메뉴 건너뛰기




Volumn 111, Issue 45, 2014, Pages E4842-E4850

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila

Author keywords

aPKC; Ci; Hh; Par6; Smo

Indexed keywords

ATYPICAL PROTEIN KINASE C; CASEIN KINASE; DNA; PROTEIN KINASE C; SMOOTHENED PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CUBITUS INTERRUPTUS; UNCLASSIFIED DRUG; CASEIN KINASE I; CI PROTEIN, DROSOPHILA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; HEDGEHOG PROTEIN, DROSOPHILA; PKC-3 PROTEIN; SMOOTHENED PROTEIN, DROSOPHILA; SONIC HEDGEHOG PROTEIN;

EID: 84909606348     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417147111     Document Type: Article
Times cited : (32)

References (50)
  • 1
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287(5785):795-801.
    • (1980) Nature , vol.287 , Issue.5785 , pp. 795-801
    • Nüsslein-Volhard, C.1    Wieschaus, E.2
  • 2
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham PW, Nakano Y, Seger C (2011) Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12(6):393-406.
    • (2011) Nat Rev Genet , vol.12 , Issue.6 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 3
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J, Hui CC (2008) Hedgehog signaling in development and cancer. Dev Cell 15(6):801-812.
    • (2008) Dev Cell , vol.15 , Issue.6 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 4
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP (2001) Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15(23):3059-3087.
    • (2001) Genes Dev , vol.15 , Issue.23 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 5
    • 0028329349 scopus 로고
    • Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
    • Basler K, Struhl G (1994) Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368(6468):208-214.
    • (1994) Nature , vol.368 , Issue.6468 , pp. 208-214
    • Basler, K.1    Struhl, G.2
  • 6
    • 0028178786 scopus 로고
    • Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    • Tabata T, Kornberg TB (1994) Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76(1):89-102.
    • (1994) Cell , vol.76 , Issue.1 , pp. 89-102
    • Tabata, T.1    Kornberg, T.B.2
  • 7
    • 0029967209 scopus 로고    scopus 로고
    • Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing
    • Lecuit T, et al. (1996) Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature 381(6581):387-393.
    • (1996) Nature , vol.381 , Issue.6581 , pp. 387-393
    • Lecuit, T.1
  • 8
    • 0029894568 scopus 로고    scopus 로고
    • Direct and long-range action of a DPP morphogen gradient
    • Nellen D, Burke R, Struhl G, Basler K (1996) Direct and long-range action of a DPP morphogen gradient. Cell 85(3):357-368.
    • (1996) Cell , vol.85 , Issue.3 , pp. 357-368
    • Nellen, D.1    Burke, R.2    Struhl, G.3    Basler, K.4
  • 9
    • 0033582646 scopus 로고    scopus 로고
    • Transducing the Dpp morphogen gradient in the wing of Drosophila: Regulation of Dpp targets by brinker
    • Campbell G, Tomlinson A (1999) Transducing the Dpp morphogen gradient in the wing of Drosophila: Regulation of Dpp targets by brinker. Cell 96(4):553-562.
    • (1999) Cell , vol.96 , Issue.4 , pp. 553-562
    • Campbell, G.1    Tomlinson, A.2
  • 10
    • 33646861115 scopus 로고    scopus 로고
    • Decoding the Hedgehog signal in animal development
    • Jia J, Jiang J (2006) Decoding the Hedgehog signal in animal development. Cell Mol Life Sci 63(11):1249-1265.
    • (2006) Cell Mol Life Sci , vol.63 , Issue.11 , pp. 1249-1265
    • Jia, J.1    Jiang, J.2
  • 12
    • 35549001736 scopus 로고    scopus 로고
    • The PAR proteins: Fundamental players in animal cell polarization
    • Goldstein B, Macara IG (2007) The PAR proteins: Fundamental players in animal cell polarization. Dev Cell 13(5):609-622.
    • (2007) Dev Cell , vol.13 , Issue.5 , pp. 609-622
    • Goldstein, B.1    Macara, I.G.2
  • 13
    • 0025285657 scopus 로고
    • Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • Tepass U, Theres C, Knust E (1990) crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61(5):787-799.
