메뉴 건너뛰기




Volumn 11, Issue 4, 2011, Pages 794-804

Conditioned media from cell lines: A complementary model to clinical specimens for the discovery of disease-specific biomarkers

Author keywords

Biomarkers; Biomedicine; Cell culture; Conditioned media; Secretome

Indexed keywords

ADIPONECTIN; ALBUMIN; ALPHA 1 ANTICHYMOTRYPSIN; BIOLOGICAL MARKER; CATHEPSIN D; CD9 ANTIGEN; COMPLEMENT; CXCL16 CHEMOKINE; CYSTATIN C; FOLLISTATIN; GALECTIN 3 BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; GROWTH DIFFERENTIATION FACTOR 15; HAPTOGLOBIN; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN; INTERLEUKIN 1BETA; PENTRAXIN 3; PERIPHERIN; PREALBUMIN; RESISTIN; SECRETOGRANIN II; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIMENTIN;

EID: 79551493048     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201000530     Document Type: Review
Times cited : (122)

References (79)
  • 1
    • 0042827269 scopus 로고    scopus 로고
    • Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics
    • Yamori, T., Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics. Cancer Chemother. Pharmacol. 2003, 52, S74-S79.
    • (2003) Cancer Chemother. Pharmacol. , vol.52
    • Yamori, T.1
  • 2
    • 33846012211 scopus 로고    scopus 로고
    • Proteomic analysis of isolated membrane fractions from superinvasive cancer cells
    • Dowling, P., Meleady, P., Dowd, A., Henry, M. et al., Proteomic analysis of isolated membrane fractions from superinvasive cancer cells. Biochim. Biophys. Acta 2007, 1774, 93-101.
    • (2007) Biochim. Biophys. Acta , vol.1774 , pp. 93-101
    • Dowling, P.1    Meleady, P.2    Dowd, A.3    Henry, M.4
  • 3
    • 53549091303 scopus 로고    scopus 로고
    • The cancer secretome: a reservoir of biomarkers
    • Xue, H., Lu, B., Lai, M., The cancer secretome: a reservoir of biomarkers. J. Transl. Med. 2008, 6, 52.
    • (2008) J. Transl. Med. , vol.6 , pp. 52
    • Xue, H.1    Lu, B.2    Lai, M.3
  • 5
    • 52049100355 scopus 로고    scopus 로고
    • Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment
    • Zhong, L., Roybal, J., Chaerkady, R., Zhang, W. et al., Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment. Cancer Res. 2008, 68, 7237-7245.
    • (2008) Cancer Res. , vol.68 , pp. 7237-7245
    • Zhong, L.1    Roybal, J.2    Chaerkady, R.3    Zhang, W.4
  • 6
    • 22044442559 scopus 로고    scopus 로고
    • Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer
    • Volmer, M. W., Stuhler, K., Zapatka, M., Schoneck, A. et al., Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer. Proteomics 2005, 5, 2587-2601.
    • (2005) Proteomics , vol.5 , pp. 2587-2601
    • Volmer, M.W.1    Stuhler, K.2    Zapatka, M.3    Schoneck, A.4
  • 7
    • 31644434206 scopus 로고    scopus 로고
    • Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach
    • Gronborg, M., Kristiansen, T. Z., Iwahori, A., Chang, R. et al., Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol. Cell. Proteomics 2006, 5, 157-171.
    • (2006) Mol. Cell. Proteomics , vol.5 , pp. 157-171
    • Gronborg, M.1    Kristiansen, T.Z.2    Iwahori, A.3    Chang, R.4
  • 8
    • 79551477069 scopus 로고    scopus 로고
    • Soluble E-cadherin as a serum biomarker candidate: elevated levels in patients with late-stage colorectal carcinoma and FAP
    • Epub ahead of print.
    • Weiss, J. V., Klein-Scory, S., Kubler, S., Reinacher-Schick, A. et al., Soluble E-cadherin as a serum biomarker candidate: elevated levels in patients with late-stage colorectal carcinoma and FAP. Int. J. Cancer. 2010. Epub ahead of print.
    • (2010) Int. J. Cancer.
    • Weiss, J.V.1    Klein-Scory, S.2    Kubler, S.3    Reinacher-Schick, A.4
  • 9
    • 33847274230 scopus 로고    scopus 로고
    • Computational classification of classically secreted proteins
    • Klee, E. W., Sosa, C. P., Computational classification of classically secreted proteins. Drug Discov. Today 2007, 12, 234-240.
