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Volumn 14, Issue 6, 2016, Pages

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN CK1GAMMA; PROTEIN SERINE THREONINE KINASE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; CASEIN KINASE I; DROSOPHILA PROTEIN; GILGAMESH PROTEIN, DROSOPHILA; HEDGEHOG PROTEIN, DROSOPHILA; PHOTOPROTEIN; SMOOTHENED PROTEIN, DROSOPHILA;

EID: 84978943176     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002481     Document Type: Article
Times cited : (45)

References (52)
  • 1
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • 19081070, .;():–
    • Jiang J, Hui CC, Hedgehog signaling in development and cancer. Developmental cell. 2008;15(6):801–12. 19081070. doi: 10.1016/j.devcel.2008.11.010
    • (2008) Developmental cell , vol.15 , Issue.6 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 2
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • 14737121, .;():–
    • Pasca di Magliano M, Hebrok M, Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer. 2003;3(12):903–11. 14737121.
    • (2003) Nat Rev Cancer , vol.3 , Issue.12 , pp. 903-911
    • Pasca di Magliano, M.1    Hebrok, M.2
  • 3
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • 23719536, .;():–. Epub 2013/05/31
    • Briscoe J, Therond PP, The mechanisms of Hedgehog signalling and its roles in development and disease. Nature reviews Molecular cell biology. 2013;14(7):418–31. Epub 2013/05/31. doi: 10.1038/nrm359823719536.
    • (2013) Nature reviews Molecular cell biology , vol.14 , Issue.7 , pp. 418-431
    • Briscoe, J.1    Therond, P.P.2
  • 4
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • 11357142, .;():–
    • Taipale J, Beachy PA, The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001;411(6835):349–54. doi: 10.1038/3507721911357142.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 5
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: paradigms and principles
    • 11731473, .;():–
    • Ingham PW, McMahon AP, Hedgehog signaling in animal development: paradigms and principles. Genes & development. 2001;15(23):3059–87. doi: 10.1101/gad.93860111731473.
    • (2001) Genes & development , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 6
    • 84906875879 scopus 로고    scopus 로고
    • Roles of Hedgehog signaling in adult organ homeostasis and repair
    • 25183867, .;():–.; PubMed Central PMCID: PMC4197719
    • Petrova R, Joyner AL, Roles of Hedgehog signaling in adult organ homeostasis and repair. Development. 2014;141(18):3458–71. doi: 10.1242/dev.08369125183867; PubMed Central PMCID: PMC4197719.
    • (2014) Development , vol.141 , Issue.18 , pp. 3458-3471
    • Petrova, R.1    Joyner, A.L.2
  • 7
    • 77953316514 scopus 로고    scopus 로고
    • Mechanism and evolution of cytosolic Hedgehog signal transduction
    • 20530542, .;():–. Epub 2010/06/10. 137/13/2079 [pii]; PubMed Central PMCID: PMC2882129
    • Wilson CW, Chuang PT, Mechanism and evolution of cytosolic Hedgehog signal transduction. Development. 2010;137(13):2079–94. Epub 2010/06/10. 137/13/2079 [pii] doi: 10.1242/dev.04502120530542; PubMed Central PMCID: PMC2882129.
    • (2010) Development , vol.137 , Issue.13 , pp. 2079-2094
    • Wilson, C.W.1    Chuang, P.T.2
  • 8
    • 84867799739 scopus 로고    scopus 로고
    • The Hedgehog signal transduction network
    • 23074268, .;():. Epub 2012/10/18.; PubMed Central PMCID: PMC3705708
    • Robbins DJ, Fei DL, Riobo NA, The Hedgehog signal transduction network. Science signaling. 2012;5(246):re6. Epub 2012/10/18. doi: 10.1126/scisignal.200290623074268; PubMed Central PMCID: PMC3705708.
    • (2012) Science signaling , vol.5 , Issue.246 , pp. re6
    • Robbins, D.J.1    Fei, D.L.2    Riobo, N.A.3
  • 9
    • 0011102935 scopus 로고    scopus 로고
    • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    • 8906787, ..;():–
    • Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996;384(6605):129–34. doi: 10.1038/384129a08906787.
