Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 8, 2014, Pages 1646-1655

  Zhu, Kai ^a   Day, Tyler ^a   Warshaviak, Dora ^a   Murrett, Colleen ^b   Friesner, Richard ^b   Pearlman, David ^a  

^a SCHRÖDINGER INC   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Antibody engineering; Antibody modeling assessment; Antibody structure modeling; CDRs; Energy function; H3 loop; HCDR3; Loop prediction; Protein structure prediction

Indexed keywords

ANTIBODY STRUCTURE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; GEOMETRY; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; PROTEIN CONFORMATION; PROTEIN DATABASE; STRUCTURAL HOMOLOGY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ANTIBODY; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION;

ANIMALS; ANTIBODIES; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS;

EID: 84904460487     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24551     Document Type: Article

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