    • (2007) Drug Discov. Today , vol.12 , pp. 234-240
    • Klee, E.W.1    Sosa, C.P.2
  • 10
    • 77957329900 scopus 로고    scopus 로고
    • Pathways of unconventional protein secretion
    • Nickel, W., Pathways of unconventional protein secretion. Curr. Opin. Biotechnol. 2010, 5, 621-626.
    • (2010) Curr. Opin. Biotechnol , vol.5 , pp. 621-626
    • Nickel, W.1
  • 11
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • Andre, F., Schartz, N. E., Movassagh, M., Flament, C. et al., Malignant effusions and immunogenic tumour-derived exosomes. Lancet 2002, 360, 295-305.
    • (2002) Lancet , vol.360 , pp. 295-305
    • Andre, F.1    Schartz, N.E.2    Movassagh, M.3    Flament, C.4
  • 12
    • 3042526342 scopus 로고    scopus 로고
    • An investigation into the human serum "interactome"
    • Zhou, M., Lucas, D. A., Chan, K. C., Issaq, H. J. et al., An investigation into the human serum "interactome". Electrophoresis 2004, 25, 1289-1298.
    • (2004) Electrophoresis , vol.25 , pp. 1289-1298
    • Zhou, M.1    Lucas, D.A.2    Chan, K.C.3    Issaq, H.J.4
  • 13
    • 33746681851 scopus 로고    scopus 로고
    • Effects of storage time and exogenous protease inhibitors on plasma protein levels
    • Ayache, S., Panelli, M., Marincola, F. M., Stroncek, D. F., Effects of storage time and exogenous protease inhibitors on plasma protein levels. Am. J. Clin. Pathol. 2006, 126, 174-184.
    • (2006) Am. J. Clin. Pathol. , vol.126 , pp. 174-184
    • Ayache, S.1    Panelli, M.2    Marincola, F.M.3    Stroncek, D.F.4
  • 14
    • 70349974679 scopus 로고    scopus 로고
    • Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer
    • Gunawardana, C. G., Kuk, C., Smith, C. R., Batruch, I. et al., Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer. J. Proteome Res. 2009, 8, 4705-4713.
    • (2009) J. Proteome Res. , vol.8 , pp. 4705-4713
    • Gunawardana, C.G.1    Kuk, C.2    Smith, C.R.3    Batruch, I.4
  • 15
    • 51649116693 scopus 로고    scopus 로고
    • Tissue culture-based breast cancer biomarker discovery platform
    • Kulasingam, V., Diamandis, E. P., Tissue culture-based breast cancer biomarker discovery platform. Int. J. Cancer 2008, 123, 2007-2012.
    • (2008) Int. J. Cancer , vol.123 , pp. 2007-2012
    • Kulasingam, V.1    Diamandis, E.P.2
  • 16
    • 1642535545 scopus 로고    scopus 로고
    • Quantitative proteomic analysis of proteins released by neoplastic prostate epithelium
    • Martin, D. B, Gifford, D. R, Wright, M. E., Keller, A. et al., Quantitative proteomic analysis of proteins released by neoplastic prostate epithelium. Cancer Res. 2004, 64, 347-355.
    • (2004) Cancer Res. , vol.64 , pp. 347-355
    • Martin, D.B.1    Gifford, D.R.2    Wright, M.E.3    Keller, A.4
  • 17
    • 66849115115 scopus 로고    scopus 로고
    • Advanced proteomic technologies for cancer biomarker discovery
    • Wong, S. C., Chan, C. M., Ma, B. B., Lam, M. Y. et al., Advanced proteomic technologies for cancer biomarker discovery. Expert Rev. Proteomics 2009, 6, 123-134.
    • (2009) Expert Rev. Proteomics , vol.6 , pp. 123-134
    • Wong, S.C.1    Chan, C.M.2    Ma, B.B.3    Lam, M.Y.4
  • 18
    • 33750137036 scopus 로고    scopus 로고
    • Improved mass spectrometric proteomic profiling of the secretome of rat vascular endothelial cells
    • Pellitteri-Hahn, M. C., Warren, M. C., Didier, D. N., Winkler, E. L. et al., Improved mass spectrometric proteomic profiling of the secretome of rat vascular endothelial cells. J. Proteome Res. 2006, 5, 2861-2864.
