Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide

European Heart Journal

Volumn 35, Issue 14, 2014, Pages 904-910

  Wang, Zeneng ^a   Tang, W H Wilson ^a   Buffa, Jennifer A ^a   Fu, Xiaoming ^a   Britt, Earl B ^a   Koeth, Robert A ^a   Levison, Bruce S ^a   Fan, Yiying ^b   Wu, Yuping ^b   Hazen, Stanley L ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

Cardiovascular disease; Choline; Gut microbiota; Myocardial infarction; Nutrition

Indexed keywords

BETAINE; C REACTIVE PROTEIN; CHOLINE; TRIMETHYLAMINE OXIDE; METHYLAMINE; TRIMETHYLOXAMINE;

ADULT; ADVERSE OUTCOME; ANGIOCARDIOGRAPHY; ANIMAL EXPERIMENT; CARDIAC PATIENT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; FEMALE; HEART INFARCTION; HUMAN; INTESTINE FLORA; MAJOR CLINICAL STUDY; MALE; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; REVIEW; ANIMAL; INTESTINE; KAPLAN MEIER METHOD; METABOLISM; MICROFLORA; MIDDLE AGED; MORTALITY; PHYSIOLOGY; PROCEDURES; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR;

ANIMALS; BETAINE; CARDIOVASCULAR DISEASES; CHOLINE; FEMALE; HUMANS; INTESTINES; KAPLAN-MEIER ESTIMATE; MALE; METHYLAMINES; MICE; MICROBIOTA; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS;

EID: 84898859680     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu002     Document Type: Review

References (24)

1. Pinotti L, Rebucci R, Fusi E, Rossi L, Baldi A. Milk choline, alpha-tocopherol and neu-trophil chemotaxis in the periparturient dairy cow. Vet Res Commun 2003;27(Suppl. 1):265-268.
2. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev 2009;67:615-623.
3. Chu DM, Wahlqvist ML, Chang HY, Yeh NH, Lee MS. Choline and betaine food sources and intakes in Taiwanese. Asia Pac J Clin Nutr 2012;21:547-557.
4. Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res 2008;49: 1187-1194.
5. Zeisel SH. Dietary choline deficiency causes DNA strand breaks and alters epigen-etic marks on DNA and histones. Mutat Res 2012;733:34-38.
6. Paoletti L, Elena C, Domizi P, Banchio C. Role of phosphatidylcholine during neur-onal differentiation. IUBMB Life 2011;63:714-720.
7. Glunde K, Jacobs MA, Bhujwalla ZM. Choline metabolism in cancer: implications for diagnosis and therapy. Expert Rev Mol Diagn 2006;6:821-829.
8. Detopoulou P, Panagiotakos DB, Antonopoulou S, Pitsavos C, Stefanadis C. Dietary choline and betaine intakesin relation to concentrationsof inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr 2008;87:424-430.
9. Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G. Repeatability and measurement error in the assessment ofcholine and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study. Nutr J 2009;8:14.
10. Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G. Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord 2007;7:20.
11. Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci USA 2008;105: 2117-2122.
12. Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK. Metabolic profiling reveals a contribution of gut micro-biota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 2006; 103:12511-6.
13. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI. A core gut microbiome in obese and lean twins. Nature 2009;457: 480-484.
14. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011;472:57-63.
15. Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab 2013;17:49-60.
16. Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, Didonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013; 19:576-585.
17. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013;368:1575-1584.
18. Body R, Griffith CA, Keevil B, McDowell G, Carley S, Ferguson J, Mackway-Jones K. Choline for diagnosis and prognosticationofacute coronary syndromesinthe Emergency Department. Clin Chim Acta 2009;404:89-94.
19. Danne O, Lueders C, Storm C, Frei U, Mockel M. Whole blood choline and plasma choline in acute coronary syndromes: prognostic and pathophysiological implications. Clin Chim Acta 2007;383:103-109.
20. Danne O, Mockel M, Lueders C, Mugge C, Zschunke GA, Lufft H, Muller C, Frei U. Prognostic implications of elevated whole blood choline levels in acute coronary syndromes. Am J Cardiol 2003;91:1060-1067.
21. LeLeiko RM, Vaccari CS, Sola S, Merchant N, Nagamia SH, Thoenes M, Khan BV. Usefulness of elevations in serum choline and free F2-isoprostane to predict 30-day cardiovascular outcomes in patients with acute coronary syndrome. Am J Cardiol 2009; 104:638-643.
22. Moller B, Hippe H, Gottschalk G. Degradation of various amine compounds by mesophilic clostridia. Arch Microbiol 1986;145:85-90.
23. Zhang AQ, Mitchell SC, Smith RL. Dietary precursors of trimethylamine in man: a pilot study. Food Chem Toxicol 1999;37:515-520.
24. Robinson BS, Snoswell AM, Setchell BP. The enterohepatic recycling of bile choline in sheep. Comp Biochem Physiol A Comp Physiol 1987;88:283-289.