메뉴 건너뛰기




Volumn 14, Issue 3, 2014, Pages 187-198

Maintaining and reprogramming genomic androgen receptor activity in prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CHELATING AGENT; DNA; DNA CHELATING AGENT; DNA TOPOISOMERASE; DNA TOPOISOMERASE 2 BETA; FORKHEAD TRANSCRIPTION FACTOR; HISTONE METHYLTRANSFERASE; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NSD2 PROTEIN; SIAH2 PROTEIN; SPOP PROTEIN; STAT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR FOXA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VELIPARIB;

EID: 84896705671     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3678     Document Type: Review
Times cited : (143)

References (115)
  • 1
    • 1042269786 scopus 로고
    • Effect of orchiectomy and irradiation on cancer of the prostate
    • Huggins, C. Effect of orchiectomy and irradiation on cancer of the prostate. Ann. Surg. 115, 1192-1200 (1942).
    • (1942) Ann. Surg. , vol.115 , pp. 1192-1200
    • Huggins, C.1
  • 2
    • 0021101744 scopus 로고
    • DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates
    • Mulder, E., Vrij, A. A. & Brinkmann, A. O. DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates. Biochem. Biophys. Res. Commun. 114, 1147-1153 (1983).
    • (1983) Biochem. Biophys. Res. Commun. , vol.114 , pp. 1147-1153
    • Mulder, E.1    Vrij, A.A.2    Brinkmann, A.O.3
  • 3
    • 3042540196 scopus 로고    scopus 로고
    • Molecular mechanisms of androgen receptor-mediated gene regulation: Structure-function analysis of the AF-1 domain
    • McEwan, I. J. Molecular mechanisms of androgen receptor-mediated gene regulation: structure-function analysis of the AF-1 domain. Endocr.-Related Cancer 11, 281-293 (2004).
    • (2004) Endocr.-Related Cancer , vol.11 , pp. 281-293
    • McEwan, I.J.1
  • 4
    • 43149125406 scopus 로고    scopus 로고
    • Structural basis for the nuclear import of the human androgen receptor
    • Cutress, M. L., Whitaker, H. C., Mills, I. G., Stewart, M. & Neal, D. E. Structural basis for the nuclear import of the human androgen receptor. J. Cell Sci. 121, 957-968 (2008).
    • (2008) J. Cell Sci. , vol.121 , pp. 957-968
    • Cutress, M.L.1    Whitaker, H.C.2    Mills, I.G.3    Stewart, M.4    Neal, D.E.5
  • 5
    • 84901827161 scopus 로고    scopus 로고
    • Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
    • Yuan, X., Cai, C., Chen, S., Yu, Z. & Balk, S. P. Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis. Oncogene http://dx.doi.org/10.1038/ onc.2013.235 (2013).
    • (2013) Oncogene
    • Yuan, X.1    Cai, C.2    Chen, S.3    Yu, Z.4    Balk, S.P.5
  • 6
    • 84872078210 scopus 로고    scopus 로고
    • Abiraterone in metastatic prostate cancer without previous chemotherapy
    • Ryan, C. J. et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. New Engl. J. Med. 368, 138-148 (2013).
    • (2013) New Engl. J. Med. , vol.368 , pp. 138-148
    • Ryan, C.J.1
  • 7
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher, H. I. et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. New Engl. J. Med. 367, 1187-1197 (2012).
    • (2012) New Engl. J. Med. , vol.367 , pp. 1187-1197
    • Scher, H.I.1
  • 8
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi, T. et al. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nature Genet. 9, 401-406 (1995).
    • (1995) Nature Genet. , vol.9 , pp. 401-406
    • Visakorpi, T.1
  • 9
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li, Y. et al. Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res. 73, 483-489 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 483-489
    • Li, Y.1
  • 10
    • 84879067087 scopus 로고    scopus 로고
    • Overcoming mutation-based resistance to antiandrogens with rational drug design
    • Balbas, M. D. et al. Overcoming mutation-based resistance to antiandrogens with rational drug design. eLife 2, e00499 (2013).
    • (2013) ELife , vol.2
    • Balbas, M.D.1
  • 11
    • 84860311841 scopus 로고    scopus 로고
    • Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
    • Urbanucci, A. et al. Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer. Oncogene 31, 2153-2163 (2012).
    • (2012) Oncogene , vol.31 , pp. 2153-2163
    • Urbanucci, A.1
  • 12
    • 67650758019 scopus 로고    scopus 로고
    • Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
    • Wang, Q. et al. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138, 245-256 (2009).