    • (2006) J. Proteome Res. , vol.5 , pp. 2861-2864
    • Pellitteri-Hahn, M.C.1    Warren, M.C.2    Didier, D.N.3    Winkler, E.L.4
  • 20
    • 54049084146 scopus 로고    scopus 로고
    • Secretome of HepG2 cells infected with dengue virus: implications for pathogenesis
    • Higa, L. M., Caruso, M. B., Canellas, F., Soares, M. R. et al., Secretome of HepG2 cells infected with dengue virus: implications for pathogenesis. Biochim. Biophys. Acta 2008, 1784, 1607-1616.
    • (2008) Biochim. Biophys. Acta , vol.1784 , pp. 1607-1616
    • Higa, L.M.1    Caruso, M.B.2    Canellas, F.3    Soares, M.R.4
  • 21
    • 33645753484 scopus 로고    scopus 로고
    • Secretory protein enrichment and analysis: an optimized approach applied on cancer cell lines using 2-D LC-MS/MS
    • Mbeunkui, F., Fodstad, O., Pannell, L. K., Secretory protein enrichment and analysis: an optimized approach applied on cancer cell lines using 2-D LC-MS/MS. J. Proteome Res. 2006, 5, 899-906.
    • (2006) J. Proteome Res. , vol.5 , pp. 899-906
    • Mbeunkui, F.1    Fodstad, O.2    Pannell, L.K.3
  • 22
    • 53549101776 scopus 로고    scopus 로고
    • Secretome-based identification of Mac-2 binding protein as a potential oral cancer marker involved in cell growth and motility
    • Weng, L. P., Wu, C. C., Hsu, B. L., Chi, L. M. et al., Secretome-based identification of Mac-2 binding protein as a potential oral cancer marker involved in cell growth and motility. J. Proteome Res. 2008, 7, 3765-3775.
    • (2008) J. Proteome Res. , vol.7 , pp. 3765-3775
    • Weng, L.P.1    Wu, C.C.2    Hsu, B.L.3    Chi, L.M.4
  • 23
    • 23144465869 scopus 로고    scopus 로고
    • A novel technique to specifically analyze the secretome of cells and tissues
    • Zwickl, H., Traxler, E., Staettner, S., Parzefall, W. et al., A novel technique to specifically analyze the secretome of cells and tissues. Electrophoresis 2005, 26, 2779-2785.
    • (2005) Electrophoresis , vol.26 , pp. 2779-2785
    • Zwickl, H.1    Traxler, E.2    Staettner, S.3    Parzefall, W.4
  • 24
    • 67049158002 scopus 로고    scopus 로고
    • Cytoplasmic proteome and secretome profiles of differently stimulated human dendritic cells
    • Gundacker, N. C., Haudek, V. J., Wimmer, H., Slany, A. et al., Cytoplasmic proteome and secretome profiles of differently stimulated human dendritic cells. J Proteome Res. 2009, 8, 2799-2811.
    • (2009) J Proteome Res. , vol.8 , pp. 2799-2811
    • Gundacker, N.C.1    Haudek, V.J.2    Wimmer, H.3    Slany, A.4
  • 25
    • 70349974392 scopus 로고    scopus 로고
    • Metabolic labeling and protein linearization technology allow the study of proteins secreted by cultured cells in serum-containing media
    • Colzani, M., Waridel, P., Laurent, J., Faes, E. et al., Metabolic labeling and protein linearization technology allow the study of proteins secreted by cultured cells in serum-containing media. J. Proteome Res. 2009, 8, 4779-4788.
    • (2009) J. Proteome Res. , vol.8 , pp. 4779-4788
    • Colzani, M.1    Waridel, P.2    Laurent, J.3    Faes, E.4
  • 26
    • 0345550275 scopus 로고    scopus 로고
    • Comparison of protein precipitation methods for sample preparation prior to proteomic analysis
    • Jiang, L., He, L., Fountoulakis, M., Comparison of protein precipitation methods for sample preparation prior to proteomic analysis. J. Chromatogr. A 2004, 1023, 317-320.
    • (2004) J. Chromatogr. A , vol.1023 , pp. 317-320
    • Jiang, L.1    He, L.2    Fountoulakis, M.3
  • 27
    • 77953146041 scopus 로고    scopus 로고
    • Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: potential usage of cystatin A for predicting nodal stage and poor prognosis
    • Chang, K. P., Wu, C. C., Chen, H. C., Chen, S. J. et al., Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: potential usage of cystatin A for predicting nodal stage and poor prognosis. Proteomics 2010, 10, 2644-2660.
