. Magn Reson Med 71(6): 1959-1972
    • (2014) Magn Reson Med , vol.71 , Issue.6 , pp. 1959-1972
    • Lu, M.1    Zhu, X.H.2    Zhang, Y.3    Chen, W.4
  • 18
    • 0017554345 scopus 로고
    • 31P nuclear magnetic resonance studies of HeLa cells
    • Evans FE, Kaplan NO (1977) 31P nuclear magnetic resonance studies of HeLa cells. Proc Natl Acad Sci USA 74(11):4909-4913
    • (1977) Proc Natl Acad Sci USA , vol.74 , Issue.11 , pp. 4909-4913
    • Evans, F.E.1    Kaplan, N.O.2
  • 19
    • 0037310043 scopus 로고    scopus 로고
    • Vivo 31P magnetic resonance spectroscopy of human brain at 7 T: An initial experience
    • Lei H, Zhu XH, Zhang XL, Ugurbil K, Chen W (2003) In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: An initial experience. Magn Reson Med 49(2): 199-205
    • (2003) Magn Reson Med , vol.49 , Issue.2 , pp. 199-205
    • Lei, H.1    Zhu, X.H.2    Zhang, X.L.3    Ugurbil, K.4    Chen, W.5
  • 20
    • 0017469321 scopus 로고
    • High-resolution 31P nuclear magnetic resonance studies of metabolism in aerobic Escherichia coli cells
    • Navon G, Ogawa S, Shulman RG, Yamane T (1977) High-resolution 31P nuclear magnetic resonance studies of metabolism in aerobic Escherichia coli cells. Proc Natl Acad Sci USA 74(3):888-891
    • (1977) Proc Natl Acad Sci USA , vol.74 , Issue.3 , pp. 888-891
    • Navon, G.1    Ogawa, S.2    Shulman, R.G.3    Yamane, T.4
  • 21
    • 44049096663 scopus 로고    scopus 로고
    • Tightly coupled brain activity and cerebral ATP metabolic rate
    • Du F, et al. (2008) Tightly coupled brain activity and cerebral ATP metabolic rate. Proc Natl Acad Sci USA 105(17):6409-6414
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.17 , pp. 6409-6414
    • Du, F.1
  • 23
    • 84905899776 scopus 로고    scopus 로고
    • Field dependence study of in vivo brain 31P MRS up to 16.4 T
    • Lu M, Chen W, Zhu XH (2014) Field dependence study of in vivo brain 31P MRS up to 16.4 T. NMR Biomed 27(9):1135-1141
    • (2014) NMR Biomed , vol.27 , Issue.9 , pp. 1135-1141
    • Lu, M.1    Chen, W.2    Zhu, X.H.3
  • 25
    • 35848932089 scopus 로고    scopus 로고
    • Differences among cell types in NAD+ compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes
    • Alano CC, et al. (2007) Differences among cell types in NAD+ compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res 85(15): 3378-3385
    • (2007) J Neurosci Res , vol.85 , Issue.15 , pp. 3378-3385
    • Alano, C.C.1
  • 26
    • 30444437034 scopus 로고    scopus 로고
    • Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools
    • McKenna MC, Waagepetersen HS, Schousboe A, Sonnewald U (2006) Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools. Biochem Pharmacol 71(4):399-407
    • (2006) Biochem Pharmacol , vol.71 , Issue.4 , pp. 399-407
    • McKenna, M.C.1    Waagepetersen, H.S.2    Schousboe, A.3    Sonnewald, U.4
  • 27
    • 0014082605 scopus 로고
    • The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
    • Williamson DH, Lund P, Krebs HA (1967) The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103(2): 514-527
    • (1967) Biochem J , vol.103 , Issue.2 , pp. 514-527
    • Williamson, D.H.1    Lund, P.2    Krebs, H.A.3
  • 28
    • 0017747012 scopus 로고
    • Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats
    • Tischler ME, Friedrichs D, Coll K, Williamson JR (1977) Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats. Arch Biochem Biophys 184(1):222-236
    • (1977) Arch Biochem Biophys , vol.184 , Issue.1 , pp. 222-236
    • Tischler, M.E.1    Friedrichs, D.2    Coll, K.3    Williamson, J.R.4
  • 29
    • 0025343842 scopus 로고
    • Regulation of oxidative phosphorylation in the mammalian cell
    • Balaban RS (1990) Regulation of oxidative phosphorylation in the mammalian cell. Am J Physiol 258(3 Pt 1):C377-C389
    • (1990) Am J Physiol , vol.258 , Issue.3 , pp. C377-C389
    • Balaban, R.S.1
  • 30
    • 0017161617 scopus 로고
    • Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria
    • Chance B (1976) Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria. Circ Res 38(5 Suppl 1):I31-I38
    • (1976) Circ Res , vol.38 , Issue.5 , pp. I31-I38
    • Chance, B.1
  • 31
    • 77958477311 scopus 로고    scopus 로고
    • Regional aerobic glycolysis in the human brain
    • Vaishnavi SN, et al. (2010) Regional aerobic glycolysis in the human brain. Proc Natl Acad Sci USA 107(41):17757-17762
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.41 , pp. 17757-17762
