Assessment of flexible backbone protein design methods for sequence library prediction in the therapeutic antibody Herceptin-HER2 interface

Protein Science

Volumn 20, Issue 6, 2011, Pages 1082-1089

  Babor, Mariana ^a,b,c   Mandell, Daniel J ^a,b   Kortemme, Tanja ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

Antibody; Backrub; Conformational ensemble; Flexible backbone; Kinematic closure; Library design; Molecular dynamics; Phage display; Protein design; Sequence space

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; PEPTIDE LIBRARY; TRASTUZUMAB;

AMINO ACID SEQUENCE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DRUG PROTEIN BINDING; GENE MUTATION; MOLECULAR DYNAMICS; MOLECULAR LIBRARY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; SIMULATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTOR, ERBB-2;

EID: 79956222955     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.632     Document Type: Article

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