    • (2010) Proteomics , vol.10 , pp. 2644-2660
    • Chang, K.P.1    Wu, C.C.2    Chen, H.C.3    Chen, S.J.4
  • 28
    • 73649144226 scopus 로고    scopus 로고
    • Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B
    • Slany, A., Haudek, V. J., Zwickl, H., Gundacker, N. C. et al., Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B. J. Proteome Res. 2010, 9, 6-21.
    • (2010) J. Proteome Res , vol.9 , pp. 6-21
    • Slany, A.1    Haudek, V.J.2    Zwickl, H.3    Gundacker, N.C.4
  • 29
    • 67049172121 scopus 로고    scopus 로고
    • Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition
    • Mathias, R. A., Wang, B., Ji, H., Kapp, E. A. et al., Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition. J. Proteome Res. 2009, 8, 2827-2837.
    • (2009) J. Proteome Res. , vol.8 , pp. 2827-2837
    • Mathias, R.A.1    Wang, B.2    Ji, H.3    Kapp, E.A.4
  • 30
    • 33746022383 scopus 로고    scopus 로고
    • Proteomic analysis of factors released from p21-overexpressing tumour cells
    • Currid, C. A., O'Connor, D. P., Chang, B. D., Gebus, C. et al., Proteomic analysis of factors released from p21-overexpressing tumour cells. Proteomics 2006, 6, 3739-3753.
    • (2006) Proteomics , vol.6 , pp. 3739-3753
    • Currid, C.A.1    O'Connor, D.P.2    Chang, B.D.3    Gebus, C.4
  • 31
    • 77956131975 scopus 로고    scopus 로고
    • The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response
    • Baggetta, R., De Andrea, M., Gariano, G. R., Mondini, M. et al., The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response. Eur. J. Immunol. 2010, 40, 2182-2189.
    • (2010) Eur. J. Immunol , vol.40 , pp. 2182-2189
    • Baggetta, R.1    De Andrea, M.2    Gariano, G.R.3    Mondini, M.4
  • 32
    • 70349972378 scopus 로고    scopus 로고
    • The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells
    • Chenau, J., Michelland, S., de Fraipont, F., Josserand, V. et al., The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells. J. Proteome Res. 2009, 8, 4579-4591.
    • (2009) J. Proteome Res. , vol.8 , pp. 4579-4591
    • Chenau, J.1    Michelland, S.2    de Fraipont, F.3    Josserand, V.4
  • 33
    • 21744435256 scopus 로고    scopus 로고
    • Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers
    • Mauri, P., Scarpa, A., Nascimbeni, A. C., Benazzi, L. et al., Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers. FASEB J. 2005, 19, 1125-1127.
    • (2005) FASEB J. , vol.19 , pp. 1125-1127
    • Mauri, P.1    Scarpa, A.2    Nascimbeni, A.C.3    Benazzi, L.4
  • 34
    • 78049240516 scopus 로고    scopus 로고
    • SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome
    • Kashyap, M. K., Harsha, H. C., Renuse, S., Pawar, H. et al., SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome. Cancer Biol. Ther. 2010, 8, 796-810.
    • (2010) Cancer Biol. Ther. , vol.8 , pp. 796-810
    • Kashyap, M.K.1    Harsha, H.C.2    Renuse, S.3    Pawar, H.4
  • 35
    • 77954746901 scopus 로고    scopus 로고
    • Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts
    • Xu, B. J., Yan, W., Jovanovic, B., An, A. Q. et al., Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts. Proteomics 2010 10 2458-2470.
    • (2010) Proteomics , vol.10 , pp. 2458-2470
    • Xu, B.J.1    Yan, W.2    Jovanovic, B.3    An, A.Q.4
  • 36
    • 58149295188 scopus 로고    scopus 로고
    • Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome
    • Gao, B. B., Stuart, L., Feener, E. P., Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome. Mol. Cell. Proteomics 2008, 7, 2399-2409.
