Immunity by equilibrium

Nature Reviews Immunology

Volumn 16, Issue 8, 2016, Pages 524-532

  Eberl, Gérard ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNITY; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; NATURAL KILLER T CELL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SUPPRESSOR CELL; TH1 CELL; THYMUS; ANIMAL; AUTOIMMUNITY; BIOLOGICAL MODEL; CYTOLOGY; DISEASE PREDISPOSITION; DISEASE RESISTANCE; HOMEOSTASIS; HOST PATHOGEN INTERACTION; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; IMMUNOMODULATION; METABOLISM;

ANIMALS; AUTOIMMUNITY; DISEASE RESISTANCE; DISEASE SUSCEPTIBILITY; HOMEOSTASIS; HOST-PATHOGEN INTERACTIONS; HUMANS; HYPERSENSITIVITY; IMMUNE SYSTEM; IMMUNE TOLERANCE; IMMUNITY; IMMUNOMODULATION; MODELS, BIOLOGICAL;

EID: 84978141968     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.75     Document Type: Review

References (144)

1. Burnet, F M., & Fenner, F. The Production of Antibodies 2nd edn (Macmillan and Co. 1949
2. Jerne, N. K. The somatic generation of immune recognition. Eur. J. Immunol. 1, 1-9 (1971
3. Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994
4. Pradeu, T., Jaeger, S., & Vivier, E. The speed of change: towards a discontinuity theory of immunity? Nat. Rev. Immunol. 13, 764-769 (2013
5. Jerne, N. K. The natural-selection theory of antibody formation. Proc. Natl Acad. Sci. USA 41, 849-857 (1955
6. Ehrlich, P in Nobel Lecture, December 11 1908 Elsevier Publishing Company, 1967
7. Burnet, F. M. The Clonal Selection Theory of Acquired Immunity (Vanderbilt Univ. Press 1959
8. Weigert, M. G., Cesari, I. M., Yonkovich, S. J., & Cohn, M. Variability in the lambda light chain sequences of mouse antibody. Nature 228, 1045-1047 (1970
9. Hozumi, N., & Tonegawa, S. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. Natl Acad. Sci. USA 73, 3628-3632 (1976
10. Bach, J. F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347, 911-920 (2002
11. Sansonetti, P. J. War and peace at mucosal surfaces. Nat. Rev. Immunol. 4, 953-964 (2004
12. Sansonetti, P. J., & Di Santo, J. P. Debugging how bacteria manipulate the immune response. Immunity 26, 149-161 (2007
13. Virgin, H. W., Wherry, E. J., & Ahmed, R. Redefining chronic viral infection. Cell 138, 30-50 (2009
14. Cahenzli, J., Koller, Y., Wyss, M., Geuking, M. B., & McCoy, K. D. Intestinal microbial diversity during early-life colonization shapes long-term IgE levels. Cell Host Microbe 14, 559-570 (2013
15. Metchnikoff, E Lectures on the Comparative Pathology of Inflammation Delivered at Pasteur Institute in 1891 (Dover Press 1989
16. Eberl, G. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol. 3, 450-460 (2010)
17. Jerne, N. K. Towards a network theory of the immune system. Ann. Immunol. (Paris) 125C, 373-389 (1974
18. Hoffmann, G. W. A theory of regulation and self-nonself discrimination in an immune network. Eur. J. Immunol. 5, 638-647 (1975
19. Rowley, D. A., Kohler, H., & Cowan, J. D. An immunologic network. Contemp. Top. Immunobiol. 9, 205-230 (1980
20. Gershon, R. K., & Kondo, K. Cell interactions in the induction of tolerance: the role of thymic lymphocytes. Immunology 18, 723-737 (1970
21. Gershon, R. K. A disquisition on suppressor T cells. Transplant Rev. 26, 170-185 1975
22. Germain, R. N. Maintaining system homeostasis: the third law of Newtonian immunology. Nat. Immunol. 13, 902-906 (2012
23. Bennett, C. L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20-21 (2001
24. Brunkow, M. E., et al. Disruption of a new forkhead/ winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68-73 (2001
25. Wildin, R. S., et al. X linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27, 18-20 (2001
26. Josefowicz, S. Z., Lu, L. F., & Rudensky, A. Y. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30, 531-564 (2012
27. Lochner, M., et al. In vivo equilibrium of proinflammatory IL 17+ and regulatory IL 10+ Foxp3+ RORγt+ T cells. J. Exp. Med. 205, 1381-1393 (2008
28. Mauri, C., & Bosma, A. Immune regulatory function of B cells. Annu. Rev. Immunol. 30, 221-241 (2012
29. Serafini, P., Borrello, I., & Bronte, V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin. Cancer Biol. 16, 53-65 (2006
30. Mosmann, T. R., & Coffman, R. L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989
31. Bettelli, E., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238 (2006
32. Harrington, L. E., et al. Interleukin 17 producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005
33. Matzinger, P. Friendly and dangerous signals: is the tissue in control? Nat. Immunol. 8, 11-13 (2007
34. Trinchieri, G., & Gerosa, F. Immunoregulation by interleukin 12. J. Leukoc. Biol. 59, 505-511 (1996
35. Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. Innate lymphoid cells: a new paradigm in immunology. Science 348, aaa6566 2015
36. Cua, D. J., et al. Interleukin 23 rather than interleukin 12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003
37. Sutton, C., Brereton, C., Keogh, B., Mills, K. H., & Lavelle, E. C. A crucial role for interleukin (IL)-1 in the induction of IL 17 producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203, 1685-1691 (2006
38. Klose, C S., et al. A T bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells. Nature 261-265 494 2013
39. Buonocore, S., et al. Innate lymphoid cells drive interleukin 23 dependent innate intestinal pathology. Nature 464, 1371-1375 (2010
40. Allen, J. E., & Sutherland, T. E. Host protective roles of type 2 immunity: parasite killing and tissue repair, flip sides of the same coin. Semin. Immunol. 26, 329-340 (2014
41. Saenz, S. A., Taylor, B. C., & Artis, D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol. Rev. 226, 172-190 (2008
42. Gordon, S., & Martinez, F. O. Alternative activation of macrophages: mechanism and functions. Immunity 32, 593-604 (2010
43. Knipper, J. A., et al. Interleukin 4 receptor α signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity 43, 803-816 (2015
44. Sadtler, K., et al. Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Science 352, 366-370 (2016
45. Tauber, A. I., & Chernyak, L. Metchnikoff and the Origins of Immunology: From Metaphor to Theory (Oxford Univ. Press
46. Besnard, A. G., et al. Dual role of IL 22 in allergic airway inflammation and its cross-talk with IL 17A. Am. J. Respir. Crit. Care Med. 183, 1153-1163 (2011
47. Matzinger, P., & Kamala, T. Tissue-based class control: the other side of tolerance. Nat. Rev. Immunol. 11, 221-230 (2011
48. Forrester, J. V., Xu, H., Kuffova, L., Dick, A. D., & McMenamin, P. G. Dendritic cell physiology and function in the eye. Immunol. Rev. 234, 282-304 (2010
49. Van der Sluis, M., et al. Muc2 deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131, 117-129 (2006
50. Vaishnava, S., et al. The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine. Science 334, 255-258 (2011
51. Mkaddem, S. B., et al. IgA, IgA receptors, and their anti-inflammatory properties. Curr. Top. Microbiol. Immunol. 382, 221-235 (2014
52. Macpherson, A. J., & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004
53. Koch, M. A., et al. The transcription factor T bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat. Immunol. 10, 595-602 (2009
54. Wohlfert, E. A., et al. GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice. J. Clin. Invest. 121, 4503-4515 (2011
55. Schiering, C., et al. The alarmin IL 33 promotes regulatory T cell function in the intestine. Nature 513, 564-568 (2014
56. Ohnmacht, C., et al. The microbiota regulates type 2 immunity through RORγt+ T cells. Science 349, 989-993 (2015
57. Wohlfert, E., & Belkaid, Y. Plasticity of Treg at infected sites. Mucosal Immunol. 3, 213-215 (2010
58. Sefik, E., et al. Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells. Science 349, 993-997 (2015
59. Hams, E., Locksley, R. M., McKenzie, A. N., & Fallon, P. G. Cutting edge: IL 25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice. J. Immunol. 191, 5349-5353 (2013
60. Molofsky, A. B., et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J. Exp. Med. 210, 535-549 (2013
61. Kim, H. Y., et al. Interleukin 17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat. Med. 20, 54-61 (2014
62. Bleriot, C., et al. Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type 2 mediated tissue repair during bacterial infection. Immunity 42, 145-158 (2015
63. Cannon, W. B. Organization for physiological homeostasis. Phys. Rev. IX 399-431 1929
64. Wick, G., et al. The immunology of fibrosis. Annu. Rev. Immunol. 31, 107-135 (2013
65. Geremia, A., et al. IL 23 responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127-1133 (2011
66. Wu, H. J., et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815-827 (2010
67. Van Praet, J. T., et al. Commensal microbiota influence systemic autoimmune responses. EMBO J. 34, 466-474 (2015
68. Theofilopoulos, A. N., Baccala, R., Beutler, B., & Kono, D. H. Type I interferons (α/β) in immunity and autoimmunity. Annu. Rev. Immunol. 23, 307-336 (2005
69. Prioult, G., & Nagler-Anderson, C. Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation? Immunol. Rev. 206, 204-218 (2005
70. von Mutius, E., & Vercelli, D. Farm living: effects on childhood asthma and allergy. Nat. Rev. Immunol. 10, 861-868 (2010
