Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation

Neuroscience

Volumn 185, Issue , 2011, Pages 150-160

  Wang, S ^a   Wang, H ^a   Guo, H ^a   Kang, L ^a   Gao, X ^a   Hu, L ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Inflammation; Microglia; Neuroprotection; Scutellarin

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SCUTELLARIN; STAT1 ALPHA PROTEIN; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; DNA BINDING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MICROGLIA; MOLECULAR MECHANICS; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; APIGENIN; BRAIN; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCURONIC ACIDS; HUMANS; INTERFERON-STIMULATED GENE FACTOR 3; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NERVE TISSUE PROTEINS; NEURAL INHIBITION; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 79956260639     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.04.005     Document Type: Article

References (49)

1. Block M.L., Hong J.S. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 2005, 76(2):77-98.
2. D'Acquisto F., May M.J., Ghosh S. Inhibition of nuclear factor kappa B (NF-κB): an emerging theme in anti-inflammatory therapies. Mol Interv 2002, 2(1):22-35.
3. D'Alimonte I., Flati V., D'Auro M., Toniato E., Martinotti S., Rathbone M.P., Jiang S., Ballerini P., Di Iorio P., Caciagli F., Ciccarelli R. Guanosine inhibits CD40 receptor expression and function induced by cytokines and b amyloid in mouse microglia cells. J Immunol 2007, 178:720-731.
4. D'Mello C., Le T., Swain M.G. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factor α signaling during peripheral organ inflammation. J Neurosci 2009, 29:2089-2102.
5. Du Y., Ma Z., Lin S., Dodel R.C., Gao F., Bales K.R., Triarhou L.C., Chernet E., Perry K.W., Nelson D.L.G., Luecke S., Phebus L.A., Bymaster F.P., Paul S.M. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A 2001, 98(25):14669-14674.
6. Fan R., Xu F., Previti M.L., Davis J., Grande A.M., Robinson J.K., Nostrand W.E. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. J Neurosci 2007, 27(12):3057-3063.
7. Hayakawa K., Mishima K., Nozako M., Hazekawa M., Mishima S., Fujioka M., Orito K., Egashira N., Iwasaki K., Fujiwara M. Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group Box1-inhibiting mechanism. Stroke 2008, 39:951-958.
8. Hong H., Liu G.Q. Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life Sci 2004, 74(24):2959-2973.
9. Hong H., Liu G.Q. Scutellarin attenuates oxidative glutamate toxicity in PC12 cells. Planta Med 2004, 70(5):427-431.
10. Jana M., Jana A., Liu X., Ghosh S., Pahan K. Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of IκBα in anti-inflammatory effect of gemfibrozil in microglia. J Immunol 2007, 179:4142-4152.
11. Jang S., Kelley K.W., Johnson R.W. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A 2008, 105(21):7534-7539.
12. Jiang B., Brecher P., Cohen R.A. Persistent activation of nuclear factor-κB by interleukin-1β and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase. Arterioscler Thromb Vasc Biol 2001, 21:1915-1920.
13. Jin R., Yang G., Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010, 87:779-789.
14. Kaushal V., Schlichter L.C. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 2008, 28:2221-2230.
15. Kim H.J., Rowe M., Ren M., Hong J.S., Chen P.S., Chuang D.M. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J Pharmacol Exp Ther 2007, 321:892-901.
16. Koduru S., Sowmyalakshmi S., Kumar R., Gomathinayagam R., Rohr J., Damodaran C. Identification of a potent herbal molecule for the treatment of breast cancer. BMC Cancer 2009, 9:41-51.
17. Liu B., Du L., Hong J.S. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther 2000, 293:607-617.
18. Liu H., Yang X., Tang R., Liu J., Xu H. Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide. Pharmacol Res 2005, 51(3):205-210.
19. Liu Y., Qin L., Li G., Zhang W., An L., Liu B., Hong J.S. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther 2003, 305:212-218.
20. Luo P., Zhang Z., Yi T., Zhang H., Liu X., Mo Z. Anti-inflammatory activity of the extracts and fractions from Erigeron multiradiatus through bioassay-guided procedures. J Ethnopharmacol 2008, 119(2):232-237.
21. Luo P., Tan Z.H., Zhang Z.F., Zhang H., Liu X.F., Mo Z.J. Scutellarin isolated from Erigeron multiradiatus inhibits high glucose-mediated vascular inflammation. Yakugaku Zasshi 2008, 128(9):1293-1299.
22. Lv W., Guo J., Li J., Huang L., Ping Q. Distribution of liposomal breviscapine in brain following intravenous injection in rats. Int JPharm 2005, 306:99-106.
23. Ma J.Y., Jiang W.W., Zhou Z.T., Li J.M., Wang H.Y. The promoting angiogenesis and anti-inflammation effect of scutellarin on polyglycolic acid scaffold of balb/c mice model. J Asian Nat Prod Res 2008, 10(11-12):1147-1153.