    • (2009) Cell , vol.138 , pp. 245-256
    • Wang, Q.1
  • 13
    • 84881541842 scopus 로고    scopus 로고
    • Genetic variants associated with the progression of hepatocellular carcinoma in hepatitis C Egyptian patients
    • Motawi, T. K., Shaker, O. G., Ismail, M. F. & Sayed, N. H. Genetic variants associated with the progression of hepatocellular carcinoma in hepatitis C Egyptian patients. Gene 527, 516-520 (2013).
    • (2013) Gene , vol.527 , pp. 516-520
    • Motawi, T.K.1    Shaker, O.G.2    Ismail, M.F.3    Sayed, N.H.4
  • 14
    • 84555187950 scopus 로고    scopus 로고
    • Mapping protein-DNA interactions using ChIP-sequencing
    • Massie, C. E. & Mills, I. G. Mapping protein-DNA interactions using ChIP-sequencing. Methods Mol. Biol. 809, 157-173 (2012).
    • (2012) Methods Mol. Biol. , vol.809 , pp. 157-173
    • Massie, C.E.1    Mills, I.G.2
  • 15
    • 68749084845 scopus 로고    scopus 로고
    • Integrated expression profiling and ChIPseq analyses of the growth inhibition response program of the androgen receptor
    • Lin, B. et al. Integrated expression profiling and ChIPseq analyses of the growth inhibition response program of the androgen receptor. PLoS ONE 4, e6589 (2009).
    • (2009) PLoS ONE , vol.4
    • Lin, B.1
  • 16
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu, J. et al. An integrated network of androgen receptor, polycomb, and TMPRSS 2-ERG gene fusions in prostate cancer progression. Cancer Cell 17, 443-454 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.1
  • 17
    • 84872391385 scopus 로고    scopus 로고
    • The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man
    • Sharma, N. L. et al. The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man. Cancer Cell 23, 35-47 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 35-47
    • Sharma, N.L.1
  • 18
    • 79960071366 scopus 로고    scopus 로고
    • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
    • Massie, C. E. et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 30, 2719-2733 (2011).
    • (2011) EMBO J. , vol.30 , pp. 2719-2733
    • Massie, C.E.1
  • 19
    • 0036674190 scopus 로고    scopus 로고
    • Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells
    • Costello, L. C. & Franklin, R. B. Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells. Hormone Metabol. Res. 34, 417-424 (2002).
    • (2002) Hormone Metabol. Res. , vol.34 , pp. 417-424
    • Costello, L.C.1    Franklin, R.B.2
  • 20
    • 77955069195 scopus 로고    scopus 로고
    • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    • Haffner, M. C. et al. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature Genet. 42, 668-675 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 668-675
    • Haffner, M.C.1
  • 21
    • 33745255099 scopus 로고    scopus 로고
    • A topoisomerase IIß-mediated dsDNA break required for regulated transcription
    • Ju, B. G. et al. A topoisomerase IIß-mediated dsDNA break required for regulated transcription. Science 312, 1798-1802 (2006).
    • (2006) Science , vol.312 , pp. 1798-1802
    • Ju, B.G.1
  • 22
    • 79959189181 scopus 로고    scopus 로고
    • Transcriptioninduced DNA double strand breaks: Both oncogenic force and potential therapeutic target? Clin
    • Haffner, M. C., De Marzo, A. M., Meeker, A. K., Nelson, W. G. & Yegnasubramanian, S. Transcriptioninduced DNA double strand breaks: both oncogenic force and potential therapeutic target? Clin. Cancer Res. 17, 3858-3864 (2011).
    • (2011) Cancer Res. , vol.17 , pp. 3858-3864
    • Haffner, M.C.1    De Marzo, A.M.2    Meeker, A.K.3    Nelson, W.G.4    Yegnasubramanian, S.5
  • 23
    • 84873524967 scopus 로고    scopus 로고
    • PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis
    • Langelier, M. F. & Pascal, J. M. PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis. Curr. Opin. Struct. Biol. 23, 134-143 (2013).
    • (2013) Curr. Opin. Struct. Biol. , vol.23 , pp. 134-143
    • Langelier, M.F.1    Pascal, J.M.2
  • 24
    • 84871516837 scopus 로고    scopus 로고
    • Dual roles of PARP-1 promote cancer growth and progression
    • Schiewer, M. J. et al. Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov. 2, 1134-1149 (2012).
    • (2012) Cancer Discov. , vol.2 , pp. 1134-1149
    • Schiewer, M.J.1
  • 25
    • 79955968629 scopus 로고    scopus 로고
    • Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusionpositive prostate cancer
    • Brenner, J. C. et al. Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusionpositive prostate cancer. Cancer Cell 19, 664-678 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 664-678
    • Brenner, J.C.1
  • 26
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644-648 (2005).
