메뉴 건너뛰기




Volumn 7, Issue 10, 2012, Pages

Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo

Author keywords

[No Author keywords available]

Indexed keywords

3,3' DIINDOLYLMETHANE; ANDROGEN RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN;

EID: 84867327385     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047186     Document Type: Article
Times cited : (48)

References (42)
  • 1
    • 0038035142 scopus 로고    scopus 로고
    • Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
    • Wang W, Yang X, Lopez de Silanes I, Carling D, Gorospe M, (2003) Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem 278: 27016-27023.
    • (2003) J Biol Chem , vol.278 , pp. 27016-27023
    • Wang, W.1    Yang, X.2    Lopez de Silanes, I.3    Carling, D.4    Gorospe, M.5
  • 2
    • 79954517977 scopus 로고    scopus 로고
    • Structure of mammalian AMPK and its regulation by ADP
    • Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, et al. (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472: 230-233.
    • (2011) Nature , vol.472 , pp. 230-233
    • Xiao, B.1    Sanders, M.J.2    Underwood, E.3    Heath, R.4    Mayer, F.V.5
  • 3
    • 70349484214 scopus 로고    scopus 로고
    • Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice
    • Fu A, Ng AC, Depatie C, Wijesekara N, He Y, et al. (2009) Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab 10: 285-295.
    • (2009) Cell Metab , vol.10 , pp. 285-295
    • Fu, A.1    Ng, A.C.2    Depatie, C.3    Wijesekara, N.4    He, Y.5
  • 4
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, et al. (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 101: 3329-3335.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5
  • 5
    • 72449131381 scopus 로고    scopus 로고
    • CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle
    • Abbott MJ, Edelman AM, Turcotte LP, (2009) CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. Am J Physiol Regul Integr Comp Physiol 297: R1724-1732.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Abbott, M.J.1    Edelman, A.M.2    Turcotte, L.P.3
  • 6
    • 33847072201 scopus 로고    scopus 로고
    • AMP-activated protein kinase as a drug target
    • Hardie DG, (2007) AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 47: 185-210.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 185-210
    • Hardie, D.G.1
  • 7
    • 28244466264 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
    • Rattan R, Giri S, Singh AK, Singh I, (2005) 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 280: 39582-39593.
    • (2005) J Biol Chem , vol.280 , pp. 39582-39593
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 11
    • 77952116629 scopus 로고    scopus 로고
    • Metformin in cancer therapy: a new perspective for an old antidiabetic drug?
    • Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F, (2010) Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 9: 1092-1099.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1092-1099
    • Ben Sahra, I.1    Le Marchand-Brustel, Y.2    Tanti, J.F.3    Bost, F.4
  • 12
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA, (2006) Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 13
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • Alimova IN, Liu B, Fan Z, Edgerton SM, Dillon T, et al. (2009) Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 8: 909-915.
    • (2009) Cell Cycle , vol.8 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3    Edgerton, S.M.4    Dillon, T.5
  • 14
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M, (2006) Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 66: 10269-10273.
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 15
    • 67650514082 scopus 로고    scopus 로고
    • Metformin induces unique biological and molecular responses in triple negative breast cancer cells
    • Liu B, Fan Z, Edgerton SM, Deng XS, Alimova IN, et al. (2009) Metformin induces unique biological and molecular responses in triple negative breast cancer cells. Cell Cycle 8: 2031-2040.
    • (2009) Cell Cycle , vol.8 , pp. 2031-2040
    • Liu, B.1    Fan, Z.2    Edgerton, S.M.3    Deng, X.S.4    Alimova, I.N.5
  • 16
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K, (2009) Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69: 7507-7511.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 17
    • 27744455616 scopus 로고    scopus 로고
    • Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
    • Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, et al. (2005) Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun 338: 694-699.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 694-699
    • Hwang, J.T.1    Park, I.J.2    Shin, J.I.3    Lee, Y.K.4    Lee, S.K.5
  • 18
    • 35648944317 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase
    • Collins QF, Liu HY, Pi J, Liu Z, Quon MJ, et al. (2007) Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase. J Biol Chem 282: 30143-30149.
    • (2007) J Biol Chem , vol.282 , pp. 30143-30149
    • Collins, Q.F.1    Liu, H.Y.2    Pi, J.3    Liu, Z.4    Quon, M.J.5
  • 19
    • 59249092573 scopus 로고    scopus 로고
    • AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells
    • Pan W, Yang H, Cao C, Song X, Wallin B, et al. (2008) AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol Rep 20: 1553-1559.
    • (2008) Oncol Rep , vol.20 , pp. 1553-1559
    • Pan, W.1    Yang, H.2    Cao, C.3    Song, X.4    Wallin, B.5
  • 20
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman DJ, Cragg GM, (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 21
    • 31544436372 scopus 로고    scopus 로고
    • Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells
    • Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, et al. (2006) Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells. Int J Cancer 118: 857-868.
    • (2006) Int J Cancer , vol.118 , pp. 857-868
    • Brew, C.T.1    Aronchik, I.2    Hsu, J.C.3    Sheen, J.H.4    Dickson, R.B.5
  • 22
    • 0036554871 scopus 로고    scopus 로고
    • Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells
    • Chinni SR, Sarkar FH, (2002) Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Cancer Res 8: 1228-1236.
    • (2002) Clin Cancer Res , vol.8 , pp. 1228-1236
    • Chinni, S.R.1    Sarkar, F.H.2
  • 23
    • 2442672870 scopus 로고    scopus 로고
    • Physiological modeling of formulated and crystalline 3,3′-diindolylmethane pharmacokinetics following oral administration in mice
    • Anderton MJ, Manson MM, Verschoyle R, Gescher A, Steward WP, et al. (2004) Physiological modeling of formulated and crystalline 3,3′-diindolylmethane pharmacokinetics following oral administration in mice. Drug Metab Dispos 32: 632-638.
    • (2004) Drug Metab Dispos , vol.32 , pp. 632-638
    • Anderton, M.J.1    Manson, M.M.2    Verschoyle, R.3    Gescher, A.4    Steward, W.P.5
  • 24
    • 33750541268 scopus 로고    scopus 로고
    • Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells
    • Bhuiyan MM, Li Y, Banerjee S, Ahmed F, Wang Z, et al. (2006) Down-regulation of androgen receptor by 3,3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. Cancer Res 66: 10064-10072.
    • (2006) Cancer Res , vol.66 , pp. 10064-10072
    • Bhuiyan, M.M.1    Li, Y.2    Banerjee, S.3    Ahmed, F.4    Wang, Z.5
  • 25
    • 34248178375 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer
    • Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH, (2007) Inhibition of angiogenesis and invasion by 3,3′-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res 67: 3310-3319.
    • (2007) Cancer Res , vol.67 , pp. 3310-3319
    • Kong, D.1    Li, Y.2    Wang, Z.3    Banerjee, S.4    Sarkar, F.H.5
  • 26
    • 33751285781 scopus 로고    scopus 로고
    • Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
    • Chen D, Cui QC, Yang H, Dou QP, (2006) Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res 66: 10425-10433.
    • (2006) Cancer Res , vol.66 , pp. 10425-10433
    • Chen, D.1    Cui, Q.C.2    Yang, H.3    Dou, Q.P.4
  • 27
    • 77957902732 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    • Kong D, Banerjee S, Ahmad A, Li Y, Wang Z, et al. (2010) Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS One 5: e12445.
    • (2010) PLoS One , vol.5
    • Kong, D.1    Banerjee, S.2    Ahmad, A.3    Li, Y.4    Wang, Z.5
  • 28
    • 34248584876 scopus 로고    scopus 로고
    • In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer
    • Banerjee S, Hussain M, Wang Z, Saliganan A, Che M, et al. (2007) In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer. Cancer Res 67: 3818-3826.
    • (2007) Cancer Res , vol.67 , pp. 3818-3826
    • Banerjee, S.1    Hussain, M.2    Wang, Z.3    Saliganan, A.4    Che, M.5
  • 29
    • 0037005993 scopus 로고    scopus 로고
    • Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis
    • Nemeth JA, Yousif R, Herzog M, Che M, Upadhyay J, et al. (2002) Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis. J Natl Cancer Inst 94: 17-25.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 17-25
