Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

Oncotarget

Volumn 7, Issue 28, 2016, Pages 43713-43730

  Shah, Supriya ^a   Carriveau, Whitney J ^a   Li, Jinyang ^a   Campbell, Sydney L ^a   Kopinski, Piotr K ^b,c   Lim, Hee Woong ^a   Daurio, Natalie ^a   Trefely, Sophie ^a   Won, Kyoung Jae ^a   Wallace, Douglas C ^b   Koumenis, Constantinos ^a   Mancuso, Anthony ^a   Wellen, Kathryn E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Acetyl CoA; AMPK; ER stress; Fatty acid metabolism; Prostate cancer

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; ADENYLATE KINASE; ANDROGEN RECEPTOR; AMP-ACTIVATED PROTEIN KINASE KINASE; ANDROGEN RECEPTOR ANTAGONIST; ANTINEOPLASTIC AGENT; AR PROTEIN, HUMAN; ENZYME INHIBITOR; PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FEEDBACK SYSTEM; GENE EXPRESSION; PROSTATE CANCER CELL LINE; SIGNAL TRANSDUCTION; CASTRATION RESISTANT PROSTATE CANCER; HUMAN; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGICAL FEEDBACK; TUMOR CELL LINE;

ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; ATP CITRATE (PRO-S)-LYASE; CELL LINE, TUMOR; ENZYME INHIBITORS; FEEDBACK, PHYSIOLOGICAL; HUMANS; MALE; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PROTEIN KINASES; RECEPTORS, ANDROGEN;

EID: 84978782668     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9666     Document Type: Article

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