Recent advances in berry supplementation and age-related cognitive decline

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 12, Issue 1, 2009, Pages 91-94

  Willis, Lauren M ^a   Shukitt Hale, Barbara ^a   Joseph, James A ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Aged; Antioxidant; Berry; Cognition; Hippocampus; Oxidative stress; Polyphenol

Indexed keywords

ANTHOCYANIN; ANTIOXIDANT; BLUEBERRY EXTRACT; ELLAGITANNIN; FLAVONOID; POLYPHENOL;

AGING; ANTIOXIDANT ACTIVITY; BERRY; BIOAVAILABILITY; BLUEBERRY; BRAIN FUNCTION; BRAIN NERVE CELL; BRAIN TOXICITY; CENTRAL NERVOUS SYSTEM; CHERRY; COGNITION; COGNITIVE DEFECT; DIET SUPPLEMENTATION; DIETARY INTAKE; FOOD INTAKE; HIPPOCAMPUS; HUMAN; NEUROPROTECTION; NONHUMAN; NOTE; SIGNAL TRANSDUCTION; SPATIAL MEMORY; STRAWBERRY; WORKING MEMORY;

AGING; ANTIOXIDANTS; BRAIN; COGNITION; DIETARY SUPPLEMENTS; FLAVONOIDS; FRAGARIA; FRUIT; HUMANS; NEURONS; PHENOLS; PHYTOTHERAPY; VACCINIUM;

ANIMALIA;

EID: 58149127262     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32831b9c6e     Document Type: Note

References (15)

1. D'Archivio M, Filesi C, Di Benedetto R, et al. Polyphenols, dietary sources and bioavailability. Ann Ist Super Sanita 2007; 43:348-361.
2. Joseph JA, Shukitt-Hale B, Lau FC. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann N Y Acad Sci 2007; 1100:470-485. This review describes the evolution of basic science research on berries, particularly blueberries, in the injured and aged central nervous system.
3. Duffy KB, Spangler EL, Devan BD, et al. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 2008; 29: 1680-1697.
4. Williams CM, El Mohsen MA, Vauzour D, et al. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med 2008; 45:295-305. This study demonstrates that improvements in cognitive behavioral functioning correlate well to alterations in neuronal signaling components in the aged brain following blueberry consumption.
5. Shukitt-Hale B, Carey AN, Jenkins D, et al. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 2007; 28:1187-1194.
6. Shukitt-Hale B, Lau FC, Joseph JA. Berry fruit supplementation and the aging brain. J Agric Food Chem 2008; 56:636-641.
7. Borges G, Roowi S, Rouanet JM, et al. The bioavailability of raspberry anthocyanins and ellagitannins in rats. Mol Nutr Food Res 2007; 51:714-725.
8. Kalt W, Blumberg JB, McDonald JE, et al. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J Agric Food Chem 2008; 56:705-712. This study utilizes an animal model similar to humans to investigate the absorption of polyphenols from blueberry feeding. These data are the first to indicate that blueberry polyphenols can accumulate in the brain following clinically relevant consumption levels.
9. Spencer JP. Flavonoids: modulators of brain function? Br J Nutr 2008; 99 (E Suppl 1):ES60-ES77. This is an excellent review of the cellular targets of a variety of flavonoids in addition to those found in berries. The studies reviewed emphasize the potential of a number of nutritional compounds to influence cell-signaling cascades leading to improved neuronal function.
10. Shukitt-Hale B, Lau FC, Carey AC, et al. Blueberry polyphenols prevent kainic acid-induced decrements in cognition and after inflammatory gene expression in rat hippocampus. Nutr Neurosci 2008; 11:172-182.
11. Lau FC, Bielinski DF, Joseph JA. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res 2007; 85:1010-1017. This is the first study to demonstrate that blueberry extract can directly influence microglial activation.
12. Joseph JA, Carey A, Brewer GJ, et al. Dopamine and abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J Alzheimer's Dis 2007; 11:433-446. This study was the first to demonstrate the ability of an extract of a whole food to directly modulate ion flux and activity of cell survival proteins in hippocampal cells.
13. Van Dyk K, Sano M. The impact of nutrition on cognition in the elderly. Neurochem Res 2007; 32:893-904.
14. Letenneur L, Proust-Lima C, Le Gouge A, et al. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 2007; 165: 1364-1371.
15. Barberger-Gateau P, Raffaitin C, Letenneur L, et al. Dietary patterns and risk of dementia: the Three-City cohort study. Neurology 2007; 69:921-930.