71. Foliaki, S., et al. Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. J. Allergy Clin. Immunol. 124, 982-989 (2009
72. Droste, J. H., et al. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin. Exp. Allergy 30, 1547-1553 (2000
73. Russell, S. L., et al. Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma. EMBO Rep. 13, 440-447 (2012
74. Olszak, T., et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336, 489-493 (2012
75. Hill, D. A., et al. Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat. Med. 18, 538-546 (2012
76. Kernbauer, E., Ding, Y., & Cadwell, K. An enteric virus can replace the beneficial function of commensal bacteria. Nature 516, 94-98 (2014
77. Moro, K., et al. Interferon and IL 27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nat. Immunol. 17, 76-86 (2016
78. Duerr, C. U., et al. Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells. Nat. Immunol. 17, 65-75 (2016
79. Thomas, S. A., & Palmiter, R. D. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 387, 94-97 (1997
80. Qiu, Y., et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308 (2014
81. Lee, M., et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160, 74-87 (2015
82. Brestoff, J. R., et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519, 242-246 (2015
83. Burcelin, R., Garidou, L., & Pomie, C. Immuno-microbiota cross and talk: the new paradigm of metabolic diseases. Semin. Immunol. 24, 67-74 (2012
84. Kim, K. A., Gu, W., Lee, I. A., Joh, E. H., & Kim, D. H. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS ONE 7, e47713 2012
85. Yang, J. Y., et al. Enteric viruses ameliorate gut inflammation via toll-like receptor 3 and toll-like receptor 7 mediated interferon-β production. Immunity 44, 889-900 (2016
86. Henry, T., et al. Type I IFN signaling constrains IL 17A/F secretion by γ? T cells during bacterial infections. J. Immunol. 184, 3755-3767 (2010
87. Wu, V., et al. Plasmacytoid dendritic cell-derived IFNα modulates Th17 differentiation during early Bordetella pertussis infection in mice. Mucosal Immunol. 9, 777-786 (2016
88. Chong, W. P., et al. NK DC crosstalk controls the autopathogenic Th17 response through an innate IFN- γ IL 27 axis. J. Exp. Med. 212, 1739-1752 (2015
89. Finlay, C. M., et al. Helminth products protect against autoimmunity via innate type 2 cytokines IL 5 and IL 33, which promote eosinophilia. J. Immunol. 196, 703-714 (2016
90. Reddy, A., & Fried, B. An update on the use of helminths to treat Crohn s and other autoimmunune diseases. Parasitol. Res. 104, 217-221 (2009
91. Gaboriau-Routhiau, V., et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31, 677-689 (2009
92. Ivanov, I. I., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009
93. Kriegel, M. A., et al. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc. Natl Acad. Sci. USA 108, 11548-11553 (2011
94. Sofi, M. H., et al. pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes 63, 632-644 (2014
95. Barton, E. S., et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447, 326-329 (2007
96. Navarini, A. A., et al. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc. Natl Acad. Sci. USA 103, 15535-15539 (2006
97. Alonso, J. M., et al. A model of meningococcal bacteremia after respiratory superinfection in influenza A virus-infected mice. FEMS Microbiol. Lett. 222, 99-106 (2003
98. McCullers, J. A. The co pathogenesis of influenza viruses with bacteria in the lung. Nat. Rev. Microbiol. 12, 252-262 (2014
99. Osborne, L. C., et al. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science 345, 578-582 (2014)
100. Baldridge, M. T., et al. Commensal microbes and interferon-α determine persistence of enteric murine norovirus infection. Science 347, 266-269 (2015
101. Skov, M., Poulsen, L. K., & Koch, C. Increased antigen-specific Th 2 response in allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis. Pediatr. Pulmonol 27, 74-79 (1999
102. Margalit, A., & Kavanagh, K. The innate immune response to Aspergillus fumigatus at the alveolar surface. FEMS Microbiol. Rev. 39, 670-687 (2015
103. Coffelt, S. B., et al. IL 17 producing γ? T cells and neutrophils conspire to promote breast cancer metastasis. Nature 522, 345-348 (2015
104. Yu, P., et al. Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J. Exp. Med. 201, 779-791 (2005
105. Coffman, R. L., Lebman, D. A., & Shrader, B. Transforming growth factor β specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J. Exp. Med. 170, 1039-1044 (1989
106. Shalapour, S., et al. Immunosuppressive plasma cells impede T cell-dependent immunogenic chemotherapy. Nature 521, 94-98 (2015
107. Sprent, J., Lo, D., Gao, E. K., & Ron, Y. T cell selection in the thymus. Immunol. Rev. 101, 173-190 (1988