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1
  • 27
    • 70849135782 scopus 로고    scopus 로고
    • Induced chromosomal proximity and gene fusions in prostate cancer
    • Mani, R. S. et al. Induced chromosomal proximity and gene fusions in prostate cancer. Science 326, 1230 (2009).
    • (2009) Science , vol.326 , pp. 1230
    • Mani, R.S.1
  • 28
    • 84873607610 scopus 로고    scopus 로고
    • Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
    • Weischenfeldt, J. et al. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 23, 159-170 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 159-170
    • Weischenfeldt, J.1
  • 29
    • 84880582339 scopus 로고    scopus 로고
    • Human erythropoietin increases the pro-angiogenic potential of A2780 ovarian adenocarcinoma cells under hypoxic conditions
    • Kriska, J. et al. Human erythropoietin increases the pro-angiogenic potential of A2780 ovarian adenocarcinoma cells under hypoxic conditions. Oncol. Rep. 30, 1455-1462 (2013).
    • (2013) Oncol. Rep. , vol.30 , pp. 1455-1462
    • Kriska, J.1
  • 30
    • 84878437130 scopus 로고    scopus 로고
    • The genomic landscape of prostate cancer
    • Spans, L. et al. The genomic landscape of prostate cancer. Int. J. Mol. Sci. 14, 10822-10851 (2013).
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 10822-10851
    • Spans, L.1
  • 31
    • 84875333536 scopus 로고    scopus 로고
    • ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients
    • Baena, E. et al. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 27, 683-698 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 683-698
    • Baena, E.1
  • 32
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver, B. S. et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nature Genet. 41, 619-624 (2009).
    • (2009) Nature Genet. , vol.41 , pp. 619-624
    • Carver, B.S.1
  • 33
    • 35548958147 scopus 로고    scopus 로고
    • New androgen receptor genomic targets show an interaction with the ETS1 transcription factor
    • Massie, C. E. et al. New androgen receptor genomic targets show an interaction with the ETS1 transcription factor. EMBO Rep. 8, 871-878 (2007).
    • (2007) EMBO Rep. , vol.8 , pp. 871-878
    • Massie, C.E.1
  • 34
    • 84856478933 scopus 로고    scopus 로고
    • Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3
    • Lee, K. S. et al. Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3. via gastric STAT3 activation. PLoS One 7, e30786 (2012).
    • (2012) Via Gastric STAT3 Activation. PLoS One , vol.7
    • Lee, K.S.1
  • 35
    • 84865619515 scopus 로고    scopus 로고
    • Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
    • Paulo, P. et al. Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements. Neoplasia 14, 600-611 (2012).
    • (2012) Neoplasia , vol.14 , pp. 600-611
    • Paulo, P.1
  • 36
    • 79953143753 scopus 로고    scopus 로고
    • H3K36 methylation antagonizes PRC2-mediated H3K27 methylation
    • Yuan, W. et al. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J. Biol. Chem. 286, 7983-7989 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 7983-7989
    • Yuan, W.1
  • 37
    • 26844520965 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
    • Cha, T. L. et al. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 310, 306-310 (2005).
    • (2005) Science , vol.310 , pp. 306-310
    • Cha, T.L.1
  • 38
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell. Metabolism 7, 11-20 (2008).
    • (2008) Cell. Metabolism , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 39
    • 84864003814 scopus 로고    scopus 로고
    • Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer
    • Eichholz, A., Ferraldeschi, R., Attard, G. & de Bono, J. S. Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer. Mol. Cell. Endocrinol. 360, 68-75 (2012).
    • (2012) Mol. Cell. Endocrinol. , vol.360 , pp. 68-75
    • Eichholz, A.1    Ferraldeschi, R.2    Attard, G.3    De Bono, J.S.4
  • 40
    • 79955975429 scopus 로고    scopus 로고
    • Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTENdeficient prostate cancer
    • Carver, B. S. et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTENdeficient prostate cancer. Cancer Cell 19, 575-586 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 575-586
    • Carver, B.S.1
  • 41
    • 34249034925 scopus 로고    scopus 로고
    • ß-Catenin activity negatively regulates bacteria-induced inflammation
    • Duan, Y. et al. ß-Catenin activity negatively regulates bacteria-induced inflammation. Lab. Invest. 87, 613-624 (2007).
    • (2007) Lab. Invest. , vol.87 , pp. 613-624
    • Duan, Y.1
  • 42
    • 84857765620 scopus 로고    scopus 로고
    • Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression
    • Shah, S., Prasad, S. & Knudsen, K. E. Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression. Cancer Res. 72, 1248-1259 (2012).
    • (2012) Cancer Res. , vol.72 , pp. 1248-1259
    • Shah, S.1    Prasad, S.2    Knudsen, K.E.3
  • 43
    • 22144486551 scopus 로고    scopus 로고
    • Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    • Carroll, J. S. et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA 1. Cell 122, 33-43 (2005).