24. Majumdar A., Cruz D., Asamoah N., Buxbaum A., Sohar I., Lobel P., Maxfield F.R. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Mol Biol Cell 2007, 18:1490-1496.
25. Mohamed R.M., McFadden G. NF-κB inhibitors: strategies from poxviruses. Cell Cycle 2009, 8(19):3125-3132.
26. Neumann H., Kotter M.R., Franklin R.J.M. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 2009, 132:288-295.
27. Neumann J., Sauerzweig S., Rönicke R., Gunzer F., Dinkel K., Ullrich O., Gunzer M., Reymann K.G. Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J Neurosci 2008, 28(23):5965-5975.
28. Novarino G., Fabrizi C., Tonini R., Denti M.A., Malchiodi-Albedi F., Lauro G.M., Sacchetti B., Paradisi S., Ferroni A., Curmi P.M., Breit S.N., Mazzanti M. Involvement of the intracellular ion channel CLIC1 in microglia-mediated β-amyloid-induced neurotoxicity. J Neurosci 2004, 24:5322-5330.
29. Pan X.D., Chen X.C., Zhu Y.G., Zhang J., Huang T.W., Chen L.M., Ye Q.Y., Huang H.P. Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia. Biochem Pharmacol 2008, 76(3):362-372.
30. Park J.S., Woo M.S., Kim D.H., Hyun J.W., Kim W.K., Lee J.C., Kim H.S. Anti-inflammatory mechanisms of isoflavone metabolites in lipopolysaccharide-stimulated microglial cells. J Pharmacol Exp Ther 2007, 320:1237-1245.
31. Plane J.M., Shen Y., Pleasure D.E., Deng W. Prospects for minocycline neuroprotection. Arch Neurol 2010, doi:10.1001/archneurol.2010.191PubMed].
32. Qin L., Liu Y., Wang T., Wei S.J., Block M.L., Wilson B., Liu B., Hong J.S. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 2004, 279:1415-1421.
33. Ranaivo H.R., Craft J.M., Hu W., Guo L., Wing L.K., Eldik L.J.V., Watterson D.M. Glia as a therapeutic target: selective suppression of human amyloid-β-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J Neurosci 2006, 26(2):662-670.
34. Repici M., Borsello T. JNK pathway as therapeutic target to prevent degeneration in thecentral nervous system. Adv Exp Med Biol 2006, 588:145-155.
35. Rock R.B., Gekker G., Hu S., Sheng W.S., Cheeran M., Lokensgard J.R., Peterson P.K. Role of microglia in central nervous system infections. Clin Microbiol Rev 2004, 17:942-964.
36. Shi S., Wu J., Dai W., Li C., Ge W. Evaluation of brain-targeted trendence of scutellarin nasal administration. Zhongguo Zhong Yao Za Zhi 2010, 35(18):2453-2456.
37. Suzuki T., Hide I., Ido K., Kohsaka S., Inoue K., Nakata Y. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J Neurosci 2004, 24(1):1-7.
38. Tambuyzer B.R., Ponsaerts P., Nouwen E.J. Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 2009, 85:352-370.
39. Tan Z.H., Yu L.H., Wei H.L., Liu G.T. The protective action of scutellarin against immunological liver injury induced by concanavalin A and its effect on pro-inflammatory cytokines in mice. J Pharm Pharmacol 2007, 59(1):115-121.
40. Tikka T., Fiebich B.L., Goldsteins G., Keinanen R., Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 2001, 21(8):2580-2588.
41. Waetzig V., Herdegen T. Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain. Neurosci Lett 2004, 361:64-67.
42. Wang L.X., Zeng J.P., Wei X.B., Wang F.W., Liu Z.P., Zhang X.M. Effects of scutellarin on apoptosis induced by cobalt chloride in PC12 cells. Chin J Physiol 2007, 50(6):301-307.
43. Wang S.X., Hu L.M., Gao X.M., Guo H., Fan G.W. Anti-inflammatory activity of Salvianolic acid B in microglia contributes to its neuroprotective effect. Neurochem Res 2010, 35:1029-1037.
44. Xiong Z., Liu C., Wang F., Li C., Wang W., Wang J., Chen J. Protective effects of breviscapine on ischemic vascular dementia in rats. Biol Pharm Bull 2006, 29(9):1880-1885.
45. Xu W., Zha R.P., Wang W.Y., Wang Y.P. Effects of scutellarin on PKCgamma in PC12 cell injury induced by oxygen and glucose deprivation. Acta Pharmacol Sin 2007, 28(10):1573-1579.
46. Yenari M.A., Xu L., Tang X.N., Qiao Y., Giffard R.G. Microglia potentiate damage to blood-brain barrier constituents improvement by minocycline in vivo and in vitro. Stroke 2006, 37:1087-1093.
47. Yu L.H., Wei H.L., Liu G.T. Scutellarin protects against lipopolysaccharide-induced acute lung injury via inhibition of NF-kappaB activation in mice. J Asian Nat Prod Res 2010, 12(3):175-184.
48. Zhang H.F., Hu X.M., Wang L.X., Xu S.Q., Zeng F.D. Protective effects of scutellarin against cerebral ischemia in rats: evidence for inhibition of the apoptosis-inducing factor pathway. Planta Med 2009, 75(2):121-126.
49. Zoppo G.J., Milner R., Mabuchi T., Hung S., Wang X., Berg G.I., Koziol J.A. Microglial activation and matrix protease generation during focal cerebral ischemia. Stroke 2007, 38:646-651.