Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline

Nature

Volumn 387, Issue 6628, 1997, Pages 94-97

  Thomas, Steven A ^a   Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; NORADRENALIN;

ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; ENERGY BALANCE; LIPID METABOLISM; METABOLIC REGULATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THERMOGENESIS; THERMOREGULATION;

EID: 0030991928     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/387094a0     Document Type: Article

References (25)

1. Landsberg, L. & Young, J. B. Catecholamines and the adrenal medulla. in Williams Textbook of Endocrinology 8th edn (eds Wilson, J. D. & Foster, D. W.) 621-705 (W.B. Saunders, Philadelphia, 1992).
2. 2-noradrenergic receptors mediate feeding induced by paraventricular nucleus injection of norepinephrine and clonidine. Eur. J. Pharmacol. 115, 11-19 (1985).
3. Nicholls, D. G. & Locke, R. M. Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64 (1984).
4. Klaus, S., Casteilla, L., Bouillard, F. & Ricquier, D. The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int. J. Biochem. 23, 791-801 (1991).
5. Rothwell, N. J. & Stock, M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35 (1979).
6. Brooks, S. L. et al. Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 286, 274-276(1980).
7. Glick, Z., Teague, R. J. & Bray, G. A. Brown adipose tissue: thermogenic response increased by a single low protein, high carbohydrate meal. Science 213, 1125-1127 (1981).
8. Jung, R. T., Shetty, P. S., James, W. P. T., Barrand, M. A. & Callingham, B. A. Reduced thermogenesis in obesity. Nature 279, 322-323 (1979).
9. Bray, G. A., York, D. A. & Fisler, J. S. Experimental obesity: a homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system. Vitam. Horm. 45, 1-125 (1989).
10. Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
11. Hamann, A., Flier, J. S. & Lowell, B. B. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137, 21-29 (1996).
12. Susulic, V. S. et al. Targeted disruption of the β-adrenergk receptor gene. J. Biol. Chem. 270, 29483-29492 (1995).
13. Thomas, S. A., Matsumoto, A. M. & Palmiter, R. D. Noradrenaline is essential for mouse fetal development. Nature 374, 643-646 (1995).
14. Silva, J. E. Full expression of uncoupling protein gene requires the concurrence of norepinephrine and triiodothyronine. Mol. Endocrinol. 2, 706-713 (1988).
15. Geloen, A., Collet, A. J., Guay, G. & Bukowiecki, L. J. β-adrenergic stimulation of brown adipocyte proliferation. Am. J. Physiol. 254, C175-C182 (1988).
16. Enerbäck, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997).
17. Larson, P. R. & Ingbar, S. H. The thyroid gland. In Williams Textbook of Endocrinology 8th edn 357-488 (eds Wilson, J. D. & Foster, D. W.) (W.B. Saunders, Philadelphia, 1992).
18. Fleury, C. et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genet. 15, 269-273 (1997).
19. Siviy, S. M., Kritikos, A., Atrens, D. M. & Shepherd, A. Effects of norepinephrine infused in the paraventricular hypothalamus on energy expenditure in the rat. Brain Res. 487, 79-88 (1989).
20. 2 adrenoceptors and energy balance. Brain Res. Bull. 26, 683-691 (1991).
21. Zolovick, A. J., Rossi III, J., Davies, R. F. & Panksepp, J. An improved pharmacoogical procedure for depletion of noradrenaline: pharmacoogy and assessment of noradrenaline-associated behaviors. Eur. J. Pharmacol. 77, 265-271 (1982).
22. Himms-Hagen, J. Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: a new hypothesis that links thermostatic and glucostatic hypotheses for control of food intake. Proc. Soc. Exp. Biol. Med. 208, 159-169 (1995).
23. Erickson, J. C., Clegg, K. E. & Palmiter, R. D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415-418 (1996).
24. Leibowitz, S. F. Brain neuropeptide Y: an integrator of endocrine, metabolic and behavioral processes. Brain Res. Bull. 27, 333-337 (1991).
25. Ahren, B., Mansson, S., Gingerich, R. L. & Havel, P. J. Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am. J. Physiol. (in the press).