    • (2005) Cell , vol.122 , pp. 33-43
    • Carroll, J.S.1
  • 44
    • 78651250284 scopus 로고    scopus 로고
    • FOXA1 is a key determinant of estrogen receptor function and endocrine response
    • Hurtado, A., Holmes, K. A., Ross-Innes, C. S., Schmidt, D. & Carroll, J. S. FOXA1 is a key determinant of estrogen receptor function and endocrine response. Nature Genet. 43, 27-33 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 27-33
    • Hurtado, A.1    Holmes, K.A.2    Ross-Innes, C.S.3    Schmidt, D.4    Carroll, J.S.5
  • 45
    • 80053610846 scopus 로고    scopus 로고
    • Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
    • Sahu, B. et al. Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer. EMBO J. 30, 3962-3976 (2011).
    • (2011) EMBO J. , vol.30 , pp. 3962-3976
    • Sahu, B.1
  • 46
    • 79959198166 scopus 로고    scopus 로고
    • Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
    • Wang, D. et al. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 474, 390-394(2011).
    • (2011) Nature , vol.474 , pp. 390-394
    • Wang, D.1
  • 47
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso, C. S. et al. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487, 239-243 (2012).
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1
  • 48
    • 34547214787 scopus 로고    scopus 로고
    • A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    • Wang, Q. et al. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol. Cell 27, 380-392 (2007).
    • (2007) Mol. Cell , vol.27 , pp. 380-392
    • Wang, Q.1
  • 49
    • 70350641827 scopus 로고    scopus 로고
    • A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes
    • Bohm, M., Locke, W. J., Sutherland, R. L., Kench, J. G. & Henshall, S. M. A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes. Oncogene 28, 3847-3856 (2009).
    • (2009) Oncogene , vol.28 , pp. 3847-3856
    • Bohm, M.1    Locke, W.J.2    Sutherland, R.L.3    Kench, J.G.4    Henshall, S.M.5
  • 50
    • 83255192190 scopus 로고    scopus 로고
    • Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells
    • Andreu-Vieyra, C. et al. Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells. Mol. Cell. Biol. 31, 4648-4662 (2011).
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 4648-4662
    • Andreu-Vieyra, C.1
  • 51
    • 84888343067 scopus 로고    scopus 로고
    • Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element
    • Clinckemalie, L. et al. Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element. Mol. Endocrinol. http://dx.doi.org/10.1210/me.2013-1098 (2013).
    • (2013) Mol. Endocrinol.
    • Clinckemalie, L.1
  • 52
    • 84873306955 scopus 로고    scopus 로고
    • Prostate cancer: Germline prediction for a commonly variable malignancy
    • Bambury, R. M. & Gallagher, D. J. Prostate cancer: germline prediction for a commonly variable malignancy. BJU Int. 110, E809-E818 (2012).
    • (2012) BJU Int. , vol.110
    • Bambury, R.M.1    Gallagher, D.J.2
  • 53
    • 84888839080 scopus 로고    scopus 로고
    • A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk
    • Karlsson, R. et al. A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. Eur. Urol. 65, 169-176 (2014).
    • (2014) Eur. Urol. , vol.65 , pp. 169-176
    • Karlsson, R.1
  • 54
    • 84876581228 scopus 로고    scopus 로고
    • HOXB13 G84E mutation in Finland: Population-based analysis of prostate, breast, and colorectal cancer risk
    • Laitinen, V. H. et al. HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk. Cancer Epidemiol. Biomarkers Prev. 22, 452-460 (2013).
    • (2013) Cancer Epidemiol. Biomarkers Prev. , vol.22 , pp. 452-460
    • Laitinen, V.H.1
  • 55
    • 70449123571 scopus 로고    scopus 로고
    • The homeodomain protein HOXB13 regulates the cellular response to androgens
    • Norris, J. D. et al. The homeodomain protein HOXB13 regulates the cellular response to androgens. Mol. Cell 36, 405-416 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 405-416
    • Norris, J.D.1
  • 56
    • 0035135081 scopus 로고    scopus 로고
    • Interleukin-6 serum level correlates with survival in advanced gastrointestinal cancer patients but is not an independent prognostic indicator
    • De Vita, F. et al. Interleukin-6 serum level correlates with survival in advanced gastrointestinal cancer patients but is not an independent prognostic indicator. J. Interferon Cytokine Res. 21, 45-52 (2001).
    • (2001) J. Interferon Cytokine Res. , vol.21 , pp. 45-52
    • De Vita, F.1
  • 57
    • 19544384144 scopus 로고    scopus 로고
    • Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage
    • Uehara, H. et al. Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage. Prostate 64, 40-49 (2005).