    • Vaishnavi, S.N.1
  • 32
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120(4): 483-495
    • (2005) Cell , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 33
    • 84865411082 scopus 로고    scopus 로고
    • The dynamic regulation of NAD metabolism in mitochondria
    • Stein LR, Imai S (2012) The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab 23(9):420-428
    • (2012) Trends Endocrinol Metab , vol.23 , Issue.9 , pp. 420-428
    • Stein, L.R.1    Imai, S.2
  • 34
    • 84896399265 scopus 로고    scopus 로고
    • Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence
    • Braidy N, et al. (2014) Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence. Biogerontology 15(2):177-198
    • (2014) Biogerontology , vol.15 , Issue.2 , pp. 177-198
    • Braidy, N.1
  • 35
    • 84893442805 scopus 로고    scopus 로고
    • Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
    • Gomes AP, et al. (2013) Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155(7):1624-1638
    • (2013) Cell , vol.155 , Issue.7 , pp. 1624-1638
    • Gomes, A.P.1
  • 36
    • 0025056547 scopus 로고
    • Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age
    • Leenders KL, et al. (1990) Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113(Pt 1):27-47
    • (1990) Brain , vol.113 , pp. 27-47
    • Leenders, K.L.1
  • 37
    • 0022881544 scopus 로고
    • Reduction in regional cerebral metabolic rate of oxygen during human aging
    • Yamaguchi T, et al. (1986) Reduction in regional cerebral metabolic rate of oxygen during human aging. Stroke 17(6):1220-1228
    • (1986) Stroke , vol.17 , Issue.6 , pp. 1220-1228
    • Yamaguchi, T.1
  • 38
    • 33847059997 scopus 로고    scopus 로고
    • The mitochondrial energy transduction system and the aging process
    • Navarro A, Boveris A (2007) The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 292(2):C670-C686
    • (2007) Am J Physiol Cell Physiol , vol.292 , Issue.2 , pp. C670-C686
    • Navarro, A.1    Boveris, A.2
  • 39
    • 73949084714 scopus 로고    scopus 로고
    • Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy
    • Boumezbeur F, et al. (2010) Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cereb Blood Flow Metab 30(1):211-221
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.1 , pp. 211-221
    • Boumezbeur, F.1
  • 40
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
    • Petersen KF, et al. (2003) Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 300(5622):1140-1142
    • (2003) Science , vol.300 , Issue.5622 , pp. 1140-1142
    • Petersen, K.F.1
  • 42
    • 77953421120 scopus 로고    scopus 로고
    • The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology
    • Wang J, et al. (2010) The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology. Biochim Biophys Acta 1804(8):1690-1694
    • (2010) Biochim Biophys Acta. , vol.1804 , Issue.8 , pp. 1690-1694
    • Wang, J.1
  • 43
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
    • Yoshino J, Mills KF, Yoon MJ, Imai S (2011) Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab 14(4):528-536
    • (2011) Cell Metab , vol.14 , Issue.4 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.4
  • 44
    • 84880879892 scopus 로고    scopus 로고
    • NAD? Metabolism: A therapeutic target for age-related metabolic disease
    • Mouchiroud L, Houtkooper RH, Auwerx J (2013) NAD? metabolism: A therapeutic target for age-related metabolic disease. Crit Rev Biochem Mol Biol 48(4):397-408
    • (2013) Crit Rev Biochem Mol Biol , vol.48 , Issue.4 , pp. 397-408
    • Mouchiroud, L.1    Houtkooper, R.H.2    Auwerx, J.3
  • 45
    • 84893441854 scopus 로고    scopus 로고
    • NAD+ deficiency in age-related mitochondrial dysfunction
    • Prolla TA, Denu JM (2014) NAD+ deficiency in age-related mitochondrial dysfunction. Cell Metab 19(2):178-180
    • (2014) Cell Metab , vol.19 , Issue.2 , pp. 178-180
    • Prolla, T.A.1    Denu, J.M.2
  • 47
    • 0030738589 scopus 로고    scopus 로고
    • Alternative respiratory pathways of Escherichia coli: Energetics and transcriptional regulation in response to electron acceptors
    • Unden G, Bongaerts J (1997) Alternative respiratory pathways of Escherichia coli: Energetics and transcriptional regulation in response to electron acceptors. Biochim Biophys Acta 1320(3):217-234.
    • (1997) Biochim Biophys Acta , vol.1320 , Issue.3 , pp. 217-234
    • Unden, G.1    Bongaerts, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.