    • (2008) Mol. Cell. Proteomics , vol.7 , pp. 2399-2409
    • Gao, B.B.1    Stuart, L.2    Feener, E.P.3
  • 37
    • 77956333493 scopus 로고    scopus 로고
    • Secretome analysis of multiple pancreatic cancer cell lines reveals perturbations of key functional networks
    • Schiarea, S., Solinas, G., Allavena, P., Scigliuolo, G. M. et al., Secretome analysis of multiple pancreatic cancer cell lines reveals perturbations of key functional networks. J. Proteome Res. 2010, 9, 4376-4392.
    • (2010) J. Proteome Res , vol.9 , pp. 4376-4392
    • Schiarea, S.1    Solinas, G.2    Allavena, P.3    Scigliuolo, G.M.4
  • 38
    • 33748269365 scopus 로고    scopus 로고
    • Quantification of immunohistochemistry - issues concerning methods, utility and semiquantitative assessment II
    • Taylor, C. R., Levenson, R. M., Quantification of immunohistochemistry - issues concerning methods, utility and semiquantitative assessment II. Histopathology 2006, 49, 411-424.
    • (2006) Histopathology , vol.49 , pp. 411-424
    • Taylor, C.R.1    Levenson, R.M.2
  • 39
    • 77952851155 scopus 로고    scopus 로고
    • Targeted label-free quantitative analysis of secretory proteins from adipocytes in response to oxidative stress
    • Choi, S., Kim, J., Yea, K., Suh, P. G. et al., Targeted label-free quantitative analysis of secretory proteins from adipocytes in response to oxidative stress. Anal. Biochem. 2010, 401, 196-202.
    • (2010) Anal. Biochem , vol.401 , pp. 196-202
    • Choi, S.1    Kim, J.2    Yea, K.3    Suh, P.G.4
  • 40
    • 76649109590 scopus 로고    scopus 로고
    • An automated and multiplexed method for high throughput peptide immunoaffinity enrichment and multiple reaction monitoring mass spectrometry-based quantification of protein biomarkers
    • Whiteaker, J. R., Zhao, L., Anderson, L., Paulovich, A. G., An automated and multiplexed method for high throughput peptide immunoaffinity enrichment and multiple reaction monitoring mass spectrometry-based quantification of protein biomarkers. Mol. Cell. Proteomics 2010, 9, 184-196.
    • (2010) Mol. Cell. Proteomics , vol.9 , pp. 184-196
    • Whiteaker, J.R.1    Zhao, L.2    Anderson, L.3    Paulovich, A.G.4
  • 41
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • Zimmet, P., Alberti, K. G., Shaw, J., Global and societal implications of the diabetes epidemic. Nature 2001, 414, 782-787.
    • (2001) Nature , vol.414 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.2    Shaw, J.3
  • 42
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: principles of pathogenesis and therapy
    • Stumvoll, M., Goldstein, B. J., van Haeften, T. W., Type 2 diabetes: principles of pathogenesis and therapy. Lancet 2005, 365, 1333-1346.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 43
    • 33750041947 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance and associated diseases
    • Mlinar, B., Marc, J., Janez, A., Pfeifer, M., Molecular mechanisms of insulin resistance and associated diseases. Clin. Chim. Acta 2007, 375, 20-35.
    • (2007) Clin. Chim. Acta , vol.375 , pp. 20-35
    • Mlinar, B.1    Marc, J.2    Janez, A.3    Pfeifer, M.4
  • 44
    • 77954675163 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus in children and adolescents
    • Mohamadi, A., Cooke, D. W., Type 2 diabetes mellitus in children and adolescents. Adolesc. Med. State Art Rev. 2010, 21, 103-119.
    • (2010) Adolesc. Med. State Art Rev. , vol.21 , pp. 103-119
    • Mohamadi, A.1    Cooke, D.W.2
  • 45
    • 77957719015 scopus 로고    scopus 로고
    • Reducing visceral adipose tissue mass is essential for improving endothelial function in type 2 diabetes prone individuals
    • Rittig, K., Hieronimus, A., Thamer, C., Machann, J. et al., Reducing visceral adipose tissue mass is essential for improving endothelial function in type 2 diabetes prone individuals. Atherosclerosis. 2010, 2, 575-579.