    • (1996) Nature , vol.384 , Issue.6605 , pp. 129-134
    • Stone, D.M.1    Hynes, M.2    Armanini, M.3    Swanson, T.A.4    Gu, Q.5    Johnson, R.L.6
  • 10
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • 8898207, .;():–
    • Chen Y, Struhl G, Dual roles for patched in sequestering and transducing Hedgehog. Cell. 1996;87(3):553–63. 8898207.
    • (1996) Cell , vol.87 , Issue.3 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 11
    • 0242361620 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    • 14597665, .;():–
    • Jia J, Tong C, Jiang J, Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes & development. 2003;17(21):2709–20. 14597665.
    • (2003) Genes & development , vol.17 , Issue.21 , pp. 2709-2720
    • Jia, J.1    Tong, C.2    Jiang, J.3
  • 12
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • 17960137, .;():–
    • Zhao Y, Tong C, Jiang J, Hedgehog regulates smoothened activity by inducing a conformational switch. Nature. 2007;450(7167):252–8. 17960137.
    • (2007) Nature , vol.450 , Issue.7167 , pp. 252-258
    • Zhao, Y.1    Tong, C.2    Jiang, J.3
  • 13
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • 17641202, .;():–
    • Rohatgi R, Milenkovic L, Scott MP, Patched1 regulates hedgehog signaling at the primary cilium. Science. 2007;317(5836):372–6. 17641202.
    • (2007) Science , vol.317 , Issue.5836 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 15
    • 79959804711 scopus 로고    scopus 로고
    • Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened
    • 21695114, ..;():.; PubMed Central PMCID: PMC3114773
    • Chen Y, Sasai N, Ma G, Yue T, Jia J, Briscoe J, et al. Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol. 2011;9(6):e1001083. doi: 10.1371/journal.pbio.100108321695114; PubMed Central PMCID: PMC3114773.
    • (2011) PLoS Biol , vol.9 , Issue.6 , pp. e1001083
    • Chen, Y.1    Sasai, N.2    Ma, G.3    Yue, T.4    Jia, J.5    Briscoe, J.6
  • 16
    • 84873735792 scopus 로고    scopus 로고
    • Decoding the phosphorylation code in Hedgehog signal transduction
    • 23337587, .;():–.; PubMed Central PMCID: PMC3567827
    • Chen Y, Jiang J, Decoding the phosphorylation code in Hedgehog signal transduction. Cell research. 2013;23(2):186–200. doi: 10.1038/cr.2013.1023337587; PubMed Central PMCID: PMC3567827.
    • (2013) Cell research , vol.23 , Issue.2 , pp. 186-200
    • Chen, Y.1    Jiang, J.2
  • 17
    • 84863012714 scopus 로고    scopus 로고
    • Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
    • 22253574, .;():. Epub 2012/01/19.; PubMed Central PMCID: PMC3254653
    • Li S, Chen Y, Shi Q, Yue T, Wang B, Jiang J, Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol. 2012;10(1):e1001239. Epub 2012/01/19. doi: 10.1371/journal.pbio.100123922253574; PubMed Central PMCID: PMC3254653.
    • (2012) PLoS Biol , vol.10 , Issue.1 , pp. e1001239
    • Li, S.1    Chen, Y.2    Shi, Q.3    Yue, T.4    Wang, B.5    Jiang, J.6
  • 18
    • 84863012620 scopus 로고    scopus 로고
    • USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization
    • 22253573, .;():. Epub 2012/01/19.; PubMed Central PMCID: PMC3254663
    • Xia R, Jia H, Fan J, Liu Y, Jia J, USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol. 2012;10(1):e1001238. Epub 2012/01/19. doi: 10.1371/journal.pbio.100123822253573; PubMed Central PMCID: PMC3254663.
    • (2012) PLoS Biol , vol.10 , Issue.1 , pp. e1001238
    • Xia, R.1    Jia, H.2    Fan, J.3    Liu, Y.4    Jia, J.5
  • 19
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    • 15616566, .;():–
    • Jia J, Tong C, Wang B, Luo L, Jiang J, Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature. 2004;432(7020):1045–50. doi: 10.1038/nature0317915616566.