    • (2005) Prostate , vol.64 , pp. 40-49
    • Uehara, H.1
  • 58
    • 34547102251 scopus 로고    scopus 로고
    • Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer
    • Araki, S. et al. Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer. Cancer Res. 67, 6854-6862 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 6854-6862
    • Araki, S.1
  • 59
    • 3242798367 scopus 로고    scopus 로고
    • NF-B activation in human prostate cancer: Important mediator or epiphenomenon?
    • Suh, J. & Rabson, A. B. NF-.B activation in human prostate cancer: important mediator or epiphenomenon? J. Cell. Biochem. 91, 100-117 (2004).
    • (2004) J. Cell. Biochem. , vol.91 , pp. 100-117
    • Suh, J.1    Rabson, A.B.2
  • 60
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • Heinrich, P. C. et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374, 1-20 (2003).
    • (2003) Biochem. J. , vol.374 , pp. 1-20
    • Heinrich, P.C.1
  • 61
    • 77949379050 scopus 로고    scopus 로고
    • B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
    • Ammirante, M., Luo, J. L., Grivennikov, S., Nedospasov, S. & Karin, M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464, 302-305 (2010).
    • (2010) Nature , vol.464 , pp. 302-305
    • Ammirante, M.1    Luo, J.L.2    Grivennikov, S.3    Nedospasov, S.4    Karin, M.5
  • 62
    • 77951036849 scopus 로고    scopus 로고
    • Aberrant activation of the androgen receptor by NF-B2/p52 in prostate cancer cells
    • Nadiminty, N. et al. Aberrant activation of the androgen receptor by NF-.B2/p52 in prostate cancer cells. Cancer Res. 70, 3309-3319 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3309-3319
    • Nadiminty, N.1
  • 63
    • 84867847457 scopus 로고    scopus 로고
    • NF.B signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression
    • McCall, P. et al. NF.B signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression. Br. J. Cancer 107, 1554-1563 (2012).
    • (2012) Br. J. Cancer , vol.107 , pp. 1554-1563
    • McCall, P.1
  • 64
    • 54049086233 scopus 로고    scopus 로고
    • Interleukin-8 signaling attenuates TRAIL-and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    • Wilson, C., Wilson, T., Johnston, P. G., Longley, D. B. & Waugh, D. J. Interleukin-8 signaling attenuates TRAIL-and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Mol. Cancer Ther. 7, 2649-2661 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2649-2661
    • Wilson, C.1    Wilson, T.2    Johnston, P.G.3    Longley, D.B.4    Waugh, D.J.5
  • 65
    • 84879974599 scopus 로고    scopus 로고
    • Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTENdeficient prostate carcinoma
    • Maxwell, P. J. et al. Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTENdeficient prostate carcinoma. Eur. Urol. 64, 177-188 (2013).
    • (2013) Eur. Urol. , vol.64 , pp. 177-188
    • Maxwell, P.J.1
  • 66
    • 84884752495 scopus 로고    scopus 로고
    • Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling
    • Fang, L. Y. et al. Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling. Cancer Res. 73, 5633-5646 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 5633-5646
    • Fang, L.Y.1
  • 67
    • 39149111601 scopus 로고    scopus 로고
    • Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells
    • Tan, S. H. et al. Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells. Cancer Res. 68, 236-248 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 236-248
    • Tan, S.H.1
  • 68
    • 24144475549 scopus 로고    scopus 로고
    • Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer
    • Horinaga, M. et al. Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer. Urology 66,671-675 (2005).
    • (2005) Urology , vol.66 , pp. 671-675
    • Horinaga, M.1
  • 69
    • 79951826165 scopus 로고    scopus 로고
    • Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo
    • Thomas, C. et al. Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo. Mol. Cancer Ther. 10, 347-359 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 347-359
    • Thomas, C.1
  • 70
    • 79952967327 scopus 로고    scopus 로고
    • Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer
    • Liao, Z. & Nevalainen, M. T. Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer. Am. J. Translat. Res. 3, 133-138 (2011).
    • (2011) Am. J. Translat. Res. , vol.3 , pp. 133-138
    • Liao, Z.1    Nevalainen, M.T.2
  • 71
    • 0036510548 scopus 로고    scopus 로고
    • Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways
    • Ueda, T., Bruchovsky, N. & Sadar, M. D. Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J. Biol. Chem. 277, 7076-7085 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 7076-7085
    • Ueda, T.1    Bruchovsky, N.2    Sadar, M.D.3
  • 72
    • 34249039594 scopus 로고    scopus 로고
    • Relative copy number gain of MYC in diagnostic needle biopsies is an independent prognostic factor for prostate cancer patients
    • Ribeiro, F. R., Henrique, R., Martins, A. T., Jeronimo, C. & Teixeira, M. R. Relative copy number gain of MYC in diagnostic needle biopsies is an independent prognostic factor for prostate cancer patients. Eur. Urol. 52, 116-125 (2007).