    • (2010) Atherosclerosis , vol.2 , pp. 575-579
    • Rittig, K.1    Hieronimus, A.2    Thamer, C.3    Machann, J.4
  • 46
    • 58149142991 scopus 로고    scopus 로고
    • Robust signaling networks of the adipose secretome
    • Breitling, R., Robust signaling networks of the adipose secretome. Trends Endocrinol. Metab. 2009, 20, 1-7.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 1-7
    • Breitling, R.1
  • 47
    • 33846515929 scopus 로고    scopus 로고
    • Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis
    • Zvonic, S., Lefevre, M., Kilroy, G., Floyd, Z. E. et al., Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis. Mol. Cell. Proteomics 2007, 6, 18-28.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 18-28
    • Zvonic, S.1    Lefevre, M.2    Kilroy, G.3    Floyd, Z.E.4
  • 48
    • 70449674747 scopus 로고    scopus 로고
    • Quantitative analysis of secretome from adipocytes regulated by insulin
    • Zhou, H., Xiao, Y., Li, R., Hong, S. et al., Quantitative analysis of secretome from adipocytes regulated by insulin. Acta Biochim. Biophys. Sin. (Shanghai) 2009, 41, 910-921.
    • (2009) Acta Biochim. Biophys. Sin. (Shanghai) , vol.41 , pp. 910-921
    • Zhou, H.1    Xiao, Y.2    Li, R.3    Hong, S.4
  • 49
    • 56849124888 scopus 로고    scopus 로고
    • Proteomic analysis of conditioned media from glucose responsive and glucose non-responsive phenotypes reveals a panel of secreted proteins associated with beta cell dysfunction
    • Dowling, P., Shields, W., Rani, S., Meleady, P. et al., Proteomic analysis of conditioned media from glucose responsive and glucose non-responsive phenotypes reveals a panel of secreted proteins associated with beta cell dysfunction. Electrophoresis 2008, 29, 4141-4149.
    • (2008) Electrophoresis , vol.29 , pp. 4141-4149
    • Dowling, P.1    Shields, W.2    Rani, S.3    Meleady, P.4
  • 50
    • 70349142602 scopus 로고    scopus 로고
    • Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium
    • Song, G., Cui, Y., Zhong, N., Han, J., Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium. J. Clin. Pathol. 2009, 62, 802-807.
    • (2009) J. Clin. Pathol. , vol.62 , pp. 802-807
    • Song, G.1    Cui, Y.2    Zhong, N.3    Han, J.4
  • 53
    • 37649019177 scopus 로고    scopus 로고
    • Panel of serum biomarkers for the diagnosis of lung cancer
    • Patz, E. F., Jr., Campa, M. J., Gottlin, E. B., Kusmartseva, I. et al., Panel of serum biomarkers for the diagnosis of lung cancer. J. Clin. Oncol. 2007, 25, 5578-5583.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 5578-5583
    • Patz Jr, E.F.1    Campa, M.J.2    Gottlin, E.B.3    Kusmartseva, I.4
  • 54
    • 76649105782 scopus 로고    scopus 로고
    • A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis
    • Matsumoto, T., Kawashima, Y., Nagashio, R., Kageyama, T. et al., A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis. Int. J. Biol. Markers 2009, 24, 282-285.
    • (2009) Int. J. Biol. Markers , vol.24 , pp. 282-285
    • Matsumoto, T.1    Kawashima, Y.2    Nagashio, R.3    Kageyama, T.4
  • 56
    • 71549131311 scopus 로고    scopus 로고
    • Cell secretome analysis using hollow fiber culture system leads to the discovery of CLIC1 protein as a novel plasma marker for nasopharyngeal carcinoma
    • Chang, Y. H., Wu, C. C., Chang, K. P., Yu, J. S. et al., Cell secretome analysis using hollow fiber culture system leads to the discovery of CLIC1 protein as a novel plasma marker for nasopharyngeal carcinoma. J. Proteome Res. 2009, 8, 5465-5474.
    • (2009) J. Proteome Res. , vol.8 , pp. 5465-5474
    • Chang, Y.H.1    Wu, C.C.2    Chang, K.P.3    Yu, J.S.4
  • 57
    • 70349972788 scopus 로고    scopus 로고
    • Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome
    • Wang, C. L., Wang, C. I., Liao, P. C., Chen, C. D. et al., Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome. J. Proteome Res. 2009, 8, 4428-4440.
    • (2009) J. Proteome Res. , vol.8 , pp. 4428-4440
    • Wang, C.L.1    Wang, C.I.2    Liao, P.C.3    Chen, C.D.4
  • 58
    • 34548182124 scopus 로고    scopus 로고
    • Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer
    • Mbeunkui, F., Metge, B. J., Shevde, L. A., Pannell, L. K., Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer. J. Proteome Res. 2007, 6, 2993-3002.