    • (2004) Nature , vol.432 , Issue.7020 , pp. 1045-1050
    • Jia, J.1    Tong, C.2    Wang, B.3    Luo, L.4    Jiang, J.5
  • 21
    • 12344305145 scopus 로고    scopus 로고
    • Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    • 15592457, .;():–
    • Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A, Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol. 2005;7(1):86–92. 15592457.
    • (2005) Nat Cell Biol , vol.7 , Issue.1 , pp. 86-92
    • Apionishev, S.1    Katanayeva, N.M.2    Marks, S.A.3    Kalderon, D.4    Tomlinson, A.5
  • 22
    • 84903779617 scopus 로고    scopus 로고
    • Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation
    • 24985345, .;():
    • Li S, Ma G, Wang B, Jiang J, Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation. Science signaling. 2014;7(332):ra62. doi: 10.1126/scisignal.200541424985345.
    • (2014) Science signaling , vol.7 , Issue.332 , pp. ra62
    • Li, S.1    Ma, G.2    Wang, B.3    Jiang, J.4
  • 23
    • 70450221494 scopus 로고    scopus 로고
    • Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
    • 19850026, .;():–. Epub 2009/10/24.; PubMed Central PMCID: PMC3160985
    • Cheng S, Maier D, Neubueser D, Hipfner DR, Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Developmental biology. 2010;337(1):99–109. Epub 2009/10/24. doi: 10.1016/j.ydbio.2009.10.01419850026; PubMed Central PMCID: PMC3160985.
    • (2010) Developmental biology , vol.337 , Issue.1 , pp. 99-109
    • Cheng, S.1    Maier, D.2    Neubueser, D.3    Hipfner, D.R.4
  • 24
    • 77956805860 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
    • 20844016, ..;():–. Epub 2010/09/17. 24/18/2054 [pii]; PubMed Central PMCID: PMC2939367
    • Chen Y, Li S, Tong C, Zhao Y, Wang B, Liu Y, et al. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes & development. 2010;24(18):2054–67. Epub 2010/09/17. 24/18/2054 [pii] doi: 10.1101/gad.194871020844016; PubMed Central PMCID: PMC2939367.
    • (2010) Genes & development , vol.24 , Issue.18 , pp. 2054-2067
    • Chen, Y.1    Li, S.2    Tong, C.3    Zhao, Y.4    Wang, B.5    Liu, Y.6
  • 25
    • 78549236202 scopus 로고    scopus 로고
    • Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus
    • 20876583, ..;():–. Epub 2010/09/30.; PubMed Central PMCID: PMC2988328
    • Jia H, Liu Y, Xia R, Tong C, Yue T, Jiang J, et al. Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. The Journal of biological chemistry. 2010;285(48):37218–26. Epub 2010/09/30. doi: 10.1074/jbc.M110.17456520876583; PubMed Central PMCID: PMC2988328.
    • (2010) The Journal of biological chemistry , vol.285 , Issue.48 , pp. 37218-37226
    • Jia, H.1    Liu, Y.2    Xia, R.3    Tong, C.4    Yue, T.5    Jiang, J.6
  • 27
    • 0038625111 scopus 로고    scopus 로고
    • Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
    • 12730121, .;():–
    • Zhu AJ, Zheng L, Suyama K, Scott MP, Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes & development. 2003;17(10):1240–52. 12730121.
    • (2003) Genes & development , vol.17 , Issue.10 , pp. 1240-1252
    • Zhu, A.J.1    Zheng, L.2    Suyama, K.3    Scott, M.P.4
  • 28
    • 0037122869 scopus 로고    scopus 로고
    • Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes
    • 11804568, .;():–. Epub 2002/01/24
    • Hummel T, Attix S, Gunning D, Zipursky SL, Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. Neuron. 2002;33(2):193–203. Epub 2002/01/24. 11804568.
