-
1
-
-
0014376435
-
Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin
-
1 Kolb, W.P., Granger, G.A., Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin. Proc. Natl. Acad. Sci. U.S.A. 61 (1968), 1250–1255.
-
(1968)
Proc. Natl. Acad. Sci. U.S.A.
, vol.61
, pp. 1250-1255
-
-
Kolb, W.P.1
Granger, G.A.2
-
2
-
-
0014400299
-
Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism
-
2 Ruddle, N.H., Waksman, B.H., Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism. J. Exp. Med. 128 (1968), 1267–1279.
-
(1968)
J. Exp. Med.
, vol.128
, pp. 1267-1279
-
-
Ruddle, N.H.1
Waksman, B.H.2
-
3
-
-
84954197918
-
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
-
3 Kalliolias, G.D., Ivashkiv, L.B., TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat. Rev. Rheumatol. 12 (2016), 49–62.
-
(2016)
Nat. Rev. Rheumatol.
, vol.12
, pp. 49-62
-
-
Kalliolias, G.D.1
Ivashkiv, L.B.2
-
4
-
-
84922602504
-
Necroptosis and its role in inflammation
-
4 Pasparakis, M., Vandenabeele, P., Necroptosis and its role in inflammation. Nature 517 (2015), 311–320.
-
(2015)
Nature
, vol.517
, pp. 311-320
-
-
Pasparakis, M.1
Vandenabeele, P.2
-
5
-
-
0030032106
-
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
-
5 Hsu, H., et al. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84 (1996), 299–308.
-
(1996)
Cell
, vol.84
, pp. 299-308
-
-
Hsu, H.1
-
6
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
6 Micheau, O., Tschopp, J., Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114 (2003), 181–190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
7
-
-
0029992609
-
Suppression of TNF-α-induced apoptosis by NF-κB
-
7 Van Antwerp, D.J., et al. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274 (1996), 787–789.
-
(1996)
Science
, vol.274
, pp. 787-789
-
-
Van Antwerp, D.J.1
-
8
-
-
33847251527
-
Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling
-
8 O'Donnell, M.A., et al. Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling. Curr. Biol. 17 (2007), 418–424.
-
(2007)
Curr. Biol.
, vol.17
, pp. 418-424
-
-
O'Donnell, M.A.1
-
9
-
-
84864389178
-
NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1
-
9 O'Donnell, M.A., et al. NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1. PLoS ONE, 7, 2012, e41238.
-
(2012)
PLoS ONE
, vol.7
, pp. e41238
-
-
O'Donnell, M.A.1
-
10
-
-
69049092633
-
NEMO/IKKgamma regulates an early NF-κB-independent cell-death checkpoint during TNF signaling
-
10 Legarda-Addison, D., et al. NEMO/IKKgamma regulates an early NF-κB-independent cell-death checkpoint during TNF signaling. Cell Death Differ. 16 (2009), 1279–1288.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1279-1288
-
-
Legarda-Addison, D.1
-
11
-
-
84883770753
-
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
-
11 Dondelinger, Y., et al. RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition. Cell Death Differ. 20 (2013), 1381–1392.
-
(2013)
Cell Death Differ.
, vol.20
, pp. 1381-1392
-
-
Dondelinger, Y.1
-
12
-
-
84960363656
-
NEMO prevents RIP Kinase 1-mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and -independent functions
-
12 Vlantis, K., et al. NEMO prevents RIP Kinase 1-mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and -independent functions. Immunity 44 (2016), 553–567.
-
(2016)
Immunity
, vol.44
, pp. 553-567
-
-
Vlantis, K.1
-
13
-
-
84947923888
-
NF-κB-independent role of IκKα/IκKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling
-
13 Dondelinger, Y., et al. NF-κB-independent role of IκKα/IκKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling. Mol. Cell 60 (2015), 63–76.