    • (1990) Cell , vol.61 , Issue.5 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 14
    • 1542283794 scopus 로고    scopus 로고
    • CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells
    • Lemmers C, et al. (2004) CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells. Mol Biol Cell 15(3):1324-1333.
    • (2004) Mol Biol Cell , vol.15 , Issue.3 , pp. 1324-1333
    • Lemmers, C.1
  • 15
    • 0029045343 scopus 로고
    • Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
    • Wodarz A, Hinz U, Engelbert M, Knust E (1995) Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82(1):67-76.
    • (1995) Cell , vol.82 , Issue.1 , pp. 67-76
    • Wodarz, A.1    Hinz, U.2    Engelbert, M.3    Knust, E.4
  • 16
    • 0037228253 scopus 로고    scopus 로고
    • Integrated activity of PDZ protein complexes regulates epithelial polarity
    • Bilder D, Schober M, Perrimon N (2003) Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol 5(1):53-58.
    • (2003) Nat Cell Biol , vol.5 , Issue.1 , pp. 53-58
    • Bilder, D.1    Schober, M.2    Perrimon, N.3
  • 17
    • 0037225708 scopus 로고    scopus 로고
    • Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization
    • Tanentzapf G, Tepass U (2003) Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization. Nat Cell Biol 5(1):46-52.
    • (2003) Nat Cell Biol , vol.5 , Issue.1 , pp. 46-52
    • Tanentzapf, G.1    Tepass, U.2
  • 18
    • 73549083198 scopus 로고    scopus 로고
    • Genetic and biochemical definition of the Hedgehog receptor
    • Zheng X, Mann RK, Sever N, Beachy PA (2010) Genetic and biochemical definition of the Hedgehog receptor. Genes Dev 24(1):57-71.
    • (2010) Genes Dev , vol.24 , Issue.1 , pp. 57-71
    • Zheng, X.1    Mann, R.K.2    Sever, N.3    Beachy, P.A.4
  • 19
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • Lum L, Beachy PA (2004) The Hedgehog response network: Sensors, switches, and routers. Science 304(5678):1755-1759.
    • (2004) Science , vol.304 , Issue.5678 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 20
    • 11144248964 scopus 로고    scopus 로고
    • Extensive phosphorylation of Smoothened in Hedgehog pathway activation
    • Zhang C, Williams EH, Guo Y, Lum L, Beachy PA (2004) Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci USA 101(52):17900-17907.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.52 , pp. 17900-17907
    • Zhang, C.1    Williams, E.H.2    Guo, Y.3    Lum, L.4    Beachy, P.A.5
  • 21
    • 12344305145 scopus 로고    scopus 로고
    • Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    • Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A (2005) Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol 7(1):86-92.
    • (2005) Nat Cell Biol , vol.7 , Issue.1 , pp. 86-92
    • Apionishev, S.1    Katanayeva, N.M.2    Marks, S.A.3    Kalderon, D.4    Tomlinson, A.5
  • 22
    • 11144237279 scopus 로고    scopus 로고
    • Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    • Jia J, Tong C, Wang B, Luo L, Jiang J (2004) Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432(7020):1045-1050.
    • (2004) Nature , vol.432 , Issue.7020 , pp. 1045-1050
    • Jia, J.1    Tong, C.2    Wang, B.3    Luo, L.4    Jiang, J.5
  • 23
    • 36049033946 scopus 로고    scopus 로고
    • Hedgehog regulates smoothened activity by inducing a conformational switch
    • Zhao Y, Tong C, Jiang J (2007) Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450(7167):252-258.
    • (2007) Nature , vol.450 , Issue.7167 , pp. 252-258
    • Zhao, Y.1    Tong, C.2    Jiang, J.3
  • 24
    • 78549236202 scopus 로고    scopus 로고
    • Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus
    • Jia H, et al. (2010) Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem 285(48):37218-37226.
    • (2010) J Biol Chem , vol.285 , Issue.48 , pp. 37218-37226
    • Jia, H.1
  • 25
    • 77956805860 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
    • Chen Y, et al. (2010) G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev 24(18):2054-2067.
