AB-Bind: Antibody binding mutational database for computational affinity predictions

Protein Science

Volumn 25, Issue 2, 2016, Pages 393-409

  Sirin, Sarah ^a   Apgar, James R ^b   Bennett, Eric M ^b   Keating, Amy E ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b PFIZER INC   (United States)

^c Massachusetts Institute of Technology   (United States)

Author keywords

affinity optimization; antibody affinity; antibody mutagenesis; computational affinity prediction; mutational database; protein interface design; protein protein interactions; scoring interface mutations; structure based modeling

Indexed keywords

ANTIBODY; PROTEIN;

ANTIBODY ENGINEERING; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CALCULATION; COMPLEX FORMATION; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENERGY; MUTAGENESIS; MUTANT; MUTATIONAL ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN DATABASE; PROTEIN FOLDING; PROTEIN FUNCTION; RECEIVER OPERATING CHARACTERISTIC; SCORING SYSTEM; SOLVATION; ANIMAL; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; BIOLOGICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HUMAN; IMMUNOLOGY; MUTATION; THERMODYNAMICS;

ANIMALS; ANTIBODIES; ANTIBODY AFFINITY; BINDING SITES, ANTIBODY; COMPUTER SIMULATION; DATABASES, PROTEIN; HUMANS; MODELS, IMMUNOLOGICAL; MUTATION; THERMODYNAMICS;

EID: 84978154328     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2829     Document Type: Article

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