-
(2015)
Mol. Cell
, vol.60
, pp. 63-76
-
-
Dondelinger, Y.1
-
14
-
-
72149117664
-
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis
-
14 Vince, J.E., et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis. J. Biol. Chem. 284 (2009), 35906–35915.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 35906-35915
-
-
Vince, J.E.1
-
15
-
-
71149105333
-
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
-
15 Haas, T.L., et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol. Cell 36 (2009), 831–844.
-
(2009)
Mol. Cell
, vol.36
, pp. 831-844
-
-
Haas, T.L.1
-
16
-
-
78650300883
-
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
-
16 Dynek, J.N., et al. c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 29 (2010), 4198–4209.
-
(2010)
EMBO J.
, vol.29
, pp. 4198-4209
-
-
Dynek, J.N.1
-
17
-
-
79953240109
-
Linear ubiquitination prevents inflammation and regulates immune signalling
-
17 Gerlach, B., et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471 (2011), 591–596.
-
(2011)
Nature
, vol.471
, pp. 591-596
-
-
Gerlach, B.1
-
18
-
-
54049155149
-
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
-
18 Varfolomeev, E., et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation. J. Biol. Chem. 283 (2008), 24295–24299.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24295-24299
-
-
Varfolomeev, E.1
-
19
-
-
50149121101
-
Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation
-
19 Mahoney, D.J., et al. Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation. Proc. Natl. Acad. Sci. U.S.A. 105 (2008), 11778–11783.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 11778-11783
-
-
Mahoney, D.J.1
-
20
-
-
66949138341
-
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
-
20 Bertrand, M.J., et al. Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity 30 (2009), 789–801.
-
(2009)
Immunity
, vol.30
, pp. 789-801
-
-
Bertrand, M.J.1
-
21
-
-
2442559290
-
Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro
-
21 Park, S.M., et al. Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro. FEBS Lett. 566 (2004), 151–156.
-
(2004)
FEBS Lett.
, vol.566
, pp. 151-156
-
-
Park, S.M.1
-
22
-
-
59649103156
-
Involvement of linear polyubiquitylation of NEMO in NF-κB activation
-
22 Tokunaga, F., et al. Involvement of linear polyubiquitylation of NEMO in NF-κB activation. Nat. Cell Biol. 11 (2009), 123–132.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
-
23
-
-
84968887534
-
LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes
-
23 Draber, P., et al. LUBAC-recruited CYLD and A20 regulate gene activation and cell death by exerting opposing effects on linear ubiquitin in signaling complexes. Cell Rep. 13 (2015), 2258–2272.
-
(2015)
Cell Rep.
, vol.13
, pp. 2258-2272
-
-
Draber, P.1
-
24
-
-
4344712350
-
TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
-
24 Kanayama, A., et al. TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol. Cell 15 (2004), 535–548.
-
(2004)
Mol. Cell
, vol.15
, pp. 535-548
-
-
Kanayama, A.1
-
25
-
-
33646034316
-
Activation of IκK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
25 Ea, C.K., et al. Activation of IκK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22 (2006), 245–257.
-
(2006)
Mol. Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
-
26
-
-
33645703930
-
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation [corrected]
-
26 Wu, C.J., et al. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation [corrected]. Nat. Cell Biol. 8 (2006), 398–406.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
-
27
-
-
67349231313
-
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
-
27 Komander, D., et al. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 10 (2009), 466–473.
-
(2009)
EMBO Rep.
, vol.10
, pp. 466-473
-
-
Komander, D.1
-
28
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation
-
28 Rahighi, S., et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation. Cell 136 (2009), 1098–1109.
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
-
29
-
-
84884345970
-
Activation of the canonical IκK complex by K63/M1-linked hybrid ubiquitin chains
-
29 Emmerich, C.H., et al. Activation of the canonical IκK complex by K63/M1-linked hybrid ubiquitin chains. Proc. Natl. Acad. Sci. U.S.A. 110 (2013), 15247–15252.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 15247-15252
-
-
Emmerich, C.H.1
-
30
-
-
84904039019
-
Regulation of NF-κB by TNF family cytokines
-
30 Hayden, M.S., Ghosh, S., Regulation of NF-κB by TNF family cytokines. Semin. Immunol. 26 (2014), 253–266.
-
(2014)
Semin. Immunol.