    • (2010) Genes Dev , vol.24 , Issue.18 , pp. 2054-2067
    • Chen, Y.1
  • 26
    • 84861225973 scopus 로고    scopus 로고
    • Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and positiondependent manner
    • Fan J, Liu Y, Jia J (2012) Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and positiondependent manner. Dev Biol 366(2):172-184.
    • (2012) Dev Biol , vol.366 , Issue.2 , pp. 172-184
    • Fan, J.1    Liu, Y.2    Jia, J.3
  • 27
    • 84885465453 scopus 로고    scopus 로고
    • Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling
    • Yang X, et al. (2013) Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. J Cell Sci 126(Pt 18):4230-4238.
    • (2013) J Cell Sci , vol.126 , pp. 4230-4238
    • Yang, X.1
  • 28
    • 84863012620 scopus 로고    scopus 로고
    • USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization
    • Xia R, Jia H, Fan J, Liu Y, Jia J (2012) USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol 10(1):e1001238.
    • (2012) PLoS Biol , vol.10 , Issue.1 , pp. e1001238
    • Xia, R.1    Jia, H.2    Fan, J.3    Liu, Y.4    Jia, J.5
  • 29
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317(5836):372-376.
    • (2007) Science , vol.317 , Issue.5836 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 30
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
    • Rohatgi R, Milenkovic L, Corcoran RB, Scott MP (2009) Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci USA 106(9):3196-3201.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.9 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3    Scott, M.P.4
  • 31
    • 62449174504 scopus 로고    scopus 로고
    • Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
    • Wang Y, Zhou Z, Walsh CT, McMahon AP (2009) Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci USA 106(8):2623-2628.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.8 , pp. 2623-2628
    • Wang, Y.1    Zhou, Z.2    Walsh, C.T.3    McMahon, A.P.4
  • 32
    • 26644460824 scopus 로고    scopus 로고
    • Vertebrate Smoothened functions at the primary cilium
    • Corbit KC, et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437(7061):1018-1021.
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1018-1021
    • Corbit, K.C.1
  • 33
    • 79959804711 scopus 로고    scopus 로고
    • Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of smoothened
    • Chen Y, et al. (2011) Sonic Hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol 9(6):e1001083.
    • (2011) PLoS Biol , vol.9 , Issue.6 , pp. e1001083
    • Chen, Y.1
  • 34
    • 77953316514 scopus 로고    scopus 로고
    • Mechanism and evolution of cytosolic Hedgehog signal transduction
    • Wilson CW, Chuang PT (2010) Mechanism and evolution of cytosolic Hedgehog signal transduction. Development 137(13):2079-2094.
    • (2010) Development , vol.137 , Issue.13 , pp. 2079-2094
    • Wilson, C.W.1    Chuang, P.T.2
  • 35
    • 41649083427 scopus 로고    scopus 로고
    • Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
    • Tian AG, Deng WM (2008) Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development 135(3):463-471.
    • (2008) Development , vol.135 , Issue.3 , pp. 463-471
    • Tian, A.G.1    Deng, W.M.2
  • 36
    • 0037041470 scopus 로고    scopus 로고
    • Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    • Jia J, et al. (2002) Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature 416(6880):548-552.
    • (2002) Nature , vol.416 , Issue.6880 , pp. 548-552
    • Jia, J.1
  • 37
    • 0037155737 scopus 로고    scopus 로고
    • Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
    • Price MA, Kalderon D (2002) Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 108(6):823-835.
    • (2002) Cell , vol.108 , Issue.6 , pp. 823-835
    • Price, M.A.1    Kalderon, D.2
  • 38
  • 39
    • 0032728958 scopus 로고    scopus 로고
    • Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
    • Wang G, Wang B, Jiang J (1999) Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev 13(21):2828-2837.