    • (2007) Eur. Urol. , vol.52 , pp. 116-125
    • Ribeiro, F.R.1    Henrique, R.2    Martins, A.T.3    Jeronimo, C.4    Teixeira, M.R.5
  • 73
    • 84870659824 scopus 로고    scopus 로고
    • An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy
    • Antonarakis, E. S. et al. An immunohistochemical signature comprising PTEN, MYC, and Ki 67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy. Cancer 118, 6063-6071 (2012).
    • (2012) Cancer , vol.118 , pp. 6063-6071
    • Antonarakis, E.S.1
  • 74
    • 84867021989 scopus 로고    scopus 로고
    • Transcriptional amplification in tumor cells with elevated c-Myc
    • Lin, C. Y. et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 151, 56-67 (2012).
    • (2012) Cell , vol.151 , pp. 56-67
    • Lin, C.Y.1
  • 75
    • 65949111749 scopus 로고    scopus 로고
    • Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer
    • Zou, J. X. et al. Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer. Cancer Res. 69, 3339-3346 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 3339-3346
    • Zou, J.X.1
  • 76
    • 70350537013 scopus 로고    scopus 로고
    • ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors
    • Ciro, M. et al. ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res. 69, 8491-8498 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8491-8498
    • Ciro, M.1
  • 77
    • 23744514308 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
    • Jang, M. K. et al. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 19, 523-534 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 523-534
    • Jang, M.K.1
  • 78
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase, A. & Cross, N. C. Aberrations of EZH2 in cancer. Clin. Cancer Res. 17, 2613-2618 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 79
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • Varambally, S. et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322, 1695-1699 (2008).
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1
  • 80
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent
    • Xu, K. et al. EZH 2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science 338, 1465-1469 (2012).
    • (2012) Science , vol.338 , pp. 1465-1469
    • Xu, K.1
  • 81
    • 84867987203 scopus 로고    scopus 로고
    • EZH2 inhibition: Targeting the crossroad of tumor invasion and angiogenesis
    • Crea, F. et al. EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis. Cancer Metastasis Rev. 31, 753-761 (2012).
    • (2012) Cancer Metastasis Rev. , vol.31 , pp. 753-761
    • Crea, F.1
  • 82
    • 81355133161 scopus 로고    scopus 로고
    • NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
    • Kuo, A. J. et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol. Cell 44, 609-620 (2011).
    • (2011) Mol. Cell , vol.44 , pp. 609-620
    • Kuo, A.J.1
  • 83
    • 84872269688 scopus 로고    scopus 로고
    • Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer
    • Asangani, I. A. et al. Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. Mol. Cell 49, 80-93 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 80-93
    • Asangani, I.A.1
  • 84
    • 84876441841 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity
    • Qi, J. et al. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell 23, 332-346 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 332-346
    • Qi, J.1
  • 85
    • 77954291438 scopus 로고    scopus 로고
    • Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors
    • Qi, J. et al. Siah 2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 18, 23-38 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 23-38
    • Qi, J.1
  • 86
    • 68149099806 scopus 로고    scopus 로고
    • The role of murine models of prostate cancer in drug target discovery and validation
    • Ahmad, I., Sansom, O. J. & Leung, H. Y. The role of murine models of prostate cancer in drug target discovery and validation. Expert Opin. Drug Discov. 4, 879-888 (2009).
    • (2009) Expert Opin. Drug Discov. , vol.4 , pp. 879-888
    • Ahmad, I.1    Sansom, O.J.2    Leung, H.Y.3
  • 87
    • 79956027131 scopus 로고    scopus 로고
    • The Siah2-HIF-FoxA2 axis in prostate cancer-new markers and therapeutic opportunities
    • Qi, J., Pellecchia, M. & Ronai, Z. A. The Siah2-HIF-FoxA2 axis in prostate cancer-new markers and therapeutic opportunities. Oncotarget 1, 379-385 (2010).
    • (2010) Oncotarget , vol.1 , pp. 379-385
    • Qi, J.1    Pellecchia, M.2    Ronai, Z.A.3
  • 88
    • 14044273722 scopus 로고    scopus 로고
    • The Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-α-induced apoptosis by impaired NF-κB signaling and target gene expression
    • Till, A. et al. The Met-196- Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-α-induced apoptosis by impaired NF-κB signaling and target gene expression. J. Biol. Chem. 280, 5994-6004 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 5994-6004
    • Till, A.1
  • 90
    • 0036681834 scopus 로고    scopus 로고
    • Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    • Kim, J. et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J. Immunol. 169, 1535-1541 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 1535-1541
    • Kim, J.1
  • 91
    • 0036242444 scopus 로고    scopus 로고
    • Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts
    • Fritz, E. A., Glant, T. T., Vermes, C., Jacobs, J. J. & Roebuck, K. A. Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts. J. Orthopaed. Res. 20, 490-498 (2002).