    • (2002) Neuron , vol.33 , Issue.2 , pp. 193-203
    • Hummel, T.1    Attix, S.2    Gunning, D.3    Zipursky, S.L.4
  • 29
    • 13844294211 scopus 로고    scopus 로고
    • The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
    • 15722192, .;():–. Epub 2005/02/22. S0898-6568(04)00297-9 [pii]
    • Knippschild U, Gocht A, Wolff S, Huber N, Lohler J, Stoter M, The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal. 2005;17(6):675–89. Epub 2005/02/22. S0898-6568(04)00297-9 [pii] doi: 10.1016/j.cellsig.2004.12.01115722192.
    • (2005) Cell Signal , vol.17 , Issue.6 , pp. 675-689
    • Knippschild, U.1    Gocht, A.2    Wolff, S.3    Huber, N.4    Lohler, J.5    Stoter, M.6
  • 30
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    • 16341016, ..;():–
    • Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, et al. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005;438(7069):867–72. 16341016.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 867-872
    • Davidson, G.1    Wu, W.2    Shen, J.3    Bilic, J.4    Fenger, U.5    Stannek, P.6
  • 31
    • 33749511242 scopus 로고    scopus 로고
    • Regulation of wingless signaling by the CKI family in Drosophila limb development
    • 16987508, .;():–
    • Zhang L, Jia J, Wang B, Amanai K, Wharton KA, Jr.Jiang J, Regulation of wingless signaling by the CKI family in Drosophila limb development. Developmental biology. 2006;299(1):221–37. 16987508.
    • (2006) Developmental biology , vol.299 , Issue.1 , pp. 221-237
    • Zhang, L.1    Jia, J.2    Wang, B.3    Amanai, K.4    Wharton, K.A.5    Jiang, J.6
  • 32
    • 77956309266 scopus 로고    scopus 로고
    • Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila
    • 20826312, .;():–. Epub 2010/09/10
    • Tan Y, Yu D, Pletting J, Davis RL, Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila. Neuron. 2010;67(5):810–20. Epub 2010/09/10. doi: 10.1016/j.neuron.2010.08.02020826312.
    • (2010) Neuron , vol.67 , Issue.5 , pp. 810-820
    • Tan, Y.1    Yu, D.2    Pletting, J.3    Davis, R.L.4
  • 33
    • 84860001608 scopus 로고    scopus 로고
    • Drosophila CK1-gamma, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking
    • 22391037, .;():–. Epub 2012/03/07.; PubMed Central PMCID: PMC3307696
    • Gault WJ, Olguin P, Weber U, Mlodzik M, Drosophila CK1-gamma, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. The Journal of cell biology. 2012;196(5):605–21. Epub 2012/03/07. doi: 10.1083/jcb.20110713722391037; PubMed Central PMCID: PMC3307696.
    • (2012) The Journal of cell biology , vol.196 , Issue.5 , pp. 605-621
    • Gault, W.J.1    Olguin, P.2    Weber, U.3    Mlodzik, M.4
  • 34
    • 80052515585 scopus 로고    scopus 로고
    • The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
    • 21852395, .;():–. Epub 2011/08/20. dev.067959 [pii]
    • Shi Q, Li S, Jia J, Jiang J, The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development. 2011;138(19):4219–31. Epub 2011/08/20. dev.067959 [pii] doi: 10.1242/dev.06795921852395.
    • (2011) Development , vol.138 , Issue.19 , pp. 4219-4231
    • Shi, Q.1    Li, S.2    Jia, J.3    Jiang, J.4
  • 35
    • 0141728540 scopus 로고    scopus 로고
    • Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
    • 14523402, .;():–
    • Ruel L, Rodriguez R, Gallet A, Lavenant-Staccini L, Therond PP, Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol. 2003;5(10):907–13. 14523402.
    • (2003) Nat Cell Biol , vol.5 , Issue.10 , pp. 907-913
    • Ruel, L.1    Rodriguez, R.2    Gallet, A.3    Lavenant-Staccini, L.4    Therond, P.P.5
  • 36
    • 0035341376 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
    • 11311363, .;():–
    • Lee T, Luo L, Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci. 2001;24(5):251–4. 11311363.