, vol.26
, pp. 253-266
-
-
Hayden, M.S.1
Ghosh, S.2
-
31
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
-
31 Wertz, I.E., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 430 (2004), 694–699.
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
-
32
-
-
84878832998
-
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
-
32 Mevissen, T.E., et al. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154 (2013), 169–184.
-
(2013)
Cell
, vol.154
, pp. 169-184
-
-
Mevissen, T.E.1
-
33
-
-
84903726513
-
The deubiquitinase activity of A20 is dispensable for NF-κB signaling
-
33 De, A., et al. The deubiquitinase activity of A20 is dispensable for NF-κB signaling. EMBO Rep. 15 (2014), 775–783.
-
(2014)
EMBO Rep.
, vol.15
, pp. 775-783
-
-
De, A.1
-
34
-
-
84878187442
-
Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme
-
34 Lu, T.T., et al. Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity 38 (2013), 896–905.
-
(2013)
Immunity
, vol.38
, pp. 896-905
-
-
Lu, T.T.1
-
35
-
-
35548974703
-
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD
-
35 Wright, A., et al. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev. Cell 13 (2007), 705–716.
-
(2007)
Dev. Cell
, vol.13
, pp. 705-716
-
-
Wright, A.1
-
36
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
-
36 Kovalenko, A., et al. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 424 (2003), 801–805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
-
37
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members
-
37 Trompouki, E., et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424 (2003), 793–796.
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
-
38
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
-
38 Brummelkamp, T.R., et al. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424 (2003), 797–801.
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
-
39
-
-
84904047854
-
Functions of caspase 8: the identified and the mysterious
-
39 Salvesen, G.S., Walsh, C.M., Functions of caspase 8: the identified and the mysterious. Semin. Immunol. 26 (2014), 246–252.
-
(2014)
Semin. Immunol.
, vol.26
, pp. 246-252
-
-
Salvesen, G.S.1
Walsh, C.M.2
-
40
-
-
84950150216
-
FLIP the switch: regulation of apoptosis and necroptosis by cFLIP
-
40 Tsuchiya, Y., et al. FLIP the switch: regulation of apoptosis and necroptosis by cFLIP. Int. J. Mol. Sci. 16 (2015), 30321–30341.
-
(2015)
Int. J. Mol. Sci.
, vol.16
, pp. 30321-30341
-
-
Tsuchiya, Y.1
-
41
-
-
84907210946
-
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
-
41 Dannappel, M., et al. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513 (2014), 90–94.
-
(2014)
Nature
, vol.513
, pp. 90-94
-
-
Dannappel, M.1
-
42
-
-
84907197966
-
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
-
42 Takahashi, N., et al. RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature 513 (2014), 95–99.
-
(2014)
Nature
, vol.513
, pp. 95-99
-
-
Takahashi, N.1
-
43
-
-
0032033132
-
The death domain kinase RIP mediates the TNF-induced NF-κB signal
-
43 Kelliher, M.A., et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8 (1998), 297–303.
-
(1998)
Immunity
, vol.8
, pp. 297-303
-
-
Kelliher, M.A.1
-
44
-
-
84878376898
-
Two coordinated mechanisms underlie tumor necrosis factor α-induced immediate and delayed IκB kinase activation
-
44 Blackwell, K., et al. Two coordinated mechanisms underlie tumor necrosis factor α-induced immediate and delayed IκB kinase activation. Mol. Cell. Biol. 33 (2013), 1901–1915.
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 1901-1915
-
-
Blackwell, K.1
-
45
-
-
79953906762
-
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8
-
45 Gentle, I.E., et al. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8. J. Biol. Chem. 286 (2011), 13282–13291.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 13282-13291
-
-
Gentle, I.E.1
-
46
-
-
76749132616
-
RIPK1 is not essential for TNFR1-induced activation of NF-κB
-
46 Wong, W.W., et al. RIPK1 is not essential for TNFR1-induced activation of NF-κB. Cell Death Differ. 17 (2010), 482–487.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 482-487