    • (2002) J. Orthopaed. Res. , vol.20 , pp. 490-498
    • Fritz, E.A.1    Glant, T.T.2    Vermes, C.3    Jacobs, J.J.4    Roebuck, K.A.5
  • 92
    • 77957001324 scopus 로고    scopus 로고
    • Bipolar androgen therapy: The rationale for rapid cycling of supraphysiologic androgen/ablation in men with castration resistant prostate cancer
    • Denmeade, S. R. & Isaacs, J. T. Bipolar androgen therapy: the rationale for rapid cycling of supraphysiologic androgen/ablation in men with castration resistant prostate cancer. Prostate 70, 1600-1607 (2010).
    • (2010) Prostate , vol.70 , pp. 1600-1607
    • Denmeade, S.R.1    Isaacs, J.T.2
  • 93
    • 77954109609 scopus 로고    scopus 로고
    • Separating the drivers from the driven: Integrative network and pathway approaches aid identification of disease biomarkers from high-throughput data
    • McDermott, J. E., Costa, M., Janszen, D., Singhal, M. & Tilton, S. C. Separating the drivers from the driven: Integrative network and pathway approaches aid identification of disease biomarkers from high-throughput data. Dis. Markers 28, 253-266 (2010).
    • (2010) Dis. Markers , vol.28 , pp. 253-266
    • McDermott, J.E.1    Costa, M.2    Janszen, D.3    Singhal, M.4    Tilton, S.C.5
  • 94
    • 34548176765 scopus 로고    scopus 로고
    • Integrating molecular and network biology to decode endocytosis
    • Schmid, E. M. & McMahon, H. T. Integrating molecular and network biology to decode endocytosis. Nature 448, 883-888 (2007).
    • (2007) Nature , vol.448 , pp. 883-888
    • Schmid, E.M.1    McMahon, H.T.2
  • 95
    • 84873020117 scopus 로고    scopus 로고
    • ChIP-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy
    • Unit 21.24 (eds Frederick M. A. et al.) Wiley
    • Rhee, H. S. & Pugh, B. F. ChIP-exo method for identifying genomic location of DNA-binding proteins with near-single-nucleotide accuracy. In Current Protocols in Molecular Biology Ch. 21, Unit 21.24 (eds Frederick M. A. et al.) (Wiley, 2012).
    • (2012) Current Protocols in Molecular Biology Ch. , vol.21
    • Rhee, H.S.1    Pugh, B.F.2
  • 96
    • 79959838441 scopus 로고    scopus 로고
    • Single-tube linear DNA amplification (LinDA) for robust ChIP-seq
    • Shankaranarayanan, P. et al. Single-tube linear DNA amplification (LinDA) for robust ChIP-seq. Nature Methods 8, 565-567 (2011).
    • (2011) Nature Methods , vol.8 , pp. 565-567
    • Shankaranarayanan, P.1
  • 97
    • 84875835782 scopus 로고    scopus 로고
    • A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples
    • Zwart, W. et al. A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples. BMC Genom. 14, 232 (2013).
    • (2013) BMC Genom. , vol.14 , pp. 232
    • Zwart, W.1
  • 98
    • 84874243484 scopus 로고    scopus 로고
    • Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor
    • Mohammed, H. et al. Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep. 3, 342-349 (2013).
    • (2013) Cell Rep. , vol.3 , pp. 342-349
    • Mohammed, H.1
  • 99
    • 33750339350 scopus 로고    scopus 로고
    • Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer
    • Rubin, M. A. & Chinnaiyan, A. M. Bioinformatics approach leads to the discovery of the TMPRSS2:ETS gene fusion in prostate cancer. Lab. Invest. 86, 1099-1102 (2006).
    • (2006) Lab. Invest. , vol.86 , pp. 1099-1102
    • Rubin, M.A.1    Chinnaiyan, A.M.2
  • 100
    • 84887616489 scopus 로고    scopus 로고
    • Whole-exome sequencing reveals recurrent somatic mutation networks in cancer
    • Liu, X., Wang, J. & Chen, L. Whole-exome sequencing reveals recurrent somatic mutation networks in cancer. Cancer Lett. 340, 270-276 (2012).
    • (2012) Cancer Lett. , vol.340 , pp. 270-276
    • Liu, X.1    Wang, J.2    Chen, L.3
  • 101
  • 102
    • 18144418888 scopus 로고    scopus 로고
    • Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays
    • Zhou, X. et al. Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genet. Cytogenet. 159, 53-57 (2005).