    • (2001) Trends Neurosci , vol.24 , Issue.5 , pp. 251-254
    • Lee, T.1    Luo, L.2
  • 37
    • 0016613341 scopus 로고
    • Minutes: mutants of drosophila autonomously affecting cell division rate
    • 1116643, .;():–
    • Morata G, Ripoll P, Minutes: mutants of drosophila autonomously affecting cell division rate. Developmental biology. 1975;42(2):211–21. 1116643.
    • (1975) Developmental biology , vol.42 , Issue.2 , pp. 211-221
    • Morata, G.1    Ripoll, P.2
  • 38
    • 84905457341 scopus 로고    scopus 로고
    • A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity
    • 25009998, .;():.; PubMed Central PMCID: PMC4091690
    • Maier D, Cheng S, Faubert D, Hipfner DR, A broadly conserved g-protein-coupled receptor kinase phosphorylation mechanism controls Drosophila smoothened activity. PLoS Genet. 2014;10(7):e1004399. doi: 10.1371/journal.pgen.100439925009998; PubMed Central PMCID: PMC4091690.
    • (2014) PLoS Genet , vol.10 , Issue.7 , pp. e1004399
    • Maier, D.1    Cheng, S.2    Faubert, D.3    Hipfner, D.R.4
  • 39
    • 84885465453 scopus 로고    scopus 로고
    • Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling
    • 23843610, ..;():–. Epub 2013/07/12
    • Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, et al. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of cell science. 2013;126(Pt 18):4230–8. Epub 2013/07/12. doi: 10.1242/jcs.12860323843610.
    • (2013) Journal of cell science , vol.126 , pp. 4230-4238
    • Yang, X.1    Mao, F.2    Lv, X.3    Zhang, Z.4    Fu, L.5    Lu, Y.6
  • 40
    • 84861225973 scopus 로고    scopus 로고
    • Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner
    • 22537496, .;():–. Epub 2012/04/28
    • Fan J, Liu Y, Jia J, Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner. Developmental biology. 2012;366(2):172–84. Epub 2012/04/28. doi: 10.1016/j.ydbio.2012.04.00722537496.
    • (2012) Developmental biology , vol.366 , Issue.2 , pp. 172-184
    • Fan, J.1    Liu, Y.2    Jia, J.3
  • 41
    • 0032585515 scopus 로고    scopus 로고
    • Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
    • 9874371, .;():–
    • Ohlmeyer JT, Kalderon D, Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature. 1998;396(6713):749–53. doi: 10.1038/255339874371.
    • (1998) Nature , vol.396 , Issue.6713 , pp. 749-753
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 42
    • 0034669178 scopus 로고    scopus 로고
    • Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
    • 11090136, .;():–.; PubMed Central PMCID: PMC317068
    • Wang G, Amanai K, Wang B, Jiang J, Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes & development. 2000;14(22):2893–905. 11090136; PubMed Central PMCID: PMC317068.
    • (2000) Genes & development , vol.14 , Issue.22 , pp. 2893-2905
    • Wang, G.1    Amanai, K.2    Wang, B.3    Jiang, J.4
  • 43
    • 0033859849 scopus 로고    scopus 로고
    • Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
    • 10862750, .;():–
    • Wang QT, Holmgren RA, Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development. 2000;127(14):3131–9. 10862750.
    • (2000) Development , vol.127 , Issue.14 , pp. 3131-3139
    • Wang, Q.T.1    Holmgren, R.A.2
  • 44
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • 19684112, ..;():–. Epub 2009/08/18. 23/16/1910 [pii]; PubMed Central PMCID: PMC2725943
    • Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, et al. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes & development. 2009;23(16):1910–28. Epub 2009/08/18. 23/16/1910 [pii] doi: 10.1101/gad.179410919684112; PubMed Central PMCID: PMC2725943.