-
-
Wong, W.W.1
-
47
-
-
43049152912
-
TNF-α induces two distinct caspase-8 activation pathways
-
47 Wang, L., et al. TNF-α induces two distinct caspase-8 activation pathways. Cell 133 (2008), 693–703.
-
(2008)
Cell
, vol.133
, pp. 693-703
-
-
Wang, L.1
-
48
-
-
62849093368
-
Death receptor signal transducers: nodes of coordination in immune signaling networks
-
48 Wilson, N.S., et al. Death receptor signal transducers: nodes of coordination in immune signaling networks. Nat. Immunol. 10 (2009), 348–355.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 348-355
-
-
Wilson, N.S.1
-
49
-
-
0036009115
-
NF-κB at the crossroads of life and death
-
49 Karin, M., Lin, A., NF-κB at the crossroads of life and death. Nat. Immunol. 3 (2002), 221–227.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
-
50
-
-
44949240664
-
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 Ligases that promote RIP1 ubiquitination
-
50 Bertrand, M.J., et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 Ligases that promote RIP1 ubiquitination. Mol. Cell 30 (2008), 689–700.
-
(2008)
Mol. Cell
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
-
51
-
-
35948994157
-
Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
51 Petersen, S.L., et al. Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12 (2007), 445–456.
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
-
52
-
-
84859424337
-
IAPs limit activation of RIP kinases by TNF receptor 1 during development
-
52 Moulin, M., et al. IAPs limit activation of RIP kinases by TNF receptor 1 during development. EMBO J. 31 (2012), 1679–1691.
-
(2012)
EMBO J.
, vol.31
, pp. 1679-1691
-
-
Moulin, M.1
-
53
-
-
84901678314
-
Cutting edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice
-
53 Berger, S.B., et al. Cutting edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J. Immunol. 192 (2014), 5476–5480.
-
(2014)
J. Immunol.
, vol.192
, pp. 5476-5480
-
-
Berger, S.B.1
-
54
-
-
84907995994
-
HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death
-
54 Peltzer, N., et al. HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death. Cell Rep. 9 (2014), 153–165.
-
(2014)
Cell Rep.
, vol.9
, pp. 153-165
-
-
Peltzer, N.1
-
55
-
-
84925358056
-
TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
-
55 Rickard, J.A., et al. TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice. Elife, 3, 2014, e03464.
-
(2014)
Elife
, vol.3
, pp. e03464
-
-
Rickard, J.A.1
-
56
-
-
84946544180
-
NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity-mediated hepatocyte apoptosis
-
56 Kondylis, V., et al. NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity-mediated hepatocyte apoptosis. Cancer Cell 28 (2015), 582–598.
-
(2015)
Cancer Cell
, vol.28
, pp. 582-598
-
-
Kondylis, V.1
-
58
-
-
84856160569
-
Caspase 8 inhibits programmed necrosis by processing CYLD
-
58 O'Donnell, M.A., et al. Caspase 8 inhibits programmed necrosis by processing CYLD. Nat. Cell Biol. 13 (2011), 1437–1442.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1437-1442
-
-
O'Donnell, M.A.1
-
59
-
-
84951176357
-
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
-
59 Wertz, I.E., et al. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 528 (2015), 370–375.
-
(2015)
Nature
, vol.528
, pp. 370-375
-
-
Wertz, I.E.1
-
60
-
-
84904725273
-
IκK regulates the deubiquitinase CYLD at the postsynaptic density
-
60 Thein, S., et al. IκK regulates the deubiquitinase CYLD at the postsynaptic density. Biochem. Biophys. Res. Commun. 450 (2014), 550–554.
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.450
, pp. 550-554
-
-
Thein, S.1
-
61
-
-
0037149542
-
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
-
61 Li, X., et al. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416 (2002), 345–347.
-
(2002)
Nature
, vol.416
, pp. 345-347
-
-
Li, X.1
-
62
-
-
0036629347
-
Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8
-
62 Fotin-Mleczek, M., et al. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. J. Cell Sci. 115 (2002), 2757–2770.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 2757-2770
-
-
Fotin-Mleczek, M.1
-
63
-
-
84947023495
-
NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis
-
63 Boutaffala, L., et al. NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis. Cell Death Differ. 22 (2015), 2020–2033.
-
(2015)
Cell Death Differ.
, vol.22
, pp. 2020-2033
-
-
Boutaffala, L.1
-
64
-
-
84888413953
-
Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis
-
64 McQuade, T., et al. Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. Biochem. J. 456 (2013), 409–415.
-
(2013)
Biochem. J.