    • (2005) Cancer Genet. Cytogenet. , vol.159 , pp. 53-57
    • Zhou, X.1
  • 103
    • 39749145837 scopus 로고    scopus 로고
    • Array comparative genomic hybridization copy number profiling: A new tool for translational research in solid malignancies
    • Costa, J. L., Meijer, G., Ylstra, B. & Caldas, C. Array comparative genomic hybridization copy number profiling: a new tool for translational research in solid malignancies. Semin. Radiat. Oncol. 18, 98-104 (2008).
    • (2008) Semin. Radiat. Oncol. , vol.18 , pp. 98-104
    • Costa, J.L.1    Meijer, G.2    Ylstra, B.3    Caldas, C.4
  • 104
    • 84876217788 scopus 로고    scopus 로고
    • Amplitude modulation of androgen signaling by c-MYC
    • Ni, M. et al. Amplitude modulation of androgen signaling by c-MYC. Genes Dev. 27, 734-748 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 734-748
    • Ni, M.1
  • 105
    • 84877934286 scopus 로고    scopus 로고
    • Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation
    • Gao, L. et al. Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation. PLoS One 8, e63563 (2013).
    • (2013) PLoS One , vol.8
    • Gao, L.1
  • 106
    • 80051590718 scopus 로고    scopus 로고
    • Coordinated regulation of polycomb group complexes through microRNAs in cancer
    • Cao, Q. et al. Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell 20, 187-199 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 187-199
    • Cao, Q.1
  • 107
    • 84879414983 scopus 로고    scopus 로고
    • The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer
    • Ezponda, T. et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene 32, 2882-2890 (2013).
    • (2013) Oncogene , vol.32 , pp. 2882-2890
    • Ezponda, T.1
  • 108
    • 84864627631 scopus 로고    scopus 로고
    • Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop
    • Yang, P. et al. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Mol. Cell. Biol. 32, 3121-3131 (2012).
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 3121-3131
    • Yang, P.1
  • 109
    • 84879085247 scopus 로고    scopus 로고
    • Androgen receptor-independent function of FoxA1 in prostate cancer metastasis
    • Jin, H. J., Zhao, J. C., Ogden, I., Bergan, R. C. & Yu, J. Androgen receptor-independent function of FoxA1 in prostate cancer metastasis. Cancer Res. 73, 3725-3736 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 3725-3736
    • Jin, H.J.1    Zhao, J.C.2    Ogden, I.3    Bergan, R.C.4    Yu, J.5
  • 110
    • 84860607999 scopus 로고    scopus 로고
    • Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer
    • Naderi, A., Meyer, M. & Dowhan, D. H. Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer. Neoplasia 14, 283-296 (2012).
    • (2012) Neoplasia , vol.14 , pp. 283-296
    • Naderi, A.1    Meyer, M.2    Dowhan, D.H.3
  • 111
    • 44449106252 scopus 로고    scopus 로고
    • A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer
    • Naderi, A. & Hughes-Davies, L. A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer. Neoplasia 10, 542-548 (2008).
    • (2008) Neoplasia , vol.10 , pp. 542-548
    • Naderi, A.1    Hughes-Davies, L.2
  • 112
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
    • Barbieri, C. E. et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nature Genet. 44, 685-689 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 685-689
    • Barbieri, C.E.1
  • 113
    • 77952716929 scopus 로고    scopus 로고
    • HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling
    • Kim, Y. R. et al. HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling. Mol. Cancer 9, 124 (2010).
    • (2010) Mol. Cancer , vol.9 , pp. 124
    • Kim, Y.R.1
  • 114
    • 68449103870 scopus 로고    scopus 로고
    • NF-κB regulates androgen receptor expression and prostate cancer growth
    • Zhang, L. et al. NF-κB regulates androgen receptor expression and prostate cancer growth. Am. J. Pathol. 175, 489-499 (2009).
    • (2009) Am. J. Pathol. , vol.175 , pp. 489-499
    • Zhang, L.1
  • 115
    • 27644466358 scopus 로고    scopus 로고
    • Nuclear localisation of nuclear factor-κB transcription factors in prostate cancer: An immunohistochemical study
    • Lessard, L., Begin, L. R., Gleave, M. E., Mes-Masson, A. M. & Saad, F. Nuclear localisation of nuclear factor-κB transcription factors in prostate cancer: an immunohistochemical study. Br. J. Cancer 93, 1019-1023 (2005).
    • (2005) Br. J. Cancer , vol.93 , pp. 1019-1023
    • Lessard, L.1    Begin, L.R.2    Gleave, M.E.3    Mes-Masson, A.M.4    Saad, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.