    • (2007) J. Proteome Res. , vol.6 , pp. 2993-3002
    • Mbeunkui, F.1    Metge, B.J.2    Shevde, L.A.3    Pannell, L.K.4
  • 59
    • 73649116726 scopus 로고    scopus 로고
    • Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach
    • Xue, H., Lu, B., Zhang, J., Wu, M. et al., Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach. J. Proteome Res. 2010, 9, 545-555.
    • (2010) J. Proteome Res , vol.9 , pp. 545-555
    • Xue, H.1    Lu, B.2    Zhang, J.3    Wu, M.4
  • 60
    • 53049099609 scopus 로고    scopus 로고
    • Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers
    • Sardana, G., Jung, K., Stephan, C., Diamandis, E. P., Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers. J. Proteome Res. 2008, 7, 3329-3338.
    • (2008) J. Proteome Res. , vol.7 , pp. 3329-3338
    • Sardana, G.1    Jung, K.2    Stephan, C.3    Diamandis, E.P.4
  • 61
    • 36749068866 scopus 로고    scopus 로고
    • Proteomics analysis of conditioned media from three breast cancer cell lines: a mine for biomarkers and therapeutic targets
    • Kulasingam, V., Diamandis, E. P., Proteomics analysis of conditioned media from three breast cancer cell lines: a mine for biomarkers and therapeutic targets. Mol. Cell. Proteomics 2007, 6, 1997-2011.
    • (2007) Mol. Cell. Proteomics , vol.6 , pp. 1997-2011
    • Kulasingam, V.1    Diamandis, E.P.2
  • 62
    • 77956301589 scopus 로고    scopus 로고
    • Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies
    • Lahat, G., Zhu, Q. S., Huang, K. L., Wang, S. et al., Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One 2010, 5, e10105.
    • (2010) PLoS One , vol.5
    • Lahat, G.1    Zhu, Q.S.2    Huang, K.L.3    Wang, S.4
  • 63
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: prevalence estimates using the 2000 census
    • Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., Evans, D. A., Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol. 2003, 60, 1119-1122.
    • (2003) Arch. Neurol. , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 64
    • 0344896762 scopus 로고    scopus 로고
    • Number of dementia sufferers in Europe between the years 2000 and 2050
    • Wancata, J., Musalek, M., Alexandrowicz, R., Krautgartner, M., Number of dementia sufferers in Europe between the years 2000 and 2050. Eur. Psychiatry 2003, 18, 306-313.
    • (2003) Eur. Psychiatry , vol.18 , pp. 306-313
    • Wancata, J.1    Musalek, M.2    Alexandrowicz, R.3    Krautgartner, M.4
  • 65
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • Liu, B., Hong, J. S., Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 2003, 304, 1-7.
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 66
    • 77957970155 scopus 로고    scopus 로고
    • Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease
    • Agostinho, P., Cunha, R. A., Oliveira, C., Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr. Pharm. Des. 2010, 25, 2766-2778.
    • (2010) Curr. Pharm. Des. , vol.25 , pp. 2766-2778
    • Agostinho, P.1    Cunha, R.A.2    Oliveira, C.3
  • 67
    • 75949087271 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
    • Tansey, M. G., Goldberg, M. S., Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol. Dis. 2010, 37, 510-518.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 510-518
    • Tansey, M.G.1    Goldberg, M.S.2
  • 68
    • 77950847889 scopus 로고    scopus 로고
    • Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers
    • Suk, K., Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers. Expert Rev. Proteomics 2010, 7, 263-274.
    • (2010) Expert Rev. Proteomics , vol.7 , pp. 263-274
    • Suk, K.1
  • 69
    • 44249099757 scopus 로고    scopus 로고
    • Neurotoxicity of microglial cathepsin D revealed by secretome analysis
    • Kim, S., Ock, J., Kim, A. K., Lee, H. W. et al., Neurotoxicity of microglial cathepsin D revealed by secretome analysis. J. Neurochem. 2007, 103, 2640-2650.
    • (2007) J. Neurochem. , vol.103 , pp. 2640-2650
    • Kim, S.1    Ock, J.2    Kim, A.K.3    Lee, H.W.4
  • 70
    • 78650304703 scopus 로고    scopus 로고
    • Analysis of glial secretome: the long pentraxin PTX3 modulates phagocytic activity of microglia
    • Jeon, H., Lee, S., Lee, W. H., Suk, K., Analysis of glial secretome: the long pentraxin PTX3 modulates phagocytic activity of microglia. J. Neuroimmunol. 2010, 1-2, 63-72.