, vol.456
, pp. 409-415
-
-
McQuade, T.1
-
65
-
-
79952623655
-
cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production
-
65 Vanlangenakker, N., et al. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ. 18 (2011), 656–665.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 656-665
-
-
Vanlangenakker, N.1
-
66
-
-
66749183275
-
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α
-
66 He, S., et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell 137 (2009), 1100–1111.
-
(2009)
Cell
, vol.137
, pp. 1100-1111
-
-
He, S.1
-
67
-
-
47549097367
-
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα
-
67 Vince, J.E., et al. TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα. J. Cell Biol. 182 (2008), 171–184.
-
(2008)
J. Cell Biol.
, vol.182
, pp. 171-184
-
-
Vince, J.E.1
-
68
-
-
84858627919
-
Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors
-
68 Varfolomeev, E., et al. Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors. Sci. Signal., 5, 2012, ra22.
-
(2012)
Sci. Signal.
, vol.5
, pp. ra22
-
-
Varfolomeev, E.1
-
69
-
-
0022369998
-
Tumor necrosis factor (TNF)
-
69 Old, L.J., Tumor necrosis factor (TNF). Science 230 (1985), 630–632.
-
(1985)
Science
, vol.230
, pp. 630-632
-
-
Old, L.J.1
-
70
-
-
84945232013
-
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8(+) T cells
-
70 Yatim, N., et al. RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8(+) T cells. Science 350 (2015), 328–334.
-
(2015)
Science
, vol.350
, pp. 328-334
-
-
Yatim, N.1
-
71
-
-
84939958700
-
Necroptosis: the Trojan horse in cell autonomous antiviral host defense
-
71 Mocarski, E.S., et al. Necroptosis: the Trojan horse in cell autonomous antiviral host defense. Virology 479–480 (2015), 160–166.
-
(2015)
Virology
, vol.479-480
, pp. 160-166
-
-
Mocarski, E.S.1
-
72
-
-
84924401688
-
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis
-
72 Kumari, S., et al. Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife, 3, 2014, e03422.
-
(2014)
Elife
, vol.3
, pp. e03422
-
-
Kumari, S.1
-
73
-
-
57149139812
-
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-κB essential modulator deficiency
-
1113–1118 e1
-
73 Pai, S.Y., et al. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-κB essential modulator deficiency. J. Allergy Clin. Immunol., 122, 2008 1113–1118 e1.
-
(2008)
J. Allergy Clin. Immunol.
, vol.122
-
-
Pai, S.Y.1
-
74
-
-
57149141634
-
Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity
-
1169–1177 e16
-
74 Hanson, E.P., et al. Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. J. Allergy Clin. Immunol., 122, 2008 1169–1177 e16.
-
(2008)
J. Allergy Clin. Immunol.
, vol.122
-
-
Hanson, E.P.1
-
75
-
-
84862265794
-
Successful treatment with infliximab for inflammatory colitis in a patient with X-linked anhidrotic ectodermal dysplasia with immunodeficiency
-
75 Mizukami, T., et al. Successful treatment with infliximab for inflammatory colitis in a patient with X-linked anhidrotic ectodermal dysplasia with immunodeficiency. J. Clin. Immunol. 32 (2012), 39–49.
-
(2012)
J. Clin. Immunol.
, vol.32
, pp. 39-49
-
-
Mizukami, T.1
-
76
-
-
84869429707
-
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
-
76 Boisson, B., et al. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat. Immunol. 13 (2012), 1178–1186.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 1178-1186
-
-
Boisson, B.1
-
77
-
-
84980347632
-
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia
-
77 Boisson, B., et al. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J. Exp. Med. 212 (2015), 939–951.
-
(2015)
J. Exp. Med.
, vol.212
, pp. 939-951
-
-
Boisson, B.1
-
78
-
-
84856495152
-
Targeting IAP proteins for therapeutic intervention in cancer
-
78 Fulda, S., Vucic, D., Targeting IAP proteins for therapeutic intervention in cancer. Nat. Rev. Drug. Discov. 11 (2012), 109–124.
-
(2012)
Nat. Rev. Drug. Discov.
, vol.11
, pp. 109-124
-
-
Fulda, S.1
Vucic, D.2
|