    • Nemeth, J.A.1    Yousif, R.2    Herzog, M.3    Che, M.4    Upadhyay, J.5
  • 30
    • 0028092988 scopus 로고
    • Critical phosphorylation sites for acetyl-CoA carboxylase activity
    • Ha J, Daniel S, Broyles SS, Kim KH, (1994) Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem 269: 22162-22168.
    • (1994) J Biol Chem , vol.269 , pp. 22162-22168
    • Ha, J.1    Daniel, S.2    Broyles, S.S.3    Kim, K.H.4
  • 31
    • 66449117931 scopus 로고    scopus 로고
    • AMP-activated protein kinase promotes human prostate cancer cell growth and survival
    • Park HU, Suy S, Danner M, Dailey V, Zhang Y, et al. (2009) AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther 8: 733-741.
    • (2009) Mol Cancer Ther , vol.8 , pp. 733-741
    • Park, H.U.1    Suy, S.2    Danner, M.3    Dailey, V.4    Zhang, Y.5
  • 32
    • 21244480367 scopus 로고    scopus 로고
    • The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    • Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG, (2005) The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem 280: 18717-18727.
    • (2005) J Biol Chem , vol.280 , pp. 18717-18727
    • Smith, E.M.1    Finn, S.G.2    Tee, A.R.3    Browne, G.J.4    Proud, C.G.5
  • 33
    • 40949131914 scopus 로고    scopus 로고
    • Mammalian target of rapamycin repression by 3,3′-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells
    • Kong D, Banerjee S, Huang W, Li Y, Wang Z, et al. (2008) Mammalian target of rapamycin repression by 3,3′-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells. Cancer Res 68: 1927-1934.
    • (2008) Cancer Res , vol.68 , pp. 1927-1934
    • Kong, D.1    Banerjee, S.2    Huang, W.3    Li, Y.4    Wang, Z.5
  • 34
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, Chen Y, Shen X, et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5
  • 35
    • 0030901556 scopus 로고    scopus 로고
    • Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase
    • Hutber CA, Hardie DG, Winder WW, (1997) Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase. Am J Physiol 272: E262-266.
    • (1997) Am J Physiol , vol.272
    • Hutber, C.A.1    Hardie, D.G.2    Winder, W.W.3
  • 36
    • 0036863086 scopus 로고    scopus 로고
    • Regulation of mammalian acetyl-CoA carboxylase
    • Munday MR, (2002) Regulation of mammalian acetyl-CoA carboxylase. Biochem Soc Trans 30: 1059-1064.
    • (2002) Biochem Soc Trans , vol.30 , pp. 1059-1064
    • Munday, M.R.1
  • 37
    • 0036087776 scopus 로고    scopus 로고
    • Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
    • Park SH, Gammon SR, Knippers JD, Paulsen SR, Rubink DS, et al. (2002) Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol 92: 2475-2482.
    • (2002) J Appl Physiol , vol.92 , pp. 2475-2482
    • Park, S.H.1    Gammon, S.R.2    Knippers, J.D.3    Paulsen, S.R.4    Rubink, D.S.5
  • 38
    • 0037025356 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    • Bolster DR, Crozier SJ, Kimball SR, Jefferson LS, (2002) AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277: 23977-23980.
    • (2002) J Biol Chem , vol.277 , pp. 23977-23980
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 39
    • 0035912833 scopus 로고    scopus 로고
    • Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor
    • Lin HK, Yeh S, Kang HY, Chang C, (2001) Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A 98: 7200-7205.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7200-7205
    • Lin, H.K.1    Yeh, S.2    Kang, H.Y.3    Chang, C.4
  • 40
    • 0035918165 scopus 로고    scopus 로고
    • Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    • Lu ML, Schneider MC, Zheng Y, Zhang X, Richie JP, (2001) Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem 276: 13442-13451.
    • (2001) J Biol Chem , vol.276 , pp. 13442-13451
    • Lu, M.L.1    Schneider, M.C.2    Zheng, Y.3    Zhang, X.4    Richie, J.P.5
  • 41
    • 0034283030 scopus 로고    scopus 로고
    • Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    • Truica CI, Byers S, Gelmann EP, (2000) Beta-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Res 60: 4709-4713.
    • (2000) Cancer Res , vol.60 , pp. 4709-4713
    • Truica, C.I.1    Byers, S.2    Gelmann, E.P.3
  • 42
    • 67649948804 scopus 로고    scopus 로고
    • WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics
    • Bisson I, Prowse DM, (2009) WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res 19: 683-697.
    • (2009) Cell Res , vol.19 , pp. 683-697
    • Bisson, I.1    Prowse, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.