    • (2010) J. Neuroimmunol , vol.1-2 , pp. 63-72
    • Jeon, H.1    Lee, S.2    Lee, W.H.3    Suk, K.4
  • 71
    • 73949112661 scopus 로고    scopus 로고
    • Ischemia-activated microglia induces neuronal injury via activation of gp91phox NADPH oxidase
    • Hur, J., Lee, P., Kim, M. J., Kim, Y., Cho, Y. W., Ischemia-activated microglia induces neuronal injury via activation of gp91phox NADPH oxidase. Biochem. Biophys. Res. Commun. 2010, 391, 1526-1530.
    • (2010) Biochem. Biophys. Res. Commun , vol.391 , pp. 1526-1530
    • Hur, J.1    Lee, P.2    Kim, M.J.3    Kim, Y.4    Cho, Y.W.5
  • 72
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: causes and consequences
    • Marusyk, A., Polyak, K., Tumor heterogeneity: causes and consequences. Biochim. Biophys. Acta 2010, 1805, 105-117.
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 73
    • 79551488768 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells
    • Epub ahead of print.
    • Ween, M. P., Lokman, N. A., Hoffmann, P., Rodgers, R. J. et al., Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells. Int. J. Cancer. 2010, Epub ahead of print.
    • (2010) Int. J. Cancer.
    • Ween, M.P.1    Lokman, N.A.2    Hoffmann, P.3    Rodgers, R.J.4
  • 74
    • 60849139466 scopus 로고    scopus 로고
    • Proteomics analysis of nasopharyngeal carcinoma cell secretome using a hollow fiber culture system and mass spectrometry
    • Wu, H. Y., Chang, Y. H., Chang, Y. C., Liao, P. C., Proteomics analysis of nasopharyngeal carcinoma cell secretome using a hollow fiber culture system and mass spectrometry. J. Proteome Res. 2009, 8, 380-389.
    • (2009) J. Proteome Res. , vol.8 , pp. 380-389
    • Wu, H.Y.1    Chang, Y.H.2    Chang, Y.C.3    Liao, P.C.4
  • 75
    • 0032109045 scopus 로고    scopus 로고
    • Hollow fibre bioreactors: an alternative to murine ascites for small scale (<1 gram) monoclonal antibody production
    • Lipman, N. S., Jackson, L. R., Hollow fibre bioreactors: an alternative to murine ascites for small scale (<1 gram) monoclonal antibody production. Res. Immunol. 1998, 149, 571-576.
    • (1998) Res. Immunol. , vol.149 , pp. 571-576
    • Lipman, N.S.1    Jackson, L.R.2
  • 76
    • 33751095666 scopus 로고    scopus 로고
    • Identity tests: determination of cell line cross-contamination
    • Cabrera, C. M., Cobo, F., Nieto, A., Cortes, J. L. et al., Identity tests: determination of cell line cross-contamination. Cytotechnology 2006, 51, 45-50.
    • (2006) Cytotechnology , vol.51 , pp. 45-50
    • Cabrera, C.M.1    Cobo, F.2    Nieto, A.3    Cortes, J.L.4
  • 77
    • 12344255887 scopus 로고    scopus 로고
    • Cell line cross-contamination: how aware are Mammalian cell culturists of the problem and how to monitor it?
    • Buehring, G. C., Eby, E. A., Eby, M. J., Cell line cross-contamination: how aware are Mammalian cell culturists of the problem and how to monitor it? In Vitro Cell. Dev. Biol. Anim. 2004, 40, 211-215.
    • (2004) In Vitro Cell. Dev. Biol. Anim. , vol.40 , pp. 211-215
    • Buehring, G.C.1    Eby, E.A.2    Eby, M.J.3
  • 79
    • 70549086957 scopus 로고    scopus 로고
    • Urgent need to develop independent biomarkers for functional, diagnostic and prognostic application in oncology research
    • Foster, C. S., Cooper, C. S., Urgent need to develop independent biomarkers for functional, diagnostic and prognostic application in oncology research. Biomarkers Med. 2009, 3, 329-333.
    • (2009) Biomarkers Med. , vol.3 , pp. 329-333
    • Foster, C.S.1    Cooper, C.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.