    • (1999) Genes Dev , vol.13 , Issue.21 , pp. 2828-2837
    • Wang, G.1    Wang, B.2    Jiang, J.3
  • 40
    • 84874359079 scopus 로고    scopus 로고
    • GLI activation by atypical protein kinase C./. Regulates the growth of basal cell carcinomas
    • Atwood SX, Li M, Lee A, Tang JY, Oro AE (2013) GLI activation by atypical protein kinase C./. regulates the growth of basal cell carcinomas. Nature 494(7438):484-488.
    • (2013) Nature , vol.494 , Issue.7438 , pp. 484-488
    • Atwood, S.X.1    Li, M.2    Lee, A.3    Tang, J.Y.4    Oro, A.E.5
  • 41
    • 0034669178 scopus 로고    scopus 로고
    • Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
    • Wang G, Amanai K, Wang B, Jiang J (2000) Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev 14(22):2893-2905.
    • (2000) Genes Dev , vol.14 , Issue.22 , pp. 2893-2905
    • Wang, G.1    Amanai, K.2    Wang, B.3    Jiang, J.4
  • 42
    • 77951896697 scopus 로고    scopus 로고
    • The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum
    • Ayers KL, Gallet A, Staccini-Lavenant L, Thérond PP (2010) The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum. Dev Cell 18(4):605-620.
    • (2010) Dev Cell , vol.18 , Issue.4 , pp. 605-620
    • Ayers, K.L.1    Gallet, A.2    Staccini-Lavenant, L.3    Thérond, P.P.4
  • 43
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef N, Neubüser D, Perez L, Cohen SM (2000) Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102(4):521-531.
    • (2000) Cell , vol.102 , Issue.4 , pp. 521-531
    • Denef, N.1    Neubüser, D.2    Perez, L.3    Cohen, S.M.4
  • 44
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty G, Petersen C, Gao L, Macara IG (2000) The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2(8):531-539.
    • (2000) Nat Cell Biol , vol.2 , Issue.8 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    Macara, I.G.4
  • 45
    • 0037434790 scopus 로고    scopus 로고
    • Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity
    • Etienne-Manneville S, Hall A (2003) Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421(6924):753-756.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 753-756
    • Etienne-Manneville, S.1    Hall, A.2
  • 46
    • 84862281704 scopus 로고    scopus 로고
    • Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement
    • Graybill C, Wee B, Atwood SX, Prehoda KE (2012) Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement. J Biol Chem 287(25):21003-21011.
    • (2012) J Biol Chem , vol.287 , Issue.25 , pp. 21003-21011
    • Graybill, C.1    Wee, B.2    Atwood, S.X.3    Prehoda, K.E.4
  • 47
    • 62349102527 scopus 로고    scopus 로고
    • PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
    • Jia H, Liu Y, Yan W, Jia J (2009) PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136(2):307-316.
    • (2009) Development , vol.136 , Issue.2 , pp. 307-316
    • Jia, H.1    Liu, Y.2    Yan, W.3    Jia, J.4
  • 48
    • 0242361620 scopus 로고    scopus 로고
    • Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    • Jia J, Tong C, Jiang J (2003) Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 17(21):2709-2720.
    • (2003) Genes Dev , vol.17 , Issue.21 , pp. 2709-2720
    • Jia, J.1    Tong, C.2    Jiang, J.3
  • 49
    • 9444269877 scopus 로고    scopus 로고
    • Requirement for Par-6 and Bazooka in Drosophila border cell migration
    • Pinheiro EM, Montell DJ (2004) Requirement for Par-6 and Bazooka in Drosophila border cell migration. Development 131(21):5243-5251.
    • (2004) Development , vol.131 , Issue.21 , pp. 5243-5251
    • Pinheiro, E.M.1    Montell, D.J.2
  • 50
    • 0030975697 scopus 로고    scopus 로고
    • Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein
    • Von Ohlen T, Lessing D, Nusse R, Hooper JE (1997) Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc Natl Acad Sci USA 94(6):2404-2409.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.6 , pp. 2404-2409
    • Von Ohlen, T.1    Lessing, D.2    Nusse, R.3    Hooper, J.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.