108. Kisielow, P., Bluthmann, H., Staerz, U. D., Steinmetz, M., & von Boehmer, H. Tolerance in T cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333, 742-746 (1988
109. Vukmanovic, S., Bevan, M. J., & Hogquist, K. A. The specificity of positive selection: MHC and peptides. Immunol. Rev. 135, 51-66 (1993
110. Jordan, M. S., et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301-306 (2001
111. Annacker, O., Pimenta-Araujo, R., Burlen-Defranoux, O., & Bandeira, A. On the ontogeny and physiology of regulatory T cells. Immunol. Rev. 182, 5-17 (2001
112. Sakaguchi, S., et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182, 18-32 (2001
113. Feuerer, M., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009
114. Kolodin, D., et al. Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell. Metab. 21, 543-557 (2015
115. Arpaia, N., et al A distinct function of regulatory T cells in tissue protection. Cell 162 1078-1089 2015
116. Streilein, J. W. Neonatal tolerance: towards an immunogenetic definition of self. Immunol. Rev. 46, 123-146 (1979
117. Wu, H. Y., & Weiner, H. L. Oral tolerance. Immunol. Res. 28, 265-284 (2003
118. Cerutti, A., Chen, K., & Chorny, A. Immunoglobulin responses at the mucosal interface. Annu. Rev. Immunol. 29, 273-293 (2011
119. Lochner, M., et al. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells. J. Exp. Med. 208, 125-134 (2011
120. Datta, S. K., et al. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc. Natl Acad. Sci. USA 107, 10638-10643 (2010
121. Snider, D. P., Marshall, J. S., Perdue, M. H., & Liang, H. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153, 647-657 (1994
122. Coley, W. B. The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin Orthop Relat Res, 3-11 (1991
123. Tsung, K., & Norton, J. A. Lessons from Coley s Toxin. Surg. Oncol. 15, 25-28 (2006
124. Silverstein, M. J., DeKernion, J., & Morton, D. L. Malignant melanoma metastatic to the bladder. Regression following intratumor injection of BCG vaccine. JAMA 229, 688 (1974
125. Solt, L. A., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472, 491-494 (2011
126. Huh, J. R., et al. Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature 472, 486-490 (2011
127. Hammad, H., et al. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med. 15, 410-416 (2009
128. Finlay, C. M., Walsh, K. P., & Mills, K. H. Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases. Immunol. Rev. 259, 206-230 (2014
129. Weinstock, J. V., & Elliott, D. E. Helminth infections decrease host susceptibility to immune-mediated diseases. J. Immunol. 193, 3239-3247 (2014
130. Driss, V., et al. The schistosome glutathione S transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2 type response with mucosal eosinophils. Mucosal Immunol. 9, 322-335 (2015
131. Janeway, C. A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 1989. 54: 1-13 J. Immunol. 191, 4475-4487 (2013
132. Zhu, J., & Paul, W. E. Peripheral CD4+ T cell differentiation regulated by networks of cytokines and transcription factors. Immunol. Rev. 238, 247-262 (2010
133. Serafini, N., Vosshenrich, C. A., & Di Santo, J. P. Transcriptional regulation of innate lymphoid cell fate. Nat. Rev. Immunol. 15, 415-428 (2015
134. Ivanov, I. I., et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL 17+ T helper cells. Cell 126, 1121-1133 (2006
135. Ciofani, M., et al A validated regulatory network for Th17 cell specification. Cell 151 289-303 2012
136. Usui, T., et al. T bet regulates Th1 responses through essential effects on GATA 3 function rather than on IFNG gene acetylation and transcription. J. Exp. Med. 203, 755-766 (2006
137. Mukasa, R., et al. Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity 32, 616-627 (2010
138. Milner, J. D., et al. Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452, 773-776 (2008
139. Minegishi, Y., et al. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature 448, 1058-1062 (2007
140. Rudra, D., et al. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat. Immunol. 13, 1010-1019 (2012
141. Zhou, L., et al. TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function. Nature 453, 236-240 (2008
142. Tindemans, I., Serafini, N., Di Santo, J. P., & Hendriks, R. W. GATA 3 function in innate and adaptive immunity. Immunity 41, 191-206 (2014
143. Yagi, R., et al. The transcription factor GATA3 is critical for the development of all IL 7Rα expressing innate lymphoid cells. Immunity 40, 378-388 (2014
144. Zhong, C., et al. Group 3 innate lymphoid cells continuously require the transcription factor GATA 3 after commitment. Nat. Immunol. 17, 169-178 (2016