The role of ATP citrate-lyase in the metabolic regulation of plasma lipids: Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076

Biochemical Journal

Volumn 334, Issue 1, 1998, Pages 113-119

  Pearce, Nigel J ^a   Yates, John W ^a   Berkhout, Theo A ^a   Jackson, Brian ^a   Tew, David ^a   Boyd, Helen ^a   Camilleri, Patrick ^a   Sweeney, Patricia ^a   Gribble, Andrew D ^a   Shaw, Anthony ^a   Groot, Pieter H E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CHOLESTEROL; GAMMA LACTONE DERIVATIVE; PRODRUG; SB 204990; TYLOXAPOL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HYPOLIPEMIA; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPOGENESIS; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTILIPEMIC AGENTS; ATP CITRATE (PRO-S)-LYASE; BIOLOGICAL AVAILABILITY; CHLOROBENZENES; CHOLESTEROL; DOGS; ENZYME INHIBITORS; FATTY ACIDS, NONESTERIFIED; HOMEOSTASIS; HUMANS; LACTONES; LIPIDS; LIVER; MALE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRIGLYCERIDES; TUMOR CELLS, CULTURED;

ANIMALIA; CANIS FAMILIARIS;

EID: 0032529044     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3340113     Document Type: Article

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