    • (2009) Genes & development , vol.23 , Issue.16 , pp. 1910-1928
    • Chen, M.H.1    Wilson, C.W.2    Li, Y.J.3    Law, K.K.4    Lu, C.S.5    Gacayan, R.6
  • 45
    • 84919908650 scopus 로고    scopus 로고
    • The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation
    • 25484239, ..;():–.; PubMed Central PMCID: PMC4272670
    • Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, et al. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chemistry & biology. 2014;21(12):1680–9. doi: 10.1016/j.chembiol.2014.10.01325484239; PubMed Central PMCID: PMC4272670.
    • (2014) Chemistry & biology , vol.21 , Issue.12 , pp. 1680-1689
    • Fan, C.W.1    Chen, B.2    Franco, I.3    Lu, J.4    Shi, H.5    Wei, S.6
  • 46
    • 0033598401 scopus 로고    scopus 로고
    • Casein kinase I transduces Wnt signals
    • 10517632, .;():–
    • Peters JM, McKay RM, McKay JP, Graff JM, Casein kinase I transduces Wnt signals. Nature. 1999;401(6751):345–50. doi: 10.1038/4383010517632.
    • (1999) Nature , vol.401 , Issue.6751 , pp. 345-350
    • Peters, J.M.1    McKay, R.M.2    McKay, J.P.3    Graff, J.M.4
  • 47
    • 66249144426 scopus 로고    scopus 로고
    • The structure and function of G-protein-coupled receptors
    • 19458711, .;():–.; PubMed Central PMCID: PMC3967846
    • Rosenbaum DM, Rasmussen SG, Kobilka BK, The structure and function of G-protein-coupled receptors. Nature. 2009;459(7245):356–63. doi: 10.1038/nature0814419458711; PubMed Central PMCID: PMC3967846.
    • (2009) Nature , vol.459 , Issue.7245 , pp. 356-363
    • Rosenbaum, D.M.1    Rasmussen, S.G.2    Kobilka, B.K.3
  • 48
    • 0032728958 scopus 로고    scopus 로고
    • Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
    • 10557210, .;():–
    • Wang GL, Wang B, Jiang J, Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes & development. 1999;13(21):2828–37. doi: 10.1101/Gad.13.21.282810557210.
    • (1999) Genes & development , vol.13 , Issue.21 , pp. 2828-2837
    • Wang, G.L.1    Wang, B.2    Jiang, J.3
  • 49
    • 0028918468 scopus 로고
    • Protein kinase A and hedgehog signaling in Drosophila limb development
    • 7867064, .;():–
    • Jiang J, Struhl G, Protein kinase A and hedgehog signaling in Drosophila limb development. Cell. 1995;80(4):563–72. doi: 10.1016/0092-8674(95)90510-37867064.
    • (1995) Cell , vol.80 , Issue.4 , pp. 563-572
    • Jiang, J.1    Struhl, G.2
  • 50
    • 0037470952 scopus 로고    scopus 로고
    • Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
    • 12663920, ..;():–
    • Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, et al. Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science. 2003;299(5615):2039–45. 12663920.
    • (2003) Science , vol.299 , Issue.5615 , pp. 2039-2045
    • Lum, L.1    Yao, S.2    Mozer, B.3    Rovescalli, A.4    Von Kessler, D.5    Nirenberg, M.6
  • 51
    • 13344261322 scopus 로고    scopus 로고
    • Hedgehog-regulated costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus
    • 15691767, ..;():–
    • Zhang W, Zhao Y, Tong C, Wang G, Wang B, Jia J, et al. Hedgehog-regulated costal2-kinase complexes control phosphorylation and proteolytic processing of cubitus interruptus. Developmental cell. 2005;8(2):267–78. 15691767.
    • (2005) Developmental cell , vol.8 , Issue.2 , pp. 267-278
    • Zhang, W.1    Zhao, Y.2    Tong, C.3    Wang, G.4    Wang, B.5    Jia, J.6
  • 52
    • 0029126148 scopus 로고
    • The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
    • 7577671, .;():–
    • Motzny CK, Holmgren R, The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech Dev. 1995;52(1):137–50. 7577671.
    • (1995) Mech Dev , vol.52 , Issue.1 , pp. 137-150
    • Motzny, C.K.1